Gram-negative bacteria recognition and photodynamic elimination by Zn-DPA based sensitizers
Biomaterials. 2024 Apr 15;308:122571. doi: 10.1016/j.biomaterials.2024.122571. Online ahead of print.ABSTRACTThe abuse and overuse of antibiotics let drug-resistant bacteria emerges. Antibacterial photodynamic therapy (APDT) has shown outstanding merits to eliminate the drug-resistant bacteria via cytotoxic reactive oxygen species produced by irradiating photosensitizer. However, most of photosensitizers are not effective for Gram-negative bacteria elimination. Herein conjugates of NBS, a photosensitizer, linked with one (NBS-DPA-Zn) or two (NBS-2DPA-Zn) equivalents of zinc-dipicolylamine (Zn-DPA) have been designed to ach...
Source: Biomaterials - April 18, 2024 Category: Materials Science Authors: Zuokai Wang Shuang Zeng Yifu Hao Wenlin Cai Wen Sun Jianjun Du Saran Long Jiangli Fan Jingyun Wang Xiaoqiang Chen Xiaojun Peng Source Type: research
NIR-responsive copper nanoliposome composites for cascaded ferrotherapy via ferroptosis actived ICD and IFN- γ released
Biomaterials. 2024 Apr 15;308:122570. doi: 10.1016/j.biomaterials.2024.122570. Online ahead of print.ABSTRACTMetallic biomaterials activate tumor ferroptosis by increasing oxidative stress, but their efficacy is severely limited in tumor microenvironment. Although interferon gamma (IFN-γ) can promote tumor ferroptosis sensitivity by inhibiting the antioxidant system and promoting lipid accumulation, this effect limited by the lack of IFN-γ accumulation in tumors. Herein, we report a near-infrared (NIR)-responsive HCuS nanocomposite (HCuS-PE@TSL-tlyp-1) that can stimulate immunogenic cell death (ICD)-mediated IFN-γ secre...
Source: Biomaterials - April 18, 2024 Category: Materials Science Authors: Junrui Wang Wenli Zhang Zhuoyan Xie Xingyue Wang Jiangshan Sun Fei Ran Weixi Jiang Yun Liu Zhigang Wang Haitao Ran Dajing Guo Source Type: research
The orientation of CpG conjugation on aluminum oxyhydroxide nanoparticles determines the immunostimulatory effects of combination adjuvants
Biomaterials. 2024 Apr 11;308:122569. doi: 10.1016/j.biomaterials.2024.122569. Online ahead of print.ABSTRACTIn subunit vaccines, aluminum salts (Alum) are commonly used as adjuvants, but with limited cellular immune responses. To overcome this limitation, CpG oligodeoxynucleotides (ODNs) have been used in combination with Alum. However, current combined usage of Alum and CpG is limited to linear mixtures, and the underlying interaction mechanism between CpG and Alum is not well understood. Thus, we propose to chemically conjugate Alum nanoparticles and CpG (with 5' or 3' end exposed) to design combination adjuvants. Our s...
Source: Biomaterials - April 16, 2024 Category: Materials Science Authors: Zhihui Liang Hang Bao Zhiying Yao Min Li Chen Chen Lei Zhang Huiyang Wang Yiyang Guo Yubin Ma Xuecheng Yang Ge Yu Jiancheng Zhang Changying Xue Bingbing Sun Chuanbin Mao Source Type: research
The orientation of CpG conjugation on aluminum oxyhydroxide nanoparticles determines the immunostimulatory effects of combination adjuvants
Biomaterials. 2024 Apr 11;308:122569. doi: 10.1016/j.biomaterials.2024.122569. Online ahead of print.ABSTRACTIn subunit vaccines, aluminum salts (Alum) are commonly used as adjuvants, but with limited cellular immune responses. To overcome this limitation, CpG oligodeoxynucleotides (ODNs) have been used in combination with Alum. However, current combined usage of Alum and CpG is limited to linear mixtures, and the underlying interaction mechanism between CpG and Alum is not well understood. Thus, we propose to chemically conjugate Alum nanoparticles and CpG (with 5' or 3' end exposed) to design combination adjuvants. Our s...
