Gut microbiota-generated metabolites: missing puzzles to hosts' health, diseases, and aging
BMB Rep. 2024 Apr 17:6194. Online ahead of print.ABSTRACTThe gut microbiota, an intricate community of bacteria residing in the gastrointestinal system, assumes a pivotal role in various physiological processes. Beyond its function in food breakdown and nutrient absorption, gut microbiota exerts a profound influence on immune and metabolic modulation by producing diverse gut microbiota-generated metabolites (GMGMs). These small molecules hold potential to impact host health via multiple pathways, which exhibit remarkable diversity, and have gained increasing attention in recent studies. Here, we elucidate the intricate imp...
Source: BMB Reports - April 17, 2024 Category: Biochemistry Authors: Yan Zhang Shibo Wei Hang Zhang Yunju Jo Jong-Sun Kang Ki-Tae Ha Jongkil Joo Hyun Joo Lee Dongryeol Ryu Source Type: research
3D epigenomics and 3D epigenopathies
BMB Rep. 2024 Apr 17:6163. Online ahead of print.ABSTRACTMammalian genomes are intricately compacted to form sophisticated 3-dimensional structures within the tiny nucleus, so called 3D genome folding. Despite their shapes reminiscent of an entangled yarn, the rapid development of molecular and next-generation sequencing technologies (NGS) has revealed that mammalian genomes are highly organized in a hierarchical order that delicately affects transcription activities. An increasing amount of evidence suggests that 3D genome folding is implicated in diseases, giving us a clue on how to identify novel therapeutic approaches....
Source: BMB Reports - April 17, 2024 Category: Biochemistry Authors: Kyung-Hwan Lee Jungyu Kim Ji Hun Kim Source Type: research
Cisd2 deficiency impairs neutrophil function by regulating calcium homeostasis via Calnexin and SERCA
BMB Rep. 2024 Apr 17:6179. Online ahead of print.ABSTRACTIn the context of aging, the susceptibility to infectious diseases increases, leading to heightened morbidity and mortality. This phenomenon, termed immunosenescence, is characterized by dysregulation in the aging immune system, including abnormal alterations in lymphocyte composition, elevated basal inflammation, and the accumulation of senescent T cells. Such changes contribute to increased autoimmune diseases, enhanced infection severity, and reduced responsiveness to vaccines. Utilizing aging animal models becomes imperative for a comprehensive understanding of i...
Source: BMB Reports - April 17, 2024 Category: Biochemistry Authors: Un Yung Choi Youn Jung Choi Shin-Ae Lee Ji-Seung Yoo Source Type: research
Emerging paradigms in cancer cell plasticity
BMB Rep. 2024 Apr 17:6190. Online ahead of print.ABSTRACTCancer cells metastasize to distant organs by altering their characteristics within the tumor microenvironment (TME) to effectively overcome challenges during the multistep tumorigenesis. Plasticity endows cancer cell with the capacity to shift between different states to invade, disseminate, and seed metastasis. The epithelial-to-mesenchymal transition (EMT) is a cellular program that abrogates cell-cell adhesions by EMT transcription factors (TF) and acquires mesenchymal features during cancer progression. On the other hand, adherent-to-suspension transition (AST) ...
Source: BMB Reports - April 17, 2024 Category: Biochemistry Authors: Hyunbin D Huh Hyun Woo Park Source Type: research
Prmt7 is required for the osteogenic differentiation of mesenchymal stem cells via modulation of BMP signaling
BMB Rep. 2024 Apr 17:6095. Online ahead of print.ABSTRACTArginine methylation, which is catalyzed by protein arginine methyltransferases (Prmts), is known to play a key role in various biological processes. However, the function of Prmts in osteogenic differentiation of mesenchymal stem cells (MSCs) has not been clearly understood. In the current study, we attempted to elucidate a positive role of Prmt7 in osteogenic differentiation. Prmt7-depleted C3H/10T1/2 cells or bone marrow mesenchymal stem cells (BMSCs) showed the attenuated expression of osteogenic specific genes and Alizarin red staining compared to the wild-type ...
Source: BMB Reports - April 17, 2024 Category: Biochemistry Authors: Tuan Anh Vuong Yan Zhang June Kim Young-Eun Leem Jong-Sun Kang Source Type: research
Gut microbiota-generated metabolites: missing puzzles to hosts' health, diseases, and aging
BMB Rep. 2024 Apr 17:6194. Online ahead of print.ABSTRACTThe gut microbiota, an intricate community of bacteria residing in the gastrointestinal system, assumes a pivotal role in various physiological processes. Beyond its function in food breakdown and nutrient absorption, gut microbiota exerts a profound influence on immune and metabolic modulation by producing diverse gut microbiota-generated metabolites (GMGMs). These small molecules hold potential to impact host health via multiple pathways, which exhibit remarkable diversity, and have gained increasing attention in recent studies. Here, we elucidate the intricate imp...
Source: BMB Reports - April 17, 2024 Category: Biochemistry Authors: Yan Zhang Shibo Wei Hang Zhang Yunju Jo Jong-Sun Kang Ki-Tae Ha Jongkil Joo Hyun Joo Lee Dongryeol Ryu Source Type: research
3D epigenomics and 3D epigenopathies
BMB Rep. 2024 Apr 17:6163. Online ahead of print.ABSTRACTMammalian genomes are intricately compacted to form sophisticated 3-dimensional structures within the tiny nucleus, so called 3D genome folding. Despite their shapes reminiscent of an entangled yarn, the rapid development of molecular and next-generation sequencing technologies (NGS) has revealed that mammalian genomes are highly organized in a hierarchical order that delicately affects transcription activities. An increasing amount of evidence suggests that 3D genome folding is implicated in diseases, giving us a clue on how to identify novel therapeutic approaches....
Source: BMB Reports - April 17, 2024 Category: Biochemistry Authors: Kyung-Hwan Lee Jungyu Kim Ji Hun Kim Source Type: research
Cisd2 deficiency impairs neutrophil function by regulating calcium homeostasis via Calnexin and SERCA
BMB Rep. 2024 Apr 17:6179. Online ahead of print.ABSTRACTIn the context of aging, the susceptibility to infectious diseases increases, leading to heightened morbidity and mortality. This phenomenon, termed immunosenescence, is characterized by dysregulation in the aging immune system, including abnormal alterations in lymphocyte composition, elevated basal inflammation, and the accumulation of senescent T cells. Such changes contribute to increased autoimmune diseases, enhanced infection severity, and reduced responsiveness to vaccines. Utilizing aging animal models becomes imperative for a comprehensive understanding of i...
Source: BMB Reports - April 17, 2024 Category: Biochemistry Authors: Un Yung Choi Youn Jung Choi Shin-Ae Lee Ji-Seung Yoo Source Type: research
Emerging paradigms in cancer cell plasticity
BMB Rep. 2024 Apr 17:6190. Online ahead of print.ABSTRACTCancer cells metastasize to distant organs by altering their characteristics within the tumor microenvironment (TME) to effectively overcome challenges during the multistep tumorigenesis. Plasticity endows cancer cell with the capacity to shift between different states to invade, disseminate, and seed metastasis. The epithelial-to-mesenchymal transition (EMT) is a cellular program that abrogates cell-cell adhesions by EMT transcription factors (TF) and acquires mesenchymal features during cancer progression. On the other hand, adherent-to-suspension transition (AST) ...
Source: BMB Reports - April 17, 2024 Category: Biochemistry Authors: Hyunbin D Huh Hyun Woo Park Source Type: research
Prmt7 is required for the osteogenic differentiation of mesenchymal stem cells via modulation of BMP signaling
BMB Rep. 2024 Apr 17:6095. Online ahead of print.ABSTRACTArginine methylation, which is catalyzed by protein arginine methyltransferases (Prmts), is known to play a key role in various biological processes. However, the function of Prmts in osteogenic differentiation of mesenchymal stem cells (MSCs) has not been clearly understood. In the current study, we attempted to elucidate a positive role of Prmt7 in osteogenic differentiation. Prmt7-depleted C3H/10T1/2 cells or bone marrow mesenchymal stem cells (BMSCs) showed the attenuated expression of osteogenic specific genes and Alizarin red staining compared to the wild-type ...
Source: BMB Reports - April 17, 2024 Category: Biochemistry Authors: Tuan Anh Vuong Yan Zhang June Kim Young-Eun Leem Jong-Sun Kang Source Type: research
The contribution of the nervous system in the cancer progression
BMB Rep. 2024 Mar 25:6191. Online ahead of print.ABSTRACTCancer progression is driven by genetic mutations, environmental factors, and intricate interactions within the tumor microenvironment (TME). The TME comprises of diverse cell types, such as cancer cells, immune cells, stromal cells, and neuronal cells. These cells mutually influence each other through various factors, including cytokines, vascular perfusion, and matrix stiffness. In the initial or developmental stage of cancer, neurotrophic factors such as nerve growth factor, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor are ass...
Source: BMB Reports - March 25, 2024 Category: Biochemistry Authors: Hongryeol Park Chan Hee Lee Source Type: research
Triamcinolone acetonide alleviates benign biliary stricture by ameliorating biliary fibrosis and inflammation
BMB Rep. 2024 Mar 25:6139. Online ahead of print.ABSTRACTWe conducted a comprehensive series of molecular biological studies aimed at unraveling the intricate mechanisms underlying the anti-fibrotic effects of triamcinolone acetonide (TA) when used in conjunction with fully covered self-expandable metal stents (FCSEMS) for the management of benign biliary strictures (BBS). To decipher the molecular mechanisms responsible for the anti-fibrotic effects of corticosteroids on gallbladder mucosa, we conducted a comprehensive analysis. This analysis included various methodologies such as immunohistochemistry, ELISA, real-time PC...
Source: BMB Reports - March 25, 2024 Category: Biochemistry Authors: Seyeon Joo See Young Joo Su Yeon Lee Yeseong Hwang Minki Kim Jae Woong Jeong Sung Ill Jang Sungsoon Fang Source Type: research
CDKN2 expression is a potential biomarker for T cell exhaustion in hepatocellular carcinoma
BMB Rep. 2024 Mar 25:6113. Online ahead of print.ABSTRACTHepatocellular Carcinoma (HCC), the predominant primary hepatic malignancy, is the prime contributor to mortality. Despite the availability of multiple surgical interventions, patient outcomes remain suboptimal. Immunotherapies have emerged as effective strategies for HCC treatment with multiple clinical advantages. However, their curative efficacy is not always satisfactory, limited by the dysfunctional T cell status. Thus, there is a pressing need to discover novel potential biomarkers indicative of T cell exhaustion (Tex) for personalized immunotherapies. One prom...
Source: BMB Reports - March 25, 2024 Category: Biochemistry Authors: Shibo Wei Yan Zhang Baeki E Kang Wonyoung Park He Guo Seungyoon Nam Jong-Sun Kang Jee-Heon Jeong Yunju Jo Dongryeol Ryu Yikun Jiang Ki-Tae Ha Source Type: research
The contribution of the nervous system in the cancer progression
BMB Rep. 2024 Mar 25:6191. Online ahead of print.ABSTRACTCancer progression is driven by genetic mutations, environmental factors, and intricate interactions within the tumor microenvironment (TME). The TME comprises of diverse cell types, such as cancer cells, immune cells, stromal cells, and neuronal cells. These cells mutually influence each other through various factors, including cytokines, vascular perfusion, and matrix stiffness. In the initial or developmental stage of cancer, neurotrophic factors such as nerve growth factor, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor are ass...
Source: BMB Reports - March 25, 2024 Category: Biochemistry Authors: Hongryeol Park Chan Hee Lee Source Type: research
Triamcinolone acetonide alleviates benign biliary stricture by ameliorating biliary fibrosis and inflammation
BMB Rep. 2024 Mar 25:6139. Online ahead of print.ABSTRACTWe conducted a comprehensive series of molecular biological studies aimed at unraveling the intricate mechanisms underlying the anti-fibrotic effects of triamcinolone acetonide (TA) when used in conjunction with fully covered self-expandable metal stents (FCSEMS) for the management of benign biliary strictures (BBS). To decipher the molecular mechanisms responsible for the anti-fibrotic effects of corticosteroids on gallbladder mucosa, we conducted a comprehensive analysis. This analysis included various methodologies such as immunohistochemistry, ELISA, real-time PC...
Source: BMB Reports - March 25, 2024 Category: Biochemistry Authors: Seyeon Joo See Young Joo Su Yeon Lee Yeseong Hwang Minki Kim Jae Woong Jeong Sung Ill Jang Sungsoon Fang Source Type: research
