A comparative in vitro and in vivo analysis of the impact of copper substitution on the cytocompatibility, osteogenic, and angiogenic properties of a borosilicate bioactive glass
J Biomed Mater Res A. 2024 Apr 15. doi: 10.1002/jbm.a.37721. Online ahead of print.ABSTRACTThe 0106-B1-bioactive glass (BG) composition (in wt %: 37.5 SiO2, 22.6 CaO, 5.9 Na2O, 4.0 P2O5, 12.0 K2O, 5.5 MgO, and 12.5 B2O3) has demonstrated favorable processing properties and promising bone regeneration potential. The present study aimed to evaluate the biological effects of the incorporation of highly pro-angiogenic copper (Cu) in 0106-B1-BG in vitro using human bone marrow-derived mesenchymal stromal cells (BMSCs) as well as its in vivo potential for bone regeneration. CuO was added to 0106-B1-BG in exchange for CaO, result...
Source: Biomed Res - April 16, 2024 Category: Research Authors: Linn Anna Fiehn Elke Kunisch Merve Saur Marcela Arango-Ospina Christian Merle S ébastien Hagmann Adrian Stiller Leena Hupa Hana Ka ňková Dagmar Galuskov á Tobias Renkawitz Aldo R Boccaccini Fabian Westhauser Source Type: research
Collagen-polyurethane-dextran hydrogels enhance wound healing by inhibiting inflammation and promoting collagen fibrillogenesis
J Biomed Mater Res A. 2024 Apr 15. doi: 10.1002/jbm.a.37724. Online ahead of print.ABSTRACTDiabetic foot ulcers are a serious complication of uncontrolled diabetes, emphasizing the need to develop wound healing strategies that are not only effective but also biocompatible, biodegradable, and safe. We aimed to create biomatrices composed of semi-interpenetrated polymer networks of collagen, polyurethane, and dextran, to enhance the wound healing process. The hydrogels were extensively characterized by various analytical techniques, including analysis of their structure, crystallinity, thermal properties, gelation process, r...
Source: Biomed Res - April 16, 2024 Category: Research Authors: Hilda Aguayo-Morales Luis E Cobos-Puc Claudia M Lopez-Badillo Ernesto Oyervides-Mu ñoz Gonzalo Ram írez-García Jes ús A Claudio-Rizo Source Type: research
Methicillin-Resistant < em > Staphylococcus aureus < /em > Carriage among Neonate Mothers, Healthcare Workers, and Environmental Samples in Neonatal Intensive Care Units: A Systematic Review
CONCLUSION: With a significant heterogeneity, our systematic review found high MRSA carriage rates in neonate mothers, healthcare workers, and across various environmental surfaces in NICUs, posing a potential risk of nosocomial infections. Urgent interventions, including regular screening and decolonization of MRSA carriers, reinforcing infection control measures, and enhancing cleaning and disinfection procedures within NICUs, are crucial. This trial is registered with CRD42023407114.PMID:38623471 | PMC:PMC11018372 | DOI:10.1155/2024/5675786 (Source: Biomed Res)
Source: Biomed Res - April 16, 2024 Category: Research Authors: Nene Kaah Keneh Sebastien Kenmoe Arnol Bowo-Ngandji Jane-Francis Tatah Kihla Akoachere Hortense Gonsu Kamga Roland Ndip Ndip Jean Thierry Ebogo-Belobo Cyprien Kengne-Nd é Donatien Serge Mbaga Nicholas Tendongfor Jean Paul Assam Assam Lucy Mande Ndip Sera Source Type: research
Correction to "Suspended graphene oxide nanoparticle for accelerated multilayer osteoblast attachment"
J Biomed Mater Res A. 2024 Apr 15. doi: 10.1002/jbm.a.37717. Online ahead of print.NO ABSTRACTPMID:38619237 | DOI:10.1002/jbm.a.37717 (Source: Biomed Res)
Source: Biomed Res - April 15, 2024 Category: Research Source Type: research
In vitro evaluation of bone cell response to novel 3D-printable nanocomposite biomaterials for bone reconstruction
J Biomed Mater Res A. 2024 Apr 15. doi: 10.1002/jbm.a.37719. Online ahead of print.ABSTRACTCritically-sized segmental bone defects represent significant challenges requiring grafts for reconstruction. 3D-printed synthetic bone grafts are viable alternatives to structural allografts if engineered to provide appropriate mechanical performance and osteoblast/osteoclast cell responses. Novel 3D-printable nanocomposites containing acrylated epoxidized soybean oil (AESO) or methacrylated AESO (mAESO), polyethylene glycol diacrylate, and nanohydroxyapatite (nHA) were produced using masked stereolithography. The effects of volume ...
