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Digoxin Attenuates Murine Experimental Colitis by Downregulating Th17-related Cytokines
Conclusions: This study has shown for the first time that treatment with digoxin can ameliorate murine experimental colitis. This finding suggests that the suppression of Th17 using reagents such as digoxin could be effective in treating Crohn's disease refractory to anti–tumor necrosis factor alpha therapy. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - April 28, 2017 Category: Gastroenterology Tags: Original Basic Science Articles Source Type: research

Simultaneously increased expression of glucocorticoid ‑induced tumor necrosis factor receptor and its ligand contributes to increased interleukin‑5/13‑producing group 2 innate lymphocytes in murine asthma.
Simultaneously increased expression of glucocorticoid‑induced tumor necrosis factor receptor and its ligand contributes to increased interleukin‑5/13‑producing group 2 innate lymphocytes in murine asthma. Mol Med Rep. 2017 Apr 21;: Authors: Zhang M, Wan J, Xu Y, Zhang D, Peng J, Qi C, Guo Q, Xia S, Su Z, Wang S, Xu H Abstract Glucocorticoid‑induced tumor necrosis factor receptor (GITR) is expressed at high levels on CD4+CD25+ regulatory T cells (Tregs). Following activation by its ligand (GITRL), GITR influences the activity of effector T cells and Tregs and participates in the development of n...
Source: Molecular Medicine Reports - April 27, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Human umbilical cord mesenchymal stem cells alleviate acute myocarditis by modulating endoplasmic reticulum stress and extracellular signal regulated 1/2-mediated apoptosis.
Authors: Zhang C, Zhou G, Cai C, Li J, Chen F, Xie L, Wang W, Zhang Y, Lai X, Ma L Abstract Acute myocarditis is a non-ischemic inflammatory disease of the myocardium, and there is currently no standard treatment. Mesenchymal stem cells (MSCs) can alleviate myosin‑induced myocarditis; however, the mechanism has not been clearly elucidated. In the present study, the authors investigated the ability of human umbilical cordMSCs (HuMSCs) to attenuate myocardial injury and dysfunction during the acute phase of experimental myocarditis. Male Lewis rats (aged 8 weeks) were injected with porcine myosin to induce myocard...
Source: Molecular Medicine Reports - April 27, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

The Rare Case of Pemphigus Vegetans in Association with Malnutrition Children in the Multidisciplinary Management
Pemphigus vegetans is a clinical variant of pemphigus vulgaris, accounting for 1 –2% of all very rare pemphigus cases in children. The involvement of the oral mucosa in this disease is usually accompanied by severe pain that aggravates the patient’s malnourished condition. Conversely, malnutrition may also reduce vulnerability towards autoimmune diseases. Although pemphigus vegetans has never been reported to develop in a child with marasmus before, we encountered a case of pemphigus vegetans in a severely malnourished patient. A 12-year-old boy in marasmic condition presented with painful, clear, fluid-filled blisters...
Source: Case Reports in Dermatology - April 27, 2017 Category: Dermatology Source Type: research

A multireferral centre retrospective cohort analysis on the experience in treatment of metastatic uveal melanoma and utilization of sequential liver-directed treatment and immunotherapy
Metastatic uveal melanoma is a rare malignancy with a poor prognosis. To date, systemic therapy has been ineffective; however, there are few data on the benefits of anti-CTLA4 or anti-PD-1 antibodies in sequence with liver-directed therapy. A retrospective cohort analysis was carried out on 37 consecutive patients managed in a tertiary referral centre examining the safety and efficacy of treatment; patterns of care; and impact on survival. The sequential treatment with transarterial chemotherapy (TAC), systemic immunotherapy (IT) and systemic chemotherapy was reviewed. In all, 18 patients in the series received sequential ...
Source: Melanoma Research - April 27, 2017 Category: Cancer & Oncology Tags: ORIGINAL ARTICLES: Clinical research Source Type: research

Eosinophils in Autoimmune Diseases
Nicola L. Diny, Noel R. Rose, Daniela Čiháková (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - April 27, 2017 Category: Allergy & Immunology Source Type: research

