Effects of Blindness on Sleep/Wakefulness States in Mice
Biol Pharm Bull. 2023;46(8):1152-1155. doi: 10.1248/bpb.b23-00210.ABSTRACTTo examine the effects of blindness on sleep/wakefulness states, we compared locomotor activity and delayed recovery from isoflurane anesthesia induced by hypnotics during light and dark periods in sighted CBA/N and blind CBA/J mice. Locomotor activity around the switch from the dark to light period significantly differed in both mice. Delayed recovery induced by brotizolam was attenuated in both periods in CBA/J mice. In addition, the period specificity of delayed recovery caused by suvorexant or diphenhydramine in CBA/N mice was abolished in CBA/J ...
Source: Biological and Pharmaceutical Bulletin - August 2, 2023 Category: Drugs & Pharmacology Authors: Yoshinori Iba Shota En Yukika Yamada Mayu Koami Nagisa Yamamoto Shinichi Sawada Naono Yamawaki Source Type: research
Development of Bitter-Taste Masked Instant Jelly Formulations of Diphenhydramine Hydrochloride with Easy-to-Consume Granules
This study developed easy-to-consume bitter taste-masking granules for the preparation of instant jelly formulations. Composite granules containing diphenhydramine hydrochloride (DPH) and polymers were prepared via spray drying. The taste-masking effect on DPH was evaluated with acceptable linearity between DPH concentration and intensity of bitterness using an electronic tongue sensor. The results indicated that ι-carrageenan could provide the greatest suppression effect on the DPH bitterness among the polymers selected for preparing spray-dried particles (SDPs). The thixotropic index (TI) of ι-carrageenan was higher th...
Source: Chemical and Pharmaceutical Bulletin - August 2, 2023 Category: Drugs & Pharmacology Authors: Mayu Fukada Kazunori Kadota Satoshi Nogami Hiromasa Uchiyama Yoshiyuki Shirakawa Yuichi Tozuka Source Type: research
Development of Bitter-Taste Masked Instant Jelly Formulations of Diphenhydramine Hydrochloride with Easy-to-Consume Granules
This study developed easy-to-consume bitter taste-masking granules for the preparation of instant jelly formulations. Composite granules containing diphenhydramine hydrochloride (DPH) and polymers were prepared via spray drying. The taste-masking effect on DPH was evaluated with acceptable linearity between DPH concentration and intensity of bitterness using an electronic tongue sensor. The results indicated that ι-carrageenan could provide the greatest suppression effect on the DPH bitterness among the polymers selected for preparing spray-dried particles (SDPs). The thixotropic index (TI) of ι-carrageenan was higher th...
Source: Chemical and Pharmaceutical Bulletin - August 2, 2023 Category: Drugs & Pharmacology Authors: Mayu Fukada Kazunori Kadota Satoshi Nogami Hiromasa Uchiyama Yoshiyuki Shirakawa Yuichi Tozuka Source Type: research
Effects of Blindness on Sleep/Wakefulness States in Mice
Biol Pharm Bull. 2023;46(8):1152-1155. doi: 10.1248/bpb.b23-00210.ABSTRACTTo examine the effects of blindness on sleep/wakefulness states, we compared locomotor activity and delayed recovery from isoflurane anesthesia induced by hypnotics during light and dark periods in sighted CBA/N and blind CBA/J mice. Locomotor activity around the switch from the dark to light period significantly differed in both mice. Delayed recovery induced by brotizolam was attenuated in both periods in CBA/J mice. In addition, the period specificity of delayed recovery caused by suvorexant or diphenhydramine in CBA/N mice was abolished in CBA/J ...
Source: Biological and Pharmaceutical Bulletin - August 2, 2023 Category: Drugs & Pharmacology Authors: Yoshinori Iba Shota En Yukika Yamada Mayu Koami Nagisa Yamamoto Shinichi Sawada Naono Yamawaki Source Type: research
Effects of Blindness on Sleep/Wakefulness States in Mice
Biol Pharm Bull. 2023;46(8):1152-1155. doi: 10.1248/bpb.b23-00210.ABSTRACTTo examine the effects of blindness on sleep/wakefulness states, we compared locomotor activity and delayed recovery from isoflurane anesthesia induced by hypnotics during light and dark periods in sighted CBA/N and blind CBA/J mice. Locomotor activity around the switch from the dark to light period significantly differed in both mice. Delayed recovery induced by brotizolam was attenuated in both periods in CBA/J mice. In addition, the period specificity of delayed recovery caused by suvorexant or diphenhydramine in CBA/N mice was abolished in CBA/J ...
