Kallikrein-related peptidase's significance in Alzheimer's disease pathogenesis: A comprehensive survey
Biochimie. 2024 Apr 10:S0300-9084(24)00076-2. doi: 10.1016/j.biochi.2024.04.001. Online ahead of print.ABSTRACTAlzheimer's disease (AD) and related dementias constitute an important global health challenge. Detailed understanding of the multiple molecular mechanisms underlying their pathogenesis constitutes a clue for the management of the disease. Kallikrein-related peptidases (KLKs), a lead family of serine proteases, have emerged as potential biomarkers and therapeutic targets in the context of AD and associated cognitive decline. Hence, KLKs were proposed to display multifaceted impacts influencing various aspects of n...
Source: Biochimie - April 12, 2024 Category: Biochemistry Authors: Ril ès Boumali Laureline Urli Meriem Naim Feryel Soualmia Kiyoka Kinugawa Isabelle Petropoulos Chahrazade El Amri Source Type: research
NADPH OXIDASE-GENERATED REACTIVE OXYGEN SPECIES ARE INVOLVED IN ESTRADIOL 17 ß-d-GLUCURONIDE-INDUCED CHOLESTASIS
Biochimie. 2024 Apr 10:S0300-9084(24)00077-4. doi: 10.1016/j.biochi.2024.04.002. Online ahead of print.ABSTRACTThe endogenous metabolite of estradiol, estradiol 17β-D-glucuronide (E17G), is considered the main responsible of the intrahepatic cholestasis of pregnancy. E17G alters the activity of canalicular transporters through a signaling pathway-dependent cellular internalization, phenomenon that was attributed to oxidative stress in different cholestatic conditions. However, there are no reports involving oxidative stress in E17G-induced cholestasis, representing this the aim of our work. Using polarized hepatocyte cult...
Source: Biochimie - April 12, 2024 Category: Biochemistry Authors: Gimena Salas Alen A Litta Anabela C Medeot Virginia Schuck Romina B Andermatten Gisel S Miszczuk Nadia Ciriaci Ma Valeria Razori Ismael R Barosso Enrique J S ánchez Pozzi Marcelo G Roma Cecilia L Basiglio Fernando A Crocenzi Source Type: research
Kallikrein-related peptidase's significance in Alzheimer's disease pathogenesis: A comprehensive survey
Biochimie. 2024 Apr 10:S0300-9084(24)00076-2. doi: 10.1016/j.biochi.2024.04.001. Online ahead of print.ABSTRACTAlzheimer's disease (AD) and related dementias constitute an important global health challenge. Detailed understanding of the multiple molecular mechanisms underlying their pathogenesis constitutes a clue for the management of the disease. Kallikrein-related peptidases (KLKs), a lead family of serine proteases, have emerged as potential biomarkers and therapeutic targets in the context of AD and associated cognitive decline. Hence, KLKs were proposed to display multifaceted impacts influencing various aspects of n...
Source: Biochimie - April 12, 2024 Category: Biochemistry Authors: Ril ès Boumali Laureline Urli Meriem Naim Feryel Soualmia Kiyoka Kinugawa Isabelle Petropoulos Chahrazade El Amri Source Type: research
NADPH OXIDASE-GENERATED REACTIVE OXYGEN SPECIES ARE INVOLVED IN ESTRADIOL 17 ß-d-GLUCURONIDE-INDUCED CHOLESTASIS
Biochimie. 2024 Apr 10:S0300-9084(24)00077-4. doi: 10.1016/j.biochi.2024.04.002. Online ahead of print.ABSTRACTThe endogenous metabolite of estradiol, estradiol 17β-D-glucuronide (E17G), is considered the main responsible of the intrahepatic cholestasis of pregnancy. E17G alters the activity of canalicular transporters through a signaling pathway-dependent cellular internalization, phenomenon that was attributed to oxidative stress in different cholestatic conditions. However, there are no reports involving oxidative stress in E17G-induced cholestasis, representing this the aim of our work. Using polarized hepatocyte cult...