GSE57152 Alternative poly(A) in Alzheimer's disase
Contributors : Shahar Barbash ; Hermona Soreq ; Alexander SeitzSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAlternative polyadenylation (APA) contributes to post-transcriptional regulation, but its role in Alzheimer ’s disease (AD) is largely unknown. Using high-resolution SQUARE multiple 3’ primer-based sequencing, we discovered massive APA differences in temporal gyrus tissues from demented AD patients compared to either healthy controls or non-demented donors with AD neuropathology (NDWP). Advanced stati stics, microfluidics RT-PCR and protein measurements validated known an...
Source: GEO: Gene Expression Omnibus - April 27, 2017 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

A review on therapeutic drug monitoring of the mTOR class of immunosuppressants: everolimus and sirolimus
AbstractImmunosuppression plays a key role in the prevention of organ rejection in transplant recipients and in the treatment of diverse autoimmune disorders. Therapeutic drug monitoring (TDM) for the mammalian target of rapamycin inhibitors (mTOR) class of immunosuppressants is mandatory in the clinical setting because of the narrow therapeutic index, high intersubject pharmacokinetic variability, under- and over-immunosuppression and adverse effects of these drugs. Immunosuppressive drug therapy is frequently individualized based on the organ transplanted, time after transplantation, and transplant centre-specific immuno...
Source: Drugs and Therapy Perspectives - April 27, 2017 Category: Drugs & Pharmacology Source Type: research

Pneumococcal and influenza vaccination rates in patients treated with corticosteroids and/or immunosuppressive therapies for systemic autoimmune diseases: A cross-sectional study
Publication date: May 2017 Source:Joint Bone Spine, Volume 84, Issue 3 Author(s): Manal Assala, Matthieu Groh, Philippe Blanche, Christine Vinter, Pascal Cohen, Véronique Le Guern, Xavier Puéchal, Luc Mouthon, Claire Le Jeunne, Odile Launay, Solen Kernéis (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 27, 2017 Category: Orthopaedics Source Type: research

Genome Engineering of Stem Cells for Autonomously Regulated, Closed-Loop Delivery of Biologic Drugs
Publication date: Available online 27 April 2017 Source:Stem Cell Reports Author(s): Jonathan M. Brunger, Ananya Zutshi, Vincent P. Willard, Charles A. Gersbach, Farshid Guilak Chronic inflammatory diseases such as arthritis are characterized by dysregulated responses to pro-inflammatory cytokines such as interleukin-1 (IL-1) and tumor necrosis factor α (TNF-α). Pharmacologic anti-cytokine therapies are often effective at diminishing this inflammatory response but have significant side effects and are used at high, constant doses that do not reflect the dynamic nature of disease activity. Using the CRISPR/Cas9 genome-en...
Source: Stem Cell Reports - April 27, 2017 Category: Stem Cells Source Type: research

Benign Exocrine Pancreatic Diseases in Inflammatory Bowel Diseases
Conclusions: The frequency of benign pancreatic disease was not high in patients with IBD and was probably similar to that seen in the general population.Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - April 26, 2017 Category: Gastroenterology Source Type: research

A New Diagnostic and Prognostic Marker in Endometrial Cancer: Neopterin
In this study, we investigated the correlation between serum and urinary neopterin levels as well as the stage of the disease in women with endometrial cancer. Increased neopterin concentrations are reported in patients with activation of macrophages by interferon-γ, which includes the following: viral infections, autoimmune disorders, allograft rejection, and various malignant tumors. In patients with several types of cancer, high-neopterin concentrations in body fluids like serum/plasma, urine, ascites, and cerebrospinal fluid indicate the course of the disease, and it is associated with poor prognosis. In the light of...
Source: International Journal of Gynecological Cancer - April 26, 2017 Category: Cancer & Oncology Tags: Uterine Cancer Source Type: research

Diffuse parenchymal lung disease
Between September 2015 and August 2016 there were >1500 publications in the field of diffuse parenchymal lung diseases (DPLDs). For the Clinical Year in Review session at the European Respiratory Society Congress that was held in London, UK, in September 2016, we selected only five articles. This selection, made from the enormous number of published papers, does not include all the relevant studies that will significantly impact our knowledge in the field of DPLDs in the near future. This review article provides our personal view on the following topics: early diagnosis of idiopathic pulmonary fibrosis, current knowledg...
Source: European Respiratory Review - April 26, 2017 Category: Respiratory Medicine Authors: Tomassetti, S., Ravaglia, C., Poletti, V. Tags: Interstitial and orphan lung disease, Respiratory clinical practice Clinical Year in Review Source Type: research

