Revisiting airway epithelial dysfunction and mechanisms in chronic obstructive pulmonary disease: Role of mitochondrial damage
Am J Physiol Lung Cell Mol Physiol. 2024 Apr 16. doi: 10.1152/ajplung.00362.2023. Online ahead of print.ABSTRACTChronic exposure to environmental hazards causes airway epithelial dysfunction, primarily impaired physical barriers, immune dysfunction, and repair or regeneration. Impairment of airway epithelial function subsequently leads to exaggerated airway inflammation and remodeling, the main features of chronic obstructive pulmonary disease (COPD). Mitochondrial damage has been identified as one of the mechanisms of airway abnormalities in COPD, which is closely related to airway inflammation and airflow limitation. In ...
Source: Am J Physiol Lung Ce... - April 16, 2024 Category: Respiratory Medicine Authors: Qinglan He Peijun Li Lihua Han Chen Yang Meiling Jiang Yingqi Wang Xiaoyu Han Yuanyuan Cao Xiaodan Liu Weibing Wu Source Type: research
Revisiting airway epithelial dysfunction and mechanisms in chronic obstructive pulmonary disease: Role of mitochondrial damage
Am J Physiol Lung Cell Mol Physiol. 2024 Apr 16. doi: 10.1152/ajplung.00362.2023. Online ahead of print.ABSTRACTChronic exposure to environmental hazards causes airway epithelial dysfunction, primarily impaired physical barriers, immune dysfunction, and repair or regeneration. Impairment of airway epithelial function subsequently leads to exaggerated airway inflammation and remodeling, the main features of chronic obstructive pulmonary disease (COPD). Mitochondrial damage has been identified as one of the mechanisms of airway abnormalities in COPD, which is closely related to airway inflammation and airflow limitation. In ...
Source: Am J Physiol Lung Ce... - April 16, 2024 Category: Respiratory Medicine Authors: Qinglan He Peijun Li Lihua Han Chen Yang Meiling Jiang Yingqi Wang Xiaoyu Han Yuanyuan Cao Xiaodan Liu Weibing Wu Source Type: research
Natural antibodies targeting LPS in pleural effusions of various etiologies
CONCLUSIONS: Our results highlight a potential role of anti-LPS NAbs in the pleural cavity that should be further explored.PMID:38591123 | DOI:10.1152/ajplung.00377.2023 (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - April 9, 2024 Category: Respiratory Medicine Authors: Ioannis Sarrigeorgiou Erasmia Rouka Ourania S Kotsiou Garyfallia Perlepe Efrosini S Gerovasileiou Konstantinos I Gourgoulianis Peggy Lymberi Sotirios G Zarogiannis Source Type: research
Chronic intermittent hypoxia elicits distinct transcriptomic responses among neurons and oligodendrocytes within the brainstem of mice
Am J Physiol Lung Cell Mol Physiol. 2024 Apr 9. doi: 10.1152/ajplung.00320.2023. Online ahead of print.ABSTRACTChronic intermittent hypoxia (CIH) is a prevalent condition characterized by recurrent episodes of oxygen deprivation, linked to respiratory and neurological disorders. Prolonged CIH is known to have adverse effects, including endothelial dysfunction, chronic inflammation, oxidative stress, and impaired neuronal function. These factors can contribute to serious comorbidities, including metabolic disorders and cardiovascular diseases. To investigate the molecular impact of CIH, we examined male C57BL/6J mice expose...
