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Genetic variant of IL-10RA and susceptibility to rheumatoid arthritis in a Chinese population
We examined 533 RA patients and 958 subjects as a control group. ThreeIL-10RA SNPs (rs9610, rs2229113 and rs3135932) were genotyped using TaqMan genotyping assays on Fluidigm 192.24 system. TheIL-10RA rs9610 A allele was increased in patient group compared with control subjects (OR  = 1.232, 95 % CI = 1.052–1.442,p = 0.030). Significant difference in genotype distribution was found in RA patients and controls (χ2 = 15.32,p <  0.001). We also discovered a statistical significance under the dominant model (GG + AG versus AA: OR = 0.676, 95 % CI = 0.546–0.837,p <  0.001). However, no significant...
Source: Clinical Rheumatology - March 24, 2017 Category: Rheumatology Source Type: research

The aggressive clinical courses of Hodgkin lymphoma primarily diagnosed as methotrexate-induced non-specific lymphoproliferative disorder in patients with rheumatoid arthritis.
Authors: Tokuhira M, Tabayashi T, Tanaka Y, Takahashi Y, Kimura Y, Tomikawa T, Anan-Nemoto T, Momose S, Higashi M, Okuyama A, Watanabe R, Amano K, Tamaru JI, Kizaki M Abstract Recently, attention has been focused on methotrexate-induced lymphoproliferative disease (MTX-LPD), and atypical phenotypes are occasionally documented. We encountered two patients with rheumatoid arthritis (RA) who were diagnosed with non-specific LPD (LPD-nos). Biopsy samples were not obtained during the initial examination when the LPD development was discovered, and the patients achieved a complete response after MTX cessation (case 1) or...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - March 24, 2017 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

A Treat-to-Target Strategy Preserves Work Capacity in a Rheumatoid Arthritis Inception Cohort Treated With Combination Conventional DMARD Therapy
Objectives: Quantification of work disability in patients with early rheumatoid arthritis (RA) receiving conventional DMARDs according to a treat-to-target strategy. Methods: This is a retrospective cohort analysis of RA patients who received combination conventional DMARDs, escalated to achieve DAS28(ESR) remission and completed an annual work and arthritis questionnaire. Random effect mixed modeling was used to assess associations between average hours worked per week (HWPW), and baseline prognostic factors. HWPW were compared with matched population averages. Cox proportional hazards modeling was employed to evaluate a...
Source: JCR: Journal of Clinical Rheumatology - March 24, 2017 Category: Rheumatology Tags: Original Articles Source Type: research

Use of Hydroxychloroquine Is Associated With Improved Lipid Profile in Rheumatoid Arthritis Patients
Conclusions: Hydroxychloroquine use was associated with lower lipid levels but not with the plasma glucose in this RA cohort. These findings support the need for a randomized trial to establish the role of HCQ in cardiovascular disease prevention in RA patients. (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - March 24, 2017 Category: Rheumatology Tags: Original Articles Source Type: research

Effect of panchakarma and Ayurvedic treatment in postpartum rheumatoid arthritis (amavata): A case study
Publication date: Available online 14 March 2017 Source:Journal of Ayurveda and Integrative Medicine Author(s): Shailesh V. Deshpande, Vaishali S. Deshpande, Shraddha S. Potdar Dream of a mother is to get involved actively in upbringing of child, which is impeded if she is suffering from painful condition like rheumatoid arthritis (RA) in postpartum phase. It causes physical incapacity and psychological trauma as well. Present case is a patient who developed RA one month after full term delivery by caesarean section. In view of symptoms, she was diagnosed as case of amavata. She received Ayurvedic treatment – Simhanada ...
Source: Journal of Ayurveda and Integrative Medicine - March 24, 2017 Category: Complementary Medicine Source Type: research

