Use of GLP1 receptor agonists in early pregnancy and reproductive safety: a multicentre, observational, prospective cohort study based on the databases of six Teratology Information Services
Conclusions
This study offers reassurance in cases of inadvertent exposure to GLP1-RA during the first trimester of pregnancy. Due to the limited sample size, larger studies are required to validate these findings. (Source: BMJ Open)
Source: BMJ Open - April 24, 2024 Category: General Medicine Authors: Dao, K., Shechtman, S., Weber-Schoendorfer, C., Diav-Citrin, O., Murad, R. H., Berlin, M., Hazan, A., Richardson, J. L., Eleftheriou, G., Rousson, V., Diezi, L., Haefliger, D., Simoes-Wüst, A. P., Addor, M.-C., Baud, D., Lamine, F., Panchaud, A., Tags: Open access, Pharmacology and therapeutics Source Type: research
Prospective cohort study of long-term neurological outcomes in retired elite athletes: the Advanced BiomaRker, Advanced Imaging and Neurocognitive (BRAIN) Health Study protocol
Introduction
Although limited, recent research suggests that contact sport participation might have an adverse long-term effect on brain health. Further work is required to determine whether this includes an increased risk of neurodegenerative disease and/or subsequent changes in cognition and behaviour. The Advanced BiomaRker, Advanced Imaging and Neurocognitive Health Study will prospectively examine the neurological, psychiatric, psychological and general health of retired elite-level rugby union and association football/soccer players.
Methods and analysis
400 retired athletes will be recruited (200 rugby union and 20...
Source: BMJ Open - April 24, 2024 Category: General Medicine Authors: Zimmerman, K. A., Hain, J. A., Graham, N. S. N., Rooney, E. J., Lee, Y., Del-Giovane, M., Parker, T. D., Friedland, D., Cross, M. J., Kemp, S., Wilson, M. G., Sylvester, R. J., Sharp, D. J. Tags: Open access, Neurology Source Type: research
Determinants of normal haemoglobin concentration among under-five children in Sub-Saharan Africa: a Positive deviance inquiry using cross-sectional study design
Conclusion
According to our finding, only four out of 10 under-five children in SSA had a normal haemoglobin level. This finding proved that anaemia among children in SSA remains a serious public health concern. Therefore, improving maternal education, provision of drugs for an intestinal parasite and early detection and treatment of maternal anaemia, febrile illness and diarrhoeal disease is important. (Source: BMJ Open)
Source: BMJ Open - April 24, 2024 Category: General Medicine Authors: Seifu, B. L., Tesema, G. A., Tebeje, T., Legesse, B. T., Yehuala, T. Z., Wuneh, A. G., Tadese, Z. B., Mare, K. U. Tags: Open access, Paediatrics Source Type: research
Is a smartphone application (BlueIce) acceptable and safe for university students who self-harm: an open study
Conclusion
BlueIce was an acceptable, safe and helpful source of support for university students struggling with self-harm thoughts and/or behaviours. This builds on previous findings with adolescents and suggests that BlueIce could be a particularly acceptable and helpful resource for university students. (Source: BMJ Open)
Source: BMJ Open - April 24, 2024 Category: General Medicine Authors: Cliffe, B., Moore, E., Whittle, K., Stallard, P. Tags: Open access, Mental health Source Type: research
The Birth and Beyond (BABY) study: protocol for a birth cohort study investigating the social and environmental determinants of pregnancy-related outcomes in Black American families
Introduction
In the USA, Black birthing people and infants experience disproportionately worse pregnancy-related health outcomes. The causes for these disparities are unknown, but evidence suggests that they are likely socially and environmentally based. Efforts to identify the determinants of these racial disparities are urgently needed to elucidate the highest priority targets for intervention. The Birth and Beyond (BABY) study evaluates how micro-level (eg, interpersonal and family) and macro-level (eg, neighbourhood and environmental) risk and resiliency factors transact to shape birth person-infant health, and underly...
