Identification and validation of DHCR7 as a diagnostic biomarker involved in the proliferation and mitochondrial function of breast cancer
CONCLUSIONS: DHCR7 was found to be a key EMRG up-regulated in BC cells. This study is the first to our knowledge to report that DHCR7 acts as an oncogene in BC, which might become a novel therapeutic target for BC patients.PMID:38526324 | DOI:10.18632/aging.205683 (Source: Aging)
Source: Aging - March 25, 2024 Category: Biomedical Science Authors: Yanfeng Wang Jiaxin Fan Yongcheng Liu Jie Du Boyu Liang Huxia Wang Zhangjun Song Source Type: research

Identification of key pathways and mRNAs in interstitial cystitis/bladder pain syndrome treatment with quercetin through bioinformatics analysis of mRNA-sequence data
CONCLUSION: In this study, we provided the DE mRNA in IC/BPS rats treated with QCT, the signaling pathways for DE enrichment, screened out the hub genes, and revealed that Lpl overexpression alleviated IC/BPS model rats.PMID:38526326 | DOI:10.18632/aging.205682 (Source: Aging)
Source: Aging - March 25, 2024 Category: Biomedical Science Authors: Guang Wang Pei Li Si-Wei Su Rui Xu Zi-Ye Huang Tong-Xin Yang Jiong-Ming Li Source Type: research

Altered brain morphology and functional connectivity in postmenopausal women: automatic segmentation of whole-brain and thalamic subnuclei and resting-state fMRI
Aging (Albany NY). 2024 Mar 23;16. doi: 10.18632/aging.205662. Online ahead of print.ABSTRACTThe transition to menopause is associated with various physiological changes, including alterations in brain structure and function. However, menopause-related structural and functional changes are poorly understood. The purpose of this study was not only to compare the brain volume changes between premenopausal and postmenopausal women, but also to evaluate the functional connectivity between the targeted brain regions associated with structural atrophy in postmenopausal women. Each 21 premenopausal and postmenopausal women underw...
Source: Aging - March 25, 2024 Category: Biomedical Science Authors: Gwang-Won Kim Kwangsung Park Yun-Hyeon Kim Gwang-Woo Jeong Source Type: research

The protective effects of Irbesartan in cognitive impairment in hypertension
Aging (Albany NY). 2024 Mar 23;16. doi: 10.18632/aging.205589. Online ahead of print.ABSTRACTVascular cognitive impairment (VCI) is claimed as the second most common type of dementia after Alzheimer's disease (AD), in which hypertension is a critical inducer. Currently, hypertension-induced cognitive impairment lacks clinical treatments. Irbesartan is a long-acting angiotensin receptor antagonist with promising antihypertensive properties. Our research will focus on the potential function of Irbesartan on hypertension-induced cognitive impairment. Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats were orally dos...
Source: Aging - March 25, 2024 Category: Biomedical Science Authors: Shengyun Hao Qian He Yuan Yuan Qiong Mu Source Type: research

Identification and validation of DHCR7 as a diagnostic biomarker involved in the proliferation and mitochondrial function of breast cancer
CONCLUSIONS: DHCR7 was found to be a key EMRG up-regulated in BC cells. This study is the first to our knowledge to report that DHCR7 acts as an oncogene in BC, which might become a novel therapeutic target for BC patients.PMID:38526324 | DOI:10.18632/aging.205683 (Source: Aging)
Source: Aging - March 25, 2024 Category: Biomedical Science Authors: Yanfeng Wang Jiaxin Fan Yongcheng Liu Jie Du Boyu Liang Huxia Wang Zhangjun Song Source Type: research

Identification of key pathways and mRNAs in interstitial cystitis/bladder pain syndrome treatment with quercetin through bioinformatics analysis of mRNA-sequence data
CONCLUSION: In this study, we provided the DE mRNA in IC/BPS rats treated with QCT, the signaling pathways for DE enrichment, screened out the hub genes, and revealed that Lpl overexpression alleviated IC/BPS model rats.PMID:38526326 | DOI:10.18632/aging.205682 (Source: Aging)
Source: Aging - March 25, 2024 Category: Biomedical Science Authors: Guang Wang Pei Li Si-Wei Su Rui Xu Zi-Ye Huang Tong-Xin Yang Jiong-Ming Li Source Type: research

Altered brain morphology and functional connectivity in postmenopausal women: automatic segmentation of whole-brain and thalamic subnuclei and resting-state fMRI
Aging (Albany NY). 2024 Mar 23;16. doi: 10.18632/aging.205662. Online ahead of print.ABSTRACTThe transition to menopause is associated with various physiological changes, including alterations in brain structure and function. However, menopause-related structural and functional changes are poorly understood. The purpose of this study was not only to compare the brain volume changes between premenopausal and postmenopausal women, but also to evaluate the functional connectivity between the targeted brain regions associated with structural atrophy in postmenopausal women. Each 21 premenopausal and postmenopausal women underw...
Source: Aging - March 25, 2024 Category: Biomedical Science Authors: Gwang-Won Kim Kwangsung Park Yun-Hyeon Kim Gwang-Woo Jeong Source Type: research

The protective effects of Irbesartan in cognitive impairment in hypertension
Aging (Albany NY). 2024 Mar 23;16. doi: 10.18632/aging.205589. Online ahead of print.ABSTRACTVascular cognitive impairment (VCI) is claimed as the second most common type of dementia after Alzheimer's disease (AD), in which hypertension is a critical inducer. Currently, hypertension-induced cognitive impairment lacks clinical treatments. Irbesartan is a long-acting angiotensin receptor antagonist with promising antihypertensive properties. Our research will focus on the potential function of Irbesartan on hypertension-induced cognitive impairment. Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats were orally dos...
Source: Aging - March 25, 2024 Category: Biomedical Science Authors: Shengyun Hao Qian He Yuan Yuan Qiong Mu Source Type: research

