Microplastics as vectors of chemical contaminants and biological agents in freshwater ecosystems: Current knowledge status and future perspectives
Environ Pollut. 2023 May 15:121829. doi: 10.1016/j.envpol.2023.121829. Online ahead of print.ABSTRACTMicroplastics (MPs) are becoming ubiquitous, and their environmental fate is becoming an issue of concern. Our review aims to synthesize current knowledge status and provide future perspectives regarding the vector effect of MPs for chemical contaminants and biological agents. The evidence in the literature indicates that MPs are a vector for persistent organic pollutants (POPs), metals and pharmaceuticals. Concentrations of chemical contaminant in orders of six-fold higher on MPs surfaces than in the surrounding environmen...
Source: Environmental Pollution - May 17, 2023 Category: Environmental Health Authors: Edgar Tumwesigye Chika Felicitas Nnadozie Frank C Akamagwuna Xavier Siwe Noundou George William Nyakairu Oghenekaro Nelson Odume Source Type: research
A randomized, double-blind pilot study of analgesic and anti-inflammatory effects of naproxen sodium and acetaminophen following dental implant placement surgery
Discussion: Naproxen sodium was more effective than acetaminophen in reducing post-operative pain and systemic inflammation following surgical placement of one or two dental implants. Further studies are needed to determine whether these findings are applicable to more complex implant cases and how they affect clinical outcomes following implant placement.Clinical Trial Registration:ClinicalTrials.gov, identifier NCT04694300 (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - May 17, 2023 Category: Drugs & Pharmacology Source Type: research
Advanced oxidation and a metrological strategy based on CLC-MS for the removal of pharmaceuticals from pore & amp; surface water
Chemosphere. 2023 May 13:138847. doi: 10.1016/j.chemosphere.2023.138847. Online ahead of print.ABSTRACTIn this work, it is studied the photolysis, electrolysis, and photo-electrolysis of a mixture of pharmaceutics (sulfadiazine, naproxen, diclofenac, ketoprofen and ibuprofen) contained in two very different types of real water matrices (obtained from surface and porewater reservoirs), trying to clarify the role of the matrix on the degradation of the pollutants. To do this, a new metrological approach was also developed for screening of pharmaceuticals in waters by capillary liquid chromatography mass spectrometry (CLC-MS)...
Source: Chemosphere - May 15, 2023 Category: Chemistry Authors: Jih ène Ben Attig Fernanda de Lourdes Souza Latifa Latrous Pablo Ca ñizares Cristina S áez Ángel Ríos Mohammed Zougagh Manuel Andr és Rodrigo Source Type: research
Advanced oxidation and a metrological strategy based on CLC-MS for the removal of pharmaceuticals from pore & amp; surface water
Chemosphere. 2023 May 13:138847. doi: 10.1016/j.chemosphere.2023.138847. Online ahead of print.ABSTRACTIn this work, it is studied the photolysis, electrolysis, and photo-electrolysis of a mixture of pharmaceutics (sulfadiazine, naproxen, diclofenac, ketoprofen and ibuprofen) contained in two very different types of real water matrices (obtained from surface and porewater reservoirs), trying to clarify the role of the matrix on the degradation of the pollutants. To do this, a new metrological approach was also developed for screening of pharmaceuticals in waters by capillary liquid chromatography mass spectrometry (CLC-MS)...
Source: Chemosphere - May 15, 2023 Category: Chemistry Authors: Jih ène Ben Attig Fernanda de Lourdes Souza Latifa Latrous Pablo Ca ñizares Cristina S áez Ángel Ríos Mohammed Zougagh Manuel Andr és Rodrigo Source Type: research
Advanced oxidation and a metrological strategy based on CLC-MS for the removal of pharmaceuticals from pore & amp; surface water
Chemosphere. 2023 May 13:138847. doi: 10.1016/j.chemosphere.2023.138847. Online ahead of print.ABSTRACTIn this work, it is studied the photolysis, electrolysis, and photo-electrolysis of a mixture of pharmaceutics (sulfadiazine, naproxen, diclofenac, ketoprofen and ibuprofen) contained in two very different types of real water matrices (obtained from surface and porewater reservoirs), trying to clarify the role of the matrix on the degradation of the pollutants. To do this, a new metrological approach was also developed for screening of pharmaceuticals in waters by capillary liquid chromatography mass spectrometry (CLC-MS)...