Source: Biochimie - April 12, 2024 Category: Biochemistry Authors: Gimena Salas Alen A Litta Anabela C Medeot Virginia Schuck Romina B Andermatten Gisel S Miszczuk Nadia Ciriaci Ma Valeria Razori Ismael R Barosso Enrique J S ánchez Pozzi Marcelo G Roma Cecilia L Basiglio Fernando A Crocenzi Source Type: research
Galactokinase-like protein from Leishmania donovani: Biochemical and structural characterization of a recombinant protein
Biochimie. 2024 Apr 4;223:31-40. doi: 10.1016/j.biochi.2024.03.017. Online ahead of print.ABSTRACTLeishmaniasis is a spectrum of conditions caused by infection with the protozoan Leishmania spp. parasites. Leishmaniasis is endemic in 98 countries around the world, and resistance to current anti-leishmanial drugs is rising. Our work has identified and characterised a previously unstudied galactokinase-like protein (GalK) in Leishmania donovani, which catalyses the MgATP-dependent phosphorylation of the C-1 hydroxyl group of d-galactose to galactose-1-phosphate. Here, we report the production of the catalytically active reco...
Source: Biochimie - April 5, 2024 Category: Biochemistry Authors: Hasana Baber Arega Aghajani B Harold Gallimore Cassandra Bethel James G Hyatt Elizabeth F B King Helen P Price Marissa L Maciej-Hulme Suat Sari Anja Winter Source Type: research
Galactokinase-like protein from Leishmania donovani: Biochemical and structural characterization of a recombinant protein
Biochimie. 2024 Apr 4;223:31-40. doi: 10.1016/j.biochi.2024.03.017. Online ahead of print.ABSTRACTLeishmaniasis is a spectrum of conditions caused by infection with the protozoan Leishmania spp. parasites. Leishmaniasis is endemic in 98 countries around the world, and resistance to current anti-leishmanial drugs is rising. Our work has identified and characterised a previously unstudied galactokinase-like protein (GalK) in Leishmania donovani, which catalyses the MgATP-dependent phosphorylation of the C-1 hydroxyl group of d-galactose to galactose-1-phosphate. Here, we report the production of the catalytically active reco...
Source: Biochimie - April 5, 2024 Category: Biochemistry Authors: Hasana Baber Arega Aghajani B Harold Gallimore Cassandra Bethel James G Hyatt Elizabeth F B King Helen P Price Marissa L Maciej-Hulme Suat Sari Anja Winter Source Type: research
Galactokinase-like protein from Leishmania donovani: Biochemical and structural characterization of a recombinant protein
Biochimie. 2024 Apr 4;223:31-40. doi: 10.1016/j.biochi.2024.03.017. Online ahead of print.ABSTRACTLeishmaniasis is a spectrum of conditions caused by infection with the protozoan Leishmania spp. parasites. Leishmaniasis is endemic in 98 countries around the world, and resistance to current anti-leishmanial drugs is rising. Our work has identified and characterised a previously unstudied galactokinase-like protein (GalK) in Leishmania donovani, which catalyses the MgATP-dependent phosphorylation of the C-1 hydroxyl group of d-galactose to galactose-1-phosphate. Here, we report the production of the catalytically active reco...
Source: Biochimie - April 5, 2024 Category: Biochemistry Authors: Hasana Baber Arega Aghajani B Harold Gallimore Cassandra Bethel James G Hyatt Elizabeth F B King Helen P Price Marissa L Maciej-Hulme Suat Sari Anja Winter Source Type: research
Galactokinase-like protein from Leishmania donovani: Biochemical and structural characterization of a recombinant protein
Biochimie. 2024 Apr 4;223:31-40. doi: 10.1016/j.biochi.2024.03.017. Online ahead of print.ABSTRACTLeishmaniasis is a spectrum of conditions caused by infection with the protozoan Leishmania spp. parasites. Leishmaniasis is endemic in 98 countries around the world, and resistance to current anti-leishmanial drugs is rising. Our work has identified and characterised a previously unstudied galactokinase-like protein (GalK) in Leishmania donovani, which catalyses the MgATP-dependent phosphorylation of the C-1 hydroxyl group of d-galactose to galactose-1-phosphate. Here, we report the production of the catalytically active reco...
Source: Biochimie - April 5, 2024 Category: Biochemistry Authors: Hasana Baber Arega Aghajani B Harold Gallimore Cassandra Bethel James G Hyatt Elizabeth F B King Helen P Price Marissa L Maciej-Hulme Suat Sari Anja Winter Source Type: research
Galactokinase-like protein from Leishmania donovani: Biochemical and structural characterization of a recombinant protein
Biochimie. 2024 Apr 3:S0300-9084(24)00075-0. doi: 10.1016/j.biochi.2024.03.017. Online ahead of print.ABSTRACTLeishmaniasis is a spectrum of conditions caused by infection with the protozoan Leishmania spp. parasites. Leishmaniasis is endemic in 98 countries around the world, and resistance to current anti-leishmanial drugs is rising. Our work has identified and characterised a previously unstudied galactokinase-like protein (GalK) in Leishmania donovani, which catalyses the MgATP-dependent phosphorylation of the C-1 hydroxyl group of d-galactose to galactose-1-phosphate. Here, we report the production of the catalytically...
Source: Biochimie - April 5, 2024 Category: Biochemistry Authors: Hasana Baber Arega Aghajani B Harold Gallimore Cassandra Bethel James G Hyatt Elizabeth F B King Helen P Price Marissa L Maciej-Hulme Suat Sari Anja Winter Source Type: research
Galactokinase-like protein from Leishmania donovani: Biochemical and structural characterization of a recombinant protein
Biochimie. 2024 Apr 3:S0300-9084(24)00075-0. doi: 10.1016/j.biochi.2024.03.017. Online ahead of print.ABSTRACTLeishmaniasis is a spectrum of conditions caused by infection with the protozoan Leishmania spp. parasites. Leishmaniasis is endemic in 98 countries around the world, and resistance to current anti-leishmanial drugs is rising. Our work has identified and characterised a previously unstudied galactokinase-like protein (GalK) in Leishmania donovani, which catalyses the MgATP-dependent phosphorylation of the C-1 hydroxyl group of d-galactose to galactose-1-phosphate. Here, we report the production of the catalytically...
Source: Biochimie - April 5, 2024 Category: Biochemistry Authors: Hasana Baber Arega Aghajani B Harold Gallimore Cassandra Bethel James G Hyatt Elizabeth F B King Helen P Price Marissa L Maciej-Hulme Suat Sari Anja Winter Source Type: research
Galactokinase-like protein from Leishmania donovani: Biochemical and structural characterization of a recombinant protein
Biochimie. 2024 Apr 3:S0300-9084(24)00075-0. doi: 10.1016/j.biochi.2024.03.017. Online ahead of print.ABSTRACTLeishmaniasis is a spectrum of conditions caused by infection with the protozoan Leishmania spp. parasites. Leishmaniasis is endemic in 98 countries around the world, and resistance to current anti-leishmanial drugs is rising. Our work has identified and characterised a previously unstudied galactokinase-like protein (GalK) in Leishmania donovani, which catalyses the MgATP-dependent phosphorylation of the C-1 hydroxyl group of d-galactose to galactose-1-phosphate. Here, we report the production of the catalytically...
Source: Biochimie - April 5, 2024 Category: Biochemistry Authors: Hasana Baber Arega Aghajani B Harold Gallimore Cassandra Bethel James G Hyatt Elizabeth F B King Helen P Price Marissa L Maciej-Hulme Suat Sari Anja Winter Source Type: research
Multifunctional host-defense peptides isolated from skin secretions of the banana tree dwelling frog Boana platanera (Hylidae; Hylinae)
Biochimie. 2024 Mar 30:S0300-9084(24)00070-1. doi: 10.1016/j.biochi.2024.03.012. Online ahead of print.ABSTRACTFive host-defense peptides (figainin 2PL, hylin PL, raniseptin PL, plasticin PL, and peptide YL) were isolated from norepinephrine-stimulated skin secretions of the banana tree dwelling frog Boana platanera (Hylidae; Hylinae) collected in Trinidad. Raniseptin PL (GVFDTVKKIGKAVGKFALGVAKNYLNS.NH2) and figainin 2PL (FLGTVLKLGKAIAKTVVPMLTNAMQP KQ.NH2) showed potent and rapid bactericidal activity against a range of clinically relevant Gram-positive and Gram-negative ESKAPE + pathogens and Clostridioides difficile. The...
