Buprenorphine Affects the Initiation and Severity of Interleukin Induced Acute Pancreatitis in Mice
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 23. doi: 10.1152/ajpgi.00083.2024. Online ahead of print.ABSTRACTAcute pancreatitis (AP) is a common disease with no targeted therapy and has varied outcomes ranging from spontaneous resolution to being lethal. While typically painful, AP can also be painless. Various agents, including opioids are used for pain control in AP; the risks, and benefits of which are often debated. Since experimental AP in mice is used to study the efficacy of potential therapies, we studied the effect of a commonly used opioid buprenorphine on the initiation and progression of AP. For this we a...
Source: Am J Physiol Gastroi... - April 23, 2024 Category: Gastroenterology Authors: Sarah Jahangir Biswajit Khatua Nabil Smichi Prasad Rajalingamgari Anoop Narayana Pillai Megan J Summers Bryce McFayden Sergiy Kostenko Naomi M Gades Vijay P Singh Source Type: research
BiliQML: A supervised machine-learning model to quantify biliary forms from digitized whole-slide liver histopathological images
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 23. doi: 10.1152/ajpgi.00058.2024. Online ahead of print.ABSTRACTThe progress of research focused on cholangiocytes and the biliary tree during development and following injury is hindered by limited available quantitative methodologies. Current techniques include two-dimensional standard histological cell-counting approaches, which are rapidly performed error-prone and lack architectural context; or three-dimensional analysis of the biliary tree in opacified livers, which introduce technical issues along with minimal quantitation. The present study aims to fill these quant...
Source: Am J Physiol Gastroi... - April 23, 2024 Category: Gastroenterology Authors: Dominick J Hellen Meredith E Fay David H Lee Caroline Klindt-Morgan Ashley Bennett Kimberly J Pachura Arash Grakoui Stacey S Huppert Paul A Dawson Wilbur A Lam Saul J Karpen Source Type: research
Patients with autoimmune liver disease have glucose disturbances that mechanistically differ from steatotic liver disease
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 16. doi: 10.1152/ajpgi.00047.2024. Online ahead of print.ABSTRACTAutoimmune liver diseases are associated with an increased risk of diabetes, yet the underlying mechanisms remain unknown. In this cross-sectional study, we investigated the glucose-regulatory disturbances in patients with autoimmune hepatitis (AIH, n=19), primary biliary cholangitis (PBC, n=15), and primary sclerosing cholangitis (PSC, n=6). Healthy individuals (n=24) and patients with metabolic dysfunction-associated steatotic liver disease (MASLD, n=18) were included as controls. Blood samples were collecte...
Source: Am J Physiol Gastroi... - April 16, 2024 Category: Gastroenterology Authors: Anne-Sofie H Jensen Henriette Ytting Mikkel P Werge Elias B Rashu Liv E Hetland Mira Thing Puria Nabilou Johan Burisch Kirstine N Bojsen-M øller Anders E Junker Lise Hobolth Christian Mortensen Flemming Tofteng Flemming Bendtsen S øren Møller Mogens Vy Source Type: research
Neuroimmunophysiology of the Gastrointestinal Tract
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 16. doi: 10.1152/ajpgi.00075.2024. Online ahead of print.ABSTRACTGut physiology is the epicentre of a web of internal communication systems (i.e., neural, immune, hormonal) mediated by cell-cell contacts, soluble factors, and external influences, such as the microbiome, diet, and the physical environment. Together these provide the signals that shape enteric homeostasis and, when they go awry, lead to disease. Faced with the seemingly paradoxical tasks of nutrient uptake (digestion) and retarding pathogen invasion (host defense), the gut integrates interactions between a va...
Source: Am J Physiol Gastroi... - April 16, 2024 Category: Gastroenterology Authors: Derek M McKay Manon Defaye Sruthi Rajeev Wallace K MacNaughton Yasmin Nasser Keith A Sharkey Source Type: research
Biomechanical Increase in Cervical Esophageal Wall Tension during Peristalsis
CONCLUSION: We conclude that there is a significant CTE increase, independent of laryngeal elevation or esophageal muscle contraction, which occurs during esophageal peristalsis. This response is a biomechanical process caused by esophageal shortening that occurs during esophageal longitudinal contraction of esophageal peristalsis.PMID:38626405 | DOI:10.1152/ajpgi.00049.2024 (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - April 16, 2024 Category: Gastroenterology Authors: Ivan M Lang Bidyut K Medda Reza Shaker Source Type: research
Patients with autoimmune liver disease have glucose disturbances that mechanistically differ from steatotic liver disease
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 16. doi: 10.1152/ajpgi.00047.2024. Online ahead of print.ABSTRACTAutoimmune liver diseases are associated with an increased risk of diabetes, yet the underlying mechanisms remain unknown. In this cross-sectional study, we investigated the glucose-regulatory disturbances in patients with autoimmune hepatitis (AIH, n=19), primary biliary cholangitis (PBC, n=15), and primary sclerosing cholangitis (PSC, n=6). Healthy individuals (n=24) and patients with metabolic dysfunction-associated steatotic liver disease (MASLD, n=18) were included as controls. Blood samples were collecte...
Source: Am J Physiol Gastroi... - April 16, 2024 Category: Gastroenterology Authors: Anne-Sofie H Jensen Henriette Ytting Mikkel P Werge Elias B Rashu Liv E Hetland Mira Thing Puria Nabilou Johan Burisch Kirstine N Bojsen-M øller Anders E Junker Lise Hobolth Christian Mortensen Flemming Tofteng Flemming Bendtsen S øren Møller Mogens Vy Source Type: research
Neuroimmunophysiology of the Gastrointestinal Tract
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 16. doi: 10.1152/ajpgi.00075.2024. Online ahead of print.NO ABSTRACTPMID:38626403 | DOI:10.1152/ajpgi.00075.2024 (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - April 16, 2024 Category: Gastroenterology Authors: Derek M McKay Manon Defaye Sruthi Rajeev Wallace K MacNaughton Yasmin Nasser Keith A Sharkey Source Type: research
Biomechanical Increase in Cervical Esophageal Wall Tension during Peristalsis
CONCLUSION: We conclude that there is a significant CTE increase, independent of laryngeal elevation or esophageal muscle contraction, which occurs during esophageal peristalsis. This response is a biomechanical process caused by esophageal shortening that occurs during esophageal longitudinal contraction of esophageal peristalsis.PMID:38626405 | DOI:10.1152/ajpgi.00049.2024 (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - April 16, 2024 Category: Gastroenterology Authors: Ivan M Lang Bidyut K Medda Reza Shaker Source Type: research
Patients with autoimmune liver disease have glucose disturbances that mechanistically differ from steatotic liver disease
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 16. doi: 10.1152/ajpgi.00047.2024. Online ahead of print.ABSTRACTAutoimmune liver diseases are associated with an increased risk of diabetes, yet the underlying mechanisms remain unknown. In this cross-sectional study, we investigated the glucose-regulatory disturbances in patients with autoimmune hepatitis (AIH, n=19), primary biliary cholangitis (PBC, n=15), and primary sclerosing cholangitis (PSC, n=6). Healthy individuals (n=24) and patients with metabolic dysfunction-associated steatotic liver disease (MASLD, n=18) were included as controls. Blood samples were collecte...