Clinical presentation and outcome of children with central diabetes insipidus associated with a self ‐limited or transient pituitary stalk thickening, diagnosed as infundibuloneurohypophysitis
ConclusionsIn this series of children INH with CDI as initial presentation, CDI was permanent and infrequently associated with anterior pituitary hormone deficiencies, despite a frequent association with non‐stalk cerebral lesions.This article is protected by copyright. All rights reserved. (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - April 26, 2017 Category: Endocrinology Authors: J Schaefers, M Cools, K De Waele, I Gies, V Beauloye, P Lysy, I Francois, D Beckers, J De Schepper Tags: Original Article Source Type: research

Crystal structure of CD27 in complex with a neutralizing noncompeting antibody
CD27 is a T-cell and B-cell co-stimulatory glycoprotein of the tumor necrosis factor (TNF) receptor superfamily that is dependent on the availability of the TNF-like ligand CD70. Therapeutic approaches to treating autoimmune diseases and cancers with antagonistic and agonistic anti-CD27 monoclonal antibodies (mAbs), respectively, have recently been developed. Mouse anti-human CD27 mAb 2177 shows potency in neutralizing CD70-induced signaling; however, it does not block the binding of soluble CD70. To provide insight into the mechanism of action of the mAb, the crystal structure of the CD27 extracellular domain in complex w...
Source: Acta Crystallographica Section F - April 26, 2017 Category: Biochemistry Authors: Teplyakov, A. Obmolova, G. Malia, T.J. Gilliland, G.L. Tags: CD27 cysteine-rich domain antibodies crystal structure epitopes tumor necrosis factor research communications Source Type: research

Other Extrahepatic Manifestations of Hepatitis C Virus Infection (Pulmonary, Idiopathic Thrombocytopenic Purpura, Nondiabetes Endocrine Disorders)
Extrahepatic manifestations of hepatitis C virus (HCV) infection are a rare but serious condition. This review summarizes the current literature on the association between HCV and endocrine and pulmonary manifestations, as well as idiopathic thrombocytopenic purpura (ITP). HCV may directly infect extrahepatic tissues and interact with the immune system predisposing for obstructive and interstitial lung disease, ITP, autoimmune thyroiditis, infertility, growth hormone and adrenal deficiency, osteoporosis, and potentially lung and thyroid cancers. However, in many cases, the current evidence is divergent and cannot sufficien...
Source: Clinics in Liver Disease - April 26, 2017 Category: Gastroenterology Authors: Daniel Segna, Jean-Fran çois Dufour Source Type: research

Dysregulated CD46 shedding interferes with Th1-contraction in systemic lupus erythematosus.
This article is protected by copyright. All rights reserved. PMID: 28444759 [PubMed - as supplied by publisher] (Source: European Journal of Immunology)
Source: European Journal of Immunology - April 26, 2017 Category: Allergy & Immunology Authors: Ellinghaus U, Cortini A, Pinder CL, Friec GL, Kemper C, Vyse TJ Tags: Eur J Immunol Source Type: research

Adipose tissue infiltration in minor salivary glands of patients with Sj ögren's syndrome: Lack of significant correlation with the disease. An image analysis of 174 cases().
Adipose tissue infiltration in minor salivary glands of patients with Sjögren's syndrome: Lack of significant correlation with the disease. An image analysis of 174 cases(). Autoimmunity. 2017 Apr 23;:1-3 Authors: Katona K, Farkas N, Sütő G, Tornóczky T Abstract Fatty infiltration in minor salivary gland biopsies and its correlation to systemic autoimmune diseases are controversial in the literature. Presence and extent of fatty infiltration in minor salivary glands of 107 Sjögren's syndrome patients and 67 age-matched sicca controls were compared with statistical analyses. No significant differen...
Source: Autoimmunity - April 25, 2017 Category: Allergy & Immunology Tags: Autoimmunity Source Type: research

Reconstruction and analysis of lncRNA-miRNA-mRNA network based on competitive endogenous RNA reveal functional lncRNAs in rheumatoid arthritis
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00094D, PaperHui Jiang, Rong Ma, Shubiao Zou, Zhuqing Li , Weiping Li Rheumatoid arthritis (RA) is an autoimmune disease with an unknown etiology, occurring in approximately 1.0% of general population. More and more studies have suggested that long non-coding RNAs (lncRNAs) could... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - April 25, 2017 Category: Molecular Biology Authors: Hui Jiang Source Type: research

