GSE171757 Effect of Epstein-Barr Virus DNA on the Transcriptional Profile of BALB/c Mouse Peripheral Blood Mononuclear Cells
Contributors : Marwa Shehab ; Hadi Hussein ; Elias A RahalSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo examine the effect of DNA from the Epstein-Barr Virus (EBV) on the transcriptional profile of mouse peripheral blood mononuclear cells (PBMCs), BALB/c mouse cells were isolated and cultured in the presence or absence of EBV DNA. RNA was extracted from these cells and then subjected to sequencing. We observed significantly enhanced expression of genes that play roles in proinflammatory processes including ones involved in autoimmune diseases such as rheumatoid arthritis. (Sour...
Source: GEO: Gene Expression Omnibus - April 9, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Methotrexate and the Risk of Dementia: A Two-Sample Mendelian Randomization Study
ConclusionThe findings of this mendelian randomization (MR) study suggest a potential causal effect of methotrexate use on the risk of dementia. However, further research is needed to validate these findings and explore the underlying mechanisms. Since methotrexate is widely prescribed for various autoimmune diseases, a better understanding of its potential impact on dementia risk is crucial for optimizing treatment strategies and addressing potential adverse effects. (Source: Neurology and Therapy)
Source: Neurology and Therapy - April 9, 2024 Category: Neurology Source Type: research
The impact of the COVID-19 pandemic on the mental health of patients diagnosed with inflammatory bowel diseases
In conclusion, the emergence of a novel viral pathogen represents a significant distress factor for patients with autoimmune diseases. Recognizing and comprehending these consequences enhances our understanding of the intricate interplay between physical and mental health and equips authorities with valuable insights to better manage future epidemics or viral outbreaks. This study underscores the importance of tailored support systems and strategies for patients with autoimmune diseases during global health crises.PMID:38585531 | PMC:PMC10994603 | DOI:10.25122/jml-2023-0475 (Source: Journal of Medicine and Life)
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Oliviu-Florentiu Sarb Vitalie Vacaras Vladimir-Petru Filip Adriana-Daniela Sarb Roxana-Delia Zaharie Nicu Draghici Dafin-Fior Muresanu Alina-Ioana Tantau Source Type: research
Current and emerging pharmacotherapies for cytokine release syndrome, neurotoxicity, and hemophagocytic lymphohistiocytosis-like syndrome due to CAR T cell therapy
Expert Opin Pharmacother. 2024 Apr 8. doi: 10.1080/14656566.2024.2340738. Online ahead of print.ABSTRACTINTRODUCTION: Chimeric antigen receptor (CAR) T cells have revolutionized treatment of multiple hematologic malignancies. Engineered cellular therapies now offer similar hope to transform management of solid tumors and autoimmune disease. However, toxicities can be serious and often require hospitalization.AREAS COVERED: We review the two chief toxicities of CAR T therapy, cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS), and the rarer immune effector cell-associated hemo...
Source: Expert Opinion on Pharmacotherapy - April 8, 2024 Category: Drugs & Pharmacology Authors: Zandra E Walton Matthew J Frigault Marcela V Maus Source Type: research
Exploration of the molecular mechanism guiding Xinfeng capsule regulatory mechanism for rheumatoid arthritis inflammation
CONCLUSIONS: XFC could effectively improve the clinical inflammatory indexes of RA. The active ingredients of XFC improved the inflammatory state of RA by regulating the TLR-signaling pathway.PMID:38586085 | PMC:PMC10994809 | DOI:10.62347/TPOQ4910 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 8, 2024 Category: Research Authors: Ziheng Zhu Lei Wan Source Type: research
Delivery technologies for therapeutic targeting of fibronectin fibrosis in autoimmunity and applications
Adv Drug Deliv Rev. 2024 Apr 6:115303. doi: 10.1016/j.addr.2024.115303. Online ahead of print.ABSTRACTFibronectin (FN) is a critical component of extracellular matrix (ECM) contributing to various physiological processes, including tissue repair and immune response regulation. FN regulates various cellular functions such as adhesion, proliferation, migration, differentiation, and cytokine release. Alterations in FN expression, deposition, and molecular structure can profoundly impact its interaction with cells, growth factors, ECM components, and associated signaling pathways, thus influencing the progress of diseases such...
