Cisd2 deficiency impairs neutrophil function by regulating calcium homeostasis via Calnexin and SERCA
BMB Rep. 2024 Apr 17:6179. Online ahead of print.ABSTRACTIn the context of aging, the susceptibility to infectious diseases increases, leading to heightened morbidity and mortality. This phenomenon, termed immunosenescence, is characterized by dysregulation in the aging immune system, including abnormal alterations in lymphocyte composition, elevated basal inflammation, and the accumulation of senescent T cells. Such changes contribute to increased autoimmune diseases, enhanced infection severity, and reduced responsiveness to vaccines. Utilizing aging animal models becomes imperative for a comprehensive understanding of i...
Source: BMB Reports - April 17, 2024 Category: Biochemistry Authors: Un Yung Choi Youn Jung Choi Shin-Ae Lee Ji-Seung Yoo Source Type: research
When DNA-damage responses meet innate and adaptive immunity
This study examines the most recent developments in the interaction between DDR elements and immunological responses. The DDR network's immune modulators' dual roles may offer new perspectives on treating infectious disorders linked to DNA damage, including cancer, and on the development of target immunotherapy.PMID:38630271 | DOI:10.1007/s00018-024-05214-2 (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - April 17, 2024 Category: Cytology Authors: Jie Tong Jiangwei Song Wuchao Zhang Jingbo Zhai Qingli Guan Huiqing Wang Gentao Liu Chunfu Zheng Source Type: research
Extranodal Rosai-Dorfman disease manifesting as Sj ögren's syndrome combined with panuveitis and hypertrophic pachymeningitis: a case report and review of literature
We present the case of a 28-year-old woman who presented with recurrent blurred vision in her right eye for 3 months. She developed blindness and atrophy in her left eye a decade prior to presentation. She subsequently developed headache, fever, and impaired mental status. Cranial magnetic resonance imaging indicated hypertrophic pachymeningitis (HP), and 18F-fluoro-2-deoxy-2-d-glucose (FDG) positron emission tomography/computed tomography revealed significant FDG uptake in the left dura mater. Autoimmune testing revealed elevated anti-nuclear, anti-SS-A, and anti-SS-B antibody levels. Incisional biopsy of the atrophic eye...
Source: Cell Research - April 17, 2024 Category: Cytology Authors: Jing Xu Meihua Huang Binsong Dong Min Jian Jinyu Chen Naiyuan Zhang Chunlian Ou Yongming Wu Dongmei Wang Source Type: research
Angiogenesis-related immune response may be the prelude to the syndesmophyte formation in Ankylosing spondylitis
CONCLUSIONS: We explored the intimate relationship between local inflammation and bone formation in AS from the perspective of nascent vascularisation. Hence, our study lays the foundation for elucidating a unified AS pathogenesis through the immune-angiogenesis-osteogenesis axis.PMID:38631220 | DOI:10.1016/j.intimp.2024.112040 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 17, 2024 Category: Allergy & Immunology Authors: Chunmei Cai Yuye Huang Liyan Li Kai Kei Miu Zhangting Wang Yujie Deng Yanzhen Cai Jinxiu Li Liang Wu Hepeng Zhu Yang Gao Jun Chen Wende Xiao Li Lu Source Type: research
Single-cell sequencing reveals distinct immune cell features in cutaneous lesions of pemphigus vulgaris and bullous pemphigoid
Clin Immunol. 2024 Apr 15:110219. doi: 10.1016/j.clim.2024.110219. Online ahead of print.ABSTRACTBullous pemphigoid (BP) and pemphigus vulgaris (PV) are two common subtypes of autoimmune bullous disease (AIBD). The key role of circulating autoreactive immune cells contributing to skin damage of AIBD has been widely recognized. Nevertheless, the immune characteristics in cutaneous lesions remain unclear. Here, we performed single-cell RNA sequencing (scRNA-seq) and single-cell VDJ sequencing (scRNA-seq) to generate transcriptional profiles for cells and T/B cell clonetype in skin lesions of BP and PV. We found that the prop...
