Corrigendum
Aging Cell, Volume 17, Issue 6, December 2018. (Source: Aging Cell)
Source: Aging Cell - November 28, 2018 Category: Cytology Tags: CORRIGENDUM Source Type: research
Issue Information
Aging Cell, Volume 17, Issue 6, December 2018. (Source: Aging Cell)
Source: Aging Cell - November 28, 2018 Category: Cytology Tags: ISSUE INFORMATION Source Type: research
Rapamycin improves healthspan but not inflammaging in nf κb1−/− mice
In this study, we investigated whether rapamycin could ameliorate age‐associated phenotypes in a mouse model of genetically enhance d NF‐κB activity (nf κb1−/−) characterized by low ‐grade chronic inflammation, accelerated aging and CLD. We found that, despite showing no beneficial effects in lifespan and inflammaging, rapamycin reduced frailty and improved long‐term memory, neuromuscular coordination and tissue architecture. Importantly, markers of cellular senescence, a k nown driver of age‐related pathology, were alleviated in rapamycin‐fed animals. Our results indicate that, in conditions of genetical...
Source: Aging Cell - November 23, 2018 Category: Cytology Authors: Clara Correia ‐Melo,
Jodie Birch,
Edward Fielder,
Dina Rahmatika,
Jennifer Taylor,
James Chapman,
Anthony Lagnado,
Bernadette M. Carroll,
Satomi Miwa,
Gavin Richardson,
Diana Jurk,
Fiona Oakley,
Jelena Mann,
Derek A. Mann,
Viktor I. Korolc Tags: ORIGINAL PAPER Source Type: research
Independent associations of TOMM40 and APOE variants with body mass index
We examined additive effects of rs2075650 and rs157580TOMM40 variants and rs429358 and rs7412APOE variants coding the ε2/ε3/ε4 polymorphism on body mass index (BMI) in age‐aggregated and age‐stratified cohort‐specific and cohort‐pooled analysis of 27,863 Caucasians aged 20–100 years from seven longitudinal studies. Minor alleles of rs2075650, rs429358, and rs7412 were individually associated with BMI (β = −1.29,p = 3.97 × 10−9;β = −1.38,p = 2.78 × 10−10; andβ = 0.58,p = 3.04 × 10−2, respectively). Conditional analysis with rs2075650 and rs429358 identified independent BMI ...
Source: Aging Cell - November 21, 2018 Category: Cytology Authors: Alexander M. Kulminski,
Yury Loika,
Irina Culminskaya,
Jian Huang,
Konstantin G. Arbeev,
Olivia Bagley,
Mary F. Feitosa,
Joseph M. Zmuda,
Kaare Christensen,
Anatoliy I. Yashin,
Long Life Family Study Research Group Tags: ORIGINAL PAPER Source Type: research
The bystander effect contributes to the accumulation of senescent cells in vivo
AbstractSenescent cells accumulate with age in multiple tissues and may cause age ‐associated disease and functional decline. In vitro, senescent cells induce senescence in bystander cells. To see how important this bystander effect may be for accumulation of senescent cells in vivo, we xenotransplanted senescent cells into skeletal muscle and skin of immunocompromised NSG mice . 3 weeks after the last transplantation, mouse dermal fibroblasts and myofibres displayed multiple senescence markers in the vicinity of transplanted senescent cells, but not where non‐senescent or no cells were injected. Adjacent to injected ...
Source: Aging Cell - November 21, 2018 Category: Cytology Authors: Paulo F. L. Silva,
Mikolaj Ogrodnik,
Olena Kucheryavenko,
Julien Glibert,
Satomi Miwa,
Kerry Cameron,
Abbas Ishaq,
Gabriele Saretzki,
Sushma Nagaraja ‐Grellscheid,
Glyn Nelson,
Thomas Zglinicki Tags: ORIGINAL ARTICLE Source Type: research
LncRNAs regulating stemness in aging
AbstractOne of the most outstanding observations from next ‐generation sequencing approaches was that only 1.5% of our genes code for proteins. The biggest part is transcribed but give rise to different families of RNAs without coding potential. The functional relevance of these abundant transcripts remains far from elucidated. Among them are the long non ‐coding RNAs (lncRNAs), a relatively large and heterogeneous group of RNAs shown to be highly tissue‐specific, indicating a prominent role in processes controlling cellular identity. In particular, lncRNAs have been linked to both stemness properties and detrimental...