Source: Am J Physiol Gastroi... - April 16, 2024 Category: Gastroenterology Authors: Anne-Sofie H Jensen Henriette Ytting Mikkel P Werge Elias B Rashu Liv E Hetland Mira Thing Puria Nabilou Johan Burisch Kirstine N Bojsen-M øller Anders E Junker Lise Hobolth Christian Mortensen Flemming Tofteng Flemming Bendtsen S øren Møller Mogens Vy Source Type: research
Neuroimmunophysiology of the Gastrointestinal Tract
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 16. doi: 10.1152/ajpgi.00075.2024. Online ahead of print.NO ABSTRACTPMID:38626403 | DOI:10.1152/ajpgi.00075.2024 (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - April 16, 2024 Category: Gastroenterology Authors: Derek M McKay Manon Defaye Sruthi Rajeev Wallace K MacNaughton Yasmin Nasser Keith A Sharkey Source Type: research
Biomechanical Increase in Cervical Esophageal Wall Tension during Peristalsis
CONCLUSION: We conclude that there is a significant CTE increase, independent of laryngeal elevation or esophageal muscle contraction, which occurs during esophageal peristalsis. This response is a biomechanical process caused by esophageal shortening that occurs during esophageal longitudinal contraction of esophageal peristalsis.PMID:38626405 | DOI:10.1152/ajpgi.00049.2024 (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - April 16, 2024 Category: Gastroenterology Authors: Ivan M Lang Bidyut K Medda Reza Shaker Source Type: research
N-glycosylation of SCAP exacerbates hepatocellular inflammation and lipid accumulation via ACSS2-mediated histone H3K27 acetylation
In conclusion, SCAP N-glycosylation aggravates inflammation and lipid accumulation through enhancing ACSS2-mediated H3K27ac in hepatocytes.PMID:38591127 | DOI:10.1152/ajpgi.00273.2023 (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - April 9, 2024 Category: Gastroenterology Authors: Xuemei Li Xiaoqin Tang Yue Xiang Zhibo Zhao Yanping Li Qiuying Ding Linkun Zhang Jingyuan Xu Lei Zhao Yao Chen Source Type: research
High-Energy Pacing Inhibits Slow Wave Dysrhythmias in the Small Intestine
This study assessed the use of pacing to suppress glucagon-induced slow wave dysrhythmias in the small intestine. Slow waves in the jejunum were mapped in vivo using a high-resolution surface-contact electrode array in pigs (n=7). Glucagon was intravenously administered to induce hyperglycemia. Slow wave propagation patterns were categorized into antegrade, retrograde, collision, pacemaker and uncoupled activity. Slow wave characteristics such as period, amplitude and speed were also quantified. Post-glucagon infusion, pacing was applied at 4 mA and 8 mA and the resulting slow waves were quantified spatiotemporally. Antegr...
Source: Am J Physiol Gastroi... - April 9, 2024 Category: Gastroenterology Authors: Nipuni D Nagahawatte Recep Avci Niranchan Paskaranandavadivel Leo K Cheng Source Type: research
Milk and < em > Lacticaseibacillus casei < /em > BL23 effects on intestinal responses in a murine model of colitis
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 9. doi: 10.1152/ajpgi.00259.2023. Online ahead of print.ABSTRACTProbiotic-containing fermented dairy foods have the potential to benefit human health, but the importance of the dairy matrix for efficacy remains unclear. We investigated the capacity of Lacticaseibacillus casei BL23 in phosphate-buffered saline (BL23-PBS), BL23-fermented milk (BL23-milk), and milk to modify intestinal and behavioral responses in a Dextran Sodium Sulfate (DSS, 3% w/v) mouse model of colitis. Significant sex-dependent differences were found such that female mice exhibited more severe colitis, g...
Source: Am J Physiol Gastroi... - April 9, 2024 Category: Gastroenterology Authors: Glory Bui Cristina Torres-Fuentes Matteo M Pusceddu Melanie G Gareau Maria L Marco Source Type: research
Oral tryptophan activates duodenal aryl hydrocarbon receptor in healthy subjects: a crossover randomized controlled trial
Conclusions: At the doses used in this study, oral tryptophan supplementation in humans induces microbial indole and host kynurenine metabolic pathways in the small intestine, known to be immunomodulatory. The results should prompt tryptophan intervention strategies in inflammatory conditions of the small intestine where the AhR pathway is impaired.PMID:38591144 | DOI:10.1152/ajpgi.00306.2023 (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - April 9, 2024 Category: Gastroenterology Authors: Gaston H Rueda Natalia Causada-Calo Rajka Borojevic Andrea Nardelli Maria Ines Pinto-Sanchez Marco Constante Josie Libertucci Vidhyalakshmi Mohan Philippe Langella Linda M P Loonen Jerry M Wells Harry Sokol Elena F Verdu Premysl Bercik Source Type: research