Source: Clinical Immunology - April 17, 2024 Category: Allergy & Immunology Authors: Zhi Hu Meiling Zheng Ziyu Guo Wenhui Zhou Wenyu Zhou Nan Yao Guiying Zhang Qianjin Lu Ming Zhao Source Type: research
Immune checkpoint inhibitors in Cancer patients with rheumatologic preexisting autoimmune diseases: a systematic review and meta-analysis
CONCLUSIONS: Patients with rheumatologic PAD, particularly those with RA, are susceptible to relapse of their rheumatologic disease following ICI therapy. ICIs are also effective for treating rheumatologic PAD patients. PROSPECTIVE REGISTER OF SYSTEMATIC REVIEWS (PROSPERO): number CRD 42,023,439,702.PMID:38632528 | DOI:10.1186/s12885-024-12256-z (Source: Cancer Control)
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Xin Liu Su Li Liyuan Ke Hongxia Cui Source Type: research
Tissue-resident memory T cells: decoding intra-organ diversity with a gut perspective
Inflamm Regen. 2024 Apr 17;44(1):19. doi: 10.1186/s41232-024-00333-6.ABSTRACTTissue-resident memory T cells (TRM) serve as the frontline of host defense, playing a critical role in protection against invading pathogens. This emphasizes their role in providing rapid on-site immune responses across various organs. The physiological significance of TRM is not just confined to infection control; accumulating evidence has revealed that TRM also determine the pathology of diseases such as autoimmune disorders, inflammatory bowel disease, and cancer. Intensive studies on the origin, mechanisms of formation and maintenance, and ph...
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Mari Murakami Source Type: research
When DNA-damage responses meet innate and adaptive immunity
This study examines the most recent developments in the interaction between DDR elements and immunological responses. The DDR network's immune modulators' dual roles may offer new perspectives on treating infectious disorders linked to DNA damage, including cancer, and on the development of target immunotherapy.PMID:38630271 | DOI:10.1007/s00018-024-05214-2 (Source: Cancer Control)
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Jie Tong Jiangwei Song Wuchao Zhang Jingbo Zhai Qingli Guan Huiqing Wang Gentao Liu Chunfu Zheng Source Type: research
Induced Regulatory T Cells as Immunotherapy in Allotransplantation and Autoimmunity: Challenges and Opportunities
J Leukoc Biol. 2024 Apr 17:qiae062. doi: 10.1093/jleuko/qiae062. Online ahead of print.ABSTRACTRegulatory T cells (Tregs) play a crucial role in the homeostasis of the immune response. Tregs are mainly generated in the thymus and are characterized by the expression of Foxp3, which is considered the Treg master transcription factor. In addition, Tregs can be induced from naïve CD4+ T cells to express Foxp3 under specific conditions both in vivo (pTregs) and in vitro (iTregs). Both subsets tTregs and pTregs are necessary for the establishment of immune tolerance to self and non-self antigens. Although it has been postulated...
Source: Journal of Leukocyte Biology - April 17, 2024 Category: Hematology Authors: Evelyn Katy Alvarez-Salazar Arimelek Cort és-Hernández Sa úl Arteaga-Cruz Gloria Soldevila Source Type: research
Population Pharmacokinetics of Adalimumab in Juvenile Idiopathic Arthritis Patients: A Retrospective Cohort Study Using Clinical Care Data
CONCLUSIONS: Five literature models effectively described adalimumab PK in this pediatric cohort, highlighting the potential for extrapolating existing models to the pediatric population. The new JIA model confirmed the effect of several known covariates and found a novel association for drug clearance with methotrexate use (lower) and uveitis (higher), which might have clinical relevance for personalized dosing in JIA.PMID:38630199 | DOI:10.1007/s40272-024-00629-7 (Source: Paediatric Drugs)
Source: Paediatric Drugs - April 17, 2024 Category: Pediatrics Authors: Amara Nassar-Sheikh Rashid Femke Hooijberg Sandy C Bergkamp Mariken P Gruppen Taco W Kuijpers Mike Nurmohamed Theo Rispens Gertjan Wolbink J Merlijn van den Berg Dieneke Schonenberg-Meinema Ron A A Math ôt Source Type: research
ALECT2 amyloidosis with concurrent IgG4-related interstitial nephritis, membranous nephropathy and diabetic kidney disease: a case report and literature review
J Nephrol. 2024 Apr 17. doi: 10.1007/s40620-024-01924-9. Online ahead of print.ABSTRACTLeukocyte chemotactic factor-2 amyloidosis (ALECT2) is a recently described subtype of amyloidosis. IgG4-related disease is a rare fibroinflammatory condition characterized by dense interstitial lymphoplasmacytic infiltrates and fibrosis. Membranous nephropathy and diabetic nephropathy are common causes of nephrotic syndrome. Here we report a 49-year-old Hispanic male patient with diabetes mellitus who presented with jaundice and pruritus. IgG4-related autoimmune pancreatitis was diagnosed through laboratory workup and ampulla biopsy. He...
