Dissemination of nonsteroidal anti-inflammatory drugs (NSAIDs) and metabolites from wastewater treatment plant to soils and agricultural crops via real-scale different agronomic practices
Environ Res. 2023 Mar 21:115731. doi: 10.1016/j.envres.2023.115731. Online ahead of print.ABSTRACTOne of the most consumed pharmaceutical subgroups across the world is nonsteroidal anti-inflammatory drugs (NSAIDs). However, the dissemination of these compounds to the natural environments through agronomic practices is a serious global problem. The hypothesis of this study is to reveal the transition of selected NSAIDs, paracetamol (PAR), diclofenac (DCF), ibuprofen (IBU), and naproxen (NAP) together with six main metabolites, detected in raw/treated wastewater (RWW/TWW) and sewage sludge generated in an urban wastewater tr...
Source: Environmental Research - March 23, 2023 Category: Environmental Health Authors: Taylan Dolu Bilgehan Nas Source Type: research
Fluorescent sensing of non-steroidal anti-inflammatory drugs naproxen and ketoprofen by dansylated squaramide-based receptors
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Giacomo Picci, Claudia Caltagirone, Maria Carla Aragoni, Massimiliano Arca, Mauro Formica, Vieri Fusi, Luca Giorgi , Filippo Ingargiola, Vito Lippolis, Eleonora Macedi, Luca Mancini, Liviana Mummolo, Luca Prodi Bis-squaramide receptors L1 –L4 bearing a dansyl moiety were synthesised and their potential applications as fluorescent probes towards non steroidal anti-inflammatory drugs naproxen and ketoprofen was investigated. A detailed photophysical characterization... The content of this RSS Feed (c) The Royal Society of Chemis...
Source: RSC - Organic and Biomolecular Chemistry - March 15, 2023 Category: Molecular Biology Authors: Giacomo Picci Source Type: research
Exposure to a rotating magnetic field as a method of increasing the skin permeability of active pharmaceutical ingredients
Eur J Pharm Biopharm. 2023 Mar 9:S0939-6411(23)00059-0. doi: 10.1016/j.ejpb.2023.02.017. Online ahead of print.ABSTRACTThe paper presents a method of increasing the permeability of various active substances through the skin by means of a rotating magnetic field. The study used 50 Hz RMF and various active pharmaceutical ingredients (APIs) such as caffeine, ibuprofen, naproxen, ketoprofen, and paracetamol. Various concentrations of active substance solutions in ethanol were used in the research, corresponding to those in commercial preparations. Each experiment was conducted for 24 hours. It was shown that, regardless of th...
Source: European Journal of Pharmaceutics and Biopharmaceutics - March 11, 2023 Category: Drugs & Pharmacology Authors: Rafa ł Rakoczy Anna Nowak Maciej Konopacki Marian Kordas Łukasz Kucharski Paula Ossowicz-Rupniewska Source Type: research
[ASAP] Supramolecular, Nanostructured Assembly of Antioxidant and Antibacterial Peptides Conjugated to Naproxen and Indomethacin for the Selective Inhibition of COX-2, Biofilm, and Inflammation in Chronic Wounds
Bioconjugate ChemistryDOI: 10.1021/acs.bioconjchem.3c00014 (Source: Bioconjugate Chemistry)
Source: Bioconjugate Chemistry - March 10, 2023 Category: Biochemistry Authors: Moumita Halder, Mukul Narula, and Yashveer Singh Source Type: research
Molecules, Vol. 28, Pages 2492: Solid & ndash;Liquid Equilibrium in Co-Amorphous Systems: Experiment and Prediction
Molecules, Vol. 28, Pages 2492: Solid–Liquid Equilibrium in Co-Amorphous Systems: Experiment and Prediction
Molecules doi: 10.3390/molecules28062492
Authors:
Alžběta Zemánková
Fatima Hassouna
Martin Klajmon
Michal Fulem
In this work, the solid–liquid equilibrium (SLE) of four binary systems combining two active pharmaceutical ingredients (APIs) capable of forming co-amorphous systems (CAMs) was investigated. The binary systems studied were naproxen-indomethacin, naproxen-ibuprofen, naproxen-probucol, and indomethacin-paracetamol. The SLE was experimentally determined by differentia...