Therapeutic effect of quercetin in collagen-induced arthritis
In conclusion, this study determined that quercetin, which was non-toxic, produced better results than methotrexate for the protection of joints from arthritic inflammation in mice. Quercetin may be an alternative treatment for RA because it modulates the main pathogenic pathways of RA. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - March 23, 2017 Category: Drugs & Pharmacology Source Type: research

A review of the ethnopharmacology, phytochemistry and pharmacology of Notopterygium incisum
Conclusion In this paper, we have reviewed various researches conducted on N. incisum especially in areas of its ethnopharmacological use, phytochemicals, pharmacology and developed analytical methods. This herb has been used over the years in treating headache, rheumatoid arthritis, cold, diaphoretic etc, prompting many types of research into identifying which compounds are responsible for these activities and their mechanism of action. More research is needed in the area of pharmacokinetics and toxicology to give further information on the clinical use and control the quality of the herb. (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - March 23, 2017 Category: Drugs & Pharmacology Source Type: research

Pre-symptomatic autoimmunity in rheumatoid arthritis: when does the disease start?
We present data to support the concept that the transitions from at-risk states to systemic autoimmunity and then to classifiable RA depend on multiple “switches”. However, further prospective studies are necessary to define the molecular basis of these switches and the specific features of pre-symptomatic autoimmunity, so that preventative treatments can be targeted to individuals at high risk for RA. In this review, we analyse mechanisms that may contribute to the development of autoimmunity in at-risk individuals and discuss the relationship between this pre-symptomatic state and subsequent development of RA. (Sourc...
Source: Seminars in Immunopathology - March 23, 2017 Category: Pathology Source Type: research

Challenges of developing a cardiovascular risk calculator for patients with rheumatoid arthritis
ConclusionEfforts to develop a specific CVD risk calculator for patients with RA yielded 2 potential models including RA disease characteristics, but neither demonstrated improved performance compared to risk calculators designed for use in the general population. Challenges encountered and lessons learned are discussed in detail. (Source: PLoS One)
Source: PLoS One - March 23, 2017 Category: Biomedical Science Authors: Cynthia S. Crowson Source Type: research

Poor prognostic factors guiding treatment decisions in rheumatoid arthritis patients: a review of data from randomized clinical trials and cohort studies
Prognostic factors are used for treatment decisions in rheumatoid arthritis (RA). High disease activity, the early presence of erosions, and autoantibody positivity are the most frequently used poor prognostic... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - March 23, 2017 Category: Rheumatology Authors: Katinka Albrecht and Angela Zink Source Type: research

Would I take antipsychotics, if I had psychotic symptoms? Examining determinants of the decision to take antipsychotics
Publication date: Available online 22 March 2017 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry Author(s): Fabrice Berna, Anja S. Göritz, Pierre-Michel Llorca, Pierre Vidailhet, Guillaume Fond, Steffen Moritz Poor adherence to treatment in schizophrenia is mainly associated to patients-related factors. However, social negative representations of schizophrenia and its treatment may also contribute to patients' decision to take or not to take antipsychotics. A web-based study on 1807 participants was conducted during which participants imagined that they had a particular chronic illness based on clin...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 22, 2017 Category: Psychiatry Source Type: research

Experimental Arthritis in the Rat Induced by the Superantigen Staphylococcal Enterotoxin A
Abstract The pathogenesis of rheumatoid arthritis (RA) is incompletely understood. Human endogenous retroviruses (HERVs) and their superantigenic envelope protein (env) have been implicated in the pathogenesis of RA. In the present investigation, the arthritogenic potential of the superantigen staphylococcal enterotoxin A (SEA) has been investigated. In the present investigation, the bacterial superantigen staphylococcal enterotoxin A (SEA) was injected into the right knee joint of 15 Lewis rats. Further nine animals received saline. Animals were sacrificed one, five and 10 days after the injection, respectively. The anti...
Source: Scandinavian Journal of Immunology - March 22, 2017 Category: Allergy & Immunology Authors: K. Gerlach, C. Tomuschat, R. Finke, M. S. Staege, C. Br ütting, J. Brandt, B. Jordan, R. Schwesig, A. Rosemeier, K.‐S. Delank, M. E. Kornhuber, A. Emmer Tags: Experimental Immunology Source Type: research

