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The Presence of Small-Size Circulating Tumor Cells Predicts Worse Prognosis in Non-Small Cell Lung Cancer Patients
CONCLUSIONS.—: Small-size CTCs are a reliable prognostic indicator and a probable predictor of the severity of disease in NSCLC patients.PMID:38631685 | DOI:10.5858/arpa.2023-0455-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 17, 2024 Category: Laboratory Medicine Authors: Qianqian Sun Weiqing Li Donghua Yang Peter Ping Lin Lina Zhang Huiqin Guo Source Type: research

Estrogen Receptor, Progesterone Receptor, and Human Epidermal Growth Factor Receptor 2 Expression Rates in Invasive Breast Carcinoma: A Study of 21 Institutions
CONCLUSIONS.—: The data from this study provide multi-institutional benchmark data to assist laboratories performing periodic comparisons as part of a quality management program. Overall expression rates were generally similar to those of other published reports, with the exception of the ER-negative and HER2-positive rates, both of which were somewhat lower.PMID:38631690 | DOI:10.5858/arpa.2022-0384-CP (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 17, 2024 Category: Laboratory Medicine Authors: Daniel D Mais Alia N Nazarullah Anthony J Guidi Suzanne Dintzis Barbara J Blond Thomas A Long Suzanne N Coulter Richard W Brown Source Type: research

Programmed Death Ligand-1 and Tumor Mutation Burden Testing of Patients With Lung Cancer for Selection of Immune Checkpoint Inhibitor Therapies: Guideline From the College of American Pathologists, Association for Molecular Pathology, International Association for the Study of Lung Cancer, Pulmonary Pathology Society, and LUNGevity Foundation
CONCLUSIONS.—: This guideline summarizes the current understanding and hurdles associated with the use of PD-L1 expression and TMB testing for immune checkpoint inhibitor therapy selection in patients with advanced non-small cell lung cancer and presents evidence-based recommendations for PD-L1 and TMB testing in the clinical setting.PMID:38625026 | DOI:10.5858/arpa.2023-0536-CP (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 16, 2024 Category: Laboratory Medicine Authors: Lynette M Sholl Mark Awad Upal Basu Roy Mary Beth Beasley Richard Walter Cartun David M Hwang Gregory Kalemkerian Fernando Lopez-Rios Mari Mino-Kenudson Ajit Paintal Kearin Reid Lauren Ritterhouse Lesley A Souter Paul E Swanson Christina B Ventura Larissa Source Type: research

Programmed Death Ligand-1 and Tumor Mutation Burden Testing of Patients With Lung Cancer for Selection of Immune Checkpoint Inhibitor Therapies: Guideline From the College of American Pathologists, Association for Molecular Pathology, International Association for the Study of Lung Cancer, Pulmonary Pathology Society, and LUNGevity Foundation
CONCLUSIONS.—: This guideline summarizes the current understanding and hurdles associated with the use of PD-L1 expression and TMB testing for immune checkpoint inhibitor therapy selection in patients with advanced non-small cell lung cancer and presents evidence-based recommendations for PD-L1 and TMB testing in the clinical setting.PMID:38625026 | DOI:10.5858/arpa.2023-0536-CP (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 16, 2024 Category: Laboratory Medicine Authors: Lynette M Sholl Mark Awad Upal Basu Roy Mary Beth Beasley Richard Walter Cartun David M Hwang Gregory Kalemkerian Fernando Lopez-Rios Mari Mino-Kenudson Ajit Paintal Kearin Reid Lauren Ritterhouse Lesley A Souter Paul E Swanson Christina B Ventura Larissa Source Type: research

The Interplay Between Human Leukocyte Antigen Antibody Profile and COVID-19 Vaccination in Waitlisted Renal Transplant Patients
CONCLUSIONS.—: Our data suggest that COVID-19 vaccination propagates anti-HLA class I and II antibodies for waitlisted renal transplant patients. The clinical significance of these antibodies needs further study. Furthermore, comorbidities, such as history of COVID-19 infection and hypertension, supplemented this effect. Anti-HLA antibody monitoring may be warranted in vaccinated, waitlisted renal transplant patients with COVID-19 vaccinations, and a history of COVID-19 infection or hypertension.PMID:38599589 | DOI:10.5858/arpa.2023-0370-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 10, 2024 Category: Laboratory Medicine Authors: Yayuan Zhao Pramath Kakodkar Henry Pan Richard Zhu Khalid Musa Abubaker Hassan Ahmed Shoker Destinie Webster Twyla Pearce Pouneh Dokouhaki Fang Wu Ahmed Mostafa Source Type: research