Source: Aging Cell - November 20, 2018 Category: Cytology Authors: Ant ónio Sousa‐Franco,
Kenny Rebelo,
Simão Teixeira da Rocha,
Bruno Bernardes de Jesus Tags: REVIEW Source Type: research
Reconciling nutritional geometry with classical dietary restriction: Effects of nutrient intake, not calories, on survival and reproduction
AbstractDietary restriction (DR) is one of the main experimental paradigms to investigate the mechanisms that determine lifespan and aging. Yet, the exact nutritional parameters responsible for DR remain unclear. Recently, the advent of the geometric framework of nutrition (GF) has refocussed interest from calories to dietary macronutrients. However, GF experiments focus on invertebrates, with the importance of macronutrients in vertebrates still widely debated. This has led to the suggestion of a fundamental difference in the mode of action of DR between vertebrates and invertebrates, questioning the suggestion of an evol...
Source: Aging Cell - November 20, 2018 Category: Cytology Authors: Joshua P. Moatt,
Murray A. Fyfe,
Elizabeth Heap,
Luke J. M. Mitchell,
Fiona Moon,
Craig A. Walling Tags: ORIGINAL PAPER Source Type: research
Temporal pattern of neuronal insulin release during Caenorhabditis elegans aging: Role of redox homeostasis
AbstractThe insulin ‐IGF‐1/DAF‐2 pathway has a central role in the determination of aging and longevity inCaenorhabditis elegans and other organisms. In this paper, we measured neuronal insulin secretion (using INS ‐22::Venus) duringC. elegans lifespan and monitored how this secretion is modified by redox homeostasis. We showed that INS ‐22::Venus secretion fluctuates during the organism lifetime reaching maximum levels in the active reproductive stage. We also demonstrate that long‐liveddaf ‐2 insulin receptor mutants show remarkable low levels of INS ‐22::Venus secretion. In contrast, we found that shor...
Source: Aging Cell - November 19, 2018 Category: Cytology Authors: Alicia N. Minniti,
H éctor Arriagada,
Soledad Zúñiga,
Marcela Bravo‐Zehnder,
Iván E. Alfaro,
Rebeca Aldunate Tags: ORIGINAL PAPER Source Type: research
Senescent cells: A new Achilles ’ heel to exploit for cancer medicine?
AbstractCellular senescence is a typical tumor ‐suppressive mechanism that restricts the proliferation of premalignant cells. However, mounting evidence suggests that senescent cells, which also persistin vivo, can promote the incidence of aging ‐related disorders principally via the senescence‐associated secretory phenotype (SASP), among which cancer is particularly devastating. Despite the beneficial effects of the SASP on certain physiological events such as wound healing and tissue repair, more studies have demonstrated that senesce nt cells can substantially contribute to pathological conditions and accelerate d...
Source: Aging Cell - November 19, 2018 Category: Cytology Authors: Boyi Zhang,
Eric W. ‐F. Lam,
Yu Sun Tags: COMMENTARY Source Type: research
Partial reprogramming induces a steady decline in epigenetic age before loss of somatic identity
AbstractInduced pluripotent stem cells (IPSCs), with their unlimited regenerative capacity, carry the promise for tissue replacement to counter age ‐related decline. However, attempts to realize in vivo iPSC have invariably resulted in the formation of teratomas. Partial reprogramming in prematurely aged mice has shown promising results in alleviating age‐related symptoms without teratoma formation. Does partial reprogramming lead to rejuve nation (i.e., “younger” cells), rather than dedifferentiation, which bears the risk of cancer? Here, we analyse the dynamics of cellular age during human iPSC reprogramming and ...