Source: Biological and Pharmaceutical Bulletin - August 2, 2023 Category: Drugs & Pharmacology Authors: Yoshinori Iba Shota En Yukika Yamada Mayu Koami Nagisa Yamamoto Shinichi Sawada Naono Yamawaki Source Type: research
Development of Bitter-Taste Masked Instant Jelly Formulations of Diphenhydramine Hydrochloride with Easy-to-Consume Granules
This study developed easy-to-consume bitter taste-masking granules for the preparation of instant jelly formulations. Composite granules containing diphenhydramine hydrochloride (DPH) and polymers were prepared via spray drying. The taste-masking effect on DPH was evaluated with acceptable linearity between DPH concentration and intensity of bitterness using an electronic tongue sensor. The results indicated that ι-carrageenan could provide the greatest suppression effect on the DPH bitterness among the polymers selected for preparing spray-dried particles (SDPs). The thixotropic index (TI) of ι-carrageenan was higher th...
Source: Chemical and Pharmaceutical Bulletin - August 2, 2023 Category: Drugs & Pharmacology Authors: Mayu Fukada Kazunori Kadota Satoshi Nogami Hiromasa Uchiyama Yoshiyuki Shirakawa Yuichi Tozuka Source Type: research
Effects of Blindness on Sleep/Wakefulness States in Mice
Biol Pharm Bull. 2023;46(8):1152-1155. doi: 10.1248/bpb.b23-00210.ABSTRACTTo examine the effects of blindness on sleep/wakefulness states, we compared locomotor activity and delayed recovery from isoflurane anesthesia induced by hypnotics during light and dark periods in sighted CBA/N and blind CBA/J mice. Locomotor activity around the switch from the dark to light period significantly differed in both mice. Delayed recovery induced by brotizolam was attenuated in both periods in CBA/J mice. In addition, the period specificity of delayed recovery caused by suvorexant or diphenhydramine in CBA/N mice was abolished in CBA/J ...
Source: Biological and Pharmaceutical Bulletin - August 2, 2023 Category: Drugs & Pharmacology Authors: Yoshinori Iba Shota En Yukika Yamada Mayu Koami Nagisa Yamamoto Shinichi Sawada Naono Yamawaki Source Type: research
Development of Bitter-Taste Masked Instant Jelly Formulations of Diphenhydramine Hydrochloride with Easy-to-Consume Granules
This study developed easy-to-consume bitter taste-masking granules for the preparation of instant jelly formulations. Composite granules containing diphenhydramine hydrochloride (DPH) and polymers were prepared via spray drying. The taste-masking effect on DPH was evaluated with acceptable linearity between DPH concentration and intensity of bitterness using an electronic tongue sensor. The results indicated that ι-carrageenan could provide the greatest suppression effect on the DPH bitterness among the polymers selected for preparing spray-dried particles (SDPs). The thixotropic index (TI) of ι-carrageenan was higher th...
Source: Chemical and Pharmaceutical Bulletin - August 2, 2023 Category: Drugs & Pharmacology Authors: Mayu Fukada Kazunori Kadota Satoshi Nogami Hiromasa Uchiyama Yoshiyuki Shirakawa Yuichi Tozuka Source Type: research
Effects of Blindness on Sleep/Wakefulness States in Mice
Biol Pharm Bull. 2023;46(8):1152-1155. doi: 10.1248/bpb.b23-00210.ABSTRACTTo examine the effects of blindness on sleep/wakefulness states, we compared locomotor activity and delayed recovery from isoflurane anesthesia induced by hypnotics during light and dark periods in sighted CBA/N and blind CBA/J mice. Locomotor activity around the switch from the dark to light period significantly differed in both mice. Delayed recovery induced by brotizolam was attenuated in both periods in CBA/J mice. In addition, the period specificity of delayed recovery caused by suvorexant or diphenhydramine in CBA/N mice was abolished in CBA/J ...
Source: Biological and Pharmaceutical Bulletin - August 2, 2023 Category: Drugs & Pharmacology Authors: Yoshinori Iba Shota En Yukika Yamada Mayu Koami Nagisa Yamamoto Shinichi Sawada Naono Yamawaki Source Type: research
Development of Bitter-Taste Masked Instant Jelly Formulations of Diphenhydramine Hydrochloride with Easy-to-Consume Granules
This study developed easy-to-consume bitter taste-masking granules for the preparation of instant jelly formulations. Composite granules containing diphenhydramine hydrochloride (DPH) and polymers were prepared via spray drying. The taste-masking effect on DPH was evaluated with acceptable linearity between DPH concentration and intensity of bitterness using an electronic tongue sensor. The results indicated that ι-carrageenan could provide the greatest suppression effect on the DPH bitterness among the polymers selected for preparing spray-dried particles (SDPs). The thixotropic index (TI) of ι-carrageenan was higher th...
