This page shows you the latest research publications in this category.
Metabonomics Research Progress on Liver Diseases.
Authors: Yu M, Zhu Y, Cong Q, Wu C Abstract Metabolomics as the new omics technique develops after genomics, transcriptomics, and proteomics and has rapid development at present. Liver diseases are worldwide public health problems. In China, chronic hepatitis B and its secondary diseases are the common liver diseases. They can be diagnosed by the combination of history, virology, liver function, and medical imaging. However, some patients seldom have relevant physical examination, so the diagnosis may be delayed. Many other liver diseases, such as drug-induced liver injury (DILI), alcoholic liver disease (ALD) and ...
Source: Canadian Journal of Gastroenterology - March 24, 2017 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research
Mixed Connective Tissue Disease and Epitope Spreading: An Historical Cohort Study
Conclusion: Epitope spreading is common in MCTD, occurring early after the diagnosis. The clinical manifestations in patients with this phenomenon differ from those without, and their clinical features change after the immunological phenomenon has occurred. (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - March 24, 2017 Category: Rheumatology Tags: Original Articles Source Type: research
Successful Treatment of Autoimmune Disease–Associated Pyoderma Gangrenosum With the IL-1 Receptor Antagonist Anakinra: A Case Series of 3 Patients
No abstract available (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - March 24, 2017 Category: Rheumatology Tags: Letters to the Editor Source Type: research
Evidence for Increased Response to Induced Endoplasmic Reticulum Stress in Myeloid Cells in Acquired Aplastic Anemia
Autoimmune response targeting the hematopoietic stem cells highlights the current understanding of acquired aplastic anemia (AAA) pathogenesis. Upregulation of the unfolded protein response is the cell’s rejoinder to a variety of stresses, which either result in restoring homeostasis or cell death by increased expression of the transcription factor C/EBP homologous protein. We hypothesized that there is an inherent increased sensitivity to various cellular stressors, including the ones that target endoplasmic reticulum (ER) in AAA leading to a decreased proliferation and potentially contributing to susceptibility to auto...
Source: Journal of Pediatric Hematology Oncology - March 24, 2017 Category: Hematology Tags: Online Articles: Original Articles Source Type: research
Antibody-Based Cancer Therapy: Successful Agents and Novel Approaches.
Abstract Since their discovery, antibodies have been viewed as ideal candidates or "magic bullets" for use in targeted therapy in the fields of cancer, autoimmunity, and chronic inflammatory disorders. A wave of antibody-dedicated research followed, which resulted in the clinical approval of a first generation of monoclonal antibodies for cancer therapy such as rituximab (1997) and cetuximab (2004), and infliximab (2002) for the treatment of autoimmune diseases. More recently, the development of antibodies that prevent checkpoint-mediated inhibition of T cell responses invigorated the field of cancer immunotherapy...
Source: International Review of Cell and Molecular Biology - March 24, 2017 Category: Cytology Authors: Hendriks D, Choi G, de Bruyn M, Wiersma VR, Bremer E Tags: Int Rev Cell Mol Biol Source Type: research
Graves' Ophthalmopathy in a Paediatric Population.
Conclusion Ophthalmic involvement in Graves' disease is rarely encountered in paediatric patients. Ophthalmologists should be aware of this entity to ensure that patients with thyroid dysfunction are identified at an early point in time. PMID: 28329893 [PubMed - as supplied by publisher] (Source: Klinische Monatsblatter fur Augenheilkunde)
Source: Klinische Monatsblatter fur Augenheilkunde - March 24, 2017 Category: Opthalmology Tags: Klin Monbl Augenheilkd Source Type: research
Clinical characteristics of patients with cerebellar ataxia associated with anti-GAD antibodies
Conclusion CA-GAD-ab is rare and its clinical presentation may hamper diagnosis. Clinicians should be able to recognize this potentially treatable autoimmune cerebellar ataxia.RESUMO A enzima ácido glutâmico descarboxilase (GAD), presente nos neurônios GABAérgicos e células beta do pâncreas, catalisa a conversão do ácido gama-aminobutírico (GABA). O cerebelo é altamente susceptível a mecanismos imunomediados, sendo a ataxia cerebelar associada ao anticorpo anti-GAD (CA-GAD) um a doença potencialmente tratável. Embora rara, sua frequência é crescente, com poucos casos descritos. Métodos Estudo retrospectivo ...