Source: Molecules - March 8, 2023 Category: Chemistry Authors: Al žběta Zemánková Fatima Hassouna Martin Klajmon Michal Fulem Tags: Article Source Type: research
[ASAP] Water Maintains the UV –Vis Spectral Features During the Insertion of Anionic Naproxen and Ibuprofen into Model Cell Membranes
The Journal of Physical Chemistry BDOI: 10.1021/acs.jpcb.2c08332 (Source: Journal of Physical Chemistry B)
Source: Journal of Physical Chemistry B - March 6, 2023 Category: Chemistry Authors: Natalia Rojas-Valencia, Sara Go ́mez, Tommaso Giovannini, Chiara Cappelli, Albeiro Restrepo, and Francisco Núñez−Zarur Source Type: research
Molecules, Vol. 28, Pages 2171: Metal Complexes with Naphthalene-Based Acetic Acids as Ligands: Structure and Biological Activity
somas
Naproxen (6–methoxy–α–methyl–2–naphthaleneacetic acid), 1–naphthylacetic acid, 2–naphthylacetic acid and 1–pyreneacetic acid are derivatives of acetic acid bearing a naphthalene-based ring. In the present review, the coordination compounds of naproxen, 1– or 2–naphthylacetato and 1–pyreneacetato ligands are discussed in regard to their structural features (nature and nuclearity of metal ions and coordination mode of ligands), their spectroscopic an...
Source: Molecules - February 26, 2023 Category: Chemistry Authors: Marialena Lazou Spyros Perontsis George Psomas Tags: Review Source Type: research
Molecules, Vol. 28, Pages 2185: Evaluation of the Defined Bacterial Consortium Efficacy in the Biodegradation of NSAIDs
yńska
Due to the increasing pollution of wastewater with non-steroidal anti-inflammatory drugs, preparations need to be developed to decompose these drugs. This work aimed to develop a bacterial consortium with a defined composition and boundary conditions for the degradation of paracetamol and selected non-steroidal anti-inflammatory drugs (NSAIDs), including ibuprofen, naproxen, and diclofenac. The defined bacterial consortium consisted of Bacillus thuringiensis B1(2015b) and Pseudomonas moorei KB4 strains in a ratio of 1:2. During the tests, it was shown that the bacterial consortium worked in the pH range from 5.5...
Source: Molecules - February 26, 2023 Category: Chemistry Authors: Ariel Marchlewicz Urszula Guzik Katarzyna Hupert-Kocurek Danuta Wojcieszy ńska Tags: Article Source Type: research
Molecules, Vol. 28, Pages 2174: Boron Lewis Acid Catalysis Enables the Direct Cyanation of Benzyl Alcohols by Means of Isonitrile as Cyanide Source
Jian-Jun Feng
The development of an efficient and straightforward method for cyanation of alcohols is of great value. However, the cyanation of alcohols always requires toxic cyanide sources. Herein, an unprecedented synthetic application of an isonitrile as a safer cyanide source in B(C6F5)3-catalyzed direct cyanation of alcohols is reported. With this approach, a wide range of valuable α-aryl nitriles was synthesized in good to excellent yields (up to 98%). The reaction can be scaled up and the practicability of this approach is further manifested in the synthesis of an anti-inflammatory drug, naproxen....
Source: Molecules - February 26, 2023 Category: Chemistry Authors: Tong-Tong Xu Jin-Lan Zhou Guang-Yuan Cong Jiang-Yi-Hui Sheng Shi-Qi Wang Yating Ma Jian-Jun Feng Tags: Article Source Type: research
Efficacy of oral nifedipine, naproxen, or placebo for pain relief during diagnostic hysteroscopy in an office setting: a randomized pilot study.
To compare nifedipine, naproxen, or placebo for pain relief during diagnostic hysteroscopy. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - February 15, 2023 Category: OBGYN Authors: Steffi van Wessel, Julie Rombaut, Astrid Vanhulle, Mark Hans Emanuel, Tjalina Hamerlynck, Steven Weyers Tags: ORIGINAL ARTICLE Source Type: research
Preparation of molecularly imprinted silica particles with amino functionality for chiral separation of ( ±)-naproxen
Chirality. 2023 Feb 7. doi: 10.1002/chir.23541. Online ahead of print.ABSTRACTHerein is the synthesis and effective use of an S-naproxen (S-NP) enantioselective adsorbent material with amino functionality for the enantioseparation of a (±)-NP racemic mixture. To begin, the S-NP enantiomer of (3-aminopropyl)triethoxysilane was used to create an amide derivative (S-NP-Si-NH2 ). In order to incorporate the S-NP enantiomeric species into the cross-linked material, the developed S-NP-Si-NH2 derivative was combined with tetraethoxysilane (TEOS) and subjected base-catalyzed sol-gel condensation polymerization procedure. The S-NP...
