Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

A rational designed multi-epitope vaccine elicited robust protective efficacy against Klebsiella pneumoniae lung infection
CONCLUSIONS: These findings suggest that mHla-EpiVac is a promising vaccine candidate against K. pneumoniae, and further validate the potential of mHla as a versatile carrier protein and adjuvant for antigen design.PMID:38643540 | DOI:10.1016/j.biopha.2024.116611 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 21, 2024 Category: Drugs & Pharmacology Authors: Jingwen Liao Xiaoli Zhang Xi Zeng Zhuo Zhao Tianjun Sun Zhenping Xia Haiming Jing Yue Yuan Zhifu Chen Qiang Gou Liqun Zhao Weijun Zhang Quanming Zou Jinyong Zhang Source Type: research

Tumor-associated carbohydrate antigens of MUC1 - Implication in cancer development
Biomed Pharmacother. 2024 Apr 20;174:116619. doi: 10.1016/j.biopha.2024.116619. Online ahead of print.ABSTRACTGlycosylation of cancerous epithelial MUC1 protein is specifically altered in comparison to that which is presented by healthy cells. One of such changes is appearing tumor-associated carbohydrate antigens (TACAs) which are rare in normal tissues and are highly correlated with poor clinical outcomes and cancer progression. This review summarizes and describes the role of Tn, T antigens, their sialylated forms as well as fucosylated Lewis epitopes in different aspects of tumor development, progression, and metastasi...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 21, 2024 Category: Drugs & Pharmacology Authors: Iwona Radziejewska Source Type: research

A high-dose of ursodeoxycholic acid treatment alleviates liver inflammation by remodeling gut microbiota and bile acid profile in a mouse model of non-alcoholic steatohepatitis
In conclusion, a high dosage of UDCA can alleviate liver inflammation, probably by modifying the composition of gut microbiota and serum bile acid profiles in NASH mice.PMID:38643542 | DOI:10.1016/j.biopha.2024.116617 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 21, 2024 Category: Drugs & Pharmacology Authors: Hu Li Mingjie Wang Peizhan Chen Mingyu Zhu Li Chen Source Type: research

Salidroside promotes angiogenesis after cerebral ischemia in mice through Shh signaling pathway
Biomed Pharmacother. 2024 Apr 20;174:116625. doi: 10.1016/j.biopha.2024.116625. Online ahead of print.ABSTRACTAIMS: The purpose of this study was to explore the impacts of salidroside on vascular regeneration, vascular structural changes and long-term neurological recuperation following cerebral ischemia and its possible mechanism.MAIN METHODS: From Day 1 to Day 28, young male mice with middle cerebral artery blockage received daily doses of salidroside and measured neurological deficits. On the 7th day after stroke, the volume of cerebral infarction was determined using TTC and HE staining. Microvascular density, astrocyt...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 21, 2024 Category: Drugs & Pharmacology Authors: Ying Li Weihong Xue Songyi Li Lili Cui Yuxiao Gao Linlin Li Rong Chen Xiao Zhang Renhao Xu Wei Jiang Xiangjian Zhang Lina Wang Source Type: research

Zhen-Wu-Tang ameliorates lupus nephritis by diminishing renal tissue-resident memory CD8 < sup > + < /sup > T cells via suppressing IL-15/STAT3 pathway
Biomed Pharmacother. 2024 Apr 20;174:116597. doi: 10.1016/j.biopha.2024.116597. Online ahead of print.ABSTRACTZhen-Wu-Tang (ZWT), a conventional herbal mixture, has been recommended for treating lupus nephritis (LN) in clinic. However, its mechanisms of action remain unknown. Here we aimed to define the immunological mechanisms underlying the effects of ZWT on LN and to determine whether it affects renal tissue-resident memory T (TRM) cells. Murine LN was induced by a single injection of pristane, while in vitro TRM cells differentiated with IL-15/TGF-β. We found that ZWT or mycophenolate mofetil treatment significantly a...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 21, 2024 Category: Drugs & Pharmacology Authors: Chun-Ling Liang Yu-Yan Wei Yi Chen Yini Luo Fenglian Qin Yuchao Chen Huazhen Liu Feifei Qiu Junbiao Wu Bin Yang Yuntao Liu Zhenhua Dai Source Type: research

919 granules improve postpartum depression through the regulation of abnormal peripheral blood IL-1 β
In this study, we collected peripheral blood from both healthy postpartum women and those with PPD, conducted single cell RNA sequencing (scRNA-seq), and used an in-house analytical tool scSTAR to reveal that PPD patients exhibit elevated proportions of peripheral blood cDC2 and Proliferation B cells, which are significantly correlated with IL-1β. Additionally, animal experiments were designed to validate that 919 granules can improve PPD by modulating the levels of peripheral blood IL-1β, providing a potential therapeutic mechanism for PPD treatment.PMID:38643545 | DOI:10.1016/j.biopha.2024.116623 (Source: Biomedicine a...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 21, 2024 Category: Drugs & Pharmacology Authors: Shusheng Wang Yan Zhao Zhicheng Yang Yujun Liu Ru Xu Ruoxin Tu Songping Liu Xin Zou Lan Zhang Jie Hao Pengfei Gao Source Type: research

Conjugation of sulpiride with a cell penetrating peptide to augment the antidepressant efficacy and reduce serum prolactin levels
In conclusion, VPALR-SUL exhibited potential for enhancing sulpiride transport across the BBB, augmenting its antidepressant effects, and reducing serum prolactin levels. This study laid a foundation for improving sulpiride delivery and developing novel antidepressants.PMID:38642503 | DOI:10.1016/j.biopha.2024.116610 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 20, 2024 Category: Drugs & Pharmacology Authors: Yuan Liang Yu Yang Ruiyan Huang Jiangyue Ning Xingyan Bao Zelong Yan Haotian Chen Li Ding Chang Shu Source Type: research

Theabrownin from Qingzhuan tea prevents high-fat diet-induced MASLD via regulating intestinal microbiota
Biomed Pharmacother. 2024 Apr 19;174:116582. doi: 10.1016/j.biopha.2024.116582. Online ahead of print.ABSTRACTThe aim of this study was to investigate whether the therapeutic effect of theabrownin extracted from Qingzhuan tea (QTB) on metabolic dysfunction-associated steatosis liver disease (MASLD) is related to the regulation of intestinal microbiota and its metabolite short-chain fatty acids (SCFAs). Mice were divided into four groups and received normal diet (ND), high-fat diet (HFD) and HFD+QTB (180, 360 mg/kg) for 8 weeks. The results showed that QTB significantly reduced the body weight of HFD mice, ameliorated liver...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 20, 2024 Category: Drugs & Pharmacology Authors: Yong Chen Chen Xie Yining Lei Dan Ye Le Wang Fang Xiong Hui Wu Qiang He Hongfu Zhou Ling Li Jun Xing Cai Wang Min Zheng Source Type: research

Role of ghrelin hormone in the development of alcohol-associated liver disease
In this study, we used a ghrelin receptor (GHSR) knockout (KO) rat model to characterize the specific contribution of ghrelin in the development of ALD with emphasis on energy homeostasis. Male Wistar wild type (WT) and GHSR-KO rats were pair-fed the Lieber-DeCarli control or ethanol diet for 6 weeks. At the end of the feeding period, glucose tolerance test was conducted, and tissue samples were collected. We observed reduced alcohol intake by GHSR-KOs compared to a previous study where WT rats were fed ethanol diet ad libitum. Further, when the WTs were pair-fed to GHSR-KOs, the KO rats exhibited resistance to develop ALD...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 19, 2024 Category: Drugs & Pharmacology Authors: Sundararajan Mahalingam Ramesh Bellamkonda Kusum K Kharbanda Madan Kumar Arumugam Vikas Kumar Carol A Casey Lorenzo Leggio Karuna Rasineni Source Type: research

Hydrogels containing KYNA promote angiogenesis and inhibit inflammation to improve the survival rate of multi-territory perforator flaps
CONCLUSION: KYNA-PF127 promotes angiogenesis through its antioxidant stress and anti-inflammatory effects, and shows potential clinical value in promoting the survival viability and drug delivery of multi-territory perforator flaps.PMID:38640710 | DOI:10.1016/j.biopha.2024.116454 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 19, 2024 Category: Drugs & Pharmacology Authors: Ya-Wei Zhang Xiaoyang Pang Yan Yang Source Type: research

Improving the mechanical and biological functions of cell sheet constructs: The interplay of human-derived periodontal ligament stem cells, endothelial cells and plasma rich in growth factors
CONCLUSIONS: hPDLSCs' triple-layer construct onto mPRGF emerges as the optimal structure for its use in regenerative therapeutics.CLINICAL RELEVANCE: These results suggest the suitability of mPRGF as a promising tool to support cell sheet formation by improving their handling and biological functions.PMID:38640711 | DOI:10.1016/j.biopha.2024.116599 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 19, 2024 Category: Drugs & Pharmacology Authors: Eduardo Anitua Mar ía Troya Mar Zalduendo Roberto Tierno Mohammad H Alkhraisat Nerea Osinalde Asier Fullaondo Ana M Zubiaga Source Type: research

