Potential therapy found for incurable pediatric brain tumor
(Northwestern University) scientists have discovered a new potential drug therapy for a rare, incurable pediatric brain tumor by targeting a genetic mutation found in children with the cancer.By inhibiting the tumor-forming consequences of the mutation using an experimental drug called GSKJ4, they delayed tumor growth and prolonged survival in mice with pediatric brainstem glioma. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 17, 2014 Category: Cancer & Oncology Source Type: news
“Potential Therapy Found for Incurable Pediatric Brain Tumor,” Robert H. Lurie Comprehensive Cancer Center at Northwestern University
Northwestern Medicine scientists have discovered a new potential drug therapy for a rare, incurable pediatric brain tumor by targeting a genetic mutation found in children with the cancer.
By inhibiting the tumor-forming consequences of the mutation using an experimental drug called GSKJ4, they delayed tumor growth and prolonged survival in mice with pediatric brainstem glioma.
Robert H. Lurie Comprehensive Cancer Center at Northwestern University is one of the 25 NCCN Member Institutions.... (Source: National Comprehensive Cancer Network)
Source: National Comprehensive Cancer Network - November 17, 2014 Category: Cancer & Oncology Source Type: news
Newly identified brain cancer mutation will aid drug development
New genetic insights into a rare and deadly form of childhood and young adult brain cancer called brainstem glioma has been identified by an international team of researchers. The researchers identified a genetic mutation in the tumor cells that plays a role in both the growth and the death of a cell. Additionally, the mutation to the newly identified gene may also contribute to the tumor’s resistance to radiation. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - June 1, 2014 Category: Science Source Type: news
Newly identified brain cancer mutation will aid drug development
(Duke University Medical Center) A collaborative effort between Duke Medicine researchers and neurosurgeons and scientists in China has produced new genetic insights into a rare and deadly form of childhood and young adult brain cancer called brainstem glioma. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 1, 2014 Category: Cancer & Oncology Source Type: news
Researcher studies pediatric brain stem tumors
Children's National researcher, Javad Nazarian, PhD, authored a new study entitled, "Comparative Multidimensional Molecular Analyses of Pediatric Diffuse Intrinsic Pontine Glioma Reveals Distinct Molecular Subtypes." The study found, for the first time, two distinct subtypes in pediatric diffuse intrinsic pontine gliomas (DIPG). It was published online in Acta Neuropathologica, a leading journal on pathology and pathogenesis of neurological disease. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - December 5, 2013 Category: Consumer Health News Tags: Neurology / Neuroscience Source Type: news
Children's National researcher authors study on pediatric brain stem tumors
(Children's National Medical Center) Children's National researcher, Javad Nazarian, Ph.D., authored a new study entitled, "Comparative Multidimensional Molecular Analyses of Pediatric Diffuse Intrinsic Pontine Glioma Reveals Distinct Molecular Subtypes." The study found, for the first time, two distinct subtypes in pediatric diffuse intrinsic pontine gliomas. It was published online in Acta Neuropathologica, a leading journal on pathology and pathogenesis of neurological disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 3, 2013 Category: Global & Universal Source Type: news
What Neoplasms are Patients with Neurofibromatosis At Risk For?
Discussion
Neurofibromatosis Type 1 (NF1) is one of many neurocutaneous diseases with a probable underestimated incidence of 1:3000. Also called phacomatoses, a review can be found at: What is the Epidemiology and Genetics of the Major Phacomatoses?
The key elements of NF1 are:
Neurofibromatosis Type 1
Epidemiology: 1:2500-3000 – most common phacomatosis
Genetics: autosomal dominant with variable penetrance, associated with chromosome 17
Neurological: various central nervous system tumors especially neurofibromas (often benign but may act malignant because of location or size, tumors may also degenerate into a ma...
Source: PediatricEducation.org - September 23, 2013 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: news
What Neoplasms are Patients with Neurofibromatosis At Risk For?
Discussion
Neurofibromatosis Type 1 (NF1) is one of many neurocutaneous diseases with a probable underestimated incidence of 1:3000. Also called phacomatoses, a review can be found at: What is the Epidemiology and Genetics of the Major Phacomatoses?
The key elements of NF1 are:
Neurofibromatosis Type 1
Epidemiology: 1:2500-3000 – most common phacomatosis
Genetics: autosomal dominant with variable penetrance, associated with chromosome 17
Neurological: various central nervous system tumors especially neurofibromas (often benign but may act malignant because of location or size, tumors may also degenerate into a ma...
Source: PediatricEducation.org - September 23, 2013 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
Commentary - Rare brainstem glioma doesn’t stop former marine
Read the full story on MD Consult:
Commentary - Rare brainstem glioma doesn’t stop former marine (Source: MD Consult: News: Top Stories)
Source: MD Consult: News: Top Stories - July 31, 2013 Category: Journals (General) Source Type: news