Source: Biomaterials - April 16, 2024 Category: Materials Science Authors: Zhihui Liang Hang Bao Zhiying Yao Min Li Chen Chen Lei Zhang Huiyang Wang Yiyang Guo Yubin Ma Xuecheng Yang Ge Yu Jiancheng Zhang Changying Xue Bingbing Sun Chuanbin Mao Source Type: research
Optical controlled and nuclear targeted CECR2 competitor to downregulate CSF-1 for metastatic breast cancer immunotherapy
This study provides a promising therapeutic target and reliable strategy for metastatic breast cancer treatment by interrupting immunosuppressive crosstalk between tumor cells and macrophages.PMID:38615488 | DOI:10.1016/j.biomaterials.2024.122568 (Source: Biomaterials)
Source: Biomaterials - April 14, 2024 Category: Materials Science Authors: Yi Cen Ying Chen Xinxuan Li Xiayun Chen Baixue Yu Mengyi Yan Ni Yan Hong Cheng Shiying Li Source Type: research
Optical controlled and nuclear targeted CECR2 competitor to downregulate CSF-1 for metastatic breast cancer immunotherapy
This study provides a promising therapeutic target and reliable strategy for metastatic breast cancer treatment by interrupting immunosuppressive crosstalk between tumor cells and macrophages.PMID:38615488 | DOI:10.1016/j.biomaterials.2024.122568 (Source: Biomaterials)
Source: Biomaterials - April 14, 2024 Category: Materials Science Authors: Yi Cen Ying Chen Xinxuan Li Xiayun Chen Baixue Yu Mengyi Yan Ni Yan Hong Cheng Shiying Li Source Type: research
Optical controlled and nuclear targeted CECR2 competitor to downregulate CSF-1 for metastatic breast cancer immunotherapy
This study provides a promising therapeutic target and reliable strategy for metastatic breast cancer treatment by interrupting immunosuppressive crosstalk between tumor cells and macrophages.PMID:38615488 | DOI:10.1016/j.biomaterials.2024.122568 (Source: Biomaterials)
Source: Biomaterials - April 14, 2024 Category: Materials Science Authors: Yi Cen Ying Chen Xinxuan Li Xiayun Chen Baixue Yu Mengyi Yan Ni Yan Hong Cheng Shiying Li Source Type: research
Nitroreductase-responsive nanoparticles for in situ fluorescence imaging and synergistic antibacterial therapy of bacterial keratitis
In this study, Cu2-xSe@BSA@NTRP nanoparticles were developed by loading nitroreductase-responsive probes (NTRPs) onto Cu2-xSe@BSA. These nanoparticles exhibited integrated fluorescence imaging and antibacterial capabilities. In vitro and in vivo experiments showed that the nanoparticles produced responsive fluorescence signals in bacteria within 30 min due to an interaction between the released NTRP and bacterial endogenous nitroreductase (NTR). When combined with low-temperature photothermal therapy (PTT), the nanoparticles effectively eliminated E. coli and S. aureus, achieved antibacterial efficacy above 95% and facilit...
Source: Biomaterials - April 11, 2024 Category: Materials Science Authors: Jing Xiang Ruifen Zou Pin Wang Xinfangzi Wang Xuefei He Fang Liu Chen Xu Aiguo Wu Source Type: research
Synergistic large segmental bone repair by 3D printed bionic scaffolds and engineered ADSC nanovesicles: Towards an optimized regenerative microenvironment
This study utilized digital laser processing (DLP)-based 3D printing technology to successfully fabricate high-precision methacryloylated polycaprolactone (PCLMA) bionic bone scaffold structures. Adipose-derived stem cell-engineered nanovesicles (ADSC-ENs) were uniformly and stably modified onto the bionic scaffold surface using a perfusion device, constructing a conducive microenvironment for tissue regeneration and long bone defect repair through the scaffold's structural design and the vesicles' biological functions. Scanning electron microscopy (SEM) examination of the scaffold surface confirmed the efficient loading o...
Source: Biomaterials - April 11, 2024 Category: Materials Science Authors: Wenbin Jiang Yichen Zhan Yifan Zhang Di Sun Guo Zhang Zhenxing Wang Lifeng Chen Jiaming Sun Source Type: research
Intranasal delivery of low-dose anti-CD124 antibody enhances treatment of chronic rhinosinusitis with nasal polyps
Biomaterials. 2024 Apr 6;308:122567. doi: 10.1016/j.biomaterials.2024.122567. Online ahead of print.ABSTRACTFrequent injections of anti-CD124 monoclonal antibody (αCD124) over long periods of time are used to treat chronic rhinosinusitis with nasal polyps (CRSwNP). Needle-free, intranasal administration (i.n.) of αCD124 is expected to provide advantages of localized delivery, improved efficacy, and enhanced medication adherence. However, delivery barriers such as the mucus and epithelium in the nasal tissue impede penetration of αCD124. Herein, two novel protamine nanoconstructs: allyl glycidyl ether conjugated protamin...
Source: Biomaterials - April 11, 2024 Category: Materials Science Authors: Jiamin Wu Natalie Jones Po-Han Chao Vanessa Chan Lukas Hohenwarter Angeline Wu Marta Bergamo Cristina Rodr íguez-Rodríguez Katayoun Saatchi Alex Liang Urs O H äfeli Zheng Tan Sarah Hedtrich Lucas J Andrew Shyh-Dar Li Source Type: research
Engineering fibronectin-templated multi-component fibrillar extracellular matrices to modulate tissue-specific cell response
Biomaterials. 2024 Apr 1;308:122560. doi: 10.1016/j.biomaterials.2024.122560. Online ahead of print.ABSTRACTCells assemble fibronectin, the major extracellular matrix (ECM) protein, into fibrillar matrices, which serve as 3D architectural scaffolds to provide, together with other ECM proteins tissue-specific environments. Although recent approaches enable to bioengineer 3D fibrillar fibronectin matrices in vitro, it remains elusive how fibronectin can be co-assembled with other ECM proteins into complex 3D fibrillar matrices that recapitulate tissue-specific compositions and cellular responses. Here, we introduce the engin...