Role of amino acids in rheumatoid arthritis studied by metabolomics
ConclusionThe results suggest that a disordered amine response is linked to RA‐associated muscle wasting and energy expenditure. (Source: APLAR Journal of Rheumatology)
Source: APLAR Journal of Rheumatology - March 22, 2017 Category: Rheumatology Authors: Min He, Amy C. Harms, Eduard Wijk, Mei Wang, Ruud Berger, Slavik Koval, Thomas Hankemeier, Jan Greef Tags: Original Article Source Type: research

Improved disease activity with fosdagrocorat (PF ‐04171327), a partial agonist of the glucocorticoid receptor, in patients with rheumatoid arthritis: a Phase 2 randomized study
ConclusionFosdagrocorat 10 and 25 mg demonstrated efficacy in improving signs and symptoms in RA patients, with manageable AEs. Additional studies are needed to assess the longer‐term safety and efficacy of fosdagrocorat. (Source: APLAR Journal of Rheumatology)
Source: APLAR Journal of Rheumatology - March 22, 2017 Category: Rheumatology Authors: Thomas Stock, Dona Fleishaker, Xin Wang, Arnab Mukherjee, Charles Mebus Tags: Original Article Source Type: research

Second-line biologic therapy optimization in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis
The Italian board for the TAilored BIOlogic therapy (ITABIO) reviewed the most consistent literature to indicate the best strategy for the second-line biologic choice in patients with rheumatoid arthritis (RA), spondyloarthritis (SpA), and psoriatic arthritis (PsA). (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - March 22, 2017 Category: Rheumatology Authors: Fabrizio Cantini, Laura Niccoli, Carlotta Nannini, Emanuele Cassar à, Olga Kaloudi, Ennio Giulio Favalli, Andrea Becciolini, Maurizio Benucci, Francesca Li Gobbi, Serena Guiducci, Rosario Foti, Marta Mosca, Delia Goletti Source Type: research

Recurrent constrictive pericarditis associated with seropositive rheumatoid arthritis: A case report
Conclusion Further large scale studies are necessary to identify the risk factorsfor recurrence. (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - March 22, 2017 Category: Surgery Source Type: research

Risk of tuberculosis in patients treated with TNF-{alpha} antagonists: a systematic review and meta-analysis of randomised controlled trials
Conclusions Findings from our meta-analysis indicate that the risk of TB may be significantly increased in patients treated with TNF-α antagonists. However, further studies are needed to reveal the biological mechanism of the increased TB risk caused by TNF-α antagonists treatment. (Source: BMJ Open)
Source: BMJ Open - March 22, 2017 Category: Journals (General) Authors: Zhang, Z., Fan, W., Yang, G., Xu, Z., Wang, J., Cheng, Q., Yu, M. Tags: Open access, Evidence based practice, Infectious diseases, Pharmacology and therapeutics, Rheumatology Research Source Type: research

Identification of a HERV ‐K env surface peptide highly recognized in RA patients: A cross‐sectional case‐control study
This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - March 21, 2017 Category: Allergy & Immunology Authors: G. Mameli, G.L. Erre, E. Caggiu, S. Mura, D. Cossu, Marco Bo, M.L. Cadoni, A Piras, N. Mundula, E. Colombo, G. Buscetta, G. Passiu, L.A. Sechi Tags: Original Article Source Type: research

OX40 signaling is involved in the autoactivation of CD4+CD28 − T cells and contributes to the pathogenesis of autoimmune arthritis
CD4+CD28 − T cells exhibit autoreactive potential in autoimmune disorders, including rheumatoid arthritis (RA). It is not well known which costimulator functions as an alternative second signal in the activation o... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - March 21, 2017 Category: Rheumatology Authors: Juean Jiang, Cuiping Liu, Mi Liu, Yu Shen, Xiaohan Hu, Qin Wang, Jian Wu, Min Wu, Qi Fang and Xueguang Zhang Source Type: research