Source: Am J Physiol Lung Ce... - April 9, 2024 Category: Respiratory Medicine Authors: Hemalatha Bhagavan Aguan D Wei Luiz M Oliveira Kimberly A Aldinger Jan-Marino Ramirez Source Type: research
Natural antibodies targeting LPS in pleural effusions of various etiologies
CONCLUSIONS: Our results highlight a potential role of anti-LPS NAbs in the pleural cavity that should be further explored.PMID:38591123 | DOI:10.1152/ajplung.00377.2023 (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - April 9, 2024 Category: Respiratory Medicine Authors: Ioannis Sarrigeorgiou Erasmia Rouka Ourania S Kotsiou Garyfallia Perlepe Efrosini S Gerovasileiou Konstantinos I Gourgoulianis Peggy Lymberi Sotirios G Zarogiannis Source Type: research
Chronic intermittent hypoxia elicits distinct transcriptomic responses among neurons and oligodendrocytes within the brainstem of mice
Am J Physiol Lung Cell Mol Physiol. 2024 Apr 9. doi: 10.1152/ajplung.00320.2023. Online ahead of print.ABSTRACTChronic intermittent hypoxia (CIH) is a prevalent condition characterized by recurrent episodes of oxygen deprivation, linked to respiratory and neurological disorders. Prolonged CIH is known to have adverse effects, including endothelial dysfunction, chronic inflammation, oxidative stress, and impaired neuronal function. These factors can contribute to serious comorbidities, including metabolic disorders and cardiovascular diseases. To investigate the molecular impact of CIH, we examined male C57BL/6J mice expose...
Source: Am J Physiol Lung Ce... - April 9, 2024 Category: Respiratory Medicine Authors: Hemalatha Bhagavan Aguan D Wei Luiz M Oliveira Kimberly A Aldinger Jan-Marino Ramirez Source Type: research
Natural antibodies targeting LPS in pleural effusions of various etiologies
CONCLUSIONS: Our results highlight a potential role of anti-LPS NAbs in the pleural cavity that should be further explored.PMID:38591123 | DOI:10.1152/ajplung.00377.2023 (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - April 9, 2024 Category: Respiratory Medicine Authors: Ioannis Sarrigeorgiou Erasmia Rouka Ourania S Kotsiou Garyfallia Perlepe Efrosini S Gerovasileiou Konstantinos I Gourgoulianis Peggy Lymberi Sotirios G Zarogiannis Source Type: research
Chronic intermittent hypoxia elicits distinct transcriptomic responses among neurons and oligodendrocytes within the brainstem of mice
Am J Physiol Lung Cell Mol Physiol. 2024 Apr 9. doi: 10.1152/ajplung.00320.2023. Online ahead of print.ABSTRACTChronic intermittent hypoxia (CIH) is a prevalent condition characterized by recurrent episodes of oxygen deprivation, linked to respiratory and neurological disorders. Prolonged CIH is known to have adverse effects, including endothelial dysfunction, chronic inflammation, oxidative stress, and impaired neuronal function. These factors can contribute to serious comorbidities, including metabolic disorders and cardiovascular diseases. To investigate the molecular impact of CIH, we examined male C57BL/6J mice expose...
Source: Am J Physiol Lung Ce... - April 9, 2024 Category: Respiratory Medicine Authors: Hemalatha Bhagavan Aguan D Wei Luiz M Oliveira Kimberly A Aldinger Jan-Marino Ramirez Source Type: research
Natural antibodies targeting LPS in pleural effusions of various etiologies
CONCLUSIONS: Our results highlight a potential role of anti-LPS NAbs in the pleural cavity that should be further explored.PMID:38591123 | DOI:10.1152/ajplung.00377.2023 (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - April 9, 2024 Category: Respiratory Medicine Authors: Ioannis Sarrigeorgiou Erasmia Rouka Ourania S Kotsiou Garyfallia Perlepe Efrosini S Gerovasileiou Konstantinos I Gourgoulianis Peggy Lymberi Sotirios G Zarogiannis Source Type: research
Chronic intermittent hypoxia elicits distinct transcriptomic responses among neurons and oligodendrocytes within the brainstem of mice
Am J Physiol Lung Cell Mol Physiol. 2024 Apr 9. doi: 10.1152/ajplung.00320.2023. Online ahead of print.ABSTRACTChronic intermittent hypoxia (CIH) is a prevalent condition characterized by recurrent episodes of oxygen deprivation, linked to respiratory and neurological disorders. Prolonged CIH is known to have adverse effects, including endothelial dysfunction, chronic inflammation, oxidative stress, and impaired neuronal function. These factors can contribute to serious comorbidities, including metabolic disorders and cardiovascular diseases. To investigate the molecular impact of CIH, we examined male C57BL/6J mice expose...
