Therapeutic efficacies of mitochondria-targeted esculetin and metformin in the improvement of age-associated atherosclerosis via regulating AMPK activation
AbstractAtherosclerosis, in general, is an age-associated cardiovascular disease wherein a progressive decline in mitochondrial function due to aging majorly contributes to the disease development. Mitochondria-derived ROS due to dysregulated endothelial cell function accentuates the progression of atherosclerotic plaque formation. To circumvent this, mitochondrially targeted antioxidants are emerging as potential candidates to combat metabolic abnormalities. Recently, we synthesized an alkyl TPP+ tagged esculetin (Mito-Esc), and in the current study, we investigated the therapeutic efficacies of Mito-Esc and metformin, a ...
Source: AGE - March 5, 2024 Category: Geriatrics Source Type: research

Label-free quantitative proteomics in serum reveals candidate biomarkers associated with low bone mineral density in Mexican postmenopausal women
AbstractPostmenopausal osteoporosis is a public health problem leading to an increased risk of fractures, negatively impacting women ’s health. The absence of sensitive and specific biomarkers for early detection of osteoporosis represents a substantial challenge for improving patient management. Herein, we aimed to identify potential candidate proteins associated with low bone mineral density (BMD) in postmenopausal women from the Mexican population. Serum samples from postmenopausal women (40 with normal BMD, 40 with osteopenia (OS), and 20 with osteoporosis (OP)) were analyzed by label-free LC–MS/MS quantitative pro...
Source: AGE - March 5, 2024 Category: Geriatrics Source Type: research

Association of skeletal muscle oxidative capacity with muscle function, sarcopenia-related exercise performance, and intramuscular adipose tissue in older adults
This study aimed to investigate the association of skeletal muscle oxidative capacity with muscle function, exercise performance, and IntraMAT content in older individuals. Thirteen older men and women participated in this study. Skeletal muscle oxidative capacity was assessed by the recovery  speed of muscle oxygen saturation after exercise using near-infrared spectroscopy from the medial gastrocnemius. We assessed two muscle functions, peak torque and time to task failure, and four sarcopenia-related exercise performances: handgrip strength, gait speed, 30-s chair stand, and Timed Up and Go. The IntraMAT content was mea...
Source: AGE - March 5, 2024 Category: Geriatrics Source Type: research

Changes in oral health during aging in a novel non-human primate model
In this study, we analyzed the oral health and microbiota of a short-lived non-human primate (i.e., marmoset), as a step towards establishing a surrogate for studying the changes that occur in oral health during human aging. We investigated the oral health of marmosets using cadaveric tissues in three different cohorts: young (aged ≤6 years), middle-aged, and older (>10 years) and assessed the gingival bacterial community using analyses of the V3 –V4 variable region of 16S rRNA gene. The oldest cohort had a significantly higher number of dental caries, increased dental attrition/erosion, and deeper periodontal pocke...
Source: AGE - March 5, 2024 Category: Geriatrics Source Type: research

Low circulating levels of miR-17 and miR-126-3p are associated with increased mortality risk in geriatric hospitalized patients affected by cardiovascular multimorbidity
AbstractMultiMorbidity (MM), defined as the co-occurrence of two or more chronic conditions, is associated with poorer health outcomes, such as recurrent hospital readmission and mortality. As a group of conditions, cardiovascular disease (CVD) exemplifies several challenges of MM, and the identification of prognostic minimally invasive biomarkers to stratify mortality risk in patients affected by cardiovascular MM is a huge challenge. Circulating miRNAs associated to inflammaging and endothelial dysfunction, such as miR-17, miR-21-5p, and miR-126-3p, are expected to have prognostic relevance. We analyzed a composite profi...
Source: AGE - March 5, 2024 Category: Geriatrics Source Type: research

Differential predictability of cognitive profiles from brain structure in older males and females
AbstractStructural brain imaging parameters may successfully predict cognitive performance in neurodegenerative diseases but mostly fail to predict cognitive abilities in healthy older adults. One important aspect contributing to this might be sex differences. Behaviorally, older males and females have been found to differ in terms of cognitive profiles, which cannot be captured by examining them as one homogenous group. In the current study, we examined whether the prediction of cognitive performance from brain structure, i.e. region-wise grey matter volume (GMV), would benefit from the investigation of sex-specific cogni...
Source: AGE - March 5, 2024 Category: Geriatrics Source Type: research

