Elucidating the network interactions between 21 secreted < em > Mycobacterium tuberculosis < /em > proteins and host proteins: the role of DnaK in enhancing < em > Mtb < /em > survival via LDHB
Acta Biochim Biophys Sin (Shanghai). 2024 Mar 28. doi: 10.3724/abbs.2024041. Online ahead of print.NO ABSTRACTPMID:38545657 | DOI:10.3724/abbs.2024041 (Source: Acta Biochimica et Biophysica Sinica)
Source: Acta Biochimica et Biophysica Sinica - March 28, 2024 Category: Biochemistry Authors: Hong Chen Xiang He He-Wei Jiang Yun-Xiao Zheng Hai-Nan Zhang Fan-Lin Wu Zhao-Wei Xu Shu-Juan Guo Sheng-Ce Tao Source Type: research

Huperzine A ameliorates neurological deficits after spontaneous subarachnoid hemorrhage through endothelial cell pyroptosis inhibition
In this study, Evans blue assay, TUNEL staining, immunofluorescence, western blot analysis, and ELISA are conducted. We find that Huperzine A can improve neurological deficits and inhibit the apoptosis of nerve cells in SAH rats. Huperzine A treatment can improve the upregulation of brain water content, damage of blood-brain barrier, fibrinogen and matrix metalloprotein 9 expressions and the downregulation of ZO-1 and occludin expressions induced by SAH. Huperzine A inhibit the expressions of proteins involved in pyroptosis in endothelial cells in SAH rats. The increase in MDA content and decrease in SOD activity in SAH ra...
Source: Acta Biochimica et Biophysica Sinica - March 26, 2024 Category: Biochemistry Authors: Qiang Hu Rong Zhang Xiaoqiao Dong Dingbo Yang Wenhua Yu Quan Du Source Type: research

Huperzine A ameliorates neurological deficits after spontaneous subarachnoid hemorrhage through endothelial cell pyroptosis inhibition
In this study, Evans blue assay, TUNEL staining, immunofluorescence, western blot analysis, and ELISA are conducted. We find that Huperzine A can improve neurological deficits and inhibit the apoptosis of nerve cells in SAH rats. Huperzine A treatment can improve the upregulation of brain water content, damage of blood-brain barrier, fibrinogen and matrix metalloprotein 9 expressions and the downregulation of ZO-1 and occludin expressions induced by SAH. Huperzine A inhibit the expressions of proteins involved in pyroptosis in endothelial cells in SAH rats. The increase in MDA content and decrease in SOD activity in SAH ra...
Source: Acta Biochimica et Biophysica Sinica - March 26, 2024 Category: Biochemistry Authors: Qiang Hu Rong Zhang Xiaoqiao Dong Dingbo Yang Wenhua Yu Quan Du Source Type: research

Integrated network pharmacology and experimental verification to explore the potential mechanism of San Ying decoction for treating triple-negative breast cancer
In this study, the active ingredients of each herbal medicine composing SYF and their target proteins are obtained from the Traditional Chinese Medicine Systems Pharmacology database. Breast cancer-related genes are obtained from the GeneCards database. Major targets and pathways related to SYF treatment in breast cancer are identified by analyzing the above data. By conducting molecular docking analysis, we find that the active ingredients quercetin and luteolin bind well to the key targets KDR1, PPARG, SOD1, and VCAM1. In vitro experiments verify that SYF can reduce the proliferation, migration, and invasion ability of T...
Source: Acta Biochimica et Biophysica Sinica - March 22, 2024 Category: Biochemistry Authors: Xiaojuan Yang Feifei Li Youyang Shi Yuanyuan Wu Rui Yang Xiaofei Liu Yang Zhang Guangtao Zhang Mei Ma Zhanyang Luo Xianghui Han Ying Xie Sheng Liu Source Type: research

Lian-Mei-Yin formula alleviates diet-induced hepatic steatosis by suppressing Yap1/FOXM1 pathway-dependent lipid synthesis
Acta Biochim Biophys Sin (Shanghai). 2024 Mar 21. doi: 10.3724/abbs.2024025. Online ahead of print.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, with a global prevalence of 25%. Patients with NAFLD are more likely to suffer from advanced liver disease, cardiovascular disease, or type II diabetes. However, unfortunately, there is still a shortage of FDA-approved therapeutic agents for NAFLD. Lian-Mei-Yin (LMY) is a traditional Chinese medicine formula used for decades to treat liver disorders. It has recently been applied to type II diabetes which is closely related to insulin r...
Source: Acta Biochimica et Biophysica Sinica - March 22, 2024 Category: Biochemistry Authors: Peiguang Zhang Jieqiong Cao Xujing Liang Zijian Su Bihui Zhang Zhenyu Wang Junye Xie Gengrui Chen Xue Chen Jinting Zhang Yanxian Feng Qin Xu Jianping Song An Hong Xiaojia Chen Yibo Zhang Source Type: research

