Human umbilical cord mesenchymal stem cell-derived exosomes alleviate the severity of experimental autoimmune encephalomyelitis and enhance lag-3 expression on foxp3 + CD4 + T cells
CONCLUSIONS: These results suggest that hUMSCs-Exs could be a promising anti-inflammatory agent to regulate T-cell responses in EAE and other autoimmune diseases. However, further research is necessary to fully understand the underlying mechanisms and Lag-3's precise role in these conditions.PMID:38627337 | DOI:10.1007/s11033-024-09433-5 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 16, 2024 Category: Molecular Biology Authors: Adel Mohammadzadeh Masoud Lahouty Hamed Charkhian Arash Adamnejad Ghafour Sahand Moazzendizaji Jafar Rezaei Shahriar Alipour Vahid Shafiei Irannejad Mohammad Hassan Khadem Ansari Source Type: research
Patients with autoimmune liver disease have glucose disturbances that mechanistically differ from steatotic liver disease
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 16. doi: 10.1152/ajpgi.00047.2024. Online ahead of print.ABSTRACTAutoimmune liver diseases are associated with an increased risk of diabetes, yet the underlying mechanisms remain unknown. In this cross-sectional study, we investigated the glucose-regulatory disturbances in patients with autoimmune hepatitis (AIH, n=19), primary biliary cholangitis (PBC, n=15), and primary sclerosing cholangitis (PSC, n=6). Healthy individuals (n=24) and patients with metabolic dysfunction-associated steatotic liver disease (MASLD, n=18) were included as controls. Blood samples were collecte...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - April 16, 2024 Category: Physiology Authors: Anne-Sofie H Jensen Henriette Ytting Mikkel P Werge Elias B Rashu Liv E Hetland Mira Thing Puria Nabilou Johan Burisch Kirstine N Bojsen-M øller Anders E Junker Lise Hobolth Christian Mortensen Flemming Tofteng Flemming Bendtsen S øren Møller Mogens Vy Source Type: research
Monoallelic KRAS (G13C) mutation triggers dysregulated expansion in induced pluripotent stem cell-derived hematopoietic progenitor cells
CONCLUSIONS: Our findings indicate that a monoallelic oncogenic KRAS can confer dysregulated expansion characteristics to non-transformed HPCs, which may constitute a pathological condition in RALD hematopoiesis. The use of iPSC-based screening platforms will lead to discovering treatments that enable selective inhibition of RAS-mutated HPC clones.PMID:38627844 | DOI:10.1186/s13287-024-03723-2 (Source: Cell Research)
Source: Cell Research - April 16, 2024 Category: Cytology Authors: Huan-Ting Lin Masatoshi Takagi Kenji Kubara Kazuto Yamazaki Fumiko Michikawa Takashi Okumura Takuya Naruto Tomohiro Morio Koji Miyazaki Hideki Taniguchi Makoto Otsu Source Type: research
Neutrophil extracellular traps (NETs) and fibrotic diseases
Int Immunopharmacol. 2024 Apr 15;133:112085. doi: 10.1016/j.intimp.2024.112085. Online ahead of print.ABSTRACTFibrosis, a common cause and serious outcome of organ failure that can affect any organ, is responsible for up to 45% of all deaths in various clinical settings. Both preclinical models and clinical trials investigating various organ systems have shown that fibrosis is a highly dynamic process. Although many studies have sought to gain understanding of the mechanism of fibrosis progression, their findings have been mixed. In recent years, increasing evidence indicates that neutrophil extracellular traps (NETs) are ...
Source: International Immunopharmacology - April 16, 2024 Category: Allergy & Immunology Authors: Xiaojiao Wu Yang Yang Source Type: research
A review: Mechanisms and molecular pathways of signaling lymphocytic activation molecule family 3 (SLAMF3) in immune modulation and therapeutic prospects
Int Immunopharmacol. 2024 Apr 15;133:112088. doi: 10.1016/j.intimp.2024.112088. Online ahead of print.ABSTRACTThe signaling lymphocytic activation molecule (SLAM) family participates in the modulation of various innate and adaptive immune responses. SLAM family (SLAMF) receptors include nine transmembrane glycoproteins, of which SLAMF3 (also known as CD229 or Ly9) has important roles in the modulation of immune responses, from the fundamental activation and suppression of immune cells to the regulation of intricate immune networks. SLAMF3 is mainly expressed in immune cells, such as T, B, and natural killer cells. It has a...
