Temporal trends in the clinical presentation of Graves ’ orbitopathy: a single–center retrospective study
ConclusionsWe found that GO severity at presentation was significantly reduced over a ten-year observation period (2005 –2006 vs. 2015–2016) in GO patients referred to our tertiary thyroid centre. TGOD ≥ 3 months was an independent predictor of GO severity. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 15, 2024 Category: Endocrinology Source Type: research

Advances in Skin-on-a-Chip Technologies for Dermatological Disease Modeling
Skin-on-a-chip (SoC) technologies are emerging as a paradigm shift in dermatology research by replicating human physiology in a dynamic manner not achievable by current animal models. Although animal models have contributed to successful clinical trials, their ability to predict human outcomes remains questionable, owing to inherent differences in skin anatomy and immune response. Covering areas including infectious diseases, autoimmune skin conditions, wound healing, drug toxicity, aging, and antiaging, SoC aims to circumvent the inherent disparities created by traditional models. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - March 15, 2024 Category: Dermatology Authors: Seo Won Cho, Hamza Malick, Soo Jung Kim, Alessandro Grattoni Tags: Review Source Type: research

National Survey of FACT-Accredited Cell Processing Facilities: Assessing Preparedness for Local Manufacturing of Immune Effector Cells
Immune effector cells (IECs) offer a new approach to address unmet medical needs, including malignancies, autoimmune diseases, and opportunistic infections.1,2 This family of biologics, also known as cellular immunotherapies, includes chimeric antigen receptor (CAR) T cells, tumor-infiltrating lymphocytes (TILs), and genetically modified T cell receptors (TCRs).3 Currently, six CAR T products have been approved by the U.S. Food and Drug Administration (FDA) for various hematological malignancies. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - March 15, 2024 Category: Hematology Authors: Magdi Elsallab, Florence Bourgeois, Marcela V. Maus Source Type: research

SHR0302 Improves Treg/Th17 Imbalance in Patients with Systemic Lupus Erythematosus
AbstractIL-6-mediated JAK1/STAT3 signaling pathway is involved in the development of Th17 cells, which play an essential role in the pathogenesis of various autoimmune diseases such as systemic lupus erythematosus (SLE). To evaluation of the regulatory and anti-inflammatory effects of the JAK1/STAT3 inhibition in SLE, we evaluated the effects of SHR0302 on regulatory T cell (Treg)/Th17 balance. Thirty-two patients with SLE and twenty-nine healthy subjects were enrolled in this study. The mRNA expression levels of anti- and pro-inflammatory cytokines, such as FOXP3, ROR- γt, IL-10, IL-17A, IL-21, and IRF-4, were determined...
Source: Indian Journal of Clinical Biochemistry - March 15, 2024 Category: Biochemistry Source Type: research

Temporal trends in the clinical presentation of Graves ’ orbitopathy: a single–center retrospective study
ConclusionsWe found that GO severity at presentation was significantly reduced over a ten-year observation period (2005 –2006 vs. 2015–2016) in GO patients referred to our tertiary thyroid centre. TGOD ≥ 3 months was an independent predictor of GO severity. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 15, 2024 Category: Endocrinology Source Type: research