Methylation of Tumor Suppressor Genes in Autoimmune Pancreatitis
Conclusions: These are the first studies characterizing methylation abnormalities in AIP. AIP's inflammatory condition may be related to carcinogenesis. Further study will elucidate methylation abnormalities associated with carcinogenesis in AIP. (Source: Pancreas)
Source: Pancreas - April 25, 2017 Category: Gastroenterology Tags: Original Articles Source Type: research

Prevalence and clinical relevance of tsh receptor blocking antibodies in autoimmune thyroid disease
Conclusions: Functional TSHR‐Ab impact thyroid status. TBAb determination is helpful in evaluation and management of patients with AITD. The TBAb assay is a relevant pool to important tool to identify potentially reversible hypothyroidism, This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - April 25, 2017 Category: Allergy & Immunology Authors: T Diana, J Krause, PD Olivo, J K önig, M Kanitz, B Decallonne, GJ Kahaly Tags: Original Article Source Type: research

Anterior ST ‐elevation myocardial infarction induced by rituximab infusion: A case report and review of the literature
This report underlines previous published reports emphasizing the awareness of such an association. This communication also warrants the importance of screening for ischaemic heart disease in selected cases of patients treated with rituximab. Rituximab is a monoclonal antibody that is approved for treatment of certain malignancies and autoimmune diseases. Generally, Rituximab is well tolerated, nevertheless some patients develop adverse effects including infusion reactions. In this report, we investigated a patient who developed ST‐elevation myocardial infarction during the drug administration. Such complication albeit ...
Source: Journal of Clinical Pharmacy and Therapeutics - April 25, 2017 Category: Drugs & Pharmacology Authors: K. Sharif, A. Watad, N. L. Bragazzi, E. Asher, A. Abu Much, Y. Horowitz, M. Lidar, Y. Shoenfeld, H. Amital Tags: Case Report Source Type: research

Correction for Pishesha et al., Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease [Correction]
IMMUNOLOGY AND INFLAMMATION Correction for “Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease,” by Novalia Pishesha, Angelina M. Bilate, Marsha C. Wibowo, Nai-Jia Huang, Zeyang Li, Rhogerry Dhesycka, Djenet Bousbaine, Hojun Li, Heide C. Patterson, Stephanie K. Dougan, Takeshi Maruyama, Harvey F. Lodish, and Hidde L.... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - April 25, 2017 Category: Science Tags: Corrections Source Type: research

Prevalence and clinical relevance of tsh receptor blocking antibodies in autoimmune thyroid disease.
CONCLUSIONS: Functional TSHR-Ab impact thyroid status. TBAb determination is helpful in evaluation and management of patients with AITD. The TBAb assay is a relevant pool to important tool to identify potentially reversible hypothyroidism, This article is protected by copyright. All rights reserved. PMID: 28439882 [PubMed - as supplied by publisher] (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - April 25, 2017 Category: Allergy & Immunology Authors: Diana T, Krause J, Olivo PD, König J, Kanitz M, Decallonne B, Kahaly GJ Tags: Clin Exp Immunol Source Type: research

Head and neck giant cell arteritis: an autoimmune disease with many faces.
CONCLUSION: A high rate of infrequent presentations of giant cell arteritis were seen in the ENT department and should be anticipated as a differential diagnosis in every older patient with odynophagia with high CRP values without cause in thorough ENT examination. OBJECTIVE: To describe the clinical manifestation of head and neck giant cell arteritis and to derive a diagnostic pathway covering atypical cases. METHOD: Single-center, retrospective analysis of cases with GCA in the head and neck region (HN-GCA) (2002-2012) to describe the clinical presentation and to derive a diagnostic pathway covering manifestati...
Source: Acta Oto-Laryngologica - April 25, 2017 Category: ENT & OMF Authors: Wirth M, Schirmer L, Hofauer B, Lenschow M, Loos D, Thuermel K, Knopf A Tags: Acta Otolaryngol Source Type: research

Helminth Immunomodulation in Autoimmune Disease
Taylor B. Smallwood, Paul R. Giacomin, Alex Loukas, Jason P. Mulvenna, Richard J. Clark, John J. Miles (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - April 24, 2017 Category: Allergy & Immunology Source Type: research

Immunology proves a great success for treating systemic autoimmune diseases – a perspective on immunopharmacology: IUPHAR Review 23
Abstract Recent advances in the bioengineering of monoclonal antibodies (mAbs) have revolutionized the treatment of several immunological and rheumatic diseases. mAbs exhibit high specificity and affinity, and are very effective targeting agents, associated with minimal off‐target adverse effects. Of several relevant immunological diseases, rheumatoid arthritis was the condition initially treated with mAbs, with great success. Currently, many immunological disorders are targeted and successfully treated using such novel approaches; these include inflammatory bowel diseases, multiple sclerosis, lupus and psoriasis. Today,...
Source: British Journal of Pharmacology - April 24, 2017 Category: Drugs & Pharmacology Authors: Masaru Ishii Tags: IUPHAR REVIEW Source Type: research

A 6-year-old boy with Wilson disease —A diagnostic dilemma
We report a clinicopathological conference of this boy to highligh t the challenges faced by pediatricians in the diagnosis of Wilson disease. ᅟ (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - April 24, 2017 Category: Gastroenterology Source Type: research

Low-dose rituximab as an adjuvant therapy in pemphigus
Conclusion: Our results show that low-dose rituximab is a well-tolerated and beneficial adjuvant therapy in recalcitrant pemphigus which helps reduce both the severity of disease as well as the dose of steroids and immunosuppressants. (Source: Indian Journal of Dermatology, Venereology and Leprology)
Source: Indian Journal of Dermatology, Venereology and Leprology - April 24, 2017 Category: Dermatology Authors: Jaya Gupta Ranjan C Raval Arti N Shah Rekha B Solanki Dhara D Patel Kaksha B Shah Ami D Badheka Keyur B Shah Neetish K Aggarwal Vaaruni Ravishankar Source Type: research

Viral hepatitis and Parkinson disease: A national record-linkage study
Conclusions: We report strong evidence in favor of an elevation of rates of subsequent PD in patients with hepatitis B and hepatitis C. These findings may be explained by factors peculiar to viral hepatitis, but whether it reflects consequences of infection, shared disease mechanisms, or the result of antiviral treatment remains to be elucidated. Further work is needed to confirm this association and to investigate pathophysiologic pathways, potentially advancing etiologic understanding of PD more broadly. (Source: Neurology)
Source: Neurology - April 24, 2017 Category: Neurology Authors: Pakpoor, J., Noyce, A., Goldacre, R., Selkihova, M., Mullin, S., Schrag, A., Lees, A., Goldacre, M. Tags: All Infections, Viral infections, Parkinson's disease/Parkinsonism, Cohort studies, Risk factors in epidemiology ARTICLE Source Type: research

IVIG treatment for repeated hypothermic attacks associated with LGI1 antibody encephalitis
Hypothermia, defined as a core body temperature of <35.0°C (<95.0°F), is a life-threatening and emergency situation. Various conditions and diseases can cause hypothermia, including environmental exposure, drug intoxication, CNS diseases, and metabolic abnormalities, such as hypopituitarism, hypoadrenalism, hypothyroidism, and hypoglycemia. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - April 24, 2017 Category: Neurology Authors: Hayashi, Y., Yamada, M., Kimura, A., Inuzuka, T. Tags: Autoimmune diseases, Encephalitis Clinical/Scientific Notes Source Type: research

Chronic eczematous dermatitis in patients with neurodegenerative diseases may be an early marker of bullous pemphigoid
The number of elderly patients with chronic pruritus has been gradually increasing in aging countries. Bullous pemphigoid, a common autoimmune blister disease in the elderly, is always heralded by pruritic eczematous dermatitis and is often associated with neurodegenerative diseases. We hypothesized that chronic eczematous dermatitis in patients with neurodegenerative diseases may be an early marker of bullous pemphigoid. By conducting retrospective chart review, we found neurodegenerative diseases are more prevalent in elderly patients with chronic eczematous dermatitis. (Source: Medical Hypotheses)
Source: Medical Hypotheses - April 24, 2017 Category: Biomedical Science Authors: Ping-Song Chou, Tsai-Ching Chou, Chung-Hsing Chang, Sebastian Yu, Chih-Hung Lee Source Type: research