Source: International Immunopharmacology - April 16, 2024 Category: Allergy & Immunology Authors: Tong Zhou Yanjie Guan Lin Sun Wentao Liu Source Type: research
Activation of the IL-6/STAT3 pathway contributes to the pathogenesis of membranous nephropathy and is a target for Mahuang Fuzi and Shenzhuo Decoction (MFSD) to repair podocyte damage
CONCLUSION: The IL-6/STAT3 signaling pathway is activated in podocytes of experimental membranous nephropathy. MFSD alleviates podocyte damage by inhibiting the IL-6/STAT3 pathway.PMID:38626520 | DOI:10.1016/j.biopha.2024.116583 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 16, 2024 Category: Drugs & Pharmacology Authors: Qihan Zhao Haoran Dai Hanxue Jiang Naiqian Zhang Fanyu Hou Yang Zheng Yu Gao Wenbin Liu Zhendong Feng Yuehong Hu Xinyue Tang Hongliang Rui Baoli Liu Source Type: research
The immunoregulatory effects of total glucosides of paeony in autoimmune diseases
J Leukoc Biol. 2024 Apr 16:qiae095. doi: 10.1093/jleuko/qiae095. Online ahead of print.ABSTRACTTotal glucoside of paeonia (TGP) and its main active ingredient paeoniflorin, extracted from the Chinese herb Paeonia Lactiflora Pallas, exhibit potent immunomodulatory effects. TGP has been shown to inhibit inflammatory responses and disease progression in experimental models of multiple autoimmune diseases (AIDs), including rheumatoid arthritis, systemic lupus erythematosus, Sjogren's syndrome, psoriasis, etc. TGP shows broad immunomodulatory effects on many immune cells such as T cells, macrophages, and dendritic cells, by reg...
Source: Journal of Leukocyte Biology - April 16, 2024 Category: Hematology Authors: Mengna Zhao Na Peng Yingbo Zhou Yuan Qu Meng Cao Qinghua Zou Qinghong Yu Liwei Lu Fan Xiao Source Type: research
Patients with autoimmune liver disease have glucose disturbances that mechanistically differ from steatotic liver disease
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 16. doi: 10.1152/ajpgi.00047.2024. Online ahead of print.ABSTRACTAutoimmune liver diseases are associated with an increased risk of diabetes, yet the underlying mechanisms remain unknown. In this cross-sectional study, we investigated the glucose-regulatory disturbances in patients with autoimmune hepatitis (AIH, n=19), primary biliary cholangitis (PBC, n=15), and primary sclerosing cholangitis (PSC, n=6). Healthy individuals (n=24) and patients with metabolic dysfunction-associated steatotic liver disease (MASLD, n=18) were included as controls. Blood samples were collecte...