Source: Arquivos de Neuro-Psiquiatria - March 24, 2017 Category: Neurology Source Type: research
The use of biologics in pregnant patients with rheumatic disease.
Authors: Østensen M Abstract INTRODUCTION: An increasing number of female patients with autoimmune diseases are treated with biologic drugs. Concerns in regard to safety of biologics during pregnancy arise in patients who have not completed their families. Areas covered: A review of the literature dealing with child outcomes of pregnancies exposed to biologics shows that TNF inhibitors (TNFi) are the best studied in regard to human pregnancy. In studies comparing exposed pregnancies to disease-matched controls no increased risk of spontaneous abortion, low birth weight, prematurity or congenital malformations has ...
Source: Expert Review of Clinical Pharmacology - March 24, 2017 Category: Drugs & Pharmacology Tags: Expert Rev Clin Pharmacol Source Type: research
Understanding the complications of anti ‐tumor necrosis factor therapy in East Asian patients with inflammatory bowel disease
Abstract Remarkable advances have been made in the treatment of inflammatory bowel disease since the introduction of anti‐tumor necrosis factor‐α agents, especially for patients who are refractory to or cannot tolerate conventional therapies. Currently, infliximab, adalimumab, and golimumab are available in the East Asian medical market, and these agents have been shown to be effective for inducing and maintaining long‐term remission of inflammatory bowel disease. Despite their clinical benefits, anti‐tumor necrosis factor therapy can also lead to increased vulnerability to infections, development of autoimmune di...
Source: Journal of Gastroenterology and Hepatology - March 24, 2017 Category: Gastroenterology Authors: Jae Hee Cheon Tags: Review Source Type: research
Perinatal outcome of placental massive perivillous fibrin deposition: a case –control study
ConclusionRegardless of their extent, MFD that covered at least 25% of the placenta was almost always accompanied by severe growth restriction and by a high risk of intrauterine fetal death. Moreover, severe MFD tend to be associated with autoimmune diseases of the mothers, and pregnancies show more often a pathologic Doppler of the umbilical arteries and more often intrauterine fetal death that the moderate form. © 2017 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis)
Source: Prenatal Diagnosis - March 24, 2017 Category: Perinatology & Neonatology Authors: Louise Devisme, Claire Chauvi ère, Hélène Franquet‐Ansart, Anastasia Chudzinski, Morgane Stichelbout, Véronique Houfflin‐Debarge, Damien Subtil Tags: Original Article Source Type: research
Study of demographic, clinical, laboratory and electromyographic symptoms in Myasthenia Gravis patients referred to the neurology clinic of Rasoul Akram hospital in 2015.
Conclusion. Due to the chronic nature of this disease, and its rising trend, educating the people for the early detection of the disease, was necessary as soon as possible so as they would be treated and an acceptable life would be provided for them. PMID: 28316694 [PubMed] (Source: Journal of Medicine and Life)
Source: Journal of Medicine and Life - March 23, 2017 Category: Journals (General) Tags: J Med Life Source Type: research
Effects of Denosumab on Bone Metabolic Markers and Bone Mineral Density in Patients Treated with Glucocorticoids.
Authors: Sawamura M, Komatsuda A, Togashi M, Wakui H, Takahashi N Abstract Objective We performed a prospective study to determine the efficacy and safety of denosumab on bone metabolic indices and bone mineral density (BMD) in 29 patients receiving long-term glucocorticoids (GCs) who had clinical risk factors for fracture. Methods Among these patients, 16 had systemic lupus erythematosus (SLE), 6 RA, 4 other autoimmune diseases, and 3 renal diseases. All patients received donosumab 60 mg at baseline and 6 months. Serum N-terminal cross-linked telopeptide of type I collagen (NTX) and bone-specific alkaline phosphat...
Source: Internal Medicine - March 23, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research
Bullying and Quality of Life in Pediatric Alopecia Areata
We report survey results that highlight the prevalence of bullying and surrounding emotional impact of AA in pediatric patients. We found that bullying was common overall and additional psychological impact, including impairment of social and home life, was even more common. Children of all ages experienced bullying. Boys reported increased physical bullying. Interestingly, those with more severe disease and longer duration of disease experienced less bullying than those with less severe disease.Skin Appendage Disord 2017;3:115-118 (Source: Skin Appendage Disorders)
Source: Skin Appendage Disorders - March 23, 2017 Category: Dermatology Source Type: research
Lupus Hepatitis and Autoimmune Hepatitis (Lupoid Hepatitis).
