Evidence-based clinical practice guideline for the pharmacologic management of acute dental pain in children: A report from the American Dental Association Science and Research Institute, the University of Pittsburgh School of Dental Medicine, and the Center for Integrative Global Oral Health at the University of Pennsylvania
CONCLUSIONS AND PRACTICAL IMPLICATIONS: Nonopioid medications, specifically nonsteroidal anti-inflammatory drugs like ibuprofen and naproxen alone or in combination with acetaminophen, are recommended for managing acute dental pain after 1 or more tooth extractions (that is, simple and surgical) and the temporary management of toothache in children (conditional recommendation, very low certainty). According to the US Food and Drug Administration, the use of codeine and tramadol in children for managing acute pain is contraindicated.PMID:37634915 | DOI:10.1016/j.adaj.2023.06.014 (Source: Journal of the American Dental Association)
Source: Journal of the American Dental Association - August 27, 2023 Category: Dentistry Authors: Alonso Carrasco-Labra Deborah E Polk Olivia Urquhart Tara Aghaloo J William Claytor Vineet Dhar Raymond A Dionne Lorena Espinoza Sharon M Gordon Elliot V Hersh Alan S Law Brian S-K Li Paul J Schwartz Katie J Suda Michael A Turturro Marjorie L Wright Tim D Source Type: research
P003/32 Traumatic cervical carotid dissection in association with fractured elongated styloid process
PresentationA 22 year old male with no comorbidities presented with a witnessed collapse, dysconjugate eye movements, dysarthria, right-sided head and neck (H&N) pain with contralateral hemiplegia and facial droop (NIHSS 14).CTH and angio showed right ICA dissection just beyond its origin causing complete occlusion. A thrombus was present at the right M1. There was partial patency in this region and in distal MCA branches with collateral supply from the ACAs-AComm.InterventionThrombolysis was performed but terminated with 1 ml tPA remaining due to patient deterioration (NIHSS 20). Repeat CTH showed evolving right middl...
Source: Journal of NeuroInterventional Surgery - August 21, 2023 Category: Neurosurgery Authors: Roberts, S., Jain, A., Islim, F., Nejadhamzeeigilani, H., Patankar, T., Prasai, A., Idrovo, L., Deniz, K. Tags: 4.2 CASE PROPOSAL - Brain AVM/AVF, spinal vascular malformations Source Type: research
Patient Information: Oral Nonprescription Pain Medications for Adults
This JAMA Patient Page describes the common oral nonprescription pain medications acetaminophen, aspirin, ibuprofen, and naproxen sodium. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - August 10, 2023 Category: General Medicine Source Type: research
Occurrence and risk assessment of pharmaceuticals in hospital wastewater in Costa Rica
Chemosphere. 2023 Aug 5:139746. doi: 10.1016/j.chemosphere.2023.139746. Online ahead of print.ABSTRACTThis work aims to determine the occurrence, hazard and prioritization of pharmaceuticals from hospital wastewater in Costa Rica through the monitoring of 70 compounds and assessing their environmental risk through a hazard quotient approach (HQ). Moreover, the quantification of selected antibiotic resistance genes (ARGs) was conducted for the first time in this matrix in this geographical location. Thirty-four pharmaceuticals were detected, being caffeine, 1,7-dimethylxanthine, acetaminophen, ibuprofen, naproxen, ciproflox...
Source: Chemosphere - August 7, 2023 Category: Chemistry Authors: Carlos E Rodr íguez-Rodríguez Didier Ram írez-Morales Mario Masis-Mora Jos é R Montiel-Mora Claudio Soto-Garita Emanuel Araya-Valverde Juan Carlos Cambronero-Heinrichs Alexandre S ànchez-Melsió Susana Brice ño-Guevara Michael Mendez-Rivera Jos é L Source Type: research
Occurrence and risk assessment of pharmaceuticals in hospital wastewater in Costa Rica
Chemosphere. 2023 Aug 5:139746. doi: 10.1016/j.chemosphere.2023.139746. Online ahead of print.ABSTRACTThis work aims to determine the occurrence, hazard and prioritization of pharmaceuticals from hospital wastewater in Costa Rica through the monitoring of 70 compounds and assessing their environmental risk through a hazard quotient approach (HQ). Moreover, the quantification of selected antibiotic resistance genes (ARGs) was conducted for the first time in this matrix in this geographical location. Thirty-four pharmaceuticals were detected, being caffeine, 1,7-dimethylxanthine, acetaminophen, ibuprofen, naproxen, ciproflox...