Source: Chemosphere - May 15, 2023 Category: Chemistry Authors: Jih ène Ben Attig Fernanda de Lourdes Souza Latifa Latrous Pablo Ca ñizares Cristina S áez Ángel Ríos Mohammed Zougagh Manuel Andr és Rodrigo Source Type: research
Evaluating ionic liquids for its potential as eco-friendly solvents for naproxen removal from water sources using COSMO-RS: Computational and experimental validation
Environ Res. 2023 May 11:116058. doi: 10.1016/j.envres.2023.116058. Online ahead of print.ABSTRACTAn emerging contaminant of concern in aqueous streams is naproxen. Due to its poor solubility, non-biodegradability, and pharmaceutically active nature, the separation is challenging. Conventional solvents employed for naproxen are toxic and harmful. Ionic liquids (ILs) have attracted great attention as greener solubilizing and separating agent for various pharmaceuticals. ILs have found extensive usage as solvents in nanotechnological processes involving enzymatic reactions and whole cells. The employment of ILs can enhance t...
Source: Environmental Research - May 13, 2023 Category: Environmental Health Authors: Huma Warsi Khan Mohd Kaif Khan Muhammad Moniruzzaman Mohammed K Al Mesfer Mohd Danish Kashif Irshad Mohammad Yusuf Hesam Kamyab Shreshivadasan Chelliapan Source Type: research
Evaluating ionic liquids for its potential as eco-friendly solvents for naproxen removal from water sources using COSMO-RS: Computational and experimental validation
Environ Res. 2023 May 11:116058. doi: 10.1016/j.envres.2023.116058. Online ahead of print.ABSTRACTAn emerging contaminant of concern in aqueous streams is naproxen. Due to its poor solubility, non-biodegradability, and pharmaceutically active nature, the separation is challenging. Conventional solvents employed for naproxen are toxic and harmful. Ionic liquids (ILs) have attracted great attention as greener solubilizing and separating agent for various pharmaceuticals. ILs have found extensive usage as solvents in nanotechnological processes involving enzymatic reactions and whole cells. The employment of ILs can enhance t...
Source: Environmental Research - May 13, 2023 Category: Environmental Health Authors: Huma Warsi Khan Mohd Kaif Khan Muhammad Moniruzzaman Mohammed K Al Mesfer Mohd Danish Kashif Irshad Mohammad Yusuf Hesam Kamyab Shreshivadasan Chelliapan Source Type: research
Multimodal analgesia did not improve post-operative pain scores, reduce opioid consumption or reduce length of stay following hip arthroscopy
ConclusionThe routine use of Zopiclone, Celecoxib and Gabapentin did not improve postoperative pain control or reduce length-of-stay following hip arthroscopy. Therefore, these medications are not recommended for routine postoperative pain control following hip arthroscopy.Level of evidencel. (Source: Knee Surgery, Sports Traumatology, Arthroscopy)
Source: Knee Surgery, Sports Traumatology, Arthroscopy - May 12, 2023 Category: Orthopaedics Source Type: research
[ASAP] Naproxen as a Turn-On Chemiluminescent Probe for Real-Time Quantification of Sulfate Radicals
Environmental Science& TechnologyDOI: 10.1021/acs.est.3c01948 (Source: Environmental Science and Technology)
Source: Environmental Science and Technology - May 11, 2023 Category: Environmental Health Authors: managing.editor at est.acs.org (American Chemical Society) Source Type: research
Design, synthesis and anti-inflammatory activity of diterpenoid alkaloids and non-steroidal anti-inflammatory drug hybrids based on molecular hybridization strategy
In this study, we synthesized 25 diterpenoid alkaloid derivatives with NSAIDs, organized into four series. Among these derivatives, lappaconitine derivative 1e demonstrated the strongest inhibition of lipopolysaccharide (LPS)-induced NO production in RAW 264.7 cells with minimal cytotoxicity. Additionally, 1e effectively suppressed the inflammatory response induced by carrageenan in vivo, with a swelling rate of only 1%. This anti-inflammatory potency was found to be significantly superior to that of naproxen. The molecular docking analysis revealed that the binding affinity of 1e was scored as -10.3 kcal/mol, suggesting t...