Epigenetic alterations in rheumatoid arthritis fibroblast-like synoviocytes
Epigenomics Ahead of Print. (Source: Future Medicine: Epigenomics)
Source: Future Medicine: Epigenomics - March 21, 2017 Category: Genetics & Stem Cells Source Type: research

[Outpatient care and disease burden of rheumatoid arthritis : Results of a  linkage of claims data and a survey of insured persons].
CONCLUSION: The results indicate that specialized rheumatological care is required to provide adequate treatment for patients with RA in Germany. Patients with higher age and patients with M06 diagnosis had less drug prescriptions and were less frequently treated by rheumatologists. PMID: 28324149 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - March 21, 2017 Category: Rheumatology Authors: Albrecht K, Luque Ramos A, Callhoff J, Hoffmann F, Minden K, Zink A Tags: Z Rheumatol Source Type: research

Comparative efficacy and tolerability of sarilumab 150 and 200  mg in patients with active rheumatoid arthritis : A Bayesian network meta-analysis of randomized controlled trials.
CONCLUSION: Sarilumab 150 and 200 mg are efficacious treatments for active RA and are well tolerated. PMID: 28324148 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - March 21, 2017 Category: Rheumatology Authors: Bae SC, Lee YH Tags: Z Rheumatol Source Type: research

Sex Differences in the Blood Concentration of Tacrolimus in Systemic Lupus Erythematosus and Rheumatoid Arthritis Patients with CYP3A5*3/*3.
Abstract The purpose of this study was to describe the impact of sex and cytochrome P450 3A5 (CYP3A5) variant on the blood concentration of tacrolimus in patients with systemic lupus erythematosus or rheumatoid arthritis. The blood concentration of tacrolimus (ng/mL) divided by the daily dose of tacrolimus (mg/day) and the patient's weight (kg) (C/D) was obtained from 55 patients. The C/D value was analysed according to genetic variation in CYP3A5 or ATP binding cassette subfamily B member 1 (ABCB1), sex, and age. The C/D value in the CYP3A5*3/*3 group was significantly higher than in the CYP3A5*1/*1 and *1/*3 gro...
Source: Biochemical Genetics - March 21, 2017 Category: Genetics & Stem Cells Authors: Ito A, Okada Y, Hashita T, Aomori T, Hiromura K, Nojima Y, Nakamura T, Araki T, Yamamoto K Tags: Biochem Genet Source Type: research

Identification of a HERV-K env surface peptide highly recognized in RA patients: A cross-sectional case-control study.
This article is protected by copyright. All rights reserved. PMID: 28324619 [PubMed - as supplied by publisher] (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - March 21, 2017 Category: Allergy & Immunology Authors: Mameli G, Erre GL, Caggiu E, Mura S, Cossu D, Bo M, Cadoni ML, Piras A, Mundula N, Colombo E, Buscetta G, Passiu G, Sechi LA Tags: Clin Exp Immunol Source Type: research

The potent inhibitory effect of β-D-mannuronic acid (M2000) as a novel NSAID with immunosuppressive property on anti-cyclic citrullinated peptide antibodies, rheumatoid factor and anti-dsDNA antibodies in patients with rheumatoid arthritis.
CONCLUSIONS: M2000 shows inhibitory effect on anti-CCP, RF, anti-dsDNA antibodies and acute phase reactants in RA patients. PMID: 28325148 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - March 21, 2017 Category: Drugs & Pharmacology Authors: Ahmadi H, Jamshidi AR, Mahmoudi M, Cuzzocrea S, Fattahi MJ, Barati A, Rehm BH, Matsou H, Mirshafiey A Tags: Curr Drug Discov Technol Source Type: research