Source: Chemosphere - August 7, 2023 Category: Chemistry Authors: Carlos E Rodr íguez-Rodríguez Didier Ram írez-Morales Mario Masis-Mora Jos é R Montiel-Mora Claudio Soto-Garita Emanuel Araya-Valverde Juan Carlos Cambronero-Heinrichs Alexandre S ànchez-Melsió Susana Brice ño-Guevara Michael Mendez-Rivera Jos é L Source Type: research
Effects of acidic non-steroidal anti-inflammatory drugs on human cytochrome P450 4A11 activity: Roles of carboxylic acid and a sulfur atom in potent inhibition by sulindac sulfide
Chem Biol Interact. 2023 Jul 25:110644. doi: 10.1016/j.cbi.2023.110644. Online ahead of print.ABSTRACTCytochrome P450 4A11 (CYP4A11) has many endogenous and exogenous compounds containing a carboxyl group in their structure as substrates. If drugs with this characteristic potently attenuate the catalytic function of CYP4A11, drug-drug interactions may occur. Acidic non-steroidal anti-inflammatory drugs (NSAIDs) possess a carboxylic acid in their structure. However, it remains unclear whether these drugs inhibit CYP4A11 activity. The present study examined the inhibitory effects of acidic NSAIDs on CYP4A11 activity using hu...
Source: Chemico-Biological Interactions - July 27, 2023 Category: Molecular Biology Authors: Hisataka Itoh Naho Yamashita Shinobu Kamijo Kazufumi Masuda Hisato Kato Satoshi Yamaori Source Type: research
Effects of acidic non-steroidal anti-inflammatory drugs on human cytochrome P450 4A11 activity: Roles of carboxylic acid and a sulfur atom in potent inhibition by sulindac sulfide
Chem Biol Interact. 2023 Jul 25;382:110644. doi: 10.1016/j.cbi.2023.110644. Online ahead of print.ABSTRACTCytochrome P450 4A11 (CYP4A11) has many endogenous and exogenous compounds containing a carboxyl group in their structure as substrates. If drugs with this characteristic potently attenuate the catalytic function of CYP4A11, drug-drug interactions may occur. Acidic non-steroidal anti-inflammatory drugs (NSAIDs) possess a carboxylic acid in their structure. However, it remains unclear whether these drugs inhibit CYP4A11 activity. The present study examined the inhibitory effects of acidic NSAIDs on CYP4A11 activity usin...
Source: Chemico-Biological Interactions - July 27, 2023 Category: Molecular Biology Authors: Hisataka Itoh Naho Yamashita Shinobu Kamijo Kazufumi Masuda Hisato Kato Satoshi Yamaori Source Type: research
Effect of salinity on the toxicity of diclofenac, ibuprofen and naproxen toward cyanobacterium Synechocystis salina
In this study, we decided to check how selected non-steroidal anti-inflammatory drugs (NSAID) affect the grow of Synechocystis salina, picocyanobacterium isolated from the Baltic Sea, with salinity as potential modulator of toxicity. S. salina was exposed to diclofenac (DCF), ibuprofen (IBF) and naproxen (NPX) (nominal 100 mg L-1) in BG11 medium and sea salt supplemented BG11 medium (38 PSU) over 96 h in continuous light at 23 °C. No acute toxicity was found in both tested salinity levels. The comparable grow rate in exposed culture compared to control culture over 4 days indicate lack of stress for several generations wh...
Source: Chemosphere - July 23, 2023 Category: Chemistry Authors: Klaudia Kropid łowska Magda Caban Source Type: research
Effect of salinity on the toxicity of diclofenac, ibuprofen and naproxen toward cyanobacterium Synechocystis salina
In this study, we decided to check how selected non-steroidal anti-inflammatory drugs (NSAID) affect the grow of Synechocystis salina, picocyanobacterium isolated from the Baltic Sea, with salinity as potential modulator of toxicity. S. salina was exposed to diclofenac (DCF), ibuprofen (IBF) and naproxen (NPX) (nominal 100 mg L-1) in BG11 medium and sea salt supplemented BG11 medium (38 PSU) over 96 h in continuous light at 23 °C. No acute toxicity was found in both tested salinity levels. The comparable grow rate in exposed culture compared to control culture over 4 days indicate lack of stress for several generations wh...
Source: Chemosphere - July 23, 2023 Category: Chemistry Authors: Klaudia Kropid łowska Magda Caban Source Type: research
Effect of salinity on the toxicity of diclofenac, ibuprofen and naproxen toward cyanobacterium Synechocystis salina
In this study, we decided to check how selected non-steroidal anti-inflammatory drugs (NSAID) affect the grow of Synechocystis salina, picocyanobacterium isolated from the Baltic Sea, with salinity as potential modulator of toxicity. S. salina was exposed to diclofenac (DCF), ibuprofen (IBF) and naproxen (NPX) (nominal 100 mg L-1) in BG11 medium and sea salt supplemented BG11 medium (38 PSU) over 96 h in continuous light at 23 °C. No acute toxicity was found in both tested salinity levels. The comparable grow rate in exposed culture compared to control culture over 4 days indicate lack of stress for several generations wh...
Source: Chemosphere - July 23, 2023 Category: Chemistry Authors: Klaudia Kropid łowska Magda Caban Source Type: research
Effect of salinity on the toxicity of diclofenac, ibuprofen and naproxen toward cyanobacterium Synechocystis salina
In this study, we decided to check how selected non-steroidal anti-inflammatory drugs (NSAID) affect the grow of Synechocystis salina, picocyanobacterium isolated from the Baltic Sea, with salinity as potential modulator of toxicity. S. salina was exposed to diclofenac (DCF), ibuprofen (IBF) and naproxen (NPX) (nominal 100 mg L-1) in BG11 medium and sea salt supplemented BG11 medium (38 PSU) over 96 h in continuous light at 23 °C. No acute toxicity was found in both tested salinity levels. The comparable grow rate in exposed culture compared to control culture over 4 days indicate lack of stress for several generations wh...
Source: Chemosphere - July 23, 2023 Category: Chemistry Authors: Klaudia Kropid łowska Magda Caban Source Type: research
The efficacy of a combination of naproxen and fexofenadine (SJP − 002) to inhibit the symptoms that are associated with viral upper respiratory tract infection: Four case reports of individuals with common cold
In conclusion, SJP − 002 reduced the severity and duration of common cold episodes. These findings warrant fur ther investigation of SJP − 002 in double-blind, placebo-controlled clinical trials. (Source: Clinical Case Reports)
Source: Clinical Case Reports - July 21, 2023 Category: General Medicine Authors: Emina I šerić,
Thomas A. Dahl,
Andrew Scholey,
Jacqueline M. Iversen,
Joris C. Verster Tags: CASE REPORT Source Type: research
Women of Childbearing Age With Hidradenitis Suppurativa Frequently Prescribed Medications With Pregnancy Risk
DISCUSSION: Nearly a third of women of childbearing age with HS are receiving medications considered teratogenic. As many female patients feel that their physicians are not counseling them regarding the impact of HS therapy on childbearing, the results of this study serve as a reminder to dermatologists and non-dermatologists managing skin disease to continue to facilitate conversations about potential pregnancy risk when prescribing medications with pregnancy risk. Peck G, Fleischer AB Jr. Women of childbearing age with hidradenitis suppurativa frequently prescribed medications with pregnancy risk. J Drugs Dermatol. 2023;...
Source: Journal of Drugs in Dermatology - July 6, 2023 Category: Dermatology Authors: Gabrielle Marie Rivin Alan B Fleischer Source Type: research