Source: Aging Cell - November 18, 2018 Category: Cytology Authors: Nelly Olova,
Daniel J. Simpson,
Riccardo E. Marioni,
Tamir Chandra Tags: SHORT TAKE Source Type: research
Autophagy and aging: Maintaining the proteome through exercise and caloric restriction
AbstractAccumulation of dysfunctional and damaged cellular proteins and organelles occurs during aging, resulting in a disruption of cellular homeostasis and progressive degeneration and increases the risk of cell death. Moderating the accrual of these defunct components is likely a key in the promotion of longevity. While exercise is known to promote healthy aging and mitigate age ‐related pathologies, the molecular underpinnings of this phenomenon remain largely unclear. However, recent evidences suggest that exercise modulates the proteome. Similarly, caloric restriction (CR), a known promoter of lifespan, is understo...
Source: Aging Cell - November 15, 2018 Category: Cytology Authors: Kurt A. Escobar,
Nathan H. Cole,
Christine M. Mermier,
Trisha A. VanDusseldorp Tags: REVIEW Source Type: research
Lymph nodes as barriers to T ‐cell rejuvenation in aging mice and nonhuman primates
AbstractIn youth, thymic involution curtails production of new na ïve T cells, placing the onus of T‐cell maintenance upon secondary lymphoid organs (SLO). This peripheral maintenance preserves the size of the T‐cell pool for much of the lifespan, but wanes in the last third of life, leading to a dearth of naïve T cells in blood and SLO, and contributing to suboptimal immune defense. Both keratinocyte growth factor (KGF) and sex steroid ablation (SSA) have been shown to transiently increase the size and cellularity of the old thymus. It is less clear whether this increase can improve protection of old animals from in...
Source: Aging Cell - November 14, 2018 Category: Cytology Authors: Heather L. Thompson,
Megan J. Smithey,
Jennifer L. Uhrlaub,
Ilija Jefti ć,
Mladen Jergović,
Sarah E. White,
Noreen Currier,
Anna M. Lang,
Afam Okoye,
Byung Park,
Louis J. Picker,
Charles D. Surh,
Janko Nikolich‐Žugich Tags: ORIGINAL PAPER Source Type: research
Carbon monoxide attenuates amyloidogenesis via down ‐regulation of NF‐κB‐mediated BACE1 gene expression
AbstractAmyloid ‐β (Aβ) peptides, the major constituent of plaques, are generated by sequential proteolytic cleavage of the amyloid precursor protein (APP) via β‐secretase (BACE1) and the γ‐secretase complex. It has been proposed that the abnormal secretion and accumulation of Aβ are the initial causativ e events in the development of Alzheimer's disease (AD). Drugs modulating this pathway could be used for AD treatment. Previous studies indicated that carbon monoxide (CO), a product of heme oxygenase (HO)‐1, protects against Aβ‐induced toxicity and promotes neuroprotection. However, the mechan ism underlyi...
Source: Aging Cell - November 9, 2018 Category: Cytology Authors: Hyo Jeong Kim,
Yeonsoo Joe,
Yingqing Chen,
Gyu Hwan Park,
Uh ‐Hyun Kim,
Hun Taeg Chung Tags: ORIGINAL ARTICLE Source Type: research
Tau ‐induced nuclear envelope invagination causes a toxic accumulation of mRNA in Drosophila
AbstractThe nucleus is a spherical dual ‐membrane bound organelle that encapsulates genomic DNA. In eukaryotes, messenger RNAs (mRNA) are transcribed in the nucleus and transported through nuclear pores into the cytoplasm for translation into protein. In certain cell types and pathological conditions, nuclei harbor tubular invaginations of the nuclear envelope known as the “nucleoplasmic reticulum.” Nucleoplasmic reticulum expansion has recently been established as a mediator of neurodegeneration in tauopathies, including Alzheimer's disease. While the presence of pore‐lined, cytoplasm‐filled, nuclear envelope in...
Source: Aging Cell - November 9, 2018 Category: Cytology Authors: Garrett L. Cornelison,
Simon A. Levy,
Tyler Jenson,
Bess Frost Tags: SHORT TAKE Source Type: research
