IGFBP7- When Endothelial gCap-ing Goes Wrong in Acute Lung Injury
Am J Respir Cell Mol Biol. 2024 Apr 16. doi: 10.1165/rcmb.2024-0146ED. Online ahead of print.NO ABSTRACTPMID:38626308 | DOI:10.1165/rcmb.2024-0146ED (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - April 16, 2024 Category: Respiratory Medicine Authors: Ranu Surolia Jaroslaw W Zmijewski Source Type: research
IGFBP7- When Endothelial gCap-ing Goes Wrong in Acute Lung Injury
Am J Respir Cell Mol Biol. 2024 Apr 16. doi: 10.1165/rcmb.2024-0146ED. Online ahead of print.NO ABSTRACTPMID:38626308 | DOI:10.1165/rcmb.2024-0146ED (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - April 16, 2024 Category: Respiratory Medicine Authors: Ranu Surolia Jaroslaw W Zmijewski Source Type: research
The Impact of Inflammation on Thermal Hyperpnea: Relevance for Heat Stress and Febrile Seizures
Am J Respir Cell Mol Biol. 2024 Apr 10. doi: 10.1165/rcmb.2023-0451OC. Online ahead of print.ABSTRACTExtreme heat caused by climate change is increasing transmission of infectious diseases resulting in a sharp rise in heat-related illness and mortality. Understanding mechanistic link between heat, inflammation and disease is thus important for public health. Thermal hyperpnea, and consequent respiratory alkalosis is crucial in febrile seizures and convulsions induced by heat stress in humans. Here we address what causes thermal hyperpnea in neonates and how is it affected by inflammation. TRPV1, a heat-activated channel is...
Source: Am J Respir Cell Mol... - April 10, 2024 Category: Respiratory Medicine Authors: Karlene T Barrett Arijit Roy Aya Ebdalla Quentin J Pittman Richard J A Wilson Morris H Scantlebury Source Type: research
The Impact of Inflammation on Thermal Hyperpnea: Relevance for Heat Stress and Febrile Seizures
Am J Respir Cell Mol Biol. 2024 Apr 10. doi: 10.1165/rcmb.2023-0451OC. Online ahead of print.ABSTRACTExtreme heat caused by climate change is increasing transmission of infectious diseases resulting in a sharp rise in heat-related illness and mortality. Understanding mechanistic link between heat, inflammation and disease is thus important for public health. Thermal hyperpnea, and consequent respiratory alkalosis is crucial in febrile seizures and convulsions induced by heat stress in humans. Here we address what causes thermal hyperpnea in neonates and how is it affected by inflammation. TRPV1, a heat-activated channel is...
Source: Am J Respir Cell Mol... - April 10, 2024 Category: Respiratory Medicine Authors: Karlene T Barrett Arijit Roy Aya Ebdalla Quentin J Pittman Richard J A Wilson Morris H Scantlebury Source Type: research
The Impact of Inflammation on Thermal Hyperpnea: Relevance for Heat Stress and Febrile Seizures
Am J Respir Cell Mol Biol. 2024 Apr 10. doi: 10.1165/rcmb.2023-0451OC. Online ahead of print.ABSTRACTExtreme heat caused by climate change is increasing transmission of infectious diseases resulting in a sharp rise in heat-related illness and mortality. Understanding mechanistic link between heat, inflammation and disease is thus important for public health. Thermal hyperpnea, and consequent respiratory alkalosis is crucial in febrile seizures and convulsions induced by heat stress in humans. Here we address what causes thermal hyperpnea in neonates and how is it affected by inflammation. TRPV1, a heat-activated channel is...
Source: Am J Respir Cell Mol... - April 10, 2024 Category: Respiratory Medicine Authors: Karlene T Barrett Arijit Roy Aya Ebdalla Quentin J Pittman Richard J A Wilson Morris H Scantlebury Source Type: research
The Impact of Inflammation on Thermal Hyperpnea: Relevance for Heat Stress and Febrile Seizures
Am J Respir Cell Mol Biol. 2024 Apr 10. doi: 10.1165/rcmb.2023-0451OC. Online ahead of print.ABSTRACTExtreme heat caused by climate change is increasing transmission of infectious diseases resulting in a sharp rise in heat-related illness and mortality. Understanding mechanistic link between heat, inflammation and disease is thus important for public health. Thermal hyperpnea, and consequent respiratory alkalosis is crucial in febrile seizures and convulsions induced by heat stress in humans. Here we address what causes thermal hyperpnea in neonates and how is it affected by inflammation. TRPV1, a heat-activated channel is...