Active matrix metalloproteinase ‐8 and periodontal bacteria depending on periodontal status in patients with rheumatoid arthritis
ConclusionThe increased aMMP‐8 levels in the RA group indicate that the presence of RA appears to have an influence on the host response at a comparable level of bacterial load and periodontal disease severity. (Source: Journal of Periodontal Research)
Source: Journal of Periodontal Research - March 20, 2017 Category: Dentistry Authors: A. Kirchner, J. J äger, B. Krohn‐Grimberghe, S. Patschan, T. Kottmann, G. Schmalz, R. F. Mausberg, R. Haak, D. Ziebolz Tags: Original Article Source Type: research

Interplay between genetic and epigenetic mechanisms in rheumatoid arthritis
Epigenomics Ahead of Print. (Source: Future Medicine: Epigenomics)
Source: Future Medicine: Epigenomics - March 20, 2017 Category: Genetics & Stem Cells Source Type: research

Anti ‐inflammatory and Antioxidant Actions of Copaiba Oil Are Related to Liver Cell Modifications in Arthritic Rats
This article is protected by copyright. All rights reserved (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - March 20, 2017 Category: Biochemistry Authors: Cristiane V. de Castro Ghizoni, Ana P. Arssufi Ames, Osmar A. Lameira, Ciomar A. Bersani Amado, Anacharis B. de S á Nakanishi, Lívia Bracht, Maria R. Marçal Natali, Rosane M. Peralta, Adelar Bracht, Jurandir F. Comar Tags: Article Source Type: research

Obesity and outcomes in rheumatoid arthritis
Dear Sir, (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - March 20, 2017 Category: Rheumatology Authors: Dilli Ram Poudel, Paras Karmacharya Source Type: research

Comorbidities in patients with alopecia areata
To the Editor: Alopecia areata (AA) is a common, polygenic, T-lymphocyte-mediated nonscarring hair loss.1 It has been associated with atopic dermatitis, allergic rhinitis, lupus erythematosus, psoriasis, thyroid disease, rheumatoid arthritis, celiac disease, and type 1 diabetes mellitus.1-3 This research letter represents a review of Cleveland Clinic Alopecia Registry to assess comorbidities present in patients given a diagnosis of AA. To identify these comorbidities, we performed a retrospective chart review. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - March 20, 2017 Category: Dermatology Authors: Ruzica Z. Conic, Rose Miller, Melissa Piliang, Wilma Bergfeld, Natasha Atanaskova Mesinkovska Tags: Research letter Source Type: research

Inflammatory ‘double hit’ model of temporomandibular joint disorder with elevated CCL2, CXCL9, CXCL10, RANTES and behavioural hypersensitivity in TNFR1/R2−/− mice
ConclusionsThese data suggest a causal feed‐forward signalling cascade of these little studied cytokines have the potential to cause recrudescence in this orofacial inflammatory pain model in the absence of TNFα signalling. SignificanceUsing a mouse model of chronic inflammatory temporomandibular joint disorder, we determined that absence of functional TNFR1/R2 induces aberrant inflammatory signalling caused by other increased pro‐inflammatory and decreased anti‐inflammatory cytokines that could serve as blood biomarkers and may predict disease progression. (Source: European Journal of Pain)
Source: European Journal of Pain - March 20, 2017 Category: Anesthesiology Authors: S.L. McIlwrath, R. Nesemeier, F. Ma, H.S. Oz, L. Zhang, K.N. Westlund Tags: Original Article Source Type: research

Type I Interferon Gene Response Is Increased in Early and Established Rheumatoid Arthritis and Correlates with Autoantibody Production
Julio E. Casta ñeda-Delgado, Yadira Bastián-Hernandez, Noe Macias-Segura, David Santiago-Algarra, Jose D. Castillo-Ortiz, Ana L. Alemán-Navarro, Pedro Martínez-Tejada, Leonor Enciso-Moreno, Yolanda Garcia-De Lira, Diana Olguín-Calderón, Leendert A. Trouw, Cesar Ramos-Remus, Jose A. Enciso-Moreno (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - March 20, 2017 Category: Allergy & Immunology Source Type: research

