The Vitamin Deficiency Linked To Autoimmune Disorders
A vitamin that reduces autoimmune disease risk by almost one-quarter. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - March 10, 2022 Category: Psychiatry & Psychology Authors: Mina Dean Tags: Nutrition Source Type: blogs

AndHealth, the Digital Health Company for Reversing Migraine and Autoimmune Diseases Raises $57 Million in Financing for Growth
AndHealth today announced the company’s closure of more than $57 million in financing by leading technology investor Francisco Partners, with participation from the American Medical Association’s venture capital arm Health 2047, Kirkland & Ellis and Twofold Ventures. AndHealth is led by former CoverMyMeds co-founder and CEO Matt Scantland and the team that helped grow healthcare […] (Source: EMR and HIPAA)
Source: EMR and HIPAA - February 11, 2022 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT AMA AMA Venture Capital AndHealth Autoimmune Diseases Chris Adams CoverMyMeds Digital Health Dr. Robert Sheeler Francisco Partners Health 2047 Health2047 ICHD-3 Kirkland & Ellis Matt Scantland Source Type: blogs

Magnetic-Plasmonic Hybrid Nanoparticles Isolate Lysosomes from Cells
Researchers at the Japan Advanced Institute of Science and Technology have developed a method to isolate intact lysosomes from cells. The technique is rapid and produces samples of high purity. Lysosomes are the garbage-disposal organelles within a cell, and they are involved in numerous diseases, from lysosomal storage diseases to autoimmune disorders, certain cancers, and neurodegenerative diseases. However, they are difficult to study, as current techniques to isolate lysosomes from cells result in samples with poor purity and damaged or altered lysosomes. This new approach uses nanotechnology to rapidly extract a high-...
Source: Medgadget - January 13, 2022 Category: Medical Devices Authors: Conn Hastings Tags: etc. Genetics Nanomedicine Pathology Source Type: blogs

Lower Hemoglobin Levels Correlate with Raised Mortality in Older People
Anemia is a lowered level of red blood cells and hemoglobin, leading to a diminished supply of oxygen to tissues and thus degraded function throughout the body. The anemia of aging, like all issues in later life, is a gradual onset, a sliding scale of dysfunction with an arbitrary line in the sand as how low hemoglobin must fall for it to be formally considered a medical condition. There are consequences prior to that point of course, as the study data here illustrates. The relationship between lower hemoglobin levels and higher mortality is linear. It is, however, an open question as to how much of this relates to downstr...
Source: Fight Aging! - December 27, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, December 27th 2021
We report that whereas microglia are characterized by marked gene-level alterations related to negative regulation of protein phosphorylation and phagocytic vesicles, astrocytes show activation of enzyme- or peptidase-inhibitor signaling after detectable changes in BBB permeability. We also identify several genes enriched in these pathways that are notably altered after BBB breakdown. Our data reveal that microglia and astrocytes play an active role in maintaining BBB stabilization and corralling infiltrating cells, and thus might potentially function in ameliorating the lesions and neurologic disabilities in CNS diseases....
Source: Fight Aging! - December 26, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Delivering Catalase to Treat Sepsis
Sepsis is a state of runaway inflammation in response to infection, a condition that is more serious and more often fatal in older individuals. With age, the immune system becomes every more overactive and inflammatory, reacting to signals created by the damaged environment of the body. This background of chronic inflammation makes it ever less likely that any given incident of greatly raised inflammatory signaling will successfully resolve. Instead inflammation can rage to the point of causing serious harm and organ failure. At present, treatments for sepsis are largely palliative, or focus on removing the infectio...
Source: Fight Aging! - December 21, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Suppression of Inflammatory Signaling as a Treatment for Frailty
Age-related frailty is accompanied by marked chronic inflammation, and indeed much of the physical weakness of frailty is likely caused by long-term inflammation and the ways in which it disrupts muscle tissue maintenance. The tools presently available to suppress inflammation are somewhat blunt, interfering in the necessary signaling needed to maintain a normal immune response, as well as in the unwanted overactivation of the immune system found in older people. Nonetheless, such tools are slowly becoming better and more selective over time, and some are now being tested as treatments for frailty. Earlier this ye...
Source: Fight Aging! - December 21, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Top 10 Digital Health News Of 2021
From the approval of a new prescription VR treatment to renewed privacy concerns, 2021 has been full of digital health developments. Indeed, some news might have gone under the radar or might require a quick refresher; so we’re wrapping up 2021 with a round-up of 10 of the most important digital health news of this year. 1. FDA-approved prescription VR treatment for chronic back pain In mid-November, the FDA authorised a virtual reality (VR) system as a prescription treatment for chronic back pain. Called EaseVRx, it combines cognitive behaviour therapy techniques and breathing exercises to help relax, distract...
Source: The Medical Futurist - December 16, 2021 Category: Information Technology Authors: Pranavsingh Dhunnoo Tags: TMF Covid-19 3D Printing Health Sensors & Trackers Portable Medical Diagnostics Security & Privacy Telemedicine & Smartphones apple telehealth blood pressure A.I. 23andme news remote care 2021 Source Type: blogs