Ten Years of Pathology on Twitter (X): Landscape and Evolution of Pathology on Twitter From 2012 to 2023
CONCLUSIONS.—: Pathology Twitter has grown during the last 10 years and has become increasingly popular for pathology education and networking. With the changing landscape of social media platforms this study provides an understanding of how pathology medical education and professional networking uses of social media are used and evolve over time.PMID:38599590 | DOI:10.5858/arpa.2023-0447-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 10, 2024 Category: Laboratory Medicine Authors: Roland Tian Eric Wang Priyadharshini Sivasubramaniam Swikrity U Baskota Anurag Sharma Matthew J Cecchini Source Type: research

The Interplay Between Human Leukocyte Antigen Antibody Profile and COVID-19 Vaccination in Waitlisted Renal Transplant Patients
CONCLUSIONS.—: Our data suggest that COVID-19 vaccination propagates anti-HLA class I and II antibodies for waitlisted renal transplant patients. The clinical significance of these antibodies needs further study. Furthermore, comorbidities, such as history of COVID-19 infection and hypertension, supplemented this effect. Anti-HLA antibody monitoring may be warranted in vaccinated, waitlisted renal transplant patients with COVID-19 vaccinations, and a history of COVID-19 infection or hypertension.PMID:38599589 | DOI:10.5858/arpa.2023-0370-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 10, 2024 Category: Laboratory Medicine Authors: Yayuan Zhao Pramath Kakodkar Henry Pan Richard Zhu Khalid Musa Abubaker Hassan Ahmed Shoker Destinie Webster Twyla Pearce Pouneh Dokouhaki Fang Wu Ahmed Mostafa Source Type: research

Ten Years of Pathology on Twitter (X): Landscape and Evolution of Pathology on Twitter From 2012 to 2023
CONCLUSIONS.—: Pathology Twitter has grown during the last 10 years and has become increasingly popular for pathology education and networking. With the changing landscape of social media platforms this study provides an understanding of how pathology medical education and professional networking uses of social media are used and evolve over time.PMID:38599590 | DOI:10.5858/arpa.2023-0447-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 10, 2024 Category: Laboratory Medicine Authors: Roland Tian Eric Wang Priyadharshini Sivasubramaniam Swikrity U Baskota Anurag Sharma Matthew J Cecchini Source Type: research

The Interplay Between Human Leukocyte Antigen Antibody Profile and COVID-19 Vaccination in Waitlisted Renal Transplant Patients
CONCLUSIONS.—: Our data suggest that COVID-19 vaccination propagates anti-HLA class I and II antibodies for waitlisted renal transplant patients. The clinical significance of these antibodies needs further study. Furthermore, comorbidities, such as history of COVID-19 infection and hypertension, supplemented this effect. Anti-HLA antibody monitoring may be warranted in vaccinated, waitlisted renal transplant patients with COVID-19 vaccinations, and a history of COVID-19 infection or hypertension.PMID:38599589 | DOI:10.5858/arpa.2023-0370-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 10, 2024 Category: Laboratory Medicine Authors: Yayuan Zhao Pramath Kakodkar Henry Pan Richard Zhu Khalid Musa Abubaker Hassan Ahmed Shoker Destinie Webster Twyla Pearce Pouneh Dokouhaki Fang Wu Ahmed Mostafa Source Type: research

Ten Years of Pathology on Twitter (X): Landscape and Evolution of Pathology on Twitter From 2012 to 2023
CONCLUSIONS.—: Pathology Twitter has grown during the last 10 years and has become increasingly popular for pathology education and networking. With the changing landscape of social media platforms this study provides an understanding of how pathology medical education and professional networking uses of social media are used and evolve over time.PMID:38599590 | DOI:10.5858/arpa.2023-0447-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 10, 2024 Category: Laboratory Medicine Authors: Roland Tian Eric Wang Priyadharshini Sivasubramaniam Swikrity U Baskota Anurag Sharma Matthew J Cecchini Source Type: research

The Interplay Between Human Leukocyte Antigen Antibody Profile and COVID-19 Vaccination in Waitlisted Renal Transplant Patients
CONCLUSIONS.—: Our data suggest that COVID-19 vaccination propagates anti-HLA class I and II antibodies for waitlisted renal transplant patients. The clinical significance of these antibodies needs further study. Furthermore, comorbidities, such as history of COVID-19 infection and hypertension, supplemented this effect. Anti-HLA antibody monitoring may be warranted in vaccinated, waitlisted renal transplant patients with COVID-19 vaccinations, and a history of COVID-19 infection or hypertension.PMID:38599589 | DOI:10.5858/arpa.2023-0370-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 10, 2024 Category: Laboratory Medicine Authors: Yayuan Zhao Pramath Kakodkar Henry Pan Richard Zhu Khalid Musa Abubaker Hassan Ahmed Shoker Destinie Webster Twyla Pearce Pouneh Dokouhaki Fang Wu Ahmed Mostafa Source Type: research