Risk factors for flare and treatment of disease flares during pregnancy in rheumatoid arthritis and axial spondyloarthritis patients
During pregnancy, patients with rheumatoid arthritis (RA) and axial spondyloarthritis (axSpA) can experience active disease, which might be influenced by adjustment of treatment around conception. The aim of t... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - March 20, 2017 Category: Rheumatology Authors: Stephanie van den Brandt, Astrid Zbinden, Dominique Baeten, Peter M. Villiger, Monika Østensen and Frauke Förger Source Type: research

MicroRNA-192 suppresses cell proliferation and induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes by downregulating caveolin 1.
In conclusion, miR-192 is downregulated in RA synovial tissues and restoration of its expression elicits growth-suppressive effects on RA-FLSs by targeting CAV1. The miR-192/CAV1 pathway may represent a novel target for prevention and treatment of RA. PMID: 28321538 [PubMed - as supplied by publisher] (Source: Molecular and Cellular Biochemistry)
Source: Molecular and Cellular Biochemistry - March 20, 2017 Category: Biochemistry Authors: Li S, Jin Z, Lu X Tags: Mol Cell Biochem Source Type: research

Novel Senescent Regulatory T-Cell Subset with Impaired Suppressive Function in Rheumatoid Arthritis
Johannes Fessler, Andrea Raicht, Rusmir Husic, Anja Ficjan, Christine Schwarz, Christina Duftner, Wolfgang Schwinger, Winfried B. Graninger, Martin H. Stradner, Christian Dejaco (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - March 19, 2017 Category: Allergy & Immunology Source Type: research

The practice pattern of hepatitis b testing in rheumatoid arthritis patients: A cross ‐national comparison between US and Taiwan
Conclusion: We found small differences in the HBV testing rates across U.S. and Taiwan. Although the rate gradually increased in the past decade, it remained low in both countries. This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - March 19, 2017 Category: Rheumatology Authors: Tzu ‐Chieh Lin, Nikroo Hashemi, Seoyoung C. Kim, Yea‐Huei Kao Yang, Kazuki Yoshida, Sara Tedeschi, Rishi Desai, Daniel H. Solomon Tags: Original Article Source Type: research

Risk of autism spectrum disorders in children born to mothers with rheumatoid arthritis: A systematic literature review
Conclusion: Observational studies suggest a potentially increased risk of ASD in children born to mothers with RA compared to children born to unaffected mothers, although data are limited. This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - March 19, 2017 Category: Rheumatology Authors: Sophie Wojcik, Sasha Bernatsky, Robert W. Platt, Christian A. Pineau, Ann E. Clarke, Éric Fombonne, Anick Bérard, Évelyne Vinet Tags: Brief Report Source Type: research

Depression Risk in Patients with Rheumatoid Arthritis in the United Kingdom
ConclusionAround 30% of RA patients developed depression within 5  years of the RA diagnosis. The depression risk was higher in women than in men. The current findings also indicate that improved detection and treatment of patients with both RA and depression are important. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - March 19, 2017 Category: Rheumatology Source Type: research

Pearls & Oy-sters: Asymmetric meningeal involvement is a common feature of rheumatoid meningitis
Rheumatoid meningitis is a rare complication of rheumatoid arthritis that requires a meningeal biopsy for diagnosis. (Source: Neurology)
Source: Neurology - March 19, 2017 Category: Neurology Authors: Choi, S.-J., Ho Park, Y., Kim, J. A., Han, J. H., Choe, G., Kim, S. Tags: Meningitis RESIDENT AND FELLOW SECTION Source Type: research

