Multiparametric ultrasound as a new concept of assessment of liver tissue damage
World J Gastroenterol. 2024 Mar 28;30(12):1663-1669. doi: 10.3748/wjg.v30.i12.1663.ABSTRACTLiver disease accounts for approximately 2 million deaths per year worldwide. All chronic liver diseases (CLDs), whether of toxic, genetic, autoimmune, or infectious origin, undergo typical histological changes in the structure of the tissue. These changes may include the accumulation of extracellular matrix material, fats, triglycerides, or tissue scarring. Noninvasive methods for diagnosing CLD, such as conventional B-mode ultrasound (US), play a significant role in diagnosis. Doppler US, when coupled with B-mode US, can be helpful...
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Angela Peltec Ioan Sporea Source Type: research
Oncology: What You May Have Missed in 2023
This article highlights important publications from 2023 on topics across a wide spectrum relating to the management of oncology patients. The literature was screened for significant new evidence that is relevant to internal medicine specialists and subspecialists whose focus is not oncology. Two articles address the importance of social interventions targeting end-of-life care for low-income and minority patients and the well-being of caregivers. Two additional articles address screening considerations in patients at risk for colorectal and lung cancer. Two more articles address safe use of hormone-related therapies to tr...
Source: Annals of Internal Medicine - April 15, 2024 Category: Internal Medicine Authors: Courtney H Coschi Lorin Dodbiba DuPont Guerry Source Type: research
Multiparametric ultrasound as a new concept of assessment of liver tissue damage
World J Gastroenterol. 2024 Mar 28;30(12):1663-1669. doi: 10.3748/wjg.v30.i12.1663.ABSTRACTLiver disease accounts for approximately 2 million deaths per year worldwide. All chronic liver diseases (CLDs), whether of toxic, genetic, autoimmune, or infectious origin, undergo typical histological changes in the structure of the tissue. These changes may include the accumulation of extracellular matrix material, fats, triglycerides, or tissue scarring. Noninvasive methods for diagnosing CLD, such as conventional B-mode ultrasound (US), play a significant role in diagnosis. Doppler US, when coupled with B-mode US, can be helpful...
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Angela Peltec Ioan Sporea Source Type: research
Mendelian Causes of Autoimmunity: the Lupus Phenotype
AbstractSystemic lupus erythematosus (SLE) is a chronic autoimmune disease that is characterized by its large heterogeneity in terms of clinical presentation and severity. The pathophysiology of SLE involves an aberrant autoimmune response against various tissues, an excess of apoptotic bodies, and an overproduction of type-I interferon. The genetic contribution to the disease is supported by studies of monozygotic twins, familial clustering, and genome-wide association studies (GWAS) that have identified numerous riskloci. In the early 70s, complement deficiencies led to the description of familial forms of SLE caused by ...
Source: Journal of Clinical Immunology - April 15, 2024 Category: Allergy & Immunology Source Type: research
Monitoring the utilization and effectiveness of Iron and Vitamin D supplementations program and its predictive factors in high schools ’ girls in Qom, Iran
Conclusion:The inadequate and incomplete rate of IVDSP in Qom was high and more than 60% of distributed supplementations have been wasted. Our results showed that students who were participated in educational orientation classes were more successful and eager in iron and vitamin D3 consumption. Therefore, it is recommended to increase interventions at individual, interpersonal, intra-organizational and inter-organizational levels in order to fully support the program and ultimately increase the efficiency of the program. (Source: Journal of Preventive Medicine and Hygiene)
Source: Journal of Preventive Medicine and Hygiene - April 15, 2024 Category: International Medicine & Public Health Authors: Abolfazl Mohammadbeigi, Dr Source Type: research
Intrinsic ecto-5'-Nucleotidase/A1R Coupling may Confer Neuroprotection to the Cerebellum in Experimental Autoimmune Encephalomyelitis
AbstractExperimental autoimmune encephalomyelitis (EAE) is widely used animal model of multiple sclerosis (MS). The disease is characterized by demyelination and neurodegeneration triggered by infiltrated autoimmune cells and their interaction with astrocytes and microglia. While neuroinflammation is most common in the spinal cord and brainstem, it is less prevalent in the cerebellum, where it predisposes to rapid disease progression. Because the induction and progression of EAE are tightly regulated by adenosinergic signaling, in the present study we compared the adenosine-producing and -degrading enzymes, ecto-5'-nucleot...
Source: Molecular Neurobiology - April 15, 2024 Category: Neurology Source Type: research
Pulmonary Manifestations of Sj ögren's Disease
Semin Respir Crit Care Med DOI: 10.1055/s-0044-1785675Sjögren's disease (SjD) is a chronic, progressive autoimmune condition of exocrine and extraglandular tissues. It can present with isolated disease characterized by lymphocytic infiltration of salivary or lacrimal glands, but in approximately one-third of the patients, lymphocytic infiltration extends beyond exocrine glands to involve extraglandular organs such as the lungs. Pulmonary complications have been reported to occur between 9 and 27% of patients with SjD across studies. Respiratory manifestations occur on a spectrum of severity and include airways disease, in...