Source: Biomaterials - April 11, 2024 Category: Materials Science Authors: Seungkuk Ahn Akanksha Jain Krishna Chaitanya Kasuba Makiko Seimiya Ryoko Okamoto Barbara Treutlein Daniel J M üller Source Type: research
Biomimetic and multifunctional nanocomposites for precision fungi theranostics
Biomaterials. 2024 Apr 4;308:122561. doi: 10.1016/j.biomaterials.2024.122561. Online ahead of print.ABSTRACTFungi infection is a serious threat to public health, but an effective antifungal strategy remains a challenge. Herein, a biomimetic nanocomposite with multifunctionalities, including fungi diagnosis, antifungal adhesion, precise fungi elimination, and cytokine sequestration, is constructed for battling Candida albicans (C. albicans) infection. By screening a range of cells, we find that the polarized macrophage cells have the strongest binding tendency toward C. albicans. Thus, their membranes were exfoliated to cam...
Source: Biomaterials - April 11, 2024 Category: Materials Science Authors: Li Wang Yueyue Gui Kexin Li Wei Tao Chao Li Jin Qiu Jiehua Ma Source Type: research
Nitroreductase-responsive nanoparticles for in situ fluorescence imaging and synergistic antibacterial therapy of bacterial keratitis
In this study, Cu2-xSe@BSA@NTRP nanoparticles were developed by loading nitroreductase-responsive probes (NTRPs) onto Cu2-xSe@BSA. These nanoparticles exhibited integrated fluorescence imaging and antibacterial capabilities. In vitro and in vivo experiments showed that the nanoparticles produced responsive fluorescence signals in bacteria within 30 min due to an interaction between the released NTRP and bacterial endogenous nitroreductase (NTR). When combined with low-temperature photothermal therapy (PTT), the nanoparticles effectively eliminated E. coli and S. aureus, achieved antibacterial efficacy above 95% and facilit...
Source: Biomaterials - April 11, 2024 Category: Materials Science Authors: Jing Xiang Ruifen Zou Pin Wang Xinfangzi Wang Xuefei He Fang Liu Chen Xu Aiguo Wu Source Type: research
Synergistic large segmental bone repair by 3D printed bionic scaffolds and engineered ADSC nanovesicles: Towards an optimized regenerative microenvironment
This study utilized digital laser processing (DLP)-based 3D printing technology to successfully fabricate high-precision methacryloylated polycaprolactone (PCLMA) bionic bone scaffold structures. Adipose-derived stem cell-engineered nanovesicles (ADSC-ENs) were uniformly and stably modified onto the bionic scaffold surface using a perfusion device, constructing a conducive microenvironment for tissue regeneration and long bone defect repair through the scaffold's structural design and the vesicles' biological functions. Scanning electron microscopy (SEM) examination of the scaffold surface confirmed the efficient loading o...
Source: Biomaterials - April 11, 2024 Category: Materials Science Authors: Wenbin Jiang Yichen Zhan Yifan Zhang Di Sun Guo Zhang Zhenxing Wang Lifeng Chen Jiaming Sun Source Type: research
Intranasal delivery of low-dose anti-CD124 antibody enhances treatment of chronic rhinosinusitis with nasal polyps
Biomaterials. 2024 Apr 6;308:122567. doi: 10.1016/j.biomaterials.2024.122567. Online ahead of print.ABSTRACTFrequent injections of anti-CD124 monoclonal antibody (αCD124) over long periods of time are used to treat chronic rhinosinusitis with nasal polyps (CRSwNP). Needle-free, intranasal administration (i.n.) of αCD124 is expected to provide advantages of localized delivery, improved efficacy, and enhanced medication adherence. However, delivery barriers such as the mucus and epithelium in the nasal tissue impede penetration of αCD124. Herein, two novel protamine nanoconstructs: allyl glycidyl ether conjugated protamin...
Source: Biomaterials - April 11, 2024 Category: Materials Science Authors: Jiamin Wu Natalie Jones Po-Han Chao Vanessa Chan Lukas Hohenwarter Angeline Wu Marta Bergamo Cristina Rodr íguez-Rodríguez Katayoun Saatchi Alex Liang Urs O H äfeli Zheng Tan Sarah Hedtrich Lucas J Andrew Shyh-Dar Li Source Type: research
