Higher paracetamol levels are associated with elevated glucocorticoid concentrations in hair: findings from a large cohort of young adults
This study addresses this gap by investigating associations between steroid hormones (cortisol, cortisone, and testosterone) and paracetamol concentrations measured in human hair, indexing a timeframe of approximately three months. The data came from a large community sample of young adults (N = 1002). Hair data were assayed using liquid chromatography-tandem mass spectrometry. Multiple regression models tested associations between paracetamol and steroid hormones, while adjusting for a wide range of potential confounders, such as sex, stressful live events, psychoactive substance use, hair colour, and body mass index. Alm...
Source: Archives of Toxicology - April 14, 2024 Category: Toxicology Authors: Lydia Johnson-Ferguson Lilly Shanahan Michelle Loher Laura Bechtiger Tina M Binz Markus Baumgartner Denis Ribeaud Manuel Eisner Boris B Quednow Source Type: research
Genotoxicity and safety pharmacology of the rVSVInd(GML)-mspSGtc vaccine against SARS-CoV-2 in Sprague-Dawley rats and Beagle dogs
Arch Toxicol. 2024 Apr 12. doi: 10.1007/s00204-024-03746-x. Online ahead of print.ABSTRACTThe emergence of coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to a pandemic, prompting rapid vaccine development. Although vaccines are effective, the occurrence of rare adverse events following vaccination highlights the necessity of determining whether the benefits outweigh the risks posed by the infection itself. The recombinant Vesicular Stomatitis Virus (rVSV) platform is a promising vector for vaccines against emerging viruses. However, limited studies have evaluated t...
Source: Archives of Toxicology - April 12, 2024 Category: Toxicology Authors: Sang-Jin Park Heeseon Park Seng-Min Back Young Ju Lee Joung-Wook Seo Dabi Kim Jeong Hwa Lee Chaewon Kwak Kang-Hyun Han Hwa-Young Son Yong-Bum Kim Source Type: research
Genotoxicity and safety pharmacology of the rVSVInd(GML)-mspSGtc vaccine against SARS-CoV-2 in Sprague-Dawley rats and Beagle dogs
Arch Toxicol. 2024 Apr 12. doi: 10.1007/s00204-024-03746-x. Online ahead of print.ABSTRACTThe emergence of coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to a pandemic, prompting rapid vaccine development. Although vaccines are effective, the occurrence of rare adverse events following vaccination highlights the necessity of determining whether the benefits outweigh the risks posed by the infection itself. The recombinant Vesicular Stomatitis Virus (rVSV) platform is a promising vector for vaccines against emerging viruses. However, limited studies have evaluated t...
Source: Archives of Toxicology - April 12, 2024 Category: Toxicology Authors: Sang-Jin Park Heeseon Park Seng-Min Back Young Ju Lee Joung-Wook Seo Dabi Kim Jeong Hwa Lee Chaewon Kwak Kang-Hyun Han Hwa-Young Son Yong-Bum Kim Source Type: research
Targeted ferritinophagy in gastrointestinal cancer: from molecular mechanisms to implications
Arch Toxicol. 2024 Apr 11. doi: 10.1007/s00204-024-03745-y. Online ahead of print.ABSTRACTGastrointestinal cancer is a significant global health burden, necessitating the development of novel therapeutic strategies. Emerging evidence has highlighted the potential of targeting ferritinophagy as a promising approach for the treatment of gastrointestinal cancer. Ferritinophagy is a form of selective autophagy that is mediated by the nuclear receptor coactivator 4 (NCOA4). This process plays a crucial role in regulating cellular iron homeostasis and has been implicated in various pathological conditions, including cancer. This...
Source: Archives of Toxicology - April 11, 2024 Category: Toxicology Authors: Zhaotian Feng Muhua Luan Wenshuai Zhu Yuanxin Xing Xiaoli Ma Yunshan Wang Yanfei Jia Source Type: research
Targeted ferritinophagy in gastrointestinal cancer: from molecular mechanisms to implications
Arch Toxicol. 2024 Apr 11. doi: 10.1007/s00204-024-03745-y. Online ahead of print.ABSTRACTGastrointestinal cancer is a significant global health burden, necessitating the development of novel therapeutic strategies. Emerging evidence has highlighted the potential of targeting ferritinophagy as a promising approach for the treatment of gastrointestinal cancer. Ferritinophagy is a form of selective autophagy that is mediated by the nuclear receptor coactivator 4 (NCOA4). This process plays a crucial role in regulating cellular iron homeostasis and has been implicated in various pathological conditions, including cancer. This...
Source: Archives of Toxicology - April 11, 2024 Category: Toxicology Authors: Zhaotian Feng Muhua Luan Wenshuai Zhu Yuanxin Xing Xiaoli Ma Yunshan Wang Yanfei Jia Source Type: research
The role of genetic polymorphisms for inducing genotoxicity in workers occupationally exposed to benzene: a systematic review
Arch Toxicol. 2024 Apr 10. doi: 10.1007/s00204-024-03744-z. Online ahead of print.ABSTRACTBenzene is used worldwide as a major raw material in a number of industrial processes and also a potent airborne pollutant emitted from traffic exhaust fume. The present systematic review aimed to identify potential associations between genetic polymorphisms and occupational benzene-induced genotoxicity. For this purpose, a total of 22 selected studies were carefully analysed. Our results revealed a positive relation between gene polymorphism and genotoxicity in individuals exposed to benzene, since 17 studies (out of 22) observed pos...
Source: Archives of Toxicology - April 10, 2024 Category: Toxicology Authors: Thiago Guedes Pinto Thayza Aires Dias Ana Claudia Muniz Renno Milena de Barros Viana Daniel Araki Ribeiro Source Type: research
Correction to: Cytotoxicity of Prymnesium parvum extracts and prymnesin analogs on epithelial fish gill cells RTgill-W1 and the human colon cell line HCEC-1CT
Arch Toxicol. 2024 Apr 9. doi: 10.1007/s00204-024-03716-3. Online ahead of print.NO ABSTRACTPMID:38592475 | DOI:10.1007/s00204-024-03716-3 (Source: Archives of Toxicology)
Source: Archives of Toxicology - April 9, 2024 Category: Toxicology Authors: Elisabeth Varga H élène-Christine Prause Matthias Riepl Nadine Hochmayr Deniz Berk Eva Attakpah Endre Kiss Nikola Medi ć Giorgia Del Favero Thomas Ostenfeld Larsen Per Juel Hansen Doris Marko Source Type: research
Correction to: Cytotoxicity of Prymnesium parvum extracts and prymnesin analogs on epithelial fish gill cells RTgill-W1 and the human colon cell line HCEC-1CT
Arch Toxicol. 2024 Apr 9. doi: 10.1007/s00204-024-03716-3. Online ahead of print.NO ABSTRACTPMID:38592475 | DOI:10.1007/s00204-024-03716-3 (Source: Archives of Toxicology)
Source: Archives of Toxicology - April 9, 2024 Category: Toxicology Authors: Elisabeth Varga H élène-Christine Prause Matthias Riepl Nadine Hochmayr Deniz Berk Eva Attakpah Endre Kiss Nikola Medi ć Giorgia Del Favero Thomas Ostenfeld Larsen Per Juel Hansen Doris Marko Source Type: research
Interaction of the chemotherapeutic agent oxaliplatin and the tyrosine kinase inhibitor dasatinib with the organic cation transporter 2
Arch Toxicol. 2024 Apr 8. doi: 10.1007/s00204-024-03742-1. Online ahead of print.ABSTRACTOxaliplatin (OHP) is effective in colorectal cancer treatment but induces peripheral neurotoxicity (OHP-induced peripheral neurotoxicity, OIPN), diminishing survivor quality of life. Organic cation transporter 2 (OCT2) is a key OHP uptake pathway in dorsal root ganglia. Competing for OCT2-mediated OHP uptake, such as with the tyrosine kinase inhibitor dasatinib, may mitigate OHP side effects. We investigated OHP and dasatinib interaction with OCT2 in human embryonic kidney 293 (HEK293) cells expressing OCT2 within a 10-3 to 10-7 M conc...
Source: Archives of Toxicology - April 8, 2024 Category: Toxicology Authors: Sara Ahmed Eltayeb Julia M Dressler Lukas Schlatt Moritz Pernecker Ute Neugebauer Uwe Karst Giuliano Ciarimboli Source Type: research
Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
Arch Toxicol. 2024 Apr 7. doi: 10.1007/s00204-024-03731-4. Online ahead of print.ABSTRACTHuman liver-derived metabolically competent HepaRG cells have been successfully employed in both two-dimensional (2D) and 3D spheroid formats for performing the comet assay and micronucleus (MN) assay. In the present study, we have investigated expanding the genotoxicity endpoints evaluated in HepaRG cells by detecting mutagenesis using two error-corrected next generation sequencing (ecNGS) technologies, Duplex Sequencing (DS) and High-Fidelity (HiFi) Sequencing. Both HepaRG 2D cells and 3D spheroids were exposed for 72 h to N-nitrosod...