Abstract Liver dysfunction occurs in approximately 50% of patients with systemic lupus erythematosus (SLE), and patients with SLE and elevated liver enzymes can present a complicated and difficult differential diagnosis. Lupus hepatitis and autoimmune hepatitis are 2 immunologic conditions involving the liver, which can have similar clinical, laboratory and systemic presentations, leading to difficulties in diagnosis. Physicians need to be aware of these 2 hepatic diseases as diagnosis and appropriate therapy need to occur early in the disease course to prevent progression to advanced liver disease. We review the ...
Source: The American Journal of the Medical Sciences - March 23, 2017 Category: Journals (General) Authors: Adiga A, Nugent K Tags: Am J Med Sci Source Type: research
A concise review of Hashimoto thyroiditis (HT) and the importance of iodine, selenium, vitamin D and gluten on the autoimmunity and dietary management of HT patients.Points that need more investigation.
Authors: Liontiris MI, Mazokopakis EE Abstract Hashimoto's thyroiditis (HT) is a chronic autoimmune thyroid disease caused by an interaction between genetic factors and environmental conditions, both of which are yet to be fully understood. The management of HT depends on its clinical manifestations, commonly including diffuse or nodular goiter with euthyroidism, subclinical hypothyroidism and permanent hypothyroidism. However, in most cases of patients with HT, lifelong levothyroxine substitution is required. The additional role of diet for the management of HT is usually overlooked. A literature search regarding ...
Source: Hellenic Journal of Nuclear Medicine - March 23, 2017 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research
Systemic Lupus Erythematosus Is Associated With Increased Adverse Postoperative Renal Outcomes and Mortality: A Historical Cohort Study Using Administrative Health Data.
CONCLUSIONS: This is, by far, the largest clinical study for postoperative outcomes of SLE patients with adequately powered statistical analyses. We concluded that SLE was associated with a higher risk of renal complications and in-hospital mortality but not cardiac events after major surgery. In SLE patients, more aggressive measures should be taken to prevent renal injury in the perioperative period. PMID: 28319545 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - March 23, 2017 Category: Anesthesiology Authors: Babazade R, Yilmaz HO, Leung SM, Zimmerman NM, Turan A Tags: Anesth Analg Source Type: research
Factors Associated with Mortality in Patients with Autoimmune Diseases Admitted to the Intensive Care Unit in Bogota, Colombia
Jorge Armando Carrizosa, Jorge Aponte, Diego Cartagena, Ricard Cervera, Maria Teresa Ospina, Alexander Sanchez (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - March 23, 2017 Category: Allergy & Immunology Source Type: research
Overview of Celiac Disease in Russia: Regional Data and Estimated Prevalence.
Authors: Savvateeva LV, Erdes SI, Antishin AS, Zamyatnin AA Abstract Celiac disease (CD) is an autoimmune enteropathy triggered by the ingestion of dietary gluten from some cereals mainly in individuals carrying the HLA-DQ2 and/or HLA-DQ8 haplotypes. As an autoimmune disease, CD is manifested in the small intestine in the form of a progressive and reversible inflammatory lesion due to immune response to self-antigens. Indeed, CD is one of the most challenging medicosocial problems in current gastroenterology. At present, the global CD prevalence is estimated at approximately 1% based on data sent from different loc...