Ten Years of Pathology on Twitter (X): Landscape and Evolution of Pathology on Twitter From 2012 to 2023
CONCLUSIONS.—: Pathology Twitter has grown during the last 10 years and has become increasingly popular for pathology education and networking. With the changing landscape of social media platforms this study provides an understanding of how pathology medical education and professional networking uses of social media are used and evolve over time.PMID:38599590 | DOI:10.5858/arpa.2023-0447-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 10, 2024 Category: Laboratory Medicine Authors: Roland Tian Eric Wang Priyadharshini Sivasubramaniam Swikrity U Baskota Anurag Sharma Matthew J Cecchini Source Type: research

Guidelines for Pathologic Diagnosis of Mesothelioma
CONCLUSIONS.—: There was consensus opinion regarding guidelines for (1) histomorphologic diagnosis of mesothelial tumors, including distinction of epithelioid, biphasic, and sarcomatoid mesothelioma; recognition of morphologic variants and patterns; and recognition of common morphologic pitfalls; (2) molecular pathogenesis of mesothelioma; (3) application of immunohistochemical markers to establish mesothelial lineage and distinguish mesothelioma from common morphologic differentials; (4) application of ancillary studies to distinguish benign from malignant mesothelial proliferations, including BAP1 and MTAP immunostains...
Source: Archives of Pathology and Laboratory Medicine - April 8, 2024 Category: Laboratory Medicine Authors: Aliya N Husain David B Chapel Richard Attanoos Mary Beth Beasley Luka Brcic Kelly Butnor Lucian R Chirieac Andrew Churg Sanja Dacic Francoise Galateau-Salle Kenzo Hiroshima Yin P Hung Sonja Klebe Thomas Krausz Andras Khoor Leslie Litzky Alberto Marchevsky Source Type: research

Guidelines for Pathologic Diagnosis of Mesothelioma
CONCLUSIONS.—: There was consensus opinion regarding guidelines for (1) histomorphologic diagnosis of mesothelial tumors, including distinction of epithelioid, biphasic, and sarcomatoid mesothelioma; recognition of morphologic variants and patterns; and recognition of common morphologic pitfalls; (2) molecular pathogenesis of mesothelioma; (3) application of immunohistochemical markers to establish mesothelial lineage and distinguish mesothelioma from common morphologic differentials; (4) application of ancillary studies to distinguish benign from malignant mesothelial proliferations, including BAP1 and MTAP immunostains...
Source: Archives of Pathology and Laboratory Medicine - April 8, 2024 Category: Laboratory Medicine Authors: Aliya N Husain David B Chapel Richard Attanoos Mary Beth Beasley Luka Brcic Kelly Butnor Lucian R Chirieac Andrew Churg Sanja Dacic Francoise Galateau-Salle Kenzo Hiroshima Yin P Hung Sonja Klebe Thomas Krausz Andras Khoor Leslie Litzky Alberto Marchevsky Source Type: research

Guidelines for Pathologic Diagnosis of Mesothelioma
CONCLUSIONS.—: There was consensus opinion regarding guidelines for (1) histomorphologic diagnosis of mesothelial tumors, including distinction of epithelioid, biphasic, and sarcomatoid mesothelioma; recognition of morphologic variants and patterns; and recognition of common morphologic pitfalls; (2) molecular pathogenesis of mesothelioma; (3) application of immunohistochemical markers to establish mesothelial lineage and distinguish mesothelioma from common morphologic differentials; (4) application of ancillary studies to distinguish benign from malignant mesothelial proliferations, including BAP1 and MTAP immunostains...
Source: Archives of Pathology and Laboratory Medicine - April 8, 2024 Category: Laboratory Medicine Authors: Aliya N Husain David B Chapel Richard Attanoos Mary Beth Beasley Luka Brcic Kelly Butnor Lucian R Chirieac Andrew Churg Sanja Dacic Francoise Galateau-Salle Kenzo Hiroshima Yin P Hung Sonja Klebe Thomas Krausz Andras Khoor Leslie Litzky Alberto Marchevsky Source Type: research