Source: Fitoterapia - May 10, 2023 Category: Biochemistry Authors: Ming-Hao Guo Peng Wen Yao Xiao Wan-Sheng Ji Xian-Li Zhou Feng Gao Lian-Hai Shan Source Type: research
Design, synthesis and anti-inflammatory activity of diterpenoid alkaloids and non-steroidal anti-inflammatory drug hybrids based on molecular hybridization strategy
In this study, we synthesized 25 diterpenoid alkaloid derivatives with NSAIDs, organized into four series. Among these derivatives, lappaconitine derivative 1e demonstrated the strongest inhibition of lipopolysaccharide (LPS)-induced NO production in RAW 264.7 cells with minimal cytotoxicity. Additionally, 1e effectively suppressed the inflammatory response induced by carrageenan in vivo, with a swelling rate of only 1%. This anti-inflammatory potency was found to be significantly superior to that of naproxen. The molecular docking analysis revealed that the binding affinity of 1e was scored as -10.3 kcal/mol, suggesting t...
Source: Fitoterapia - May 10, 2023 Category: Biochemistry Authors: Ming-Hao Guo Peng Wen Yao Xiao Wan-Sheng Ji Xian-Li Zhou Feng Gao Lian-Hai Shan Source Type: research
Selective quantification of diclofenac from groundwater and pharmaceutical samples by magnetic molecularly imprinted polymer-based sorbent coupled with the HPLC-PDA detection
Environ Sci Pollut Res Int. 2023 May 9. doi: 10.1007/s11356-023-27431-1. Online ahead of print.ABSTRACTDiclofenac (DCF) is a pharmaceutical contaminant of water bodies and therefore, improvement of analytical techniques for its removal and quantitation is one of the current interests of analysts. Herein, DCF selective magnetic molecularly imprinted polymer (MMIP) has been fabricated and characterized by Fourier transform-infrared spectroscopy, thermogravimetric analysis, vibrating scanning magnetometer, scanning electron microscopy, high-resolution transmission electron microscope, energy-dispersive X-ray spectroscopy, and...
Source: Environmental Science and Pollution Research International - May 8, 2023 Category: Environmental Health Authors: Sahil Thakur Irshad Mohiuddin Raghubir Singh Varinder Kaur Source Type: research
Use of non-steroidal anti-inflammatory drugs in renal transplant patients: A retrospective study
CONCLUSION: We observed possible NSAID-induced AKI to an extent of around 15.2% in our renal transplant patients. No significant differences were observed in the incidence of AKI between various NSAIDs and none of them had either graft failure or death.PMID:37154186 | DOI:10.3233/JRS-220065 (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - May 8, 2023 Category: Drugs & Pharmacology Authors: Kannan Sridharan Shamik Shah Source Type: research
Selective quantification of diclofenac from groundwater and pharmaceutical samples by magnetic molecularly imprinted polymer-based sorbent coupled with the HPLC-PDA detection
Environ Sci Pollut Res Int. 2023 May 9. doi: 10.1007/s11356-023-27431-1. Online ahead of print.ABSTRACTDiclofenac (DCF) is a pharmaceutical contaminant of water bodies and therefore, improvement of analytical techniques for its removal and quantitation is one of the current interests of analysts. Herein, DCF selective magnetic molecularly imprinted polymer (MMIP) has been fabricated and characterized by Fourier transform-infrared spectroscopy, thermogravimetric analysis, vibrating scanning magnetometer, scanning electron microscopy, high-resolution transmission electron microscope, energy-dispersive X-ray spectroscopy, and...
Source: Environmental Science and Pollution Research International - May 8, 2023 Category: Environmental Health Authors: Sahil Thakur Irshad Mohiuddin Raghubir Singh Varinder Kaur Source Type: research