Source: Journal of Immunology Research - March 23, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
A novel multi-network approach reveals tissue-specific cellular modulators of fibrosis in systemic sclerosis
ConclusionsOur results suggest that the innate immune system is central to SSc disease processes but that subtle distinctions exist between tissues. Our approach provides a framework for examining molecular signatures of disease in fibrosis and autoimmune diseases and for leveraging publicly available data to understand common and tissue-specific disease processes in complex human diseases. (Source: Genome Medicine)
Source: Genome Medicine - March 23, 2017 Category: Genetics & Stem Cells Source Type: research
Defects in myosin VB are associated with a spectrum of previously undiagnosed low γ‐glutamyltransferase cholestasis
Conclusion: MYO5B deficiency may underlie 20% of previously undiagnosed low‐GGT cholestasis. MYO5B deficiency appears to impair targeting of BSEP to the canalicular membrane with hampered bile acid excretion, resulting in a spectrum of cholestasis without diarrhea. (Hepatology 2017). (Source: Hepatology)
Source: Hepatology - March 23, 2017 Category: Internal Medicine Authors: Yi ‐Ling Qiu, Jing‐Yu Gong, Jia‐Yan Feng, Ren‐Xue Wang, Jun Han, Teng Liu, Yi Lu, Li‐Ting Li, Mei‐Hong Zhang, Jonathan A. Sheps, Neng‐Li Wang, Yan‐Yan Yan, Jia‐Qi Li, Lian Chen, Christoph H. Borchers, Bence Sipos, A.S. Knisely, Victor Li Tags: Autoimmune, Cholestatic and Biliary Disease Source Type: research
International, evidence-based consensus diagnostic criteria for HHV-8-negative/idiopathic multicentric Castleman disease
Human herpesvirus-8 (HHV-8)–negative, idiopathic multicentric Castleman disease (iMCD) is a rare and life-threatening disorder involving systemic inflammatory symptoms, polyclonal lymphoproliferation, cytopenias, and multiple organ system dysfunction caused by a cytokine storm often including interleukin-6. iMCD accounts for one third to one half of all cases of MCD and can occur in individuals of any age. Accurate diagnosis is challenging, because no standard diagnostic criteria or diagnostic biomarkers currently exist, and there is significant overlap with malignant, autoimmune, and infectious disorders. An interna...
Source: Blood - March 23, 2017 Category: Hematology Authors: Fajgenbaum, D. C., Uldrick, T. S., Bagg, A., Frank, D., Wu, D., Srkalovic, G., Simpson, D., Liu, A. Y., Menke, D., Chandrakasan, S., Lechowicz, M. J., Wong, R. S. M., Pierson, S., Paessler, M., Rossi, J.-F., Ide, M., Ruth, J., Croglio, M., Suarez, A., Kry Tags: Free Research Articles, Lymphoid Neoplasia, Clinical Trials and Observations Source Type: research
Inflammatory and Autoimmune Manifestations in X-linked carriers of Chronic Granulomatous Disease in the United Kingdom
Capsule summary: It has been recognized that X-linked carriers may have skin (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 23, 2017 Category: Allergy & Immunology Authors: Alexandra C. Battersby, Helen Braggins, Mark S. Pearce, Catherine M. Cale, Siobhan O. Burns, Scott Hackett, Stephen Hughes, Dawn Barge, David Goldblatt, Andrew R. Gennery Source Type: research
Entamoeba histolytica Nosode in the Homeopathic Treatment of Ulcerative Colitis
Homœopathic Links 2017; 30: 028-034 DOI: 10.1055/s-0037-1598095Ulcerative colitis is a severe chronic and invalidating autoimmune disease of the gastrointestinal tract. Conventional medical treatment is based on intestinal local and systemic anti-inflammatory drugs, local and systemic steroids, and systemic immunosuppressant agents with multiple side effects. A case of steroid-dependent immunosuppressant-treated patient is illustrated. Homeopathic treatment rapidly improved the clinical picture and allowed withdrawal of immunosuppressants, but did not prevent long-term relapsing intestinal and extraintestinal inflammation...
Source: Homoeopathic Links - March 23, 2017 Category: Complementary Medicine Authors: Solerio, Enrico Tags: Materia Medica and Cases Source Type: research
[Editors' Choice] Preempting autoimmune disease with induced antigen tolerance
Transfusion of red blood cells with antigenic peptides added to surface proteins is being explored as a tolerance-inducing intervention for autoimmune disease. (Source: Science Translational Medicine)
Source: Science Translational Medicine - March 22, 2017 Category: Biomedical Science Authors: Dupnik, K. Tags: Editors ' Choice Source Type: research
Seroprevalence survey of selective anti-neuronal autoantibodies in patients with first-episode schizophrenia and chronic schizophrenia
Autoimmune encephalopathy caused by autoantibodies against neuronal cell-surface proteins in the brain is a newly discovered disease category associated with psychiatric disorders. Correct diagnosis of this condition relies on the detection of specific autoantibodies in the blood or cerebral spinal fluid in addition to the clinical presentations. The study aimed to understand the seroprevalence of selective anti-neuronal autoantibodies in our patients with schizophrenia. First, we screened for six anti-neuronal autoantibodies in an archived blood sample collected from patients with the first-episode schizophrenia. (Source:...
