Recognition of nonself is necessary to activate Drosophila ’s immune response against an insect parasite
Innate immune responses can be activated by pathogen-associated molecular patterns (PAMPs), danger signals released by damaged tissues, or the absence of self-molecules that inhibit immunity. As PAMPs are typi... (Source: BMC Biology)
Source: BMC Biology - April 22, 2024 Category: Biology Authors: Alexandre B. Leit ão, Ramesh Arunkumar, Jonathan P. Day, Nancy Hanna, Aarathi Devi, Matthew P. Hayes and Francis M. Jiggins Tags: Research article Source Type: research
Fast and accurate variant identification tool for sequencing-based studies
Accurate identification of genetic variants, such as point mutations and insertions/deletions (indels), is crucial for various genetic studies into epidemic tracking, population genetics, and disease diagnosis... (Source: BMC Biology)
Source: BMC Biology - April 22, 2024 Category: Biology Authors: Jeffry M. Gaston, Eric J. Alm and An-Ni Zhang Tags: Research article Source Type: research
Listeria-vectored cervical cancer vaccine candidate strains reduce MDSCs via the JAK-STAT signaling pathway
Immunosuppressive status is prevalent in cancer patients and increases the complexity of tumor immunotherapy. It has been found that Listeria-vectored tumor vaccines had the potential ability of two-side regulato... (Source: BMC Biology)
Source: BMC Biology - April 19, 2024 Category: Biology Authors: Yunwen Zhang, Yao Lei, Qian Ou, Mengdie Chen, Sicheng Tian, Jing Tang, Ruidan Li, Qian Liang, Zhaobin Chen and Chuan Wang Tags: Research article Source Type: research
Prediction of blood –brain barrier penetrating peptides based on data augmentation with Augur
The blood –brain barrier serves as a critical interface between the bloodstream and brain tissue, mainly composed of pericytes, neurons, endothelial cells, and tightly connected basal membranes. It plays a pivo... (Source: BMC Biology)
Source: BMC Biology - April 19, 2024 Category: Biology Authors: Zhi-Feng Gu, Yu-Duo Hao, Tian-Yu Wang, Pei-Ling Cai, Yang Zhang, Ke-Jun Deng, Hao Lin and Hao Lv Tags: Research article Source Type: research
Genomic insights into the seawater adaptation in Cyprinidae
Cyprinidae, the largest fish family, encompasses approximately 367 genera and 3006 species. While they exhibit remarkable adaptability to diverse aquatic environments, it is exceptionally rare to find them in ... (Source: BMC Biology)
Source: BMC Biology - April 19, 2024 Category: Biology Authors: Ying Wang, Xuejing Zhang, Jing Wang, Cheng Wang, Fei Xiong, Yuting Qian, Minghui Meng, Min Zhou, Wenjun Chen, Zufa Ding, Dan Yu, Yang Liu, Yumei Chang, Shunping He and Liandong Yang Tags: Research article Source Type: research
GATA3 functions downstream of BRCA1 to promote DNA damage repair and suppress dedifferentiation in breast cancer
Inadequate DNA damage repair promotes aberrant differentiation of mammary epithelial cells. Mammary luminal cell fate is mainly determined by a few transcription factors including GATA3. We previously reported... (Source: BMC Biology)
Source: BMC Biology - April 16, 2024 Category: Biology Authors: Xuejie Wang, Feng Bai, Xiong Liu, Bin Peng, Xingzhi Xu, Hongquan Zhang, Li Fu, Wei-Guo Zhu, Bin Wang and Xin-Hai Pei Tags: Research article Source Type: research
Nuclear lamina component KAKU4 regulates chromatin states and transcriptional regulation in the Arabidopsis genome
The nuclear lamina links the nuclear membrane to chromosomes and plays a crucial role in regulating chromatin states and gene expression. However, current knowledge of nuclear lamina in plants is limited compa... (Source: BMC Biology)
Source: BMC Biology - April 12, 2024 Category: Biology Authors: Yaxin Cao, Hengyu Yan, Minghao Sheng, Yue Liu, Xinyue Yu, Zhongqiu Li, Wenying Xu and Zhen Su Tags: Research article Source Type: research
A network of transcription factors in complex with a regulating cell cycle cyclin orchestrates fungal oxidative stress responses
Response to oxidative stress is universal in almost all organisms and the mitochondrial membrane protein, BbOhmm, negatively affects oxidative stress responses and virulence in the insect fungal pathogen, Beauver... (Source: BMC Biology)