Fight Aging! Newsletter, December 13th 2021
In conclusion, there is a good amount of pre-clinical and clinical data showing a strong positive correlation between reduction of senescent cells frequencies and functional improvement of skin. Whether senescence of skin cells makes a significant causal contribution to skin ageing can still not be conclusively decided, however. Nonetheless, there is strong evidence existing today to assume that better understanding of cell senescence in skin may lead to a breakthrough in interventions into skin ageing. Isomerization of Tau May be Involved in Alzheimer's Disease https://www.fightaging.org/archives/2021/12/isom...
Source: Fight Aging! - December 12, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The Aging of Lymph Nodes as a Potentially Important Component of Declining Immune Function
An overly simplistic view of the lymphatic system is that it is network of highways and collaboration centers for the cells of the immune system. Immune cells use lymphatic vessels to travel about the body, while the hundreds of lymph nodes scattered throughout the lymphatic system are important locations at which immune cells exchange information about signatures of infection and damage, managing the immune response. Like all tissues, lymph nodes are structured in certain ways, and that structure is degraded by the processes of aging. Lymph nodes become fibrotic, for example, and these changes impede the activities of imm...
Source: Fight Aging! - December 7, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Cytomegalovirus Harmfully Alters Immune Cell Populations in the Aging Immune System
The aging of the immune system isn't just a matter of becoming vulnerable to commonplace infectious diseases, such as influenza. The immune system also removes senescent cells and cancerous cells, both of which present sizable risks to health in later life. Additionally, immune cells participate in normal tissue maintenance in a variety of ways. Further, the chronic inflammation characteristic of an aged immune system disrupts the normal function of many types of cell and tissue, contributing to a diverse range of age-related conditions. For most people, cytomegalovirus (CMV) is an apparently innocuous persistent he...
Source: Fight Aging! - December 6, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, December 6th 2021
In this study, they found these drugs can kill senescent cells from cultures of human fat tissue. The tissue was donated by individuals with obesity who were known to have metabolic troubles. Without treatment, the human fat tissues induced metabolic problems in immune-deficient mice. After treatment with dasatinib and quercetin, the harmful effects of the fat tissue were almost eliminated. Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity Insulin resistance is a pathological state often associated with obesity, representing a major risk factor for type 2...
Source: Fight Aging! - December 5, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Results from a Trial of the Senolytic Fisetin in a Single Individual with Autoimmunity
Today's materials from the Intraclear Biologics team may be of interest to those following the development of senolytic therapies. Since the Mayo Clinic has yet to publish results from their clinical trials of fisetin as a senolytic therapy, and may not do so for a few years yet, it is good to see even preliminary data from other sources. Senolytic therapies selectively destroy senescent cells, though only one approach (the combination of dasatinib and quercetin) has been definitely shown to destroy significant numbers of senescent cells in humans. Data has yet to be published on whether fisetin performs as well in humans ...
Source: Fight Aging! - November 30, 2021 Category: Research Authors: Reason Tags: Self-Experimentation Source Type: blogs

Fight Aging! Newsletter, November 29th 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - November 28, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The Truth About Food Intolerances
  Ever since the 1990s, food intolerances are proving to be a rapidly growing problem: intolerances to nightshades, so-called FODMAPs, fructose, histamine-containing foods and others. But why? And does just eliminating the food solve the problem? We need to view food intolerances as a warning sign of the process that causes food intolerances in the first place: disruptions of bowel flora and especially small intestinal bacterial overgrowth, SIBO. Unrecognized or ignored and SIBO can lead over time to weight gain, type 2 diabetes, autoimmune conditions, neurodegenerative diseases, even gastrointestinal cancers. Recogni...
Source: Wheat Belly Blog - November 5, 2021 Category: Cardiology Authors: Dr. Davis Tags: Open defiant health food intolerances podcast super gut Source Type: blogs