Source: Schizophrenia Research - March 22, 2017 Category: Psychiatry Authors: Chia-Hsiang Chen, Min-Chih Cheng, Chih-Min Liu, Chen-Chung Liu, Ko-Huan Lin, Hai-Gwo Hwu Source Type: research
Are the autoimmune/inflammatory syndrome induced by adjuvants (ASIA) and the undifferentiated connective tissue disease (UCTD) related to each other? A case-control study of environmental exposures
AbstractThe autoimmune/inflammatory syndrome induced by adjuvants (ASIA) is an entity that includes different autoimmune conditions observed after exposure to an adjuvant. Patients with undifferentiated connective tissue disease (UCTD) present many signs and symptoms of ASIA, alluding to the idea that an exposure to adjuvants can be a trigger also for UCTD. The aim of this case-control study was to investigate exposure to adjuvants prior to disease onset in patients affected by UCTD. Ninety-two UCTD patients and 92 age- and sex-matched controls with no malignancy, chronic infections, autoimmune disease nor family history o...
Source: Immunologic Research - March 22, 2017 Category: Allergy & Immunology Source Type: research
Role of amino acids in rheumatoid arthritis studied by metabolomics
ConclusionThe results suggest that a disordered amine response is linked to RA‐associated muscle wasting and energy expenditure. (Source: APLAR Journal of Rheumatology)
Source: APLAR Journal of Rheumatology - March 22, 2017 Category: Rheumatology Authors: Min He, Amy C. Harms, Eduard Wijk, Mei Wang, Ruud Berger, Slavik Koval, Thomas Hankemeier, Jan Greef Tags: Original Article Source Type: research
A novel bispecific molecule delivered by recombinant AAV2 suppresses ocular inflammation and choroidal neovascularization
In this study, we engineered a secreted chimeric VEGF inhibitor domain (VID), a complement inhibitor domain (CID) and a dual inhibitor (ACVP1). Vectors expressing these three inhibitors were constructed and packaged into AAV2 (sextY‐F) particles. The expression and secretion of the proteins were validated by Western blot. The effects of these inhibitors expressed from AAV2 vectors were examined in endotoxin‐induced uveitis (EIU), experimental autoimmune uveoretinitis (EAU) and choroidal neovascularization (CNV) mouse models. The AAV2 vectors expressing the CID‐ and ACVP1‐attenuated inflammation in EIU and EAU model...
Source: Journal of Cellular and Molecular Medicine - March 22, 2017 Category: Molecular Biology Authors: Yiming Li, Ping Zhu, Amrisha Verma, Tuhina Prasad, Hongxin Deng, Dechao Yu, Qiuhong Li Tags: Original Article Source Type: research
Autoimmune disease linked with increased dementia risk.
Authors: Abstract Autoimmune disease could be linked to a heightened risk of dementia, say researchers from the University of Oxford. PMID: 28327041 [PubMed - in process] (Source: Nursing Standard)
Source: Nursing Standard - March 22, 2017 Category: Nursing Tags: Nurs Stand Source Type: research
Identification of a HERV ‐K env surface peptide highly recognized in RA patients: A cross‐sectional case‐control study
This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - March 21, 2017 Category: Allergy & Immunology Authors: G. Mameli, G.L. Erre, E. Caggiu, S. Mura, D. Cossu, Marco Bo, M.L. Cadoni, A Piras, N. Mundula, E. Colombo, G. Buscetta, G. Passiu, L.A. Sechi Tags: Original Article Source Type: research
Pan-European survey of the topical ocular use of cyclosporine A.
CONCLUSIONS: Medical practice surrounding ocular cyclosporine A use in European Union nations differs based on variations in concentration, dosage, prescription indication, formulation, availability and distribution, manufacturing, quality, and regulatory monitoring. PMID: 28318723 [PubMed - as supplied by publisher] (Source: Journal Francais d Ophtalmologie)
Source: Journal Francais d Ophtalmologie - March 21, 2017 Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
Editors ’ Picks
Gender differences are observed in the activity of multiple immunological pathways, even in healthy individuals. Many autoimmune diseases, both systemic and organ-specific, are characterized by a greater prevalence in females than males. Liang and colleagues identified a female-biased molecular signature, involving immunological factors, in association with autoimmune disease susceptibility, and this signature was independent of age or sex hormone regulation but was regulated by the putative transcription factor VGLL3, which had strong female-biased expression. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - March 21, 2017 Category: Dermatology Tags: Editorial Source Type: research
The blood in systemic disease
Systemic disease has protean manifestations. Most frequently observed is anaemia of chronic disease, anaemia can also be autoimmune, microangiopathic, mechanical or caused by haematinic deficiency, bone marrow replacement or pure red cell aplasia. The platelet count can be increased or decreased. The number of neutrophils, eosinophils, monocytes and lymphocytes can be increased, but neutropenia, eosinopenia and lymphopenia can also occur. Leucocytes can appear activated. Systemic disease can lead to thromboembolism, haemorrhage or disseminated intravascular coagulation. (Source: Medicine)
Source: Medicine - March 21, 2017 Category: Internal Medicine Authors: Barbara Bain Tags: The blood in systemic disease Source Type: research
Predicting the effects of potentially therapeutic modified peptides on polyclonal T cell populations in a mouse model of multiple sclerosis
Altered peptide ligands (APLs) have routinely been studied in clonal populations of Th cells that express a single T cell receptor (TCR), but results generated in this manner poorly predict the effects of APLs on polyclonal Th cells in vivo, contributing to the failure of phase II clinical trials of APLs in autoimmune diseases such as multiple sclerosis (MS). We have used a panel of APLs derived from an encephalitogenic epitope of myelin proteolipid protein to investigate the relationship between antigen cross-reactivity in a polyclonal environment, encephalitogenicity, and the capacity of an APL to provide protection agai...
Source: Journal of Neuroimmunology - March 21, 2017 Category: Allergy & Immunology Authors: Evan L. Sauer, Elisabeth Trifilieff, Judith M. Greer Source Type: research
Two decades of glatiramer acetate: From initial discovery to the current development of generics
Multiple sclerosis (MS) is a chronic, incurable, inflammatory disease of the central nervous system. In the United States, several Food and Drug Administration (FDA)-approved disease-modifying treatments (DMTs) are available, including glatiramer acetate (GA; Copaxone ®), one of the most longstanding treatments. GA was discovered serendipitously in the late 1960s/early 1970s while attempting to produce a synthetic antigen capable of inducing experimental autoimmune encephalomyelitis (EAE), an animal model of autoimmune inflammatory CNS disorders, including MS. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - March 21, 2017 Category: Neurology Authors: Bianca Weinstock-Guttman, Kavita V. Nair, Joseph L. Glajch, Tanmoy C. Ganguly, Daniel Kantor Tags: Review Article Source Type: research
Identification of a HERV-K env surface peptide highly recognized in RA patients: A cross-sectional case-control study.
This article is protected by copyright. All rights reserved. PMID: 28324619 [PubMed - as supplied by publisher] (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - March 21, 2017 Category: Allergy & Immunology Authors: Mameli G, Erre GL, Caggiu E, Mura S, Cossu D, Bo M, Cadoni ML, Piras A, Mundula N, Colombo E, Buscetta G, Passiu G, Sechi LA Tags: Clin Exp Immunol Source Type: research
Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease [Immunology and Inflammation]
Current therapies for autoimmune diseases rely on traditional immunosuppressive medications that expose patients to an increased risk of opportunistic infections and other complications. Immunoregulatory interventions that act prophylactically or therapeutically to induce antigen-specific tolerance might overcome these obstacles. Here we use the transpeptidase sortase to covalently attach disease-associated autoantigens to... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - March 20, 2017 Category: Science Authors: Novalia Pishesha, Angelina M. Bilate, Marsha C. Wibowo, Nai-Jia Huang, Zeyang Li, Rhogerry Dhesycka, Djenet Bousbaine, Hojun Li, Heide C. Patterson, Stephanie K. Dougan, Takeshi Maruyama, Harvey F. Lodish, Hidde L. Ploegh Tags: Biological Sciences Source Type: research
The universe of ANA testing: a case for point-of-care ANA testing
AbstractTesting for total antinuclear antibodies (ANA) is a critical tool for diagnosis and management of autoimmune diseases at both the primary care and subspecialty settings. Repurposing of ANA from a test for lupus to a test for any autoimmune condition has driven the increase in ANA requests. Changes in ANA referral patterns include early or subclinical autoimmune disease detection in patients with low pre-test probability and use of negative ANA results to rule out underlying autoimmune disease. A positive result can lead to further diagnostic considerations. Currently, ANA tests are performed in centralized laborato...