Source: BMC Biology - April 12, 2024 Category: Biology Authors: Yanze Kan, Zhangjiang He, Nemat O. Keyhani, Ning Li, Shuaishuai Huang, Xin Zhao, Pengfei Liu, Fanqin Zeng, Min Li, Zhibing Luo and Yongjun Zhang Tags: Research article Source Type: research
Chromosome-level genome assembly of Hippophae tibetana provides insights into high-altitude adaptation and flavonoid biosynthesis
As an endemic shrub of the Qinghai-Tibetan Plateau (QTP), the distribution of Hippophae tibetana Schlecht. ranges between 2800 and 5200 m above sea level. As the most basal branch of the Hippophae genus, H. tibet... (Source: BMC Biology)
Source: BMC Biology - April 12, 2024 Category: Biology Authors: Guoyun Zhang, Yating Song, Ning Chen, Jihua Wei, Jianguo Zhang and Caiyun He Tags: Research article Source Type: research
Targeting of REST with rationally-designed small molecule compounds exhibits synergetic therapeutic potential in human glioblastoma cells
Glioblastoma (GBM) is an aggressive brain cancer associated with poor prognosis, intrinsic heterogeneity, plasticity, and therapy resistance. In some GBMs, cell proliferation is fueled by a transcriptional reg... (Source: BMC Biology)
Source: BMC Biology - April 12, 2024 Category: Biology Authors: Svetlana B. Panina, Joshua V. Schweer, Qian Zhang, Gaurav Raina, Haley A. Hardtke, Seungjin Kim, Wanjie Yang, Dionicio Siegel and Y. Jessie Zhang Tags: Research article Source Type: research
A cilia-bound unconventional secretory pathway for Drosophila odorant receptors
Post-translational transport is a vital process which ensures that each protein reaches its site of function. Though most do so via an ordered ER-to-Golgi route, an increasing number of proteins are now shown ... (Source: BMC Biology)
Source: BMC Biology - April 12, 2024 Category: Biology Authors: Najat Dzaki and Mattias Alenius Tags: Research article Source Type: research
Integrative analysis of transcriptomic and epigenomic data reveals distinct patterns for developmental and housekeeping gene regulation
Regulation of transcription is central to the emergence of new cell types during development, and it often involves activation of genes via proximal and distal regulatory regions. The activity of regulatory el... (Source: BMC Biology)
Source: BMC Biology - April 10, 2024 Category: Biology Authors: Irina Abnizova, Carine Stapel, Rene te Boekhorst, Jimmy Tsz Hang Lee and Martin Hemberg Tags: Research article Source Type: research
Fossil-calibrated molecular clock data enable reconstruction of steps leading to differentiated multicellularity and anisogamy in the Volvocine algae
Throughout its nearly four-billion-year history, life has undergone evolutionary transitions in which simpler subunits have become integrated to form a more complex whole. Many of these transitions opened the ... (Source: BMC Biology)
Source: BMC Biology - April 10, 2024 Category: Biology Authors: Charles Ross Lindsey, Andrew H. Knoll, Matthew D. Herron and Frank Rosenzweig Tags: Research article Source Type: research
High incidence of imperforate vagina in ADGRA3-deficient mice
Ten percent of the female population suffers from congenital abnormalities of the vagina, uterus, or oviducts, with severe consequences for reproductive and psychological health. Yet, the underlying causes of ... (Source: BMC Biology)
Source: BMC Biology - April 8, 2024 Category: Biology Authors: Jone Marita Kvam, Maja Lind Nybo, Lola Torz, Riia Karolina Sustarsic, Kristian H øj Reveles Jensen, John Erik Nielsen, Hanne Frederiksen, Sarina Gadgaard, Katja Spiess, Steen Seier Poulsen, Jesper Skovhus Thomsen, Pamela Cowin, Martin Blomberg Jensen, Ta Tags: Research article Source Type: research
Bacterial accumulation in intestinal folds induced by physical and biological factors
The gut microbiota, vital for host health, influences metabolism, immune function, and development. Understanding the dynamic processes of bacterial accumulation within the gut is crucial, as it is closely rel... (Source: BMC Biology)
Source: BMC Biology - April 5, 2024 Category: Biology Authors: Jinyou Yang, Toma Isaka, Kenji Kikuchi, Keiko Numayama-Tsuruta and Takuji Ishikawa Tags: Research article Source Type: research