Source: Biochimie - April 1, 2024 Category: Biochemistry Authors: J Michael Conlon Ananyaa Sridhar Dawood Khan Taylor S Cunning Jack J Delaney Megan G Taggart Nigel G Ternan J érôme Leprince Laurent Coquet Thierry Jouenne Samir Attoub Milena Mechkarska Source Type: research
Multifunctional host-defense peptides isolated from skin secretions of the banana tree dwelling frog Boana platanera (Hylidae; Hylinae)
Biochimie. 2024 Mar 30:S0300-9084(24)00070-1. doi: 10.1016/j.biochi.2024.03.012. Online ahead of print.ABSTRACTFive host-defense peptides (figainin 2PL, hylin PL, raniseptin PL, plasticin PL, and peptide YL) were isolated from norepinephrine-stimulated skin secretions of the banana tree dwelling frog Boana platanera (Hylidae; Hylinae) collected in Trinidad. Raniseptin PL (GVFDTVKKIGKAVGKFALGVAKNYLNS.NH2) and figainin 2PL (FLGTVLKLGKAIAKTVVPMLTNAMQP KQ.NH2) showed potent and rapid bactericidal activity against a range of clinically relevant Gram-positive and Gram-negative ESKAPE + pathogens and Clostridioides difficile. The...
Source: Biochimie - April 1, 2024 Category: Biochemistry Authors: J Michael Conlon Ananyaa Sridhar Dawood Khan Taylor S Cunning Jack J Delaney Megan G Taggart Nigel G Ternan J érôme Leprince Laurent Coquet Thierry Jouenne Samir Attoub Milena Mechkarska Source Type: research
Multifunctional host-defense peptides isolated from skin secretions of the banana tree dwelling frog Boana platanera (Hylidae; Hylinae)
Biochimie. 2024 Mar 30:S0300-9084(24)00070-1. doi: 10.1016/j.biochi.2024.03.012. Online ahead of print.ABSTRACTFive host-defense peptides (figainin 2PL, hylin PL, raniseptin PL, plasticin PL, and peptide YL) were isolated from norepinephrine-stimulated skin secretions of the banana tree dwelling frog Boana platanera (Hylidae; Hylinae) collected in Trinidad. Raniseptin PL (GVFDTVKKIGKAVGKFALGVAKNYLNS.NH2) and figainin 2PL (FLGTVLKLGKAIAKTVVPMLTNAMQP KQ.NH2) showed potent and rapid bactericidal activity against a range of clinically relevant Gram-positive and Gram-negative ESKAPE + pathogens and Clostridioides difficile. The...
Source: Biochimie - April 1, 2024 Category: Biochemistry Authors: J Michael Conlon Ananyaa Sridhar Dawood Khan Taylor S Cunning Jack J Delaney Megan G Taggart Nigel G Ternan J érôme Leprince Laurent Coquet Thierry Jouenne Samir Attoub Milena Mechkarska Source Type: research
Cathepsin D inhibition during neuronal differentiation selectively affects individual proteins instead of overall protein turnover
Biochimie. 2024 Mar 27:S0300-9084(24)00071-3. doi: 10.1016/j.biochi.2024.03.013. Online ahead of print.ABSTRACTCathepsin D (CTSD) is a lysosomal aspartic protease and its inherited deficiency causes a severe pediatric neurodegenerative disease called neuronal ceroid lipofuscinosis (NCL) type 10. The lysosomal dysfunction in the affected patients leads to accumulation of undigested lysosomal cargo especially in none-dividing cells, such as neurons, resulting in death shortly after birth. To explore which proteins are mainly affected by the lysosomal dysfunction due to CTSD deficiency, Lund human mesencephalic (LUHMES) cells...
Source: Biochimie - March 29, 2024 Category: Biochemistry Authors: Johannes Schneider Julia Mitschke Mahima Bhat Daniel Vogele Oliver Schilling Thomas Reinheckel Lisa He ß Source Type: research
