Fight Aging! Newsletter, February 8th 2021
This study was divided in two phases: CALERIE-1 and CALERIE-2. CALERIE-1 study was performed to assess the possible effects induced by a reduction of 10-30% of caloric intake on body composition parameters and lipid profile after 6 and 12 months in a population of middle-aged non-obese subjects. CALERIE-1 results showed an improvement in lipid and glycemic profile and a reduction in body weight (BW) and fat mass.
CALERIE-2 was the largest multi-center study on CRD. A total of 220 subjects were enrolled randomly with a 2:1 allocation into two subgroups: 145 in the CRD group and 75 in the ad libitum group. The CRD gro...
Source: Fight Aging! - February 7, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Amyloidosis Contributes to Muscle Aging, and NAD+ Upregulation Reduces Amyloid Burden
In this study, improved mitochondrial function reduced the burden of amyloid in muscle tissue. Separately, the researchers also removed amyloid from tissues in a targeted way, and found that this improved mitochondrial function. Thus the relationship appears bidirectional. Amyloid degrades mitochondrial function, while forcing an improvement in mitochondrial function gives cells a greater ability to clear amyloid.
NAD+ can restore age-related muscle deterioration
The older we grow, the weaker our muscles get, riddling old age with frailty and physical disability. Researchers have now looked at the issue thr...
Source: Fight Aging! - February 1, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Precision Medicine and the Reinvention of Human Disease (Book Index)
In January, 2018, Academic Press published my bookPrecision Medicine and the Reinvention of Human Disease. This book has an excellent " look inside " at itsGoogle book site, which includes the Table of Contents. In addition, I thought it might be helpful to see the topics listed in the Book ' s index. Note that page numbers followed by f indicate figures, t indicate tables, and ge indicate glossary terms.AAbandonware, 270, 310geAb initio, 34, 48ge, 108geABL (abelson leukemia) gene, 28, 58ge, 95 –97Absidia corymbifera, 218Acanthameoba, 213Acanthosis nigricans, 144geAchondroplasia, 74, 143ge, 354geAcne, 54ge, 198, 220geAcq...
Source: Specified Life - January 23, 2018 Category: Information Technology Tags: index jules berman jules j berman precision medicine Source Type: blogs
A Possible Path to Preventing TDP-43 Aggregation
TDP-43 is known to increase with age, and also forms aggregates observed in ALS and frontemporal dementia, among other conditions. The increased amount of TDP-43 alone, even without aggregates, appears to diminish the cellular housekeeping process of autophagy, with detrimental long term consequences. Artificially reducing the levels of TDP-43 too far will produce other issues, however, as this disrupts correct microglial function in the brain, making the microglia too aggressive when it comes to dismantling synaptic connections between brain cells. Thus building a therapy that targets TDP-43 isn't as straightforward as it...
Source: Fight Aging! - July 19, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Indirect Evidence for Misfolded Proteins that Accumulate in Muscle to Contribute to the Progression of Sarcopenia
One of the differences between old tissue and young tissue is an accumulation of misfolded proteins, normally soluable, into solid aggregates. The best known of these are the varieties of amyloid that are clearly associated with specific diseases and are present in significant amounts in patient tissues. These are far from the only proteins that accumulate in such a way, however, and there are many more types of misfolded or damaged proteins that do not form aggregates. Unfortunately the mapping of aggregates by tissue to specific consequences in the course of degenerative aging is far from complete. In the paper I'll poin...
Source: Fight Aging! - December 23, 2016 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
MKSAP: 61-year-old man with generalized weakness
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.
A 61-year-old man is evaluated for a 10-month history of generalized weakness. He reports no pain or myalgia. History is significant for hypercholesterolemia treated with a stable dose of simvastatin for the past 3 years.
On physical examination, temperature is normal, blood pressure is 138/74 mm Hg, pulse rate is 70/min, and respiration rate is 16/min. BMI is 27. There is symmetric weakness of the arm and thigh muscles with slightly reduced grip and power of the finger flexors. No muscle tenderness is noted. Th...
Source: Kevin, M.D. - Medical Weblog - August 20, 2016 Category: Journals (General) Authors: < a href="http://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Neurology Source Type: blogs
LITFL Review 184
Welcome to the 184th LITFL Review. Your regular and reliable source for the highest highlights, sneakiest sneak peeks and loudest shout-outs from the webbed world of emergency medicine and critical care. Each week the LITFL team casts the spotlight on the blogosphere’s best and brightest and deliver a bite-sized chuck of FOAM.
The Most Fair Dinkum Ripper Beauts of the Week
Here’s an awesome new echo resource from the Nepean Hospital ICU in Penrith, NSW, Australia, containing basic and advanced physics and scanning resources. [SO]
The Best of #FOAMed Emergency Medicine
Boring EM reviews the relevance of IN...
Source: Life in the Fast Lane - May 31, 2015 Category: Emergency Medicine Authors: Marjorie Lazoff, MD Tags: Education LITFL review Source Type: blogs
NIH and Other Public Private Partnerships to Research Treatments for Multiple Diseases
Over the past few weeks, the National Institutes of Health (NIH) has made a number of important announcements regarding collaborations with industry as well as the funding of several new research initiatives. Below is a summary of these stories.
NIH Partners With Eli Lilly and Others on Rare Diseases
FierceBiotechResearch reported that NIH selected four (4) new preclinical drug development studies to uncover new therapies for rare diseases. The projects will be funded through the Therapeutics for Rare and Neglected Diseases (TRND) program under NIH's National Center for Advancing Translational Sciences, NCATS, whic...
Source: Policy and Medicine - October 4, 2013 Category: Health Medicine and Bioethics Commentators Authors: Thomas Sullivan Source Type: blogs
Not exactly fraud
Obviously the cause of science, and therefore the cause of humanity, is harmed when scientists make up results or misrepresent their findings in a scientific paper. I get outraged about it, but it probably isn't all that common.Even so, false beliefs often persist for a long time. Steven A. Greenberg, in BMJ, tells us how this can happen. This is an excellent and important piece of work which gores some very powerful, oxen, so I recommend it even though it may be somewhat heavy going.To translate it into English, what Greenberg did was to study all the papers addressing a claim or hypothesis that an uncommon muscle disease...
Source: Stayin' Alive - September 16, 2013 Category: Health Medicine and Bioethics Commentators Source Type: blogs