Source: Chirality - February 8, 2023 Category: Molecular Biology Authors: Abeer Abdulaziz H Bukhari Source Type: research
Preparation of molecularly imprinted silica particles with amino functionality for chiral separation of ( ±)-naproxen
Chirality. 2023 Feb 7. doi: 10.1002/chir.23541. Online ahead of print.ABSTRACTHerein is the synthesis and effective use of an S-naproxen (S-NP) enantioselective adsorbent material with amino functionality for the enantioseparation of a (±)-NP racemic mixture. To begin, the S-NP enantiomer of (3-aminopropyl)triethoxysilane was used to create an amide derivative (S-NP-Si-NH2 ). In order to incorporate the S-NP enantiomeric species into the cross-linked material, the developed S-NP-Si-NH2 derivative was combined with tetraethoxysilane (TEOS) and subjected base-catalyzed sol-gel condensation polymerization procedure. The S-NP...
Source: Chirality - February 8, 2023 Category: Molecular Biology Authors: Abeer Abdulaziz H Bukhari Source Type: research
Efficiently photocatalysis activation of peroxydisulfate by Fe-doped g-C < sub > 3 < /sub > N < sub > 5 < /sub > for pharmaceuticals and personal care products degradation
In this study, a Fe-doped g-C3N5 (Fe@g-C3N5) was synthesized as a photocatalyst for catalyzing the PDS-based AOPs to degrade tetracycline hydrochloride (TH) at pH 3 and Naproxen (NPX) at pH 7. The photocatalytic performance of Fe@g-C3N5 was 19% and 67% higher than g-C3N5 and g-C3N4 for degradation of TH at pH 3, respectively, while it was 21% and 35% at pH 7. The Fe:N ratio in Fe@g-C3N5, was calculated as 1:3.79, indicating that the doped Fe atom formed a FeN4 structure with an adjacent two-layer graphite structure of g-C3N5, which improved the charge separation capacity of g-C3N5 and act as a new reaction center that can ...
Source: Environmental Pollution - February 3, 2023 Category: Environmental Health Authors: Juanjuan Liu Chaocheng Zhao Jingtang Zheng Muhammad Saboor Siddique Hankun Yang Wenzheng Yu Source Type: research
Efficiently photocatalysis activation of peroxydisulfate by Fe-doped g-C < sub > 3 < /sub > N < sub > 5 < /sub > for pharmaceuticals and personal care products degradation
In this study, a Fe-doped g-C3N5 (Fe@g-C3N5) was synthesized as a photocatalyst for catalyzing the PDS-based AOPs to degrade tetracycline hydrochloride (TH) at pH 3 and Naproxen (NPX) at pH 7. The photocatalytic performance of Fe@g-C3N5 was 19% and 67% higher than g-C3N5 and g-C3N4 for degradation of TH at pH 3, respectively, while it was 21% and 35% at pH 7. The Fe:N ratio in Fe@g-C3N5, was calculated as 1:3.79, indicating that the doped Fe atom formed a FeN4 structure with an adjacent two-layer graphite structure of g-C3N5, which improved the charge separation capacity of g-C3N5 and act as a new reaction center that can ...
Source: Environmental Pollution - February 3, 2023 Category: Environmental Health Authors: Juanjuan Liu Chaocheng Zhao Jingtang Zheng Muhammad Saboor Siddique Hankun Yang Wenzheng Yu Source Type: research
Masking the Taste of Fixed-Dose Combination Drugs: Particular NSAIDs Can Efficiently Mask the Bitterness of Famotidine
This study aimed to evaluate the bitterness of famotidine (FAM) combined with each of three non-steroidal anti-inflammatory drugs (NSAIDs): ibuprofen (IBU), flurbiprofen (FLU), and naproxen (NAP), which have potential as fixed-dose combination (FDC) drugs. We evaluated the bitterness of FAM and each NSAID by taste sensor AN0 and C00, respectively. FAM showed high sensor output representing sensitivity to bitterness, whereas three NSAIDs did not show large sensor output, suggesting that the bitterness intensities of three NSAIDs were lower than that of FAM. The bitterness of FAM on sensor AN0 was suppressed in a concentrati...
Source: Chemical and Pharmaceutical Bulletin - February 1, 2023 Category: Drugs & Pharmacology Authors: Rio Uno Kyoko Ohkawa Honami Kojima Tamami Haraguchi Minoru Ozeki Ikuo Kawasaki Miyako Yoshida Masaaki Habara Hidekazu Ikezaki Takahiro Uchida Source Type: research
