Vagus nerve stimulation alleviates cardiac dysfunction and inflammatory markers during heart failure in rats
This study aimed to investigate its therapeutic effects on three main components of heart failure: cardiac function, cardiac remodeling and central neuroinflammation using a pressure overload (PO) rat model. Male Sprague-Dawley rats were divided into four groups: PO, PO + VNS, PO + VNS sham, and controls. All rats, except controls, underwent a PO surgery to constrict the thoracic aorta (~50 %) to induce HFrEF. Open loop VNS therapy was continuously administered to PO + VNS rats at 20 Hz, 1.0 mA for 60 days. Evaluation of cardiac function and structure via echocardiograms showed decreases in stroke volume and relative eject...
Source: Autonomic Neuroscience - March 21, 2024 Category: Neuroscience Authors: Misty M Owens Suman Dalal Aleksandra Radovic Luciano Fernandes Hassan Syed Mary-Katherine Herndon Coty Cooper Krishna Singh Eric Beaumont Source Type: research

Vagus nerve stimulation alleviates cardiac dysfunction and inflammatory markers during heart failure in rats
This study aimed to investigate its therapeutic effects on three main components of heart failure: cardiac function, cardiac remodeling and central neuroinflammation using a pressure overload (PO) rat model. Male Sprague-Dawley rats were divided into four groups: PO, PO + VNS, PO + VNS sham, and controls. All rats, except controls, underwent a PO surgery to constrict the thoracic aorta (~50 %) to induce HFrEF. Open loop VNS therapy was continuously administered to PO + VNS rats at 20 Hz, 1.0 mA for 60 days. Evaluation of cardiac function and structure via echocardiograms showed decreases in stroke volume and relative eject...
Source: Autonomic Neuroscience - March 21, 2024 Category: Neuroscience Authors: Misty M Owens Suman Dalal Aleksandra Radovic Luciano Fernandes Hassan Syed Mary-Katherine Herndon Coty Cooper Krishna Singh Eric Beaumont Source Type: research

Vagus nerve stimulation alleviates cardiac dysfunction and inflammatory markers during heart failure in rats
This study aimed to investigate its therapeutic effects on three main components of heart failure: cardiac function, cardiac remodeling and central neuroinflammation using a pressure overload (PO) rat model. Male Sprague-Dawley rats were divided into four groups: PO, PO + VNS, PO + VNS sham, and controls. All rats, except controls, underwent a PO surgery to constrict the thoracic aorta (~50 %) to induce HFrEF. Open loop VNS therapy was continuously administered to PO + VNS rats at 20 Hz, 1.0 mA for 60 days. Evaluation of cardiac function and structure via echocardiograms showed decreases in stroke volume and relative eject...
Source: Autonomic Neuroscience - March 21, 2024 Category: Neuroscience Authors: Misty M Owens Suman Dalal Aleksandra Radovic Luciano Fernandes Hassan Syed Mary-Katherine Herndon Coty Cooper Krishna Singh Eric Beaumont Source Type: research

Vagus nerve stimulation alleviates cardiac dysfunction and inflammatory markers during heart failure in rats
This study aimed to investigate its therapeutic effects on three main components of heart failure: cardiac function, cardiac remodeling and central neuroinflammation using a pressure overload (PO) rat model. Male Sprague-Dawley rats were divided into four groups: PO, PO + VNS, PO + VNS sham, and controls. All rats, except controls, underwent a PO surgery to constrict the thoracic aorta (~50 %) to induce HFrEF. Open loop VNS therapy was continuously administered to PO + VNS rats at 20 Hz, 1.0 mA for 60 days. Evaluation of cardiac function and structure via echocardiograms showed decreases in stroke volume and relative eject...
Source: Autonomic Neuroscience - March 21, 2024 Category: Neuroscience Authors: Misty M Owens Suman Dalal Aleksandra Radovic Luciano Fernandes Hassan Syed Mary-Katherine Herndon Coty Cooper Krishna Singh Eric Beaumont Source Type: research