The role of neutrophil proteases in LPS-induced production of regulatory rheumatoid factor that suppresses autoimmunity.
CONCLUSION: Thus, the pre-split IgG and Fc fragments of IgG formed by LPS-activated neutrophils are the potential physiological activators of regRF production. PMID: 28440198 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 24, 2017 Category: Endocrinology Authors: Stolyarova E, Beduleva L, Sidorov A, Menshikov I, Terentiev A, Vachrusheva K Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Autoimmune myocarditis in systemic sclerosis: an unusual form of scleroderma heart disease presentation
We report the case of a patient who developed autoimmune myocarditis at an early stage of systemic sclerosis, who completely recovered from cardiac dysfunction under optimal medical therapy for heart failure and immunosuppression. This challenging case aims at increasing awareness around the fact that the heart is a target organ of scleroderma disease. It also highlights the importance of screening and early diagnosis of cardiac involvement, because a timely treatment may impact the quality of life of these patients and improve their prognosis. (Source: ESC Heart Failure)
Source: ESC Heart Failure - April 23, 2017 Category: Cardiology Authors: Ana Rita Ramalho, Susana Costa, Francisco Silva, Paulo Donato, F átima Franco, Guilherme Mariano Pêgo Tags: Case Report Source Type: research

Inheritable and sporadic non-autoimmune hyperthyroidism
Publication date: Available online 22 April 2017 Source:Best Practice &amp; Research Clinical Endocrinology &amp; Metabolism Author(s): Carolina Ferraz, Ralf Paschke Hyperthyroidism is a clinical state that results from high thyroid hormone levels which has multiple etiologies, manifestations, and potential therapies. Excluding the autoimmune Graves disease, autonomic adenomas account for the most import cause of non-autoimmune hyperthyroidism. Activating germline mutations of the TSH receptor are rare etiologies for hyperthyroidism. They can be inherited in an autosomal dominant manner (familial or hereditary, FN...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - April 23, 2017 Category: Endocrinology Source Type: research

Antimicrobial Peptides: Role in Human Disease and Potential as Immunotherapies
Publication date: Available online 21 April 2017 Source:Pharmacology &amp; Therapeutics Author(s): César de la Fuente-Núñez, Osmar N. Silva, Timothy K. Lu, Octavio Luiz Franco Antimicrobial peptides (AMPs) have evolved through billions of years as part of our innate immune system. These agents are produced by various cells throughout the human body and play important roles in our ability to respond to infections. In this review, we outline evidence linking AMP expression with a range of inflammatory and autoimmune human diseases. Finally, we highlight the promise of endogenous AMP induction for the treatment of dis...
Source: Pharmacology and Therapeutics - April 23, 2017 Category: Drugs & Pharmacology Source Type: research

Effect of Halofuginone on the Pathogenesis of Autoimmune Thyroid Disease in Different Mice Models.
CONCLUSION: Treatment with HF significantly decreased the incidence of AIT by decreasing the number of CD4+IL-17+ T cells. PMID: 28440200 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 23, 2017 Category: Endocrinology Authors: Hou X, Zhou J, Yang R, Liu S, Bi M, Liu T, Fan C, Guan H, Li Y, Shan Z, Teng W Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Primary Sj ögren's syndrome in patients with celiac disease.
CONCLUSION: The prevalence of SS in CD is low, so there is no need for serologic screening of all patients with CD for SS. PMID: 28425227 [PubMed - in process] (Source: Turkish Journal of Medical Sciences)
Source: Turkish Journal of Medical Sciences - April 22, 2017 Category: Journals (General) Tags: Turk J Med Sci Source Type: research

[Tropical dermatology-relevant disorders of the scalp].
Authors: Montag A Abstract People whose ancestors came from tropical regions present specific structural characteristics of their skin and hair, including the scalp region. On the one hand, this is for protection against the challenges of these climatic zones; on the other hand, this may lead to an enhanced sensitivity against certain dermatological diseases, either of autoimmune, chronic inflammatory, infectious, or of mechanical origin. A collection of these are discussed in this article. PMID: 28421255 [PubMed - as supplied by publisher] (Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete)
Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete - April 22, 2017 Category: Dermatology Tags: Hautarzt Source Type: research