Source: Am J Physiol Gastroi... - April 16, 2024 Category: Gastroenterology Authors: Anne-Sofie H Jensen Henriette Ytting Mikkel P Werge Elias B Rashu Liv E Hetland Mira Thing Puria Nabilou Johan Burisch Kirstine N Bojsen-M øller Anders E Junker Lise Hobolth Christian Mortensen Flemming Tofteng Flemming Bendtsen S øren Møller Mogens Vy Source Type: research
Patients with autoimmune liver disease have glucose disturbances that mechanistically differ from steatotic liver disease
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 16. doi: 10.1152/ajpgi.00047.2024. Online ahead of print.ABSTRACTAutoimmune liver diseases are associated with an increased risk of diabetes, yet the underlying mechanisms remain unknown. In this cross-sectional study, we investigated the glucose-regulatory disturbances in patients with autoimmune hepatitis (AIH, n=19), primary biliary cholangitis (PBC, n=15), and primary sclerosing cholangitis (PSC, n=6). Healthy individuals (n=24) and patients with metabolic dysfunction-associated steatotic liver disease (MASLD, n=18) were included as controls. Blood samples were collecte...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - April 16, 2024 Category: Physiology Authors: Anne-Sofie H Jensen Henriette Ytting Mikkel P Werge Elias B Rashu Liv E Hetland Mira Thing Puria Nabilou Johan Burisch Kirstine N Bojsen-M øller Anders E Junker Lise Hobolth Christian Mortensen Flemming Tofteng Flemming Bendtsen S øren Møller Mogens Vy Source Type: research
Patients with autoimmune liver disease have glucose disturbances that mechanistically differ from steatotic liver disease
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 16. doi: 10.1152/ajpgi.00047.2024. Online ahead of print.ABSTRACTAutoimmune liver diseases are associated with an increased risk of diabetes, yet the underlying mechanisms remain unknown. In this cross-sectional study, we investigated the glucose-regulatory disturbances in patients with autoimmune hepatitis (AIH, n=19), primary biliary cholangitis (PBC, n=15), and primary sclerosing cholangitis (PSC, n=6). Healthy individuals (n=24) and patients with metabolic dysfunction-associated steatotic liver disease (MASLD, n=18) were included as controls. Blood samples were collecte...
Source: Am J Physiol Gastroi... - April 16, 2024 Category: Gastroenterology Authors: Anne-Sofie H Jensen Henriette Ytting Mikkel P Werge Elias B Rashu Liv E Hetland Mira Thing Puria Nabilou Johan Burisch Kirstine N Bojsen-M øller Anders E Junker Lise Hobolth Christian Mortensen Flemming Tofteng Flemming Bendtsen S øren Møller Mogens Vy Source Type: research
The unique interplay between antinuclear antibodies and nuclear molecules in the pathogenesis of SLE
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease that primarily affects young women and causes a wide range of inflammatory manifestations. The hallmark of SLE is the production of antibodies to components of the cell nucleus (antinuclear antibodies or ANAs). These antibodies can bind to DNA, RNA and protein complexes with nucleic acids. Among ANAs, antibodies to DNA (anti-DNA) are markers for classification and disease activity, waxing and waning in many patients. In the blood, anti-DNA antibodies can bind DNA to form immune complexes with two distinct roles in pathogenesis: renal deposition to provok...
Source: Arthritis and Rheumatology - April 16, 2024 Category: Rheumatology Authors: David S. Pisetsky Tags: Review Source Type: research
The Epidemiology of Hospital-Treated Alopecia Areata in Denmark, 1995 –2016
ConclusionThis cohort study reported incidence rates and prevalence over time and characteristics of individuals with hospital-treated AA in Denmark, which are in agreement with those previously reported in this population. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - April 16, 2024 Category: Dermatology Source Type: research
Molecules, Vol. 29, Pages 1803: A Novel IRAK4 Inhibitor DW18134 Ameliorates Peritonitis and Inflammatory Bowel Disease
In conclusion, our findings reported a novel IRAK4 inhibitor, DW18134, as a promising candidate for treating inflammatory diseases, including peritonitis and IBD. (Source: Molecules)
Source: Molecules - April 16, 2024 Category: Chemistry Authors: Yuqing Huang Yi Ning Zhiwei Chen Peiran Song Haotian Tang Wenhao Shi Zhipeng Wan Gege Huang Qiupei Liu Yun Chen Yu Zhou Yuantong Li Zhengsheng Zhan Jian Ding Wenhu Duan Hua Xie Tags: Article Source Type: research
Quantitative measurements of M2BPGi depend on liver fibrosis and inflammation
ConclusionsThe quantitative measurement system for M2BPGi depends on liver fibrosis and inflammation, regardless of etiology. Liver inflammation complicates the interpretation of M2BPGi-Qt results when assessing the fibrosis stage. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - April 16, 2024 Category: Gastroenterology Source Type: research