Source: Biomed Res - April 15, 2024 Category: Research Authors: Zahra Haghpanah Dibakar Mondal Nikan Momenbeitollahi Sadaf Mohsenkhani Kiyoumars Zarshenas Yutong Jin Michael Watson Thomas Willett Maud Gorbet Source Type: research
Identification of Novel Molecular and Clinical Biomarkers of Survival in Glioblastoma Multiforme Patients: A Study Based on The Cancer Genome Atlas Data
This study is aimed at investigating the genetic alterations and clinical features of GBM patients to find predictors of survival. GBM patients' methylation and gene expression data along with clinical information from TCGA were retrieved. The most overrepresented pathways were identified independently for each omics dataset. From the genes found in at least 30% of these pathways, one gene that was identified in both sets was further examined using the Kaplan-Meier method for survival analysis. Additionally, three groups of patients who started radio and chemotherapy at different times were identified, and the influence of...
Source: Biomed Res - April 12, 2024 Category: Research Authors: Lu ísa Esteves Francisco Caramelo Domingos Roda Isabel Marques Carreira Joana Barbosa Melo Ilda Patr ícia Ribeiro Source Type: research
Bonding Effectiveness of Saliva-Contaminated Monolithic Zirconia Ceramics Using Different Decontamination Protocols
CONCLUSIONS: Universal cleaning agents can be preferred as an efficient cleaning method with 10-MDP-containing cement after saliva contamination for better adhesive bond strength of 4 mm crown preparation height of monolithic zirconia ceramics.PMID:38606199 | PMC:PMC11008971 | DOI:10.1155/2024/6670159 (Source: Biomed Res)
Source: Biomed Res - April 12, 2024 Category: Research Authors: Necla Demir Ozge Genc Ipek Balevi Akkese Meral Arslan Malkoc Mutlu Ozcan Source Type: research
Effect of radiation cross-linked collagen scaffold in alveolar ridge preservation of extraction socket
This study aimed to evaluate the properties of radiation cross-linked collagen scaffold (RCS) and its efficacy for alveolar ridge preservation (ARP). RCS was prepared from collagen dispersion by electron beam irradiation and freeze-drying. The microstructure, swelling ratio, area alteration and mechanical properties of RCS were characterized. Fifty-four New Zealand rabbits performing incisor extraction on maxilla and mandible were randomly assigned into positive, sham operation or treatment groups. Micro-computed tomography (micro-CT) scans, performed after 1, 4, and 12 weeks of surgery, were to assess changes in ridge hei...
Source: Biomed Res - April 12, 2024 Category: Research Authors: Hongwei Li Chen Yang Gong Chen Bozhao Wang Jian Li Ling Xu Source Type: research
Identification of Novel Molecular and Clinical Biomarkers of Survival in Glioblastoma Multiforme Patients: A Study Based on The Cancer Genome Atlas Data
This study is aimed at investigating the genetic alterations and clinical features of GBM patients to find predictors of survival. GBM patients' methylation and gene expression data along with clinical information from TCGA were retrieved. The most overrepresented pathways were identified independently for each omics dataset. From the genes found in at least 30% of these pathways, one gene that was identified in both sets was further examined using the Kaplan-Meier method for survival analysis. Additionally, three groups of patients who started radio and chemotherapy at different times were identified, and the influence of...