Medication adherence and persistence over time with self-administered TNF-alpha inhibitors among young adult, middle-aged and older patients with rheumatologic conditions
Self-injectable TNF inhibitors are increasingly used early in the chronic treatment of moderate to severe rheumatologic conditions. We estimated medication adherence/persistence over time following initiation in young adult and older adult patients with rheumatoid arthritis, ankylosing spondylitis or psoriatic arthritis. (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - March 19, 2017 Category: Rheumatology Authors: Gregory S. Calip, Sruthi Adimadhyam, Shan Xing, Julian C. Rincon, Wan-Ju Lee, Rebekah H. Anguiano Source Type: research

Utility of Dose Frequency Adjustment in Tocilizumab Administration for Rheumatoid Arthritis.
CONCLUSION: Adjusting the dose frequency of intravenous TCZ is a useful strategy. PMID: 28298563 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - March 19, 2017 Category: Rheumatology Tags: J Rheumatol Source Type: research

Progressive Multifocal Leukoencephalopathy and Rheumatoid Arthritis Treatments
Publication date: Available online 18 March 2017 Source:Joint Bone Spine Author(s): Gaëlle Clavel, Antoine Moulignier, Luca Semerano Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system due to reactivation of the JC virus (JCV). PML is extremely uncommon despite the high prevalence of the virus in the general population. No specific treatment is available, and the prognosis is bleak. The diagnosis is based on brain imaging findings, detection of the JCV genome in cerebrospinal fluid samples and, in some cases, histological studies of the brain lesions. The pathophysiol...
Source: Joint Bone Spine - March 18, 2017 Category: Orthopaedics Source Type: research

Intraoperative neuro-monitoring in reverse total shoulder arthroplasty
This study included 15 shoulders of 15 patients (11 females and 4 males) who underwent RSA. The mean age was 74.8 years old. Nine shoulders had cuff tear arthropathy, four had massive rotator cuff tear, two had osteoarthritis and one had rheumatoid arthritis. Somatosensory evoked potential (SEP) of median nerve, transcranial motor evoked potentials (TcMEP) and free-electromyograms (free-EMG) from all arm myotomes were continuously monitored. (Source: Journal of Shoulder and Elbow Surgery)
Source: Journal of Shoulder and Elbow Surgery - March 18, 2017 Category: Orthopaedics Authors: Satoshi Shinagawa, Atsushi Yamamoto, Tsuyoshi Ichinose, Tsuyoshi Sasaki, Noritaka Hamano, Hitoshi Shitara, Daisuke Shimoyama, Tsutomu Kobayashi, Toshihisa Osawa, Kenji Takagishi Source Type: research

PTPN22 -1123G > C polymorphism and anti-cyclic citrullinated protein antibodies in rheumatoid arthritis.
CONCLUSION: The PTPN22 -1123CC genotype is a protector factor to RA in a Mexican-mestizo population and is associated with low anti-CCP antibodies. PMID: 28291534 [PubMed - as supplied by publisher] (Source: Medicina Clinica)
Source: Medicina Clinica - March 18, 2017 Category: Journals (General) Tags: Med Clin (Barc) Source Type: research

Advances in rheumatoid arthritis.
Authors: Jones G, Nash P, Hall S Abstract There are now eight approved biological disease-modifying antirheumatic drugs (bDMARDs), two biosimilars and one targeted synthetic DMARD in Australia with a number of new products and biosimilars in the pipeline. bDMARDs have excellent efficacy, especially when combined with traditional DMARDs, and a well characterised but manageable safety profile. These expanded therapeutic options have revolutionised patient care and made remission (including drug free remission) a realistic goal. Evidence of a "window of opportunity" that changes the long term phenotype of the disease ...
Source: Medical Journal of Australia - March 18, 2017 Category: Journals (General) Tags: Med J Aust Source Type: research

Staphylococcus aureus bacteremia in patients with rheumatoid arthritis – data from the prospective INSTINCT cohