Novel enzyme ‐resistant pancreatic polypeptide analogs evoke pancreatic beta‐cell rest, enhance islet cell turnover, and inhibit food intake in mice
In conclusion, Pro3 amino acid substitution of PP, either alone or together with mid-chain acylation, creates PP analogs with benefits on beta-cell rest, islet cell turnover, and energy regulation that may be applicable to the treatment of diabetes and obesity. (Source: BioFactors)
Source: BioFactors - April 19, 2024 Category: Biochemistry Authors: Wuyun Zhu,
Neil Tanday,
Ryan A. Lafferty,
Peter R. Flatt,
Nigel Irwin Tags: RESEARCH ARTICLE Source Type: research
Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway
In conclusion, our study reveals for the first time that nerolidol can ameliorate hippocampal damage, neuroinflammation, synaptic, ER, and mitochondrial damage in diabetic rats. Furthermore, we suggest that nerolidol may inhibit NLRP3 inflammasome activation via MAPK and AKT signaling pathways. These findings provide a new experimental basis for the use of nerolidol to ameliorate diabetes-induced brain tissue damage and the associated disease. AbstractDespite the observation of diabetes-induced brain tissue damage and impaired learning and memory, the underlying mechanism of damage remains elusive, and effective, targeted ...
Source: BioFactors - April 17, 2024 Category: Biochemistry Authors: Yining Lei,
Manqin Li,
Xinran Liu,
Lu Zhang,
Ruyi Zhang,
Fei Cai Tags: RESEARCH ARTICLE Source Type: research
Issue Information
(Source: BioFactors)
Source: BioFactors - April 13, 2024 Category: Biochemistry Tags: ISSUE INFORMATION Source Type: research
Issue Information ‐ Cover
(Source: BioFactors)
Source: BioFactors - April 12, 2024 Category: Biochemistry Tags: ISSUE INFORMATION ‐ COVER Source Type: research
SP1/CTR1 ‐mediated oxidative stress‐induced cuproptosis in intervertebral disc degeneration
This study highlights the importance of cuproptosis in IDD progression and provides a promising therapeutic target for IDD treatment. (Source: BioFactors)
Source: BioFactors - April 11, 2024 Category: Biochemistry Authors: Xuanzuo Chen,
Kanglu Li,
Yan Xiao,
Wei Wu,
Hui Lin,
Xiangcheng Qing,
Shuo Tian,
Sheng Liu,
Shiqing Feng,
Baichuan Wang,
Zengwu Shao,
Yizhong Peng Tags: RESEARCH ARTICLE Source Type: research
Myokines: A central point in managing redox homeostasis and quality of life
The present review provides a comprehensive overview of skeletal muscle secreted myokines in managing redox homeostasis and quality of life. Additionally, probable strategies will be also discussed which provide a solution for betterment of life. AbstractRedox homeostasis is a crucial phenomenon that is obligatory for maintaining the healthy status of cells. However, the loss of redox homeostasis may lead to numerous diseases that ultimately result in a compromised quality of life. Skeletal muscle is an endocrine organ that secretes hundreds of myokines. Myokines are peptides and cytokines produced and released by muscle f...
Source: BioFactors - April 5, 2024 Category: Biochemistry Authors: Richa Rathor,
Geetha Suryakumar Tags: REVIEW ARTICLE Source Type: research
Soluble klotho induces the heat shock factor 1 through EGR1 expression
The transcription factor array approach was used to identify novel signaling pathways that are regulated by klotho gene/proteins. Klotho deficiency (kl−/−) largely decreased HSF1 levels and impaired heat shock protein expression. Additionally, klotho transcriptionally regulates HSF1 by modulating EGR-1. AbstractKlotho is an antiaging protein that has multiple functions. The purpose of this study is to investigate whether soluble klotho plays a role in cellular stress response pathways. We found that klotho deficiency (kl−/−) largely decreased HSF1 levels and impaired heat shock protein expression. Interestingly, re...
Source: BioFactors - April 4, 2024 Category: Biochemistry Authors: Soo ‐A Kim,
Nguyen Khanh Toan,
Sang‐Gun Ahn Tags: RESEARCH ARTICLE Source Type: research
SUMO ‐specific proteases: SENPs in oxidative stress‐related signaling and diseases
This article aims to illustrate the significant contribution of SENPs to the oxidative stress pathway through deSUMOylation by reviewing their structure and classification, their roles in oxidative stress, and the changes in their expression and activity in several typical oxida tive stress-related diseases. (Source: BioFactors)
Source: BioFactors - April 2, 2024 Category: Biochemistry Authors: Yaqi Jiao,
Xiaojuan Zhang,
Zhenshan Yang Tags: REVIEW ARTICLE Source Type: research
Indicaxanthin prevents eryptosis induced by cigarette smoke extract by interfering with active Fas ‐mediated signaling
In conclusion, Ind concentrations comparable to nutritionally relevant plasma concentrations, can prevent Fas-mediated RBC death signaling induced by CSE, which suggests that di etary intake of cactus pear fruits may limit the deleterious effects of cigarette smoking. (Source: BioFactors)
Source: BioFactors - March 24, 2024 Category: Biochemistry Authors: Ignazio Restivo,
Ilenia Concetta Giardina,
Rosario Barone,
Antonio Cilla,
Stefano Burgio,
Mario Allegra,
Luisa Tesoriere,
Alessandro Attanzio Tags: RESEARCH ARTICLE Source Type: research
Lactate dehydrogenase A is implicated in the pathogenesis of B ‐cell lymphoma through regulation of the FER signaling pathway
It is the first to report that LDHA may affect the metabolic activity of B-cell lymphoma through the FER pathway, such as mitochondrial membrane potential, ATP generation, and glycolysis, and further affect its proliferation, invasion, and in vivo development. It, therefore, provides new insights into potential therapeutic strategies targeting LDHA/FER for the treatment of B-cell lymphoma. AbstractLactate dehydrogenase A (LDHA) is highly expressed in various tumors. However, the role of LDHA in the pathogenesis of B-cell lymphoma remains unclear. Analysis of data from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expr...
Source: BioFactors - March 23, 2024 Category: Biochemistry Authors: Xiumei Feng,
Jing Ren,
Xunqi Zhang,
Dexiao Kong,
Linlin Yin,
Qian Zhou,
Shunye Wang,
Ai Li,
Yanan Guo,
Yongjing Wang,
Xiaoli Feng,
Xiaoyun Wang,
Jianhua Niu,
Yang Jiang,
Chengyun Zheng Tags: RESEARCH ARTICLE Source Type: research
The interlacing anticancer effect of pharmacologic ascorbate, chloroquine, and resveratrol
Our present study first described that the combined Ph-Asc, Res, and CQ co-treatment exerted a synergistic cytotoxic effect on KRAS mutant PDAC cells. Both Ph-Asc and Res caused DSBs in the DNA, accompanied by cell cycle arrest and cell death. Ph-Asc-induced cytotoxicity shows strong ROS dependence, while Res-induced cytotoxicity seems to be independent of ROS generation; Res treatment induced significant elevation of caspase-3/7 activity while Ph-Asc-induced cell death proved to be caspase-independent. The fact that both Ph-Asc and Res are natural compounds without significant harmful effects on normal cells, and the thir...
Source: BioFactors - March 16, 2024 Category: Biochemistry Authors: Kinga Makk ‐Merczel,
Dóra Varga,
Péter Hajdinák,
András Szarka Tags: RESEARCH ARTICLE Source Type: research