Source: Advanced Drug Delivery Reviews - April 8, 2024 Category: Drugs & Pharmacology Authors: Jacob D Bonadio Ghazal Bashiri Patrick Halligan Michael Kegel Fatima Ahmed Karin Wang Source Type: research
Toosendanin inhibits T-cell proliferation through the P38 MAPK signalling pathway
Eur J Pharmacol. 2024 Apr 6:176562. doi: 10.1016/j.ejphar.2024.176562. Online ahead of print.ABSTRACTIn recent years, immunosuppressants have shown significant success in the treatment of autoimmune diseases. Therefore, there is an urgent need to develop additional immunosuppressants that offer more options for patients. Toosendanin has been shown to have immunosuppressive activity in vitro as well as effects on autoimmune hepatitis (AIH) in vivo. Toosendanin did not induce apoptosis in activated T-cells but did affect the survival rate of naive T-cells. Toosendanin did not affect the expression of CD25 or secretion of IL-...
Source: European Journal of Pharmacology - April 8, 2024 Category: Drugs & Pharmacology Authors: Ting Zhang Xing-Yan Luo Lin Jing Chunfen Mo Huijie Guo Shuxia Yang Yantang Wang Ketian Zhao Yi Lai Yang Liu Source Type: research
The impact of the COVID-19 pandemic on the mental health of patients diagnosed with inflammatory bowel diseases
In conclusion, the emergence of a novel viral pathogen represents a significant distress factor for patients with autoimmune diseases. Recognizing and comprehending these consequences enhances our understanding of the intricate interplay between physical and mental health and equips authorities with valuable insights to better manage future epidemics or viral outbreaks. This study underscores the importance of tailored support systems and strategies for patients with autoimmune diseases during global health crises.PMID:38585531 | PMC:PMC10994603 | DOI:10.25122/jml-2023-0475 (Source: Journal of Medicine and Life)
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Oliviu-Florentiu Sarb Vitalie Vacaras Vladimir-Petru Filip Adriana-Daniela Sarb Roxana-Delia Zaharie Nicu Draghici Dafin-Fior Muresanu Alina-Ioana Tantau Source Type: research
Current and emerging pharmacotherapies for cytokine release syndrome, neurotoxicity, and hemophagocytic lymphohistiocytosis-like syndrome due to CAR T cell therapy
Expert Opin Pharmacother. 2024 Apr 8. doi: 10.1080/14656566.2024.2340738. Online ahead of print.ABSTRACTINTRODUCTION: Chimeric antigen receptor (CAR) T cells have revolutionized treatment of multiple hematologic malignancies. Engineered cellular therapies now offer similar hope to transform management of solid tumors and autoimmune disease. However, toxicities can be serious and often require hospitalization.AREAS COVERED: We review the two chief toxicities of CAR T therapy, cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS), and the rarer immune effector cell-associated hemo...
Source: Expert Opinion on Pharmacotherapy - April 8, 2024 Category: Drugs & Pharmacology Authors: Zandra E Walton Matthew J Frigault Marcela V Maus Source Type: research
Exploration of the molecular mechanism guiding Xinfeng capsule regulatory mechanism for rheumatoid arthritis inflammation
CONCLUSIONS: XFC could effectively improve the clinical inflammatory indexes of RA. The active ingredients of XFC improved the inflammatory state of RA by regulating the TLR-signaling pathway.PMID:38586085 | PMC:PMC10994809 | DOI:10.62347/TPOQ4910 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 8, 2024 Category: Research Authors: Ziheng Zhu Lei Wan Source Type: research
Delivery technologies for therapeutic targeting of fibronectin fibrosis in autoimmunity and applications
Adv Drug Deliv Rev. 2024 Apr 6:115303. doi: 10.1016/j.addr.2024.115303. Online ahead of print.ABSTRACTFibronectin (FN) is a critical component of extracellular matrix (ECM) contributing to various physiological processes, including tissue repair and immune response regulation. FN regulates various cellular functions such as adhesion, proliferation, migration, differentiation, and cytokine release. Alterations in FN expression, deposition, and molecular structure can profoundly impact its interaction with cells, growth factors, ECM components, and associated signaling pathways, thus influencing the progress of diseases such...