Source: BMJ Open - April 23, 2024 Category: General Medicine Authors: Lin, B., Middleton, R. R., Terefe, B., Appleton, A. A., Feingold, B. J., Lynch, T., Pieterse, A. L., Rogers, R., Armah, A. E., Bierce, L. F., Flagg, A. M., McCarthy, S. Tags: Open access, Public health Source Type: research
REporting quality of PilOt randomised controlled trials in surgery (REPORTS): a methodological survey protocol
Introduction
The aim of this methodological review is to evaluate the completeness of reporting of surgical pilot and feasibility randomised trials as per the Consolidated Standards of Reporting Trials (CONSORT) extension to randomised pilot and feasibility trials. Moreover, we aim to assess for the presence of spin reporting and inconsistency between abstract and main text reporting in surgical pilot and feasibility randomised trials.
Methods and analysis
A comprehensive, electronic search strategy will be used to identify studies indexed in Medline, Embase and Cochrane Central Register of Controlled Trials (CENTRAL) dat...
Source: BMJ Open - April 23, 2024 Category: General Medicine Authors: McKechnie, T., Kazi, T., Wang, A., Zhang, S., Thabane, A., Nanji, K., Doumouras, A. G., Eskicioglu, C., Thabane, L., Parpia, S., Bhandari, M. Tags: Open access, Epidemiology Source Type: research
Safety of different concentrations of glycerine enema for meconium evacuation in preterm infants: study protocol for a randomised controlled trial
This study protocol is for a single-centre, two-arm, parallel-group, double-blind and non-inferiority randomised controlled trial. Participants will be recruited from a NICU in a teriary class A hospital in China, and eligible infants will be randomly allocated to either the glycerine (mL): saline (mL) group in a 3:7 ratio or the 1:9 ratio group. The enema procedure will adhere to the standardised operational protocols. Primary outcomes encompass necrotising enterocolitis and rectal bleeding, while secondary outcomes encompass feeding parameters, meconium passage outcomes and splanchnic regional oxygen saturation. Analyses...
Source: BMJ Open - April 23, 2024 Category: General Medicine Authors: Li, X., Liu, C., Zhang, J., Yu, Q., Guo, X., Hu, Y., Shi, J. Tags: Open access, Intensive care Source Type: research
Explore the effect of apparent temperature and air pollutants on the admission rate of acute myocardial infarction in Chongqing, China: a time-series study
Conclusion
The occurrence of decreased apparent temperature levels was discovered to be linked with a heightened relative risk of hospitalisations for AMI. PM2.5 and NO2 have an effect modification on the association between apparent temperature and admission rate of AMI. (Source: BMJ Open)
Source: BMJ Open - April 23, 2024 Category: General Medicine Authors: Bai, X., Ming, X., Zhao, M., Zhou, L. Tags: Open access, Epidemiology Source Type: research
Survival status and predictors of mortality among preterm neonates admitted in Bench Sheko Zone, Sheka Zone and Keffa Zone Governmental Hospitals, Southwest Ethiopia (2021): prospective follow-up study
Conclusion and recommendation
The rate of preterm neonatal mortality was high compared with the Ethiopia Demographic and Health Survey report nationally. Healthcare workers should encourage KMC services and breastfeeding initiation and prevent preterm neonates from being anaemic to increase their chances of survival. (Source: BMJ Open)
Source: BMJ Open - April 23, 2024 Category: General Medicine Authors: Mihretu, E., Genie, Y. D., Adugnaw, E., Shibabaw, A. T. Tags: Open access, Paediatrics Source Type: research
Risk stratification and prognosis prediction using cardiac biomarkers in COVID-19: a single-centre retrospective cohort study
Conclusions
Elevation of cardiac biomarkers was associated with poor prognosis of COVID-19 patients. (Source: BMJ Open)
Source: BMJ Open - April 23, 2024 Category: General Medicine Authors: Sano, M., Toyota, T., Morimoto, T., Noguchi, Y., Shigeno, R., Murai, R., Okada, T., Sasaki, Y., Taniguchi, T., Kim, K., Kobori, A., Ehara, N., Kinoshita, M., Doi, A., Tomii, K., Kihara, Y., Furukawa, Y. Tags: Open access, Cardiovascular medicine, COVID-19 Source Type: research
VaNoLaH trial: a study protocol--a multinational randomised controlled trial including two identical substudies comparing vaginal versus vNOTES (vaginal natural orifice transluminal surgery) hysterectomy or laparoscopic versus vNOTES hysterectomy
Introduction
Hysterectomy is one of the most common surgeries performed in women. Minimally invasive methods are on the rise globally as they have been shown to decrease surgical morbidity compared with abdominal hysterectomy. Hysterectomy by vaginal natural orifice transluminal endoscopic surgery (vNOTES) is the latest innovation. It combines the vaginal approach and endoscopy via the vagina. Large pragmatic randomised controlled trials (RCTs) are lacking comparing outcomes after vNOTES, vaginal hysterectomy (VH) and laparoscopic hysterectomy (LH).