Construction of preclinical evidence for propofol in the treatment of reperfusion injury after acute myocardial infarction: A systematic review and meta-analysis
This study presents a comprehensive analysis of 48 relevant animal studies investigating propofol's preventive effects on MIRI. Propofol administration demonstrated a reduction in myocardial IS and decreased levels of myocardial injury biomarkers (CK-MB, LDH, cTnI). Moreover, propofol improved myocardial function parameters (+dp/dtmax, -dP/dtmax, LVEF, LVFS), exhibited favorable effects on inflammatory markers (IL-6, TNF-α) and oxidative stress markers (SOD, MDA), and reduced myocardial cell apoptotic index (AI). These findings suggest propofol exerts cardioprotective effects by reducing myocardial injury, decreasing infa...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 19, 2024 Category: Drugs & Pharmacology Authors: Tao Li Yanwei Li Yiwei Zeng Xin Zhou Su Zhang Yulan Ren Source Type: research

Interaction of selected alkoxy naringenin oximes with model and bacterial membranes
Biomed Pharmacother. 2024 Apr 16;174:116581. doi: 10.1016/j.biopha.2024.116581. Online ahead of print.ABSTRACTNaringenin is a flavonoid found in many fruits and herbs, most notably in grapefruits. In recent years, this compound and its derivatives have been of great interest due to their high biological activity, including fungicidal and bactericidal effects, also in relation to multidrug-resistant bacteria. Membrane interactions of naringenin oxime (NO) and its 7-O-alkyl (7-alkoxy) derivatives, such as methyl (7MENO), ethyl (7ETNO), isopropyl (7IPNO), n-butyl (7BUNO) and n-pentyl (7PENO) were studied. Thermotropic propert...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 18, 2024 Category: Drugs & Pharmacology Authors: Olga Weso łowska Anna Duda-Madej Maria B łaszczyk Kamila Środa-Pomianek Joanna Koz łowska Miros ław Anioł Source Type: research

Intratumoural delivery of TRAIL mRNA induces colon cancer cell apoptosis
Biomed Pharmacother. 2024 Apr 17;174:116603. doi: 10.1016/j.biopha.2024.116603. Online ahead of print.ABSTRACTNovel strategies in intratumoral injection and emerging immunotherapies have heralded a new era of precise cancer treatments. The affinity of SARS-CoV-2 to ACE2 receptors, a feature which facilitates virulent human infection, is leveraged in this research. Colon cancer cells, with their high ACE2 expression, provide a potentially strategic target for using this SARS-CoV-2 feature. While the highly expression of ACE2 is observed in several cancer types, the idea of using the viral spike protein for targeting colon c...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 18, 2024 Category: Drugs & Pharmacology Authors: Tingxuan Gu Mengqiao Wang Xiaorong Fu Xueli Tian Juanjuan Bi Ning Lu Chen Chen Shijia Yan Ang Li Luyun Wang Xiang Li Kangdong Liu Zigang Dong Source Type: research

Identification of Riluzole derivatives as novel calmodulin inhibitors with neuroprotective activity by a joint synthesis, biosensor, and computational guided strategy
Biomed Pharmacother. 2024 Apr 17;174:116602. doi: 10.1016/j.biopha.2024.116602. Online ahead of print.ABSTRACTThe development of new molecules for the treatment of calmodulin related cardiovascular or neurodegenerative diseases is an interesting goal. In this work, we introduce a novel strategy with four main steps: (1) chemical synthesis of target molecules, (2) Förster Resonance Energy Transfer (FRET) biosensor development and in vitro biological assay of new derivatives, (3) Cheminformatics models development and in vivo activity prediction, and (4) Docking studies. This strategy is illustrated with a case study. First...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 18, 2024 Category: Drugs & Pharmacology Authors: Maider Baltasar-Marchueta Leire Llona Sara M-Alicante Iratxe Barbolla Markel Garcia Ibarluzea Rafael Ramis Ane Miren Salomon Brenda Fundora Ariane Araujo Arantza Muguruza-Montero Eider Nu ñez Scarlett P érez-Olea Christian Villanueva Aritz Leonardo Soni Source Type: research