Source: Advanced Drug Delivery Reviews - April 8, 2024 Category: Drugs & Pharmacology Authors: Jacob D Bonadio Ghazal Bashiri Patrick Halligan Michael Kegel Fatima Ahmed Karin Wang Source Type: research
Toosendanin inhibits T-cell proliferation through the P38 MAPK signalling pathway
Eur J Pharmacol. 2024 Apr 6:176562. doi: 10.1016/j.ejphar.2024.176562. Online ahead of print.ABSTRACTIn recent years, immunosuppressants have shown significant success in the treatment of autoimmune diseases. Therefore, there is an urgent need to develop additional immunosuppressants that offer more options for patients. Toosendanin has been shown to have immunosuppressive activity in vitro as well as effects on autoimmune hepatitis (AIH) in vivo. Toosendanin did not induce apoptosis in activated T-cells but did affect the survival rate of naive T-cells. Toosendanin did not affect the expression of CD25 or secretion of IL-...
Source: European Journal of Pharmacology - April 8, 2024 Category: Drugs & Pharmacology Authors: Ting Zhang Xing-Yan Luo Lin Jing Chunfen Mo Huijie Guo Shuxia Yang Yantang Wang Ketian Zhao Yi Lai Yang Liu Source Type: research
The impact of the COVID-19 pandemic on the mental health of patients diagnosed with inflammatory bowel diseases
In conclusion, the emergence of a novel viral pathogen represents a significant distress factor for patients with autoimmune diseases. Recognizing and comprehending these consequences enhances our understanding of the intricate interplay between physical and mental health and equips authorities with valuable insights to better manage future epidemics or viral outbreaks. This study underscores the importance of tailored support systems and strategies for patients with autoimmune diseases during global health crises.PMID:38585531 | PMC:PMC10994603 | DOI:10.25122/jml-2023-0475 (Source: Journal of Medicine and Life)
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Oliviu-Florentiu Sarb Vitalie Vacaras Vladimir-Petru Filip Adriana-Daniela Sarb Roxana-Delia Zaharie Nicu Draghici Dafin-Fior Muresanu Alina-Ioana Tantau Source Type: research
Exploration of the molecular mechanism guiding Xinfeng capsule regulatory mechanism for rheumatoid arthritis inflammation
CONCLUSIONS: XFC could effectively improve the clinical inflammatory indexes of RA. The active ingredients of XFC improved the inflammatory state of RA by regulating the TLR-signaling pathway.PMID:38586085 | PMC:PMC10994809 | DOI:10.62347/TPOQ4910 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 8, 2024 Category: Research Authors: Ziheng Zhu Lei Wan Source Type: research
The impact of the COVID-19 pandemic on the mental health of patients diagnosed with inflammatory bowel diseases
In conclusion, the emergence of a novel viral pathogen represents a significant distress factor for patients with autoimmune diseases. Recognizing and comprehending these consequences enhances our understanding of the intricate interplay between physical and mental health and equips authorities with valuable insights to better manage future epidemics or viral outbreaks. This study underscores the importance of tailored support systems and strategies for patients with autoimmune diseases during global health crises.PMID:38585531 | PMC:PMC10994603 | DOI:10.25122/jml-2023-0475 (Source: Journal of Medicine and Life)
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Oliviu-Florentiu Sarb Vitalie Vacaras Vladimir-Petru Filip Adriana-Daniela Sarb Roxana-Delia Zaharie Nicu Draghici Dafin-Fior Muresanu Alina-Ioana Tantau Source Type: research