Source: Archives of Toxicology - April 7, 2024 Category: Toxicology Authors: Ji-Eun Seo Yuan Le Javier Revollo Jaime Miranda-Colon Hannah Xu Page McKinzie Nan Mei Tao Chen Robert H Heflich Tong Zhou Timothy Robison Jessica A Bonzo Xiaoqing Guo Source Type: research
Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
Arch Toxicol. 2024 Apr 7. doi: 10.1007/s00204-024-03731-4. Online ahead of print.ABSTRACTHuman liver-derived metabolically competent HepaRG cells have been successfully employed in both two-dimensional (2D) and 3D spheroid formats for performing the comet assay and micronucleus (MN) assay. In the present study, we have investigated expanding the genotoxicity endpoints evaluated in HepaRG cells by detecting mutagenesis using two error-corrected next generation sequencing (ecNGS) technologies, Duplex Sequencing (DS) and High-Fidelity (HiFi) Sequencing. Both HepaRG 2D cells and 3D spheroids were exposed for 72 h to N-nitrosod...
Source: Archives of Toxicology - April 7, 2024 Category: Toxicology Authors: Ji-Eun Seo Yuan Le Javier Revollo Jaime Miranda-Colon Hannah Xu Page McKinzie Nan Mei Tao Chen Robert H Heflich Tong Zhou Timothy Robison Jessica A Bonzo Xiaoqing Guo Source Type: research
Dissecting the networks underlying diverse brain disorders after prenatal glucocorticoid overexposure
Arch Toxicol. 2024 Apr 6. doi: 10.1007/s00204-024-03733-2. Online ahead of print.ABSTRACTNew human life begins in the uterus in a period of both extreme plasticity and sensitivity to environmental disturbances. The fetal stage is also a vital period for central nervous system development, with experiences at this point profoundly and permanently shaping brain structure and function. As such, some brain disorders may originate in utero. Glucocorticoids, a class of essential stress hormones, play indispensable roles in fetal development, but overexposure may have lasting impacts on the brain. In this review, we summarize dat...
Source: Archives of Toxicology - April 6, 2024 Category: Toxicology Authors: Baixiu Zheng Yanrong Zheng Weiwei Hu Zhong Chen Source Type: research
Human metabolism of four synthetic benzimidazole opioids: isotonitazene, metonitazene, etodesnitazene, and metodesnitazene
Arch Toxicol. 2024 Apr 6. doi: 10.1007/s00204-024-03735-0. Online ahead of print.ABSTRACTFollowing isotonitazene scheduling in 2019, the availability of alternative 2-benzylbenzimidazole opioids (nitazenes) on the global drug market increased, resulting in many fatalities worldwide. Nitazenes are potent µ-opioid receptor agonists with strong narcotic/analgesic effects, and their concentrations in biological matrices are low, making the detection of metabolite biomarkers of consumption crucial to document use in clinical and forensic settings. However, there is little to no data on the metabolism of the most recently avail...
Source: Archives of Toxicology - April 6, 2024 Category: Toxicology Authors: Omayema Taoussi Diletta Berardinelli Simona Zaami Francesco Tavoletta Giuseppe Basile Robert Kronstrand Volker Auw ärter Francesco P Busard ò Jeremy Carlier Source Type: research
Dissecting the networks underlying diverse brain disorders after prenatal glucocorticoid overexposure
Arch Toxicol. 2024 Apr 6. doi: 10.1007/s00204-024-03733-2. Online ahead of print.ABSTRACTNew human life begins in the uterus in a period of both extreme plasticity and sensitivity to environmental disturbances. The fetal stage is also a vital period for central nervous system development, with experiences at this point profoundly and permanently shaping brain structure and function. As such, some brain disorders may originate in utero. Glucocorticoids, a class of essential stress hormones, play indispensable roles in fetal development, but overexposure may have lasting impacts on the brain. In this review, we summarize dat...
Source: Archives of Toxicology - April 6, 2024 Category: Toxicology Authors: Baixiu Zheng Yanrong Zheng Weiwei Hu Zhong Chen Source Type: research
Human metabolism of four synthetic benzimidazole opioids: isotonitazene, metonitazene, etodesnitazene, and metodesnitazene
Arch Toxicol. 2024 Apr 6. doi: 10.1007/s00204-024-03735-0. Online ahead of print.ABSTRACTFollowing isotonitazene scheduling in 2019, the availability of alternative 2-benzylbenzimidazole opioids (nitazenes) on the global drug market increased, resulting in many fatalities worldwide. Nitazenes are potent µ-opioid receptor agonists with strong narcotic/analgesic effects, and their concentrations in biological matrices are low, making the detection of metabolite biomarkers of consumption crucial to document use in clinical and forensic settings. However, there is little to no data on the metabolism of the most recently avail...
Source: Archives of Toxicology - April 6, 2024 Category: Toxicology Authors: Omayema Taoussi Diletta Berardinelli Simona Zaami Francesco Tavoletta Giuseppe Basile Robert Kronstrand Volker Auw ärter Francesco P Busard ò Jeremy Carlier Source Type: research