Source: Seminars in Respiratory and Critical Care Medicine - April 15, 2024 Category: Respiratory Medicine Authors: Byrne, Louise McCarthy, Cormac Fabre, Aurelie Gupta, Nishant Tags: Review Article Source Type: research
Shared genetic architecture between autoimmune disorders and B-cell acute lymphoblastic leukemia: insights from large-scale genome-wide cross-trait analysis
To study the shared genetic structure between autoimmune diseases and B-cell acute lymphoblastic leukemia (B-ALL) and identify the shared risk loci and genes and genetic mechanisms involved. (Source: BMC Medicine)
Source: BMC Medicine - April 15, 2024 Category: Internal Medicine Authors: Xinghao Yu, Yiyin Chen, Jia Chen, Yi Fan, Huimin Lu, Depei Wu and Yang Xu Tags: Research article Source Type: research
Ocular manifestations of liver disease: an important diagnostic aid
ConclusionsBuilding strong associations between ocular and liver pathology will allow for early detection of such conditions, leading to the early implementation of management strategies. While this review outlines several of the existing connections between hepatic and ophthalmic disease, further research is needed in the area in order to strengthen these associations. (Source: International Ophthalmology)
Source: International Ophthalmology - April 15, 2024 Category: Opthalmology Source Type: research
Anti-synthase syndrome associated with SARS-Cov-2 infection
Anti-synthetase syndrome (AS) is a rare autoimmune idiopathic inflammatory myopathy (IIM) with diverse manifestations, including arthritis, interstitial lung disease (ILD), Raynaud ’s phenomenon, unexplained pe... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - April 15, 2024 Category: Respiratory Medicine Authors: Xing-Yue Chen, Jun Chen, Li-Jia Zhi, Kun-Lan Long and Pei-Yang Gao Tags: Case Report Source Type: research
Metabolic Regulation of the Th17/Treg Balance in Inflammatory Bowel Disease
Pharmacol Res. 2024 Apr 12:107184. doi: 10.1016/j.phrs.2024.107184. Online ahead of print.ABSTRACTInflammatory bowel disease (IBD) is a long-lasting and inflammatory autoimmune condition affecting the gastrointestinal tract, impacting millions of individuals globally. The balance between T helper 17 (Th17) cells and regulatory T cells (Tregs) is pivotal in the pathogenesis and progression of IBD. This review summarizes the pivotal role of Th17/Treg equilibrium in maintaining intestinal homeostasis, elucidating how its dysregulation contributes to the development and exacerbation of IBD. It comprehensively synthesizes the c...
Source: Cell Research - April 14, 2024 Category: Cytology Authors: Shunfen Zhang Ruqing Zhong Shanlong Tang Liang Chen Hongfu Zhang Source Type: research
Exploring the molecular mechanisms and shared gene signatures between celiac disease and ulcerative colitis based on bulk RNA and single-cell sequencing: Experimental verification
In conclusion, our study elucidated that abnormal immune response could be the common pathogenesis of UC and CeD, and REG4 might be a key potential biomarker and therapeutic target for the comorbidity of these two diseases.PMID:38615385 | DOI:10.1016/j.intimp.2024.112059 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 14, 2024 Category: Allergy & Immunology Authors: Changshan Wan Tao Ji Liwei Wang Qiuyan Wu Qiuyu Chen Yali Wang Yaqian Li Fengming He Wentian Liu Weilong Zhong Bangmao Wang Source Type: research
Role of auto-antibodies in the mechanisms of dengue pathogenesis and its progression: a comprehensive review
Arch Microbiol. 2024 Apr 15;206(5):214. doi: 10.1007/s00203-024-03954-0.ABSTRACTA complex interaction among virulence factors, host-genes and host immune system is considered to be responsible for dengue virus (DENV) infection and disease progression. Generation of auto-antibodies during DENV infection is a major phenomenon that plays a role in the pathophysiology of dengue hemorrhagic fever and dengue shock syndrome. Hemostasis, thrombocytopenia, hepatic endothelial dysfunction, and autoimmune blistering skin disease (pemphigus) are different clinical manifestations of dengue pathogenesis; produced due to the molecular mi...
Source: Archives of Microbiology - April 14, 2024 Category: Microbiology Authors: Tanusree Ghorai Avipsha Sarkar Anirban Roy Bijita Bhowmick Debadatta Nayak Satadal Das Source Type: research
Elevation of circulating DNAs of disease-associated cytokines in serum cell-free DNA from patients with alopecia areata
In this study, we aimed to investigate the clinical significance of cfDNA and the circulating DNAs of disease-associated cytokines in AA patients. Serum samples were obtained from 63 patients with AA and 32 healthy controls (HC). Using droplet digital polymerase chain reaction, circulating C-X-C motif chemokine ligand (CXCL) 9, CXCL10, CXCL11, C-X-C motif chemokine receptor 3, interferon (IFN)-γ, interleukin (IL) -7, IL-15, and Janus kinase (JAK) 2 were detectable in both HC and AA patients. Among the detectable DNAs, copies of circulating CXCL9, CXCL11, IL-15, IFN-γ, and JAK2 were significantly higher in AA patients tha...
Source: BioScience Trends - April 14, 2024 Category: Biomedical Science Authors: Soichiro Sawamura Tselmeg M Myangat Ikko Kajihara Katsunari Makino Jun Aoi Shinichi Masuguchi Satoshi Fukushima Source Type: research
Exploring the molecular mechanisms and shared gene signatures between celiac disease and ulcerative colitis based on bulk RNA and single-cell sequencing: Experimental verification
In conclusion, our study elucidated that abnormal immune response could be the common pathogenesis of UC and CeD, and REG4 might be a key potential biomarker and therapeutic target for the comorbidity of these two diseases.PMID:38615385 | DOI:10.1016/j.intimp.2024.112059 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 14, 2024 Category: Allergy & Immunology Authors: Changshan Wan Tao Ji Liwei Wang Qiuyan Wu Qiuyu Chen Yali Wang Yaqian Li Fengming He Wentian Liu Weilong Zhong Bangmao Wang Source Type: research