Gallic acid attenuates LPS-induced inflammation in Caco-2 cells by suppressing the activation of the NF- κB/MAPK signaling pathway
Acta Biochim Biophys Sin (Shanghai). 2024 Mar 22. doi: 10.3724/abbs.2024008. Online ahead of print.ABSTRACTInflammatory bowel disease (IBD) is a chronic inflammatory disease characterized by intestinal barrier dysfunction, inflammatory synergistic effects and excessive tissue injury. Gallic acid (GA) is renowned for its remarkable biological activity, encompassing anti-inflammatory and antioxidant properties. However, the underlying mechanisms by which GA protects against intestinal inflammation have not been fully elucidated. The aim of this study is to investigate the effect of GA on the inflammation of a lipopolysacchar...
Source: Acta Biochimica et Biophysica Sinica - March 22, 2024 Category: Biochemistry Authors: Chu Chu Huan Ru Yuyan Chen Jinhua Xu Caihong Wang Yuanxiang Jin Source Type: research

Integrated network pharmacology and experimental verification to explore the potential mechanism of San Ying decoction for treating triple-negative breast cancer
In this study, the active ingredients of each herbal medicine composing SYF and their target proteins are obtained from the Traditional Chinese Medicine Systems Pharmacology database. Breast cancer-related genes are obtained from the GeneCards database. Major targets and pathways related to SYF treatment in breast cancer are identified by analyzing the above data. By conducting molecular docking analysis, we find that the active ingredients quercetin and luteolin bind well to the key targets KDR1, PPARG, SOD1, and VCAM1. In vitro experiments verify that SYF can reduce the proliferation, migration, and invasion ability of T...
Source: Acta Biochimica et Biophysica Sinica - March 22, 2024 Category: Biochemistry Authors: Xiaojuan Yang Feifei Li Youyang Shi Yuanyuan Wu Rui Yang Xiaofei Liu Yang Zhang Guangtao Zhang Mei Ma Zhanyang Luo Xianghui Han Ying Xie Sheng Liu Source Type: research

Lian-Mei-Yin formula alleviates diet-induced hepatic steatosis by suppressing Yap1/FOXM1 pathway-dependent lipid synthesis
Acta Biochim Biophys Sin (Shanghai). 2024 Mar 21. doi: 10.3724/abbs.2024025. Online ahead of print.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, with a global prevalence of 25%. Patients with NAFLD are more likely to suffer from advanced liver disease, cardiovascular disease, or type II diabetes. However, unfortunately, there is still a shortage of FDA-approved therapeutic agents for NAFLD. Lian-Mei-Yin (LMY) is a traditional Chinese medicine formula used for decades to treat liver disorders. It has recently been applied to type II diabetes which is closely related to insulin r...
Source: Acta Biochimica et Biophysica Sinica - March 22, 2024 Category: Biochemistry Authors: Peiguang Zhang Jieqiong Cao Xujing Liang Zijian Su Bihui Zhang Zhenyu Wang Junye Xie Gengrui Chen Xue Chen Jinting Zhang Yanxian Feng Qin Xu Jianping Song An Hong Xiaojia Chen Yibo Zhang Source Type: research

Gallic acid attenuates LPS-induced inflammation in Caco-2 cells by suppressing the activation of the NF- κB/MAPK signaling pathway
Acta Biochim Biophys Sin (Shanghai). 2024 Mar 22. doi: 10.3724/abbs.2024008. Online ahead of print.ABSTRACTInflammatory bowel disease (IBD) is a chronic inflammatory disease characterized by intestinal barrier dysfunction, inflammatory synergistic effects and excessive tissue injury. Gallic acid (GA) is renowned for its remarkable biological activity, encompassing anti-inflammatory and antioxidant properties. However, the underlying mechanisms by which GA protects against intestinal inflammation have not been fully elucidated. The aim of this study is to investigate the effect of GA on the inflammation of a lipopolysacchar...
Source: Acta Biochimica et Biophysica Sinica - March 22, 2024 Category: Biochemistry Authors: Chu Chu Huan Ru Yuyan Chen Jinhua Xu Caihong Wang Yuanxiang Jin Source Type: research

Integrated network pharmacology and experimental verification to explore the potential mechanism of San Ying decoction for treating triple-negative breast cancer
In this study, the active ingredients of each herbal medicine composing SYF and their target proteins are obtained from the Traditional Chinese Medicine Systems Pharmacology database. Breast cancer-related genes are obtained from the GeneCards database. Major targets and pathways related to SYF treatment in breast cancer are identified by analyzing the above data. By conducting molecular docking analysis, we find that the active ingredients quercetin and luteolin bind well to the key targets KDR1, PPARG, SOD1, and VCAM1. In vitro experiments verify that SYF can reduce the proliferation, migration, and invasion ability of T...
Source: Acta Biochimica et Biophysica Sinica - March 22, 2024 Category: Biochemistry Authors: Xiaojuan Yang Feifei Li Youyang Shi Yuanyuan Wu Rui Yang Xiaofei Liu Yang Zhang Guangtao Zhang Mei Ma Zhanyang Luo Xianghui Han Ying Xie Sheng Liu Source Type: research