Source: Am J Respir Cell Mol... - April 10, 2024 Category: Respiratory Medicine Authors: Karlene T Barrett Arijit Roy Aya Ebdalla Quentin J Pittman Richard J A Wilson Morris H Scantlebury Source Type: research
The Impact of Inflammation on Thermal Hyperpnea: Relevance for Heat Stress and Febrile Seizures
Am J Respir Cell Mol Biol. 2024 Apr 10. doi: 10.1165/rcmb.2023-0451OC. Online ahead of print.ABSTRACTExtreme heat caused by climate change is increasing transmission of infectious diseases resulting in a sharp rise in heat-related illness and mortality. Understanding mechanistic link between heat, inflammation and disease is thus important for public health. Thermal hyperpnea, and consequent respiratory alkalosis is crucial in febrile seizures and convulsions induced by heat stress in humans. Here we address what causes thermal hyperpnea in neonates and how is it affected by inflammation. TRPV1, a heat-activated channel is...
Source: Am J Respir Cell Mol... - April 10, 2024 Category: Respiratory Medicine Authors: Karlene T Barrett Arijit Roy Aya Ebdalla Quentin J Pittman Richard J A Wilson Morris H Scantlebury Source Type: research
Local, Quantitative Morphometry of Fibroproliferative Lung Injury Using Laminin
Am J Respir Cell Mol Biol. 2024 Apr 9. doi: 10.1165/rcmb.2023-0294MA. Online ahead of print.ABSTRACTInvestigations into the mechanisms of injury and repair in fibroproliferative disease require consideration of the spatial heterogeneity inherent in the disease. Most scoring of fibrotic remodeling in preclinical animal models rely on the modified Ashcroft score, which is a semi-quantitative scoring rubric of macroscopic resolution. The obvious limitations inherent in manual pathohistological grading have generated an unmet need for unbiased, repeatable scoring of fibroproliferative burden in tissue. Using computer vision ap...
Source: Am J Respir Cell Mol... - April 9, 2024 Category: Respiratory Medicine Authors: Brendan P Cox Riley T Hannan Noora Batrash Pearl Raichura Anne I Sperling Yun Michael Shim Jeffrey M Sturek Source Type: research
Unconventional Activation of IRE1 Enhances TH17 Responses and Promotes Airway Neutrophilia
This study found that the UPR sensor IRE1 is induced in the murine lung with fungal asthma and is highly expressed in TH17 cells relative to naïve CD4+ T cells. Cytokine (e.g. IL-23) signals induce the IRE1-XBP1s axis in a JAK2-dependent manner. This noncanonical activation of the IRE1-XBP1s pathway promotes UPRs and cytokine secretion by both human and mouse TH17 cells. Ern1 (encoding IRE1)-deficiency decreases the expression of ER stress factors and impairs the differentiation and cytokine secretion of TH17 cells. Genetic ablation of Ern1 leads to alleviated TH17 responses and airway neutrophilia in a fungal airway infl...
Source: Am J Respir Cell Mol... - April 9, 2024 Category: Respiratory Medicine Authors: Dandan Wu Xing Zhang Kourtney M Zimmerly Ruoning Wang Amanda Livingston Takao Iwawaki Ashok Kumar Xiang Wu Matthew Campen Michael A Mandell Meilian Liu Xuexian O Yang Source Type: research
Local, Quantitative Morphometry of Fibroproliferative Lung Injury Using Laminin
Am J Respir Cell Mol Biol. 2024 Apr 9. doi: 10.1165/rcmb.2023-0294MA. Online ahead of print.ABSTRACTInvestigations into the mechanisms of injury and repair in fibroproliferative disease require consideration of the spatial heterogeneity inherent in the disease. Most scoring of fibrotic remodeling in preclinical animal models rely on the modified Ashcroft score, which is a semi-quantitative scoring rubric of macroscopic resolution. The obvious limitations inherent in manual pathohistological grading have generated an unmet need for unbiased, repeatable scoring of fibroproliferative burden in tissue. Using computer vision ap...