Rapid measurement of ageing by automated monitoring of movement of C. elegans populations
AbstractFinding new interventions that slow ageing and maintain human health is a huge challenge of our time. The nematodeCaenorhabditis elegans offers a rapid in vivo method to determine whether a compound extends its 2 to 3-week lifespan. Measuring lifespan is the standard method to monitor ageing, but a compound that extends lifespan will not necessarily maintain health. Here, we describe the automated monitoring ofC. elegans movement from early to mid-adulthood as a faster healthspan-based method to measure ageing. Using the WormGazer ™ technology, multiple Petri dishes each containing severalC. elegans worms are ima...
Source: AGE - March 5, 2024 Category: Geriatrics Source Type: research

Role of the kisspeptin-KISS1R axis in the pathogenesis of chronic kidney disease and uremic cardiomyopathy
AbstractThe prevalence of chronic kidney disease (CKD) is increasing globally, especially in elderly patients. Uremic cardiomyopathy is a common cardiovascular complication of CKD, characterized by left ventricular hypertrophy (LVH), diastolic dysfunction, and fibrosis. Kisspeptins and their receptor, KISS1R, exert a pivotal influence on kidney pathophysiology and modulate age-related pathologies across various organ systems. KISS1R agonists, including kisspeptin-13 (KP-13), hold promise as novel therapeutic agents within age-related biological processes and kidney-related disorders. Our investigation aimed to elucidate th...
Source: AGE - March 5, 2024 Category: Geriatrics Source Type: research

Intermittent working memory training during adulthood protects against age-related long-term spatial reference memory decline in rats
AbstractEngagement in cognitive activity in adulthood is one of the factors that enable successful cognitive aging, both in humans and rodents. However, some studies emphasize that the beneficial effect on cognition of such an activity may reflect carry over from one test situation to another, including memory for procedural aspects of the behavioral tasks, and thus question whether this effect can be limited to the trained cognitive domain or whether it can be transferred to an untrained ones. In the current study, we assessed whether adulthood intermittent working memory training has beneficial effect on long-term memory...
Source: AGE - March 5, 2024 Category: Geriatrics Source Type: research

The 24-h profile of the DNA repair enzyme 8-oxoguanine glycosylase 1 (OGG1) is associated with age, TNF- α, and waist circumference in healthy adults
This study aimed (1) to investigate how 24-h profiles for OGG1 change during healthy aging and (2) to analyze the relationship of OGG1 with TNF-α, central body fat, cortisol and oxidative DNA/RNA damage. In a cross-sectional study in 20 healthy older and 20 young women, salivary levels of OGG1, TNF-α, cortisol and oxidative DNA/RNA damage were quantified by ELISAs every 4 h for a 24-h period. Trunk circumferences were taken as measures of central body fat. Older women, compared to young women, exhibited significantly lower protein levels of OGG1 throughout the whole 24-h period, a 2.5 t imes lower 24-h mean level for OG...
Source: AGE - March 5, 2024 Category: Geriatrics Source Type: research

Correction to: Higher testosterone and testosterone/estradiol ratio in men are associated with decreased Pheno ‑/GrimAge and DNA‑methylation based PAI1
(Source: AGE)
Source: AGE - March 5, 2024 Category: Geriatrics Source Type: research

Correction to: Functional mobility and physical fitness are improved through a multicomponent training program in institutionalized older adults
(Source: AGE)
Source: AGE - March 5, 2024 Category: Geriatrics Source Type: research

Correction to: Old plasma dilution reduces human biological age: a clinical study
(Source: AGE)
Source: AGE - March 5, 2024 Category: Geriatrics Source Type: research

Correction to: Therapeutic efficacies of mitochondria ‑targeted esculetin and metformin in the improvement of age‑associated atherosclerosis via regulating AMPK activation
(Source: AGE)
Source: AGE - March 5, 2024 Category: Geriatrics Source Type: research

Correction to: Blood biomarker profiles and exceptional longevity: comparison of centenarians and non ‑centenarians in a 35‑year follow‑up of the Swedish AMORIS cohort
(Source: AGE)
Source: AGE - March 5, 2024 Category: Geriatrics Source Type: research