Status of Epstein-Barr Virus Coinfection with Helicobacter pylori in Gastric Cancer.
Authors: Singh S, Jha HC Abstract Epstein-Barr virus is a ubiquitous human herpesvirus whose primary infection causes mononucleosis, Burkett's lymphoma, nasopharyngeal carcinoma, autoimmune diseases, and gastric cancer (GC). The persistent infection causes malignancies in lymph and epithelial cells. Helicobacter pylori causes gastritis in human with chronic inflammation. This chronic inflammation is thought to be the cause of genomic instability. About 45%-word population have a probability of having both pathogens, namely, H. pylori and EBV. Approximately 180 per hundred thousand population is developing GC along ...
Source: Journal of Oncology - April 22, 2017 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Methylprednisolone liver toxicity: A new case and a French regional pharmacovigilance survey
In conclusion, these cases we report here strongly illustrates that high-dose MP-induced liver injury can occur in patients treated for MS or auto-immune disorder. Unintended re-challenge can confirm the diagnosis and can help to distinguish it from autoimmune hepatitis. Performing liver function tests routinely both before and after MP administration would be beneficial, as the timely recognition of this complication and early drug withdrawal may prevent progression of severe necrosis hepatic injury. (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - April 22, 2017 Category: Gastroenterology Source Type: research

CCL20 neutralization by a monoclonal antibody in healthy subjects selectively inhibits recruitment of CCR6+ cells in an experimental suction blister
ConclusionsThese results indicate a relationship between PK, target engagement and PD, suggesting a selective inhibition of recruitment of CCR6+ cells by GSK3050002 and support further development of GSK3050002 in autoimmune and inflammatory diseases. (Source: British Journal of Clinical Pharmacology)
Source: British Journal of Clinical Pharmacology - April 22, 2017 Category: Drugs & Pharmacology Authors: Gerben Bouma, Stefano Zamuner, Kirsty Hicks, Andrew Want, Jo ão Oliveira, Arpita Choudhury, Sara Brett, Darren Robertson, Leigh Felton, Virginia Norris, Disala Fernando, Michael Herdman, Ruth Tarzi Tags: PHARMACOKINETIC DYNAMIC RELATIONSHIPS Source Type: research

Pathogenic role of anti –signal recognition protein and anti–3‐Hydroxy‐3‐methylglutaryl‐CoA reductase antibodies in necrotizing myopathies: Myofiber atrophy and impairment of muscle regeneration in necrotizing autoimmune myopathies
ObjectiveImmune‐mediated necrotizing myopathies (IMNM) may be associated with either anti–signal recognition protein (SRP) or anti–3‐hydroxy‐3‐methylglutaryl‐CoA reductase (HMGCR) antibodies (Abs), and the titer of these Abs is correlated with disease activity. We investigated whether anti‐SRP and anti‐HMGCR Abs could be involved in muscle damage. MethodsMuscle biopsies of patients were analyzed for atrophy and regeneration by measuring fiber size and by performing immunostaining of neonatal myosin heavy chain. To further understand the role of the Abs in the pathology, we performed muscle cell coculture ...
Source: Annals of Neurology - April 22, 2017 Category: Neurology Authors: Louiza Arouche ‐Delaperche, Yves Allenbach, Damien Amelin, Corinna Preusse, Vincent Mouly, Wladimir Mauhin, Gaelle Dzangue Tchoupou, Laurent Drouot, Olivier Boyer, Werner Stenzel, Gillian Butler‐Browne, Olivier Benveniste Tags: Research Article Source Type: research

Severe Primary Autoimmune Thrombocytopenia (ITP) in Pregnancy: a National Cohort Study
ConclusionsCurrent UK management of severe ITP in pregnancy results in an exceptionally low morbidity and mortality for the neonate. Mothers with ITP remain at increased risk of severe post‐partum haemorrhage and should be delivered at units that have the capacity to manage severe PPH effectively. Whilst balancing risks for pregnancy of prophylactic antenatal treatment in asymptomatic women against observed low disease morbidity, we may be over treating asymptomatic patients.This article is protected by copyright. All rights reserved. (Source: BJOG: An International Journal of Obstetrics and Gynaecology)
Source: BJOG: An International Journal of Obstetrics and Gynaecology - April 22, 2017 Category: OBGYN Authors: A Care, S Pavord, M Knight, Z Alfirevic Tags: Main Research Article Source Type: research

Autoimmune hepatitis: from current knowledge and clinical practice to future research agenda
This article is protected by copyright. All rights reserved. (Source: Liver International)
Source: Liver International - April 22, 2017 Category: Gastroenterology Authors: Marcial Sebode, Johannes Hartl, Diego Vergani, Ansgar W Lohse, Tags: Review Source Type: research