Source: Autoimmunity Highlights - March 20, 2017 Category: Allergy & Immunology Source Type: research
An Activating Mutation in STAT3 Results in Neonatal Diabetes Through Reduced Insulin Synthesis
Neonatal diabetes mellitus (NDM) is a rare form of diabetes diagnosed within the first 6 months of life. Genetic studies have allowed the identification of several genes linked to the development of NDM; however, genetic causes for ~20% of the cases remain to be clarified. Most cases of NDM involve isolated diabetes, but sometimes NDM appears in association with other pathological conditions, including autoimmune diseases. Recent reports have linked activating mutations in STAT3 with early-onset autoimmune disorders that include diabetes of autoimmune origin, but the functional impact of STAT3-activating mutations have not...
Source: Diabetes - March 20, 2017 Category: Endocrinology Authors: Velayos, T.; Martinez, R.; Alonso, M.; Garcia-Etxebarria, K.; Aguayo, A.; Camarero, C.; Urrutia, I.; Martinez de LaPiscina, I.; Barrio, R.; Santin, I.; Castano, L. Tags: Pathophysiology Source Type: research
Identification of Unique Antigenic Determinants in the Amino Terminus of IA-2 (ICA512) in Childhood and Adult Autoimmune Diabetes: New Biomarker Development
CONCLUSIONS We developed a new antibody biomarker identifying novel antigenic determinants within the N terminus of IA-2. IA-2ec autoantibodies can be detected in patients with type 1 diabetes and in a subgroup of adult autoimmune patients with type 2 diabetes phenotype negative for conventional islet autoantibody testing. These observations suggest that islet autoimmunity may be more common in clinically diagnosed type 2 diabetes than previously observed. (Source: Diabetes Care)
Source: Diabetes Care - March 20, 2017 Category: Endocrinology Authors: Acevedo-Calado, M.; James, E. A.; Morran, M. P.; Pietropaolo, S. L.; Ouyang, Q.; Arribas-Layton, D.; Songini, M.; Liguori, M.; Casu, A.; Auchus, R. J.; Huang, S.; Yu, L.; Michels, A.; Gianani, R.; Pietropaolo, M. Tags: Emerging Technologies and Therapeutics Source Type: research
CCR6+ Th cells in the cerebrospinal fluid of persons with multiple sclerosis are dominated by pathogenic non-classic Th1 cells and GM-CSF-only-secreting Th cells
Publication date: Available online 20 March 2017 Source:Brain, Behavior, and Immunity Author(s): S.M. Restorick, L. Durant, S. Kalra, G. Hassan-Smith, E. Rathbone, M.R. Douglas, S.J. Curnow Considerable attention has been given to CCR6+ IL-17-secreting CD4+ T cells (Th17) in the pathology of a number of autoimmune diseases including multiple sclerosis (MS). However, other Th subsets also play important pathogenic roles, including those that secrete IFNγ and GM-CSF. CCR6 expression by Th17 cells allows their migration across the choroid plexus into the cerebrospinal fluid (CSF), where they are involved in the early phase ...
Source: Brain, Behavior, and Immunity - March 20, 2017 Category: Neurology Source Type: research
Regulatory T cell frequency, but not plasma IL-33 levels, represents potential immunological biomarker to predict clinical response to intravenous immunoglobulin therapy
Intravenous immunoglobulin (IVIG) is a polyspecific pooled immunoglobulin G preparation and one of the commonly used therapeutics for autoimmune diseases including those of neurological origin. A recent report... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - March 20, 2017 Category: Neurology Authors: Mohan S. Maddur, Emmanuel Stephen-Victor, Mrinmoy Das, Praveen Prakhar, Varun K. Sharma, Vikas Singh, Magalie Rabin, Jamma Trinath, Kithiganahalli N. Balaji, Francis Bolgert, Jean-Michel Vallat, Laurent Magy, Srini V. Kaveri and Jagadeesh Bayry Source Type: research
Low ‐dose interleukin‐2 promotes STAT‐5 phosphorylation, Treg survival and CTLA‐4‐dependent function in autoimmune liver diseases
We reported recently that the hepatic microenvironment is deficient in interleukin (IL)−2, a cytokine essential for Treg survival and function. Consequently, few liver‐infiltrating Treg demonstrate signal transducer and activator of transcription‐5 (STAT‐5) phosphorylation. To establish the potential of IL‐2 to enhance Treg therapy, we investigated the effects of very low dose Proleukin (VLDP) on the phosphorylation of STAT‐5 and the subsequent survival and function of Treg and T effector cells from the blood and livers of patients with autoimmune liver diseases. VLDP, at less than 5 IU/ml, resulted in selectiv...