Source: Chemical and Pharmaceutical Bulletin - August 2, 2023 Category: Drugs & Pharmacology Authors: Mayu Fukada Kazunori Kadota Satoshi Nogami Hiromasa Uchiyama Yoshiyuki Shirakawa Yuichi Tozuka Source Type: research
Effects of Blindness on Sleep/Wakefulness States in Mice
Biol Pharm Bull. 2023;46(8):1152-1155. doi: 10.1248/bpb.b23-00210.ABSTRACTTo examine the effects of blindness on sleep/wakefulness states, we compared locomotor activity and delayed recovery from isoflurane anesthesia induced by hypnotics during light and dark periods in sighted CBA/N and blind CBA/J mice. Locomotor activity around the switch from the dark to light period significantly differed in both mice. Delayed recovery induced by brotizolam was attenuated in both periods in CBA/J mice. In addition, the period specificity of delayed recovery caused by suvorexant or diphenhydramine in CBA/N mice was abolished in CBA/J ...
Source: Biological and Pharmaceutical Bulletin - August 2, 2023 Category: Drugs & Pharmacology Authors: Yoshinori Iba Shota En Yukika Yamada Mayu Koami Nagisa Yamamoto Shinichi Sawada Naono Yamawaki Source Type: research
Development of Bitter-Taste Masked Instant Jelly Formulations of Diphenhydramine Hydrochloride with Easy-to-Consume Granules
This study developed easy-to-consume bitter taste-masking granules for the preparation of instant jelly formulations. Composite granules containing diphenhydramine hydrochloride (DPH) and polymers were prepared via spray drying. The taste-masking effect on DPH was evaluated with acceptable linearity between DPH concentration and intensity of bitterness using an electronic tongue sensor. The results indicated that ι-carrageenan could provide the greatest suppression effect on the DPH bitterness among the polymers selected for preparing spray-dried particles (SDPs). The thixotropic index (TI) of ι-carrageenan was higher th...
Source: Chemical and Pharmaceutical Bulletin - August 2, 2023 Category: Drugs & Pharmacology Authors: Mayu Fukada Kazunori Kadota Satoshi Nogami Hiromasa Uchiyama Yoshiyuki Shirakawa Yuichi Tozuka Source Type: research
Development of Bitter-Taste Masked Instant Jelly Formulations of Diphenhydramine Hydrochloride with Easy-to-Consume Granules
This study developed easy-to-consume bitter taste-masking granules for the preparation of instant jelly formulations. Composite granules containing diphenhydramine hydrochloride (DPH) and polymers were prepared via spray drying. The taste-masking effect on DPH was evaluated with acceptable linearity between DPH concentration and intensity of bitterness using an electronic tongue sensor. The results indicated that ι-carrageenan could provide the greatest suppression effect on the DPH bitterness among the polymers selected for preparing spray-dried particles (SDPs). The thixotropic index (TI) of ι-carrageenan was higher th...
Source: Chemical and Pharmaceutical Bulletin - August 2, 2023 Category: Drugs & Pharmacology Authors: Mayu Fukada Kazunori Kadota Satoshi Nogami Hiromasa Uchiyama Yoshiyuki Shirakawa Yuichi Tozuka Source Type: research
Effects of Blindness on Sleep/Wakefulness States in Mice
Biol Pharm Bull. 2023;46(8):1152-1155. doi: 10.1248/bpb.b23-00210.ABSTRACTTo examine the effects of blindness on sleep/wakefulness states, we compared locomotor activity and delayed recovery from isoflurane anesthesia induced by hypnotics during light and dark periods in sighted CBA/N and blind CBA/J mice. Locomotor activity around the switch from the dark to light period significantly differed in both mice. Delayed recovery induced by brotizolam was attenuated in both periods in CBA/J mice. In addition, the period specificity of delayed recovery caused by suvorexant or diphenhydramine in CBA/N mice was abolished in CBA/J ...
Source: Biological and Pharmaceutical Bulletin - August 2, 2023 Category: Drugs & Pharmacology Authors: Yoshinori Iba Shota En Yukika Yamada Mayu Koami Nagisa Yamamoto Shinichi Sawada Naono Yamawaki Source Type: research
Effects of Blindness on Sleep/Wakefulness States in Mice
Biol Pharm Bull. 2023;46(8):1152-1155. doi: 10.1248/bpb.b23-00210.ABSTRACTTo examine the effects of blindness on sleep/wakefulness states, we compared locomotor activity and delayed recovery from isoflurane anesthesia induced by hypnotics during light and dark periods in sighted CBA/N and blind CBA/J mice. Locomotor activity around the switch from the dark to light period significantly differed in both mice. Delayed recovery induced by brotizolam was attenuated in both periods in CBA/J mice. In addition, the period specificity of delayed recovery caused by suvorexant or diphenhydramine in CBA/N mice was abolished in CBA/J ...
Source: Biological and Pharmaceutical Bulletin - August 2, 2023 Category: Drugs & Pharmacology Authors: Yoshinori Iba Shota En Yukika Yamada Mayu Koami Nagisa Yamamoto Shinichi Sawada Naono Yamawaki Source Type: research