Gastrointestinal dysfunction in the valproic acid induced model of social deficit in rats
Auton Neurosci. 2024 Feb 29;253:103161. doi: 10.1016/j.autneu.2024.103161. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) has increased in incidence over the past several decades, and is associated with a range of co-morbidities including gastrointestinal (GI) dysfunctions including gastroesophageal reflux, abdominal pain, bloating, constipation and/or diarrhea. Several animal models have been used that replicate several aspects of ASD but no single model has been able to replicate the entire disease pathophysiology. In humans, prenatal exposure to valproic acid (VPA) has been identified as a significant risk...
Source: Autonomic Neuroscience - March 10, 2024 Category: Neuroscience Authors: Ashley N Varley Kirsteen N Browning Source Type: research

Gastrointestinal dysfunction in the valproic acid induced model of social deficit in rats
Auton Neurosci. 2024 Feb 29;253:103161. doi: 10.1016/j.autneu.2024.103161. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) has increased in incidence over the past several decades, and is associated with a range of co-morbidities including gastrointestinal (GI) dysfunctions including gastroesophageal reflux, abdominal pain, bloating, constipation and/or diarrhea. Several animal models have been used that replicate several aspects of ASD but no single model has been able to replicate the entire disease pathophysiology. In humans, prenatal exposure to valproic acid (VPA) has been identified as a significant risk...
Source: Autonomic Neuroscience - March 10, 2024 Category: Neuroscience Authors: Ashley N Varley Kirsteen N Browning Source Type: research

Gastrointestinal dysfunction in the valproic acid induced model of social deficit in rats
Auton Neurosci. 2024 Feb 29;253:103161. doi: 10.1016/j.autneu.2024.103161. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) has increased in incidence over the past several decades, and is associated with a range of co-morbidities including gastrointestinal (GI) dysfunctions including gastroesophageal reflux, abdominal pain, bloating, constipation and/or diarrhea. Several animal models have been used that replicate several aspects of ASD but no single model has been able to replicate the entire disease pathophysiology. In humans, prenatal exposure to valproic acid (VPA) has been identified as a significant risk...
Source: Autonomic Neuroscience - March 10, 2024 Category: Neuroscience Authors: Ashley N Varley Kirsteen N Browning Source Type: research

Gastrointestinal dysfunction in the valproic acid induced model of social deficit in rats
Auton Neurosci. 2024 Feb 29;253:103161. doi: 10.1016/j.autneu.2024.103161. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) has increased in incidence over the past several decades, and is associated with a range of co-morbidities including gastrointestinal (GI) dysfunctions including gastroesophageal reflux, abdominal pain, bloating, constipation and/or diarrhea. Several animal models have been used that replicate several aspects of ASD but no single model has been able to replicate the entire disease pathophysiology. In humans, prenatal exposure to valproic acid (VPA) has been identified as a significant risk...
Source: Autonomic Neuroscience - March 10, 2024 Category: Neuroscience Authors: Ashley N Varley Kirsteen N Browning Source Type: research

Gastrointestinal dysfunction in the valproic acid induced model of social deficit in rats
Auton Neurosci. 2024 Feb 29;253:103161. doi: 10.1016/j.autneu.2024.103161. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) has increased in incidence over the past several decades, and is associated with a range of co-morbidities including gastrointestinal (GI) dysfunctions including gastroesophageal reflux, abdominal pain, bloating, constipation and/or diarrhea. Several animal models have been used that replicate several aspects of ASD but no single model has been able to replicate the entire disease pathophysiology. In humans, prenatal exposure to valproic acid (VPA) has been identified as a significant risk...
Source: Autonomic Neuroscience - March 10, 2024 Category: Neuroscience Authors: Ashley N Varley Kirsteen N Browning Source Type: research

Gastrointestinal dysfunction in the valproic acid induced model of social deficit in rats
Auton Neurosci. 2024 Feb 29;253:103161. doi: 10.1016/j.autneu.2024.103161. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) has increased in incidence over the past several decades, and is associated with a range of co-morbidities including gastrointestinal (GI) dysfunctions including gastroesophageal reflux, abdominal pain, bloating, constipation and/or diarrhea. Several animal models have been used that replicate several aspects of ASD but no single model has been able to replicate the entire disease pathophysiology. In humans, prenatal exposure to valproic acid (VPA) has been identified as a significant risk...
Source: Autonomic Neuroscience - March 10, 2024 Category: Neuroscience Authors: Ashley N Varley Kirsteen N Browning Source Type: research