Source: Am J Respir Cell Mol... - April 9, 2024 Category: Respiratory Medicine Authors: Brendan P Cox Riley T Hannan Noora Batrash Pearl Raichura Anne I Sperling Yun Michael Shim Jeffrey M Sturek Source Type: research
Unconventional Activation of IRE1 Enhances TH17 Responses and Promotes Airway Neutrophilia
This study found that the UPR sensor IRE1 is induced in the murine lung with fungal asthma and is highly expressed in TH17 cells relative to naïve CD4+ T cells. Cytokine (e.g. IL-23) signals induce the IRE1-XBP1s axis in a JAK2-dependent manner. This noncanonical activation of the IRE1-XBP1s pathway promotes UPRs and cytokine secretion by both human and mouse TH17 cells. Ern1 (encoding IRE1)-deficiency decreases the expression of ER stress factors and impairs the differentiation and cytokine secretion of TH17 cells. Genetic ablation of Ern1 leads to alleviated TH17 responses and airway neutrophilia in a fungal airway infl...
Source: Am J Respir Cell Mol... - April 9, 2024 Category: Respiratory Medicine Authors: Dandan Wu Xing Zhang Kourtney M Zimmerly Ruoning Wang Amanda Livingston Takao Iwawaki Ashok Kumar Xiang Wu Matthew Campen Michael A Mandell Meilian Liu Xuexian O Yang Source Type: research
DACH1 Attenuates Airway Inflammation in COPD by Activating NRF2 Signaling
This study aims to elucidate the role and underlying mechanism of DACH1 in airway inflammation of COPD. DACH1 expression was measured in lung tissues of patients with COPD. Airway epithelium-specific DACH1 knockdown mice and AAV-transfected DACH1 overexpressed mice were used to investigate its role and potential for therapeutic targeting in experimental COPD caused by CS. Furthermore, we discovered a potential mechanism of DACH1 in inflammation induced by cigarette smoke extract simulation (CSE) in vitro. Compared to non-smokers and smokers without COPD, COPD patients had reduced DACH1 expression, especially in the airway ...
Source: Am J Respir Cell Mol... - April 8, 2024 Category: Respiratory Medicine Authors: Qian Huang Yiya Gu Jixing Wu Yuan Zhan Zhesong Deng Shanshan Chen Maocuo Peng Ruonan Yang Jinkun Chen Jungang Xie Source Type: research
DACH1 Attenuates Airway Inflammation in COPD by Activating NRF2 Signaling
This study aims to elucidate the role and underlying mechanism of DACH1 in airway inflammation of COPD. DACH1 expression was measured in lung tissues of patients with COPD. Airway epithelium-specific DACH1 knockdown mice and AAV-transfected DACH1 overexpressed mice were used to investigate its role and potential for therapeutic targeting in experimental COPD caused by CS. Furthermore, we discovered a potential mechanism of DACH1 in inflammation induced by cigarette smoke extract simulation (CSE) in vitro. Compared to non-smokers and smokers without COPD, COPD patients had reduced DACH1 expression, especially in the airway ...
Source: Am J Respir Cell Mol... - April 8, 2024 Category: Respiratory Medicine Authors: Qian Huang Yiya Gu Jixing Wu Yuan Zhan Zhesong Deng Shanshan Chen Maocuo Peng Ruonan Yang Jinkun Chen Jungang Xie Source Type: research
Cell Crosstalk in Alveolar Microenvironment: From Lung Injury to Fibrosis
Am J Respir Cell Mol Biol. 2024 Apr 5. doi: 10.1165/rcmb.2023-0426TR. Online ahead of print.ABSTRACTAlveoli are complex microenvironments composed of various cell types, including epithelial, fibroblast, endothelial, and immune cells, which work together to maintain a delicate balance in the lung environment, ensuring proper growth, development, and an effective response to lung injuries. However, prolonged inflammation or aging can disrupt normal interactions between these cells, leading to impaired repair processes and a substantial decline in lung function. Therefore, it is essential to understand the key mechanisms und...
Source: Am J Respir Cell Mol... - April 5, 2024 Category: Respiratory Medicine Authors: Licheng Song Kuan Li Huaiyong Chen Lixin Xie Source Type: research
Cell Crosstalk in Alveolar Microenvironment: From Lung Injury to Fibrosis
Am J Respir Cell Mol Biol. 2024 Apr 5. doi: 10.1165/rcmb.2023-0426TR. Online ahead of print.ABSTRACTAlveoli are complex microenvironments composed of various cell types, including epithelial, fibroblast, endothelial, and immune cells, which work together to maintain a delicate balance in the lung environment, ensuring proper growth, development, and an effective response to lung injuries. However, prolonged inflammation or aging can disrupt normal interactions between these cells, leading to impaired repair processes and a substantial decline in lung function. Therefore, it is essential to understand the key mechanisms und...
Source: Am J Respir Cell Mol... - April 5, 2024 Category: Respiratory Medicine Authors: Licheng Song Kuan Li Huaiyong Chen Lixin Xie Source Type: research