Source: Am J Physiol Lung Ce... - April 9, 2024 Category: Respiratory Medicine Authors: Hemalatha Bhagavan Aguan D Wei Luiz M Oliveira Kimberly A Aldinger Jan-Marino Ramirez Source Type: research
Natural antibodies targeting LPS in pleural effusions of various etiologies
CONCLUSIONS: Our results highlight a potential role of anti-LPS NAbs in the pleural cavity that should be further explored.PMID:38591123 | DOI:10.1152/ajplung.00377.2023 (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - April 9, 2024 Category: Respiratory Medicine Authors: Ioannis Sarrigeorgiou Erasmia Rouka Ourania S Kotsiou Garyfallia Perlepe Efrosini S Gerovasileiou Konstantinos I Gourgoulianis Peggy Lymberi Sotirios G Zarogiannis Source Type: research
Chronic intermittent hypoxia elicits distinct transcriptomic responses among neurons and oligodendrocytes within the brainstem of mice
Am J Physiol Lung Cell Mol Physiol. 2024 Apr 9. doi: 10.1152/ajplung.00320.2023. Online ahead of print.ABSTRACTChronic intermittent hypoxia (CIH) is a prevalent condition characterized by recurrent episodes of oxygen deprivation, linked to respiratory and neurological disorders. Prolonged CIH is known to have adverse effects, including endothelial dysfunction, chronic inflammation, oxidative stress, and impaired neuronal function. These factors can contribute to serious comorbidities, including metabolic disorders and cardiovascular diseases. To investigate the molecular impact of CIH, we examined male C57BL/6J mice expose...
Source: Am J Physiol Lung Ce... - April 9, 2024 Category: Respiratory Medicine Authors: Hemalatha Bhagavan Aguan D Wei Luiz M Oliveira Kimberly A Aldinger Jan-Marino Ramirez Source Type: research
Natural antibodies targeting LPS in pleural effusions of various etiologies
CONCLUSIONS: Our results highlight a potential role of anti-LPS NAbs in the pleural cavity that should be further explored.PMID:38591123 | DOI:10.1152/ajplung.00377.2023 (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - April 9, 2024 Category: Respiratory Medicine Authors: Ioannis Sarrigeorgiou Erasmia Rouka Ourania S Kotsiou Garyfallia Perlepe Efrosini S Gerovasileiou Konstantinos I Gourgoulianis Peggy Lymberi Sotirios G Zarogiannis Source Type: research
Chronic intermittent hypoxia elicits distinct transcriptomic responses among neurons and oligodendrocytes within the brainstem of mice
Am J Physiol Lung Cell Mol Physiol. 2024 Apr 9. doi: 10.1152/ajplung.00320.2023. Online ahead of print.ABSTRACTChronic intermittent hypoxia (CIH) is a prevalent condition characterized by recurrent episodes of oxygen deprivation, linked to respiratory and neurological disorders. Prolonged CIH is known to have adverse effects, including endothelial dysfunction, chronic inflammation, oxidative stress, and impaired neuronal function. These factors can contribute to serious comorbidities, including metabolic disorders and cardiovascular diseases. To investigate the molecular impact of CIH, we examined male C57BL/6J mice expose...
Source: Am J Physiol Lung Ce... - April 9, 2024 Category: Respiratory Medicine Authors: Hemalatha Bhagavan Aguan D Wei Luiz M Oliveira Kimberly A Aldinger Jan-Marino Ramirez Source Type: research
Low global arginine bioavailability: a common phenomenon in pulmonary hypertension
Am J Physiol Lung Cell Mol Physiol. 2024 Apr 1;326(4):L514-L515. doi: 10.1152/ajplung.00026.2024.NO ABSTRACTPMID:38587550 | DOI:10.1152/ajplung.00026.2024 (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - April 8, 2024 Category: Respiratory Medicine Authors: Dunia Hatabah Teresa De Marco Dana P McGlothlin Mary Malloy Loretta Z Reyes Rawan Korman Gregory J Kato Claudia R Morris Source Type: research