Source: Biomed Res - April 12, 2024 Category: Research Authors: Lu ísa Esteves Francisco Caramelo Domingos Roda Isabel Marques Carreira Joana Barbosa Melo Ilda Patr ícia Ribeiro Source Type: research
Bonding Effectiveness of Saliva-Contaminated Monolithic Zirconia Ceramics Using Different Decontamination Protocols
CONCLUSIONS: Universal cleaning agents can be preferred as an efficient cleaning method with 10-MDP-containing cement after saliva contamination for better adhesive bond strength of 4 mm crown preparation height of monolithic zirconia ceramics.PMID:38606199 | PMC:PMC11008971 | DOI:10.1155/2024/6670159 (Source: Biomed Res)
Source: Biomed Res - April 12, 2024 Category: Research Authors: Necla Demir Ozge Genc Ipek Balevi Akkese Meral Arslan Malkoc Mutlu Ozcan Source Type: research
Effect of radiation cross-linked collagen scaffold in alveolar ridge preservation of extraction socket
This study aimed to evaluate the properties of radiation cross-linked collagen scaffold (RCS) and its efficacy for alveolar ridge preservation (ARP). RCS was prepared from collagen dispersion by electron beam irradiation and freeze-drying. The microstructure, swelling ratio, area alteration and mechanical properties of RCS were characterized. Fifty-four New Zealand rabbits performing incisor extraction on maxilla and mandible were randomly assigned into positive, sham operation or treatment groups. Micro-computed tomography (micro-CT) scans, performed after 1, 4, and 12 weeks of surgery, were to assess changes in ridge hei...
Source: Biomed Res - April 12, 2024 Category: Research Authors: Hongwei Li Chen Yang Gong Chen Bozhao Wang Jian Li Ling Xu Source Type: research
Identification of Novel Molecular and Clinical Biomarkers of Survival in Glioblastoma Multiforme Patients: A Study Based on The Cancer Genome Atlas Data
This study is aimed at investigating the genetic alterations and clinical features of GBM patients to find predictors of survival. GBM patients' methylation and gene expression data along with clinical information from TCGA were retrieved. The most overrepresented pathways were identified independently for each omics dataset. From the genes found in at least 30% of these pathways, one gene that was identified in both sets was further examined using the Kaplan-Meier method for survival analysis. Additionally, three groups of patients who started radio and chemotherapy at different times were identified, and the influence of...
Source: Biomed Res - April 12, 2024 Category: Research Authors: Lu ísa Esteves Francisco Caramelo Domingos Roda Isabel Marques Carreira Joana Barbosa Melo Ilda Patr ícia Ribeiro Source Type: research
Bonding Effectiveness of Saliva-Contaminated Monolithic Zirconia Ceramics Using Different Decontamination Protocols
CONCLUSIONS: Universal cleaning agents can be preferred as an efficient cleaning method with 10-MDP-containing cement after saliva contamination for better adhesive bond strength of 4 mm crown preparation height of monolithic zirconia ceramics.PMID:38606199 | PMC:PMC11008971 | DOI:10.1155/2024/6670159 (Source: Biomed Res)
Source: Biomed Res - April 12, 2024 Category: Research Authors: Necla Demir Ozge Genc Ipek Balevi Akkese Meral Arslan Malkoc Mutlu Ozcan Source Type: research
Effect of radiation cross-linked collagen scaffold in alveolar ridge preservation of extraction socket
This study aimed to evaluate the properties of radiation cross-linked collagen scaffold (RCS) and its efficacy for alveolar ridge preservation (ARP). RCS was prepared from collagen dispersion by electron beam irradiation and freeze-drying. The microstructure, swelling ratio, area alteration and mechanical properties of RCS were characterized. Fifty-four New Zealand rabbits performing incisor extraction on maxilla and mandible were randomly assigned into positive, sham operation or treatment groups. Micro-computed tomography (micro-CT) scans, performed after 1, 4, and 12 weeks of surgery, were to assess changes in ridge hei...
Source: Biomed Res - April 12, 2024 Category: Research Authors: Hongwei Li Chen Yang Gong Chen Bozhao Wang Jian Li Ling Xu Source Type: research
Synthetic strategy for the production of electrically polarized polyvinylidene fluoride-trifluoroethylene-co-polymer osseo-functionalized with hydroxyapatite scaffold
J Biomed Mater Res A. 2024 Apr 10. doi: 10.1002/jbm.a.37720. Online ahead of print.ABSTRACTThe physiological mechanism of bone tissue regeneration is intricately organized and involves several cell types, intracellular, and extracellular molecular signaling networks. To overcome the drawbacks of autografts and allografts, a number of synthetically produced scaffolds have been manufactured by integrating ceramics, polymers, and their hybrid-composites. Considering the fact that natural bone is composed primarily of collagen and hydroxyapatite, ceramic-polymer composite materials seem to be the most viable alternative to bon...
Source: Biomed Res - April 11, 2024 Category: Research Authors: Subhasmita Swain Rojaleen Lenka Tapash Rautray Source Type: research