Methods
Multicentre pragmatic RCT aiming to recruit 1000 women aged 18&nd...
Source: BMJ Open - April 23, 2024 Category: General Medicine Authors: Baekelandt, J. F., Stuart, A., Wagenius, J., Laenen, A., Mol, B. W., Deprest, J., Bosteels, J. J. A. Tags: Open access, Obstetrics & Gynaecology Obstetrics and gynaecology Source Type: research
Prevalence and social determinants of anxiety and depression among adults in Ghana: a systematic review and meta-analysis protocol
Introduction
Anxiety and depression pose a significant global health challenge, especially affecting adults in low-income and middle-income countries. In many low-income and middle-income countries, including those in sub-Saharan Africa, social determinants such as access to affordable health services, conflict, food insecurity, and poverty may be associated with the prevalence of anxiety and depression, further contributing to health disparities. To mitigate the burden of anxiety and depression in sub-Saharan Africa, it is essential to develop country-level tailored mental health policies and strategies. For example, Ghan...
Source: BMJ Open - April 23, 2024 Category: General Medicine Authors: Awortwe, V., Daivadanam, M., Adjorlolo, S., Olsson, E. M., Coumoundouros, C., Woodford, J. Tags: Open access, Mental health Source Type: research
Infection and telomere length: a systematic review protocol
Introduction
Telomeres are a measure of cellular ageing with potential links to diseases such as cardiovascular diseases and cancer. Studies have shown that some infections may be associated with telomere shortening, but whether an association exists across all types and severities of infections and in which populations is unclear. Therefore we aim to collate available evidence to enable comparison and to inform future research in this field.
Methods and analysis
We will search for studies involving telomere length and infection in various databases including MEDLINE (Ovid interface), EMBASE (Ovid interface), Web of Scien...
Source: BMJ Open - April 23, 2024 Category: General Medicine Authors: Tunnicliffe, L., Muzambi, R., Bartlett, J. W., Howe, L., Abdul Basit, K., Warren-Gash, C. Tags: Open access, Epidemiology Source Type: research
Self-directed digital interventions for the improvement of emotion regulation--effectiveness for mental health and functioning in adolescents: protocol for a systematic review
Introduction
Research suggests that problems with emotion regulation, that is, how a person manages and responds to an emotional experience, are related to a range of psychological disorders (eg, bipolar disorder, anxiety and depression). Interventions targeting emotion regulation have been shown to improve mental health in adults, but evidence on related interventions for adolescents is still emerging. Increasingly, self-directed digital interventions (eg, mobile apps) are being developed to target emotion regulation in this population, but questions remain about their effectiveness. This systematic review aimed to synthe...
Source: BMJ Open - April 23, 2024 Category: General Medicine Authors: Thomson, A., Lawrence, E. G., Oliver, B. R., Wright, B., Hosang, G. M. Tags: Open access, Mental health Source Type: research
Temporal trends and the association between self-rated oral health and falls in community-dwelling older adults in South Korea: a secondary analysis of survey data
Conclusions
Older adults with poor SROH, especially women, had more fall accidents, making them a priority target for fall prevention strategies. This study suggests considering SROH status when identifying fall risk factors in community-dwelling older adults. (Source: BMJ Open)
Source: BMJ Open - April 23, 2024 Category: General Medicine Authors: Seo, H.-J., Ahn, S.-K., Choi, M.-J. Tags: Open access, Epidemiology Source Type: research