CMS121: a novel approach to mitigate aging-related obesity and metabolic dysfunction
CONCLUSIONS: The diminished de novo lipogenesis, which is associated with increased acetyl-CoA, acylcarnitine, and butyrate metabolite levels, could contribute to safeguarding not only the peripheral system but also the aging brain. By mimicking the effects of ketogenic diets, CMS121 holds promise for metabolic diseases such as obesity and diabetes, since these diets are hard to follow over the long term.PMID:38517358 | DOI:10.18632/aging.205673 (Source: Aging)
Source: Aging - March 22, 2024 Category: Biomedical Science Authors: Alcir L Dafre Saadia Zahid Jessica Jorge Probst Antonio Currais Jingting Yu David Schubert Pamela Maher Source Type: research

Geraniol attenuates oxidative stress and neuroinflammation-mediated cognitive impairment in D galactose-induced mouse aging model
Aging (Albany NY). 2024 Mar 20;16. doi: 10.18632/aging.205677. Online ahead of print.ABSTRACTD-galactose (D-gal) administration was proven to induce cognitive impairment and aging in rodents' models. Geraniol (GNL) belongs to the acyclic isoprenoid monoterpenes. GNL reduces inflammation by changing important signaling pathways and cytokines, and thus it is plausible to be used as a medicine for treating disorders linked to inflammation. Herein, we examined the therapeutic effects of GNL on D-gal-induced oxidative stress and neuroinflammation-mediated memory loss in mice. The study was conducted using six groups of mice (6 ...
Source: Aging - March 22, 2024 Category: Biomedical Science Authors: Peramaiyan Rajendran Fatma J Al-Saeedi Rebai Ben Ammar Basem M Abdallah Enas M Ali Najla Khaled Al Abdulsalam Sujatha Tejavat Duaa Althumairy Vishnu Priya Veeraraghavan Sarah Abdulaziz Alamer Gamal M Bekhet Emad A Ahmed Source Type: research

Omilancor mitigates the senescence of nucleus pulposus cells induced by DDP through targeting MAP2K6
CONCLUSIONS: Omilancor shows promise as a treatment for IDD by targeting MAP2K6-mediated cellular senescence.PMID:38517363 | DOI:10.18632/aging.205588 (Source: Aging)
Source: Aging - March 22, 2024 Category: Biomedical Science Authors: Fang Yafeng Shi Xinpeng Wei Rong Cui Guofeng Source Type: research

Phoenixin 20 ameliorates pulmonary arterial hypertension via inhibiting inflammation and oxidative stress
Aging (Albany NY). 2024 Mar 19;15. doi: 10.18632/aging.205468. Online ahead of print.ABSTRACTPulmonary arterial hypertension (PAH) is a severe pathophysiological syndrome resulting in heart failure, which is found to be induced by pulmonary vascular remodeling mediated by oxidative stress (OS) and inflammation. Phoenixin-20 (PNX-20) is a reproductive peptide first discovered in mice with potential suppressive properties against OS and inflammatory response. Our study will explore the possible therapeutic functions of PHN-20 against PAH for future clinical application. Rats were treated with normal saline, PHN-20 (100 ng/g ...
Source: Aging - March 22, 2024 Category: Biomedical Science Authors: Yaqin Chai Xing Gu HongJun Zhang Xinting Xu Lizhan Chen Source Type: research

Identification and validation of ferroptosis-related gene SLC2A1 as a novel prognostic biomarker in AKI
CONCLUSIONS: In summary, our study not only identifies SLC2A1 as diagnostic biomarker for AKI, but also sheds light on the role of it in AKI progression, providing novel insights for the clinical diagnosis and treatment of AKI.PMID:38517368 | DOI:10.18632/aging.205669 (Source: Aging)
Source: Aging - March 22, 2024 Category: Biomedical Science Authors: Huaying Wang Yuanyuan Li Xinran Liu Yonggui Wu Source Type: research

CRIF1 attenuates doxorubicin-mediated mitochondrial dysfunction and myocardial senescence via regulating PXDN
CONCLUSIONS: CRIF1 plays a protective role against DOX-caused mitochondrial dysfunction and myocardial senescence partly through downregulating PXDN.PMID:38517371 | DOI:10.18632/aging.205664 (Source: Aging)
Source: Aging - March 22, 2024 Category: Biomedical Science Authors: Lina Zhou Guilan Zhai Ge Tian Source Type: research

Single cell RNA-seq identifies a FOS/JUN-related monocyte signature associated with clinical response of heart failure patients with mesenchymal stem cell therapy
In this study, we collected samples from 4 HF patients before and after MSC therapy and performed scRNA-seq. After the MSC therapy, the proportion of CD14+ monocytes decreased significantly in both the treatment response and non-response groups, with a more pronounced decrease in the treatment response group. The therapy-response and non-response group were clearly separated in the UMAP plot, while the CD14+ monocytes in the therapy-response group before and after MSC therapy were very similar, but there were significant differences in the non-response group. By further performing NMF analysis, we identified 11 subsets of ...
Source: Aging - March 22, 2024 Category: Biomedical Science Authors: Hui Yuan Pengfei Zhang Yuanfeng Xin Zhongmin Liu Bingren Gao Source Type: research