Serum soluble ST2 is a promising prognostic biomarker in HBV-related acute-on-chronic liver failure
Conclusion Serum sST2 may act as a promising biomarker to assess severity and predict prognosis of patients with HBV-ACLF and help for the early identification and optimal treatment of HBV-ACLF patients at high risk of mortality. (Source: Hepatobiliary and Pancreatic Diseases International)
Source: Hepatobiliary and Pancreatic Diseases International - April 22, 2017 Category: Gastroenterology Source Type: research

Serum levels and tissue expression of interleukin-31 in dermatitis herpetiformis and bullous pemphigoid
Pruritus is one of the main symptoms in various skin diseases and even an important skin manifestation of systemic dermatoses [1]. Among autoimmune bullous disorders, it is well known that dermatitis herpetiformis (DH) and bullous pemphigoid (BP) are especially itchy. There has been only a study on the pruritic condition of these diseases, in which the role of neuropeptides was investigated in the pathogenesis of DH and BP. The authors found the increased expression of corticotropin releasing factor in both DH and BP, along with the increased expression of endothelin B receptor in DH [2]. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - April 22, 2017 Category: Dermatology Authors: Diletta Bonciani, Lavinia Quintarelli, Elena Del Bianco, Beatrice Bianchi, Marzia Caproni Tags: Letter to the Editor Source Type: research

Use of low dose naltrexone and change in use of prescription drugs in patients with inflammatory bowel disease – A drug utilization cohort study based on the Norwegian prescription register
Introduction: Naltrexone is a non-selective opioid antagonist traditionally used to treat opioid and alcohol addiction. Low Dose Naltrexone (LDN), 3-5 mg/day, has gained popularity as an off-label adjunctive therapy for several autoimmune diseases, including inflammatory bowel disease (IBD). Studies have shown improved quality of life, reduced area of inflamed intestine, reduced C-reactive protein and lower Crohn ’s Disease Activity Index. (Source: Research in Social and Administrative Pharmacy)
Source: Research in Social and Administrative Pharmacy - April 21, 2017 Category: Pharmaceuticals Authors: Pia Simonsen, Lars Sm åbrekke, Guttorm Raknes Source Type: research

Genes, Vol. 8, Pages 126: Functional Analysis of the rs774872314, rs116171003, rs200231898 and rs201107751 Polymorphisms in the Human RORγT Gene Promoter Region
In this study, we functionally examined four naturally occurring polymorphisms located within one of the previously identified GC-boxes in the promoter region of the gene. The single nucleotide polymorphisms (SNPs) rs774872314, rs116171003 and rs201107751 negatively influe nced the activity of the RORγT promoter in a gene reporter system and eliminated or reduced Sp1 and Sp2 transcription factor binding, as evidenced by the electrophoretic mobility shift assay (EMSA) technique. Furthermore, we investigated the frequency of these SNPs in the Polish population and obse rved the presence of rs116171003 at a frequency of 3.42...
Source: Genes - April 21, 2017 Category: Genetics & Stem Cells Authors: Marcin Ratajewski Marcin S łomka Kaja Kara ś Marta Sobalska-Kwapis Ma łgorzata Korycka-Machała Anna Sa łkowska Jaros ław Dziadek Dominik Strapagiel Jaros ław Dastych Tags: Brief Report Source Type: research

A trimeric structural fusion of an antagonistic tumor necrosis factor-{alpha} mutant enhances molecular stability and enables facile modification [Protein Structure and Folding]
Tumor necrosis factor-α (TNF) exerts its biological effect through two types of receptors, p55 TNF receptor (TNFR1) and p75 TNF receptor (TNFR2). An inflammatory response is known to be induced mainly by TNFR1, whereas an anti-inflammatory reaction is thought to be mediated by TNFR2 in some autoimmune diseases. We have been investigating the use of an antagonistic TNF mutant (TNFR1-selective antagonistic TNF mutant (R1antTNF)) to reveal the pharmacological effect of TNFR1-selective inhibition as a new therapeutic modality. Here, we aimed to further improve and optimize the activity and behavior of this mutant protein both...
Source: Journal of Biological Chemistry - April 21, 2017 Category: Chemistry Authors: Masaki Inoue, Daisuke Ando, Haruhiko Kamada, Shintaro Taki, Mayumi Niiyama, Yohei Mukai, Takashi Tadokoro, Katsumi Maenaka, Taisuke Nakayama, Yuji Kado, Tsuyoshi Inoue, Yasuo Tsutsumi, Shin-ichi Tsunoda Tags: Methods and Resources Source Type: research