New antifungal kills without toxic side effects
The antifungal Amphotericin B (AmB) is an old and effective drug—it saved many COVID-19 patients whose compromised immune systems failed to stop secondary fungal infections. But it sometimes causes life-threatening kidney damage. Now, after more than a decade of sleuthing into this toxicity, researchers have not only found an explanation, but used it and a robotic “chemist” to devise a powerful antifungal alternative without any obvious side effects in mice and human cells. And the strategy that led to the discovery of the compound, described today in
Nature
, may offer a route for detoxifying other antimic...
Source: ScienceNOW - November 8, 2023 Category: Science Source Type: news
Aspergillosis Status Affected by Nebulized Amphotericin B Aspergillosis Status Affected by Nebulized Amphotericin B
The time to first exacerbation was prolonged with nebulized amphotericin therapy.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 29, 2023 Category: Consumer Health News Tags: Pulmonary Medicine News Source Type: news
Africa: WHO and Gilead Sciences Extend Collaborative Agreement to Enhance Access to Treatment for Visceral Leishmaniasis
[WHO] The World Health Organization (WHO) and Gilead Sciences have signed a new agreement for the donation of 304,700 vials of AmBisome (liposomal amphotericin B for injection), for the treatment of visceral leishmaniasis in countries most impacted by the disease, extending their previous agreement to 2025. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - January 27, 2023 Category: African Health Source Type: news
Liposomal Amphotericin B for HIV-Associated Cryptococcal Meningitis Liposomal Amphotericin B for HIV-Associated Cryptococcal Meningitis
When treating HIV-associated cryptococcal meningitis, a single dose of liposomal amphotericin B is just as effective as 7 days of therapy with amphotericin B deoxycholate, according to results of a new clinical trial.Reuters Health Information (Source: Medscape Hiv-Aids Headlines)
Source: Medscape Hiv-Aids Headlines - March 24, 2022 Category: Infectious Diseases Tags: HIV/AIDS News Source Type: news
European CHMP recommend license extension of posaconazole (Noxafil) for fungal infections
The licence extension recommended for approval is for use in invasive aspergillosis in adults and children above 2 years age and 40kg weight with disease that is refractory to amphotericin B or itraconazole or in patients who are intolerant of these medicines. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - November 16, 2021 Category: Consumer Health News Source Type: news
Invasive pulmonary aspergillosis caused by Aspergillus terreus diagnosed using virtual bronchoscopic navigation and endobronchial ultrasonography with guide sheath and successfully treated with liposomal amphotericin B
Invasive aspergillosis is a significant cause of mortality in patients with hematological malignancy. Early diagnosis of invasive pulmonary aspergillosis (IPA) by bronchoscopy is recommended but is often difficult to perform because of small lesion size and bleeding risk due to thrombocytopenia. A 71-year-old woman had received initial induction therapy for acute myeloid leukemia. On day 22 of chemotherapy, she had a high fever, and the chest computed tomography scan revealed a 20-mm-sized nodule with a halo sign. Bronchoscopy assisted by virtual bronchoscopic navigation (VBN) and endobronchial ultrasonography with a guide...
Source: Current Awareness Service for Health (CASH) - November 12, 2021 Category: Consumer Health News Source Type: news
Cryptococcal Meningitis: Single-Dose Regimen Noninferior Cryptococcal Meningitis: Single-Dose Regimen Noninferior
Mortality from cryptococcal meningitis with a single-dose regimen of liposomal amphotericin B is similar to the longer, more toxic standard of care, but controversy continues over pricing and supply.Medscape Medical News (Source: Medscape Hiv-Aids Headlines)
Source: Medscape Hiv-Aids Headlines - July 29, 2021 Category: Infectious Diseases Tags: HIV/AIDS News Source Type: news
Govt exempts raw material imports of Amphotericin B and Covid testing kits till September end
The exemption is in line with the government's Make in India policy and likely to further bring down prices of the products for consumers, said experts. (Source: The Economic Times)
Source: The Economic Times - July 13, 2021 Category: Consumer Health News Source Type: news
Active black fungus cases at 27,142, Centre ready to boost availability of Amphotericin B
The Minister of State for Chemicals and Fertilisers noted that domestic production of Amphotericin B has already gone up five folds so far. While increasing the domestic production, the government has also placed an order to import 9,05,000 Liposomal Amphotericin B vials, he added. (Source: The Economic Times)
Source: The Economic Times - June 18, 2021 Category: Consumer Health News Source Type: news
No discrimination over allocation of drugs to treat Mucormycosis: Centre to Bombay HC
While Amphotericin B, the drug used for treating Mucormycosis, was in short supply, the Union government had been trying its best to meet the demands raised by all state governments, he said. (Source: The Economic Times)
Source: The Economic Times - June 16, 2021 Category: Consumer Health News Source Type: news
Government imposes restrictions on export of Amphotericin-B injections
According to a notification issued by the Directorate General of Foreign Trade (DGFT), export of the injections have been put in the restricted category. This means that an exporter would need permission or licence from the directorate for its outbound shipments. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - June 1, 2021 Category: Pharmaceuticals Source Type: news
"Additional 30,100 vials of Amphotericin-B allocated to states, UTs"
"Additional 30,100 vials of #Amphotericin-B have been allocated to all the States/UTs and Central Institutions today," the Union Minister for Chemicals and Fertilisers DV Sadananda Gowda tweeted on Monday. He said an additional 1,930 vials of Amphotericin-B has been allocated to Karnataka. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - May 31, 2021 Category: Pharmaceuticals Source Type: news
Over 50k imported vials of Amphotericin-B arrive in India, says minister Mansukh L Mandaviya
Amphotericin-B is used to treat Mucormycosis, also known as black fungus, which damages the nose, eyes, sinuses, and sometimes even the brain. (Source: The Economic Times)
Source: The Economic Times - May 28, 2021 Category: Consumer Health News Source Type: news
Zydus Cadila, Taiwan's TLC ink pact to market black fungus drug in India
The Central Drugs Standard Control Organization has approved the new drug application (NDA) of TLC for Amphotericin B Liposome for Injection 50mg for immediate importation as per approved usage and indication, Zydus Cadila said. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - May 26, 2021 Category: Pharmaceuticals Source Type: news
Govt allocates additional 23,680 vials of Amphotericin-B to states/UTs: Sadananda Gowda
As per the Union Health Ministry, Mucormycosis is being detected among patients who are recovering or have recovered from COVID-19. (Source: The Economic Times)
Source: The Economic Times - May 22, 2021 Category: Consumer Health News Source Type: news