Source: Journal of Nephrology - April 17, 2024 Category: Urology & Nephrology Authors: Muhammad Shaheen Anchit Bharat Allon N Friedman Shunhua Guo Source Type: research
Diagnostic Approach to Interstitial Lung Diseases Associated with Connective Tissue Diseases
Semin Respir Crit Care Med. 2024 Apr 17. doi: 10.1055/s-0044-1785674. Online ahead of print.ABSTRACTInterstitial lung disorders are a group of respiratory diseases characterized by interstitial compartment infiltration, varying degrees of infiltration, and fibrosis, with or without small airway involvement. Although some are idiopathic (e.g., idiopathic pulmonary fibrosis, idiopathic interstitial pneumonias, and sarcoidosis), the great majority have an underlying etiology, such as systemic autoimmune rheumatic disease (SARD, also called Connective Tissue Diseases or CTD), inhalational exposure to organic matter, medication...
Source: Respiratory Care - April 17, 2024 Category: Respiratory Medicine Authors: Ana C Zamora Lewis J Wesselius Michael B Gotway Henry D Tazelaar Alejandro Diaz-Arumir Vivek Nagaraja Source Type: research
Acute onset of constrictive pericarditis due to acute myelomonocytic leukemia: A case and literature review
Intern Med. 2024 Apr 16. doi: 10.2169/internalmedicine.3505-24. Online ahead of print.ABSTRACTWe herein present a fatal case of constrictive pericarditis (CP) due to acute myelomonocytic leukemia (AMML) in a patient who initially complained of an acute onset of chest pain two days after COVID-19 vaccination. An autopsy revealed pericardial infiltration of leukemic cells. CP is rarely associated with leukemia and only 14 cases have been reported in the literature. The etiology of CP in previous reports included leukemic infiltration, graft-versus-host disease, drug-induced, post-radiation, autoimmune, and otherwise unidenti...
Source: Internal Medicine - April 17, 2024 Category: Internal Medicine Authors: Naoki Kosaka Takanori Uchiyama Masahiro Onozawa Jun Nagai Jiro Koya Suguru Ishizaka Toshiyuki Nagai Yohei Ikebe Kenjiro Kato Zen-Ichi Tanei Jun Sakakibara-Konishi Yuta Hasegawa Hiroyuki Ohigashi Hideki Goto Daigo Hashimoto Hideki Ujiie Satoshi Hirano Sato Source Type: research
Construction of ceRNA network mediated by circRNAs screening from microarray and identification of novel biomarkers for myasthenia gravis
CONCLUSIONS: We found that circFRMD4, circPIGB and circNUP214 can be considered as valuable potential novel biomarkers for AchR + MG. CircFRMD4 participate in the development of AchR + MG via targeting binding with miR-145-5p.PMID:38631652 | DOI:10.1016/j.gene.2024.148463 (Source: Gene)
Source: Gene - April 17, 2024 Category: Genetics & Stem Cells Authors: Xiaotong Kong Tao Wu Hanlu Cai Zhimin Chen Yu Wang Ping He Peifang Liu Lei Li Shanshan Peng Fanfan Xu Jianjian Wang Huixue Zhang Lihua Wang Source Type: research
Cisd2 deficiency impairs neutrophil function by regulating calcium homeostasis via Calnexin and SERCA
BMB Rep. 2024 Apr 17:6179. Online ahead of print.ABSTRACTIn the context of aging, the susceptibility to infectious diseases increases, leading to heightened morbidity and mortality. This phenomenon, termed immunosenescence, is characterized by dysregulation in the aging immune system, including abnormal alterations in lymphocyte composition, elevated basal inflammation, and the accumulation of senescent T cells. Such changes contribute to increased autoimmune diseases, enhanced infection severity, and reduced responsiveness to vaccines. Utilizing aging animal models becomes imperative for a comprehensive understanding of i...
Source: BMB Reports - April 17, 2024 Category: Biochemistry Authors: Un Yung Choi Youn Jung Choi Shin-Ae Lee Ji-Seung Yoo Source Type: research