Source: Clinical and Experimental Immunology - March 19, 2017 Category: Allergy & Immunology Authors: H. C. Jeffery, L. E. Jeffery, P. Lutz, M. Corrigan, G. J. Webb, G. M. Hirschfield, D. H. Adams, Y. H. Oo Tags: Original Article Source Type: research
Newly diagnosed immune thrombocytopenia adults: Clinical epidemiology, exposure to treatments, and evolution. Results of the CARMEN multicenter prospective cohort
In conclusion, severe bleeding is rare at ITP onset. Associated autoimmune diseases and recent infections were frequent. Antinuclear antibodies seem predictors of chronicity. Intravenous corticosteroids and IVIg were frequently used. (Source: American Journal of Hematology)
Source: American Journal of Hematology - March 19, 2017 Category: Hematology Authors: Guillaume Moulis, Johanne Germain, Thibault Comont, Natacha Brun, Claire Dingremont, Brice Castel, Sophie Arista, Laurent Sailler, Maryse Lapeyre ‐Mestre, Odile Beyne‐Rauzy, Bertrand Godeau, Daniel Adoue, Tags: RESEARCH ARTICLE Source Type: research
Autoimmune neuropsychiatric disorders associated with infection
There have been many observations of the relationship between infectious disease and behaviour changes such as the development of tics documented in medical literature over a long period of time. Paediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) is a controversial diagnosis because it relies on linking a causal association between a common childhood illness with less common psychiatric symptoms. This case report describes a possible case of PANDAS in a young person, the course of treatment and its outcome. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - March 19, 2017 Category: Neurology Authors: Rachael Lawrence, Jonathan Baggott Tags: Case notes Source Type: research
Gastrointestinal and liver lesions in primary childhood Sj ögren syndrome
We report five cases of primary childhood SS with gastrointestinal and liver lesions. Multiple gastric biopsies in four cases revealed atrophic gastritis in the antrum of the stomach or chronic gastritis. Liver biopsies in two c ases revealed nonalcoholic steatohepatitis. Careful clinical approach and follow-up for gastrointestinal and liver lesions are required. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 19, 2017 Category: Rheumatology Source Type: research
Autologous hematopoietic stem cell transplantation for pediatric multiple sclerosis: a registry-based study of the Autoimmune Diseases Working Party (ADWP) and Pediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT)
en & D Farge (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - March 19, 2017 Category: Hematology Authors: J Burman K Kirgizov K Carlson M Badoglio G L Mancardi G De Luca B Casanova J Ouyang R Bembeeva J Haas P Bader J Snowden D Farge Source Type: research
Simultaneous induction of Graves ’ hyperthyroidism and Graves’ ophthalmopathy by TSHR genetic immunization in BALB/c mice
ConclusionWe have successfully established an animal model manifesting Graves ’ hyperthyroidism and ophthalmopathy, which provides a useful tool for future study of the pathological features and the development of novel therapies of the diseases. (Source: PLoS One)
Source: PLoS One - March 19, 2017 Category: Biomedical Science Authors: Nan Xia Source Type: research
Evaluation of transient elastography in assessing liver fibrosis in patients with autoimmune hepatitis
ConclusionsTransient elastography is an accurate and reliable noninvasive tool in assessing liver fibrosis in AIH. Hepatic inflammatory activity had no significant effect on LSM determination. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - March 19, 2017 Category: Gastroenterology Authors: Qinyu Xu, Li Sheng, Han Bao, Xiaoyu Chen, Canjie Guo, Hai Li, Xiong Ma, Dekai Qiu, Jing Hua Tags: Hepatology Source Type: research
miRNAs: novel regulators of autoimmunity-mediated pancreatic β-cell destruction in type 1 diabetes.
Abstract MicroRNAs (miRNAs) are a series of conserved, short, non-coding RNAs that modulate gene expression in a posttranscriptional manner. miRNAs are involved in almost every physiological and pathological process. Type 1 diabetes (T1D) is an autoimmune disease that is the result of selective destruction of pancreatic β-cells driven by the immune system. miRNAs are also important participants in T1D pathogenesis. Herein, we review the most recent data on the potential involvement of miRNAs in T1D. Specifically, we focus on two aspects: the roles of miRNAs in maintaining immune homeostasis and regulating β-cell...
Source: Cellular and Molecular Immunology - March 19, 2017 Category: Molecular Biology Authors: Zheng Y, Wang Z, Zhou Z Tags: Cell Mol Immunol Source Type: research