Lian-Mei-Yin formula alleviates diet-induced hepatic steatosis by suppressing Yap1/FOXM1 pathway-dependent lipid synthesis
Acta Biochim Biophys Sin (Shanghai). 2024 Mar 21. doi: 10.3724/abbs.2024025. Online ahead of print.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, with a global prevalence of 25%. Patients with NAFLD are more likely to suffer from advanced liver disease, cardiovascular disease, or type II diabetes. However, unfortunately, there is still a shortage of FDA-approved therapeutic agents for NAFLD. Lian-Mei-Yin (LMY) is a traditional Chinese medicine formula used for decades to treat liver disorders. It has recently been applied to type II diabetes which is closely related to insulin r...
Source: Acta Biochimica et Biophysica Sinica - March 22, 2024 Category: Biochemistry Authors: Peiguang Zhang Jieqiong Cao Xujing Liang Zijian Su Bihui Zhang Zhenyu Wang Junye Xie Gengrui Chen Xue Chen Jinting Zhang Yanxian Feng Qin Xu Jianping Song An Hong Xiaojia Chen Yibo Zhang Source Type: research

Gallic acid attenuates LPS-induced inflammation in Caco-2 cells by suppressing the activation of the NF- κB/MAPK signaling pathway
Acta Biochim Biophys Sin (Shanghai). 2024 Mar 22. doi: 10.3724/abbs.2024008. Online ahead of print.ABSTRACTInflammatory bowel disease (IBD) is a chronic inflammatory disease characterized by intestinal barrier dysfunction, inflammatory synergistic effects and excessive tissue injury. Gallic acid (GA) is renowned for its remarkable biological activity, encompassing anti-inflammatory and antioxidant properties. However, the underlying mechanisms by which GA protects against intestinal inflammation have not been fully elucidated. The aim of this study is to investigate the effect of GA on the inflammation of a lipopolysacchar...
Source: Acta Biochimica et Biophysica Sinica - March 22, 2024 Category: Biochemistry Authors: Chu Chu Huan Ru Yuyan Chen Jinhua Xu Caihong Wang Yuanxiang Jin Source Type: research

Integrated network pharmacology and experimental verification to explore the potential mechanism of San Ying decoction for treating triple-negative breast cancer
In this study, the active ingredients of each herbal medicine composing SYF and their target proteins are obtained from the Traditional Chinese Medicine Systems Pharmacology database. Breast cancer-related genes are obtained from the GeneCards database. Major targets and pathways related to SYF treatment in breast cancer are identified by analyzing the above data. By conducting molecular docking analysis, we find that the active ingredients quercetin and luteolin bind well to the key targets KDR1, PPARG, SOD1, and VCAM1. In vitro experiments verify that SYF can reduce the proliferation, migration, and invasion ability of T...
Source: Acta Biochimica et Biophysica Sinica - March 22, 2024 Category: Biochemistry Authors: Xiaojuan Yang Feifei Li Youyang Shi Yuanyuan Wu Rui Yang Xiaofei Liu Yang Zhang Guangtao Zhang Mei Ma Zhanyang Luo Xianghui Han Ying Xie Sheng Liu Source Type: research

Lian-Mei-Yin formula alleviates diet-induced hepatic steatosis by suppressing Yap1/FOXM1 pathway-dependent lipid synthesis
Acta Biochim Biophys Sin (Shanghai). 2024 Mar 21. doi: 10.3724/abbs.2024025. Online ahead of print.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, with a global prevalence of 25%. Patients with NAFLD are more likely to suffer from advanced liver disease, cardiovascular disease, or type II diabetes. However, unfortunately, there is still a shortage of FDA-approved therapeutic agents for NAFLD. Lian-Mei-Yin (LMY) is a traditional Chinese medicine formula used for decades to treat liver disorders. It has recently been applied to type II diabetes which is closely related to insulin r...
Source: Acta Biochimica et Biophysica Sinica - March 22, 2024 Category: Biochemistry Authors: Peiguang Zhang Jieqiong Cao Xujing Liang Zijian Su Bihui Zhang Zhenyu Wang Junye Xie Gengrui Chen Xue Chen Jinting Zhang Yanxian Feng Qin Xu Jianping Song An Hong Xiaojia Chen Yibo Zhang Source Type: research

Gallic acid attenuates LPS-induced inflammation in Caco-2 cells by suppressing the activation of the NF- κB/MAPK signaling pathway
Acta Biochim Biophys Sin (Shanghai). 2024 Mar 22. doi: 10.3724/abbs.2024008. Online ahead of print.ABSTRACTInflammatory bowel disease (IBD) is a chronic inflammatory disease characterized by intestinal barrier dysfunction, inflammatory synergistic effects and excessive tissue injury. Gallic acid (GA) is renowned for its remarkable biological activity, encompassing anti-inflammatory and antioxidant properties. However, the underlying mechanisms by which GA protects against intestinal inflammation have not been fully elucidated. The aim of this study is to investigate the effect of GA on the inflammation of a lipopolysacchar...
Source: Acta Biochimica et Biophysica Sinica - March 22, 2024 Category: Biochemistry Authors: Chu Chu Huan Ru Yuyan Chen Jinhua Xu Caihong Wang Yuanxiang Jin Source Type: research