Gastrointestinal dysfunction in the valproic acid induced model of social deficit in rats
Auton Neurosci. 2024 Feb 29;253:103161. doi: 10.1016/j.autneu.2024.103161. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) has increased in incidence over the past several decades, and is associated with a range of co-morbidities including gastrointestinal (GI) dysfunctions including gastroesophageal reflux, abdominal pain, bloating, constipation and/or diarrhea. Several animal models have been used that replicate several aspects of ASD but no single model has been able to replicate the entire disease pathophysiology. In humans, prenatal exposure to valproic acid (VPA) has been identified as a significant risk...
Source: Autonomic Neuroscience - March 10, 2024 Category: Neuroscience Authors: Ashley N Varley Kirsteen N Browning Source Type: research

Gastrointestinal dysfunction in the valproic acid induced model of social deficit in rats
Auton Neurosci. 2024 Feb 29;253:103161. doi: 10.1016/j.autneu.2024.103161. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) has increased in incidence over the past several decades, and is associated with a range of co-morbidities including gastrointestinal (GI) dysfunctions including gastroesophageal reflux, abdominal pain, bloating, constipation and/or diarrhea. Several animal models have been used that replicate several aspects of ASD but no single model has been able to replicate the entire disease pathophysiology. In humans, prenatal exposure to valproic acid (VPA) has been identified as a significant risk...
Source: Autonomic Neuroscience - March 10, 2024 Category: Neuroscience Authors: Ashley N Varley Kirsteen N Browning Source Type: research

Gastrointestinal dysfunction in the valproic acid induced model of social deficit in rats
Auton Neurosci. 2024 Feb 29;253:103161. doi: 10.1016/j.autneu.2024.103161. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) has increased in incidence over the past several decades, and is associated with a range of co-morbidities including gastrointestinal (GI) dysfunctions including gastroesophageal reflux, abdominal pain, bloating, constipation and/or diarrhea. Several animal models have been used that replicate several aspects of ASD but no single model has been able to replicate the entire disease pathophysiology. In humans, prenatal exposure to valproic acid (VPA) has been identified as a significant risk...
Source: Autonomic Neuroscience - March 10, 2024 Category: Neuroscience Authors: Ashley N Varley Kirsteen N Browning Source Type: research

Assessment of cardiovascular functioning following sport-related concussion: A physiological perspective
Auton Neurosci. 2024 Feb 24;252:103160. doi: 10.1016/j.autneu.2024.103160. Online ahead of print.ABSTRACTThere is still much uncertainty surrounding the approach to diagnosing and managing a sport-related concussion (SRC). Neurobiological recovery may extend beyond clinical recovery following SRC, highlighting the need for objective physiological parameters to guide diagnosis and management. With an increased understanding of the connection between the heart and the brain, the utility of assessing cardiovascular functioning following SRC has gained attention. As such, this review focuses on the assessment of cardiovascular...
Source: Autonomic Neuroscience - March 1, 2024 Category: Neuroscience Authors: Chase J Ellingson M Abdullah Shafiq Cody A Ellingson J Patrick Neary Payam Dehghani Jyotpal Singh Source Type: research

Innate and adaptive immune system consequences of post-traumatic stress disorder
Auton Neurosci. 2024 Feb 23;252:103159. doi: 10.1016/j.autneu.2024.103159. Online ahead of print.ABSTRACTIn the field of psychiatry, biological markers are rarely, if ever, used in the diagnosis of mental health disorders. Clinicians rely primarily on patient histories and behavioral symptoms to identify specific psychopathologies, which makes diagnosis highly subjective. Moreover, therapies for mental health disorders are aimed specifically at attenuating behavioral manifestations, which overlooks the pathophysiological indices of the disease. This is highly evident in posttraumatic stress disorder (PTSD) where inflammati...
Source: Autonomic Neuroscience - March 1, 2024 Category: Neuroscience Authors: Tatlock H Lauten Tamara Natour Adam J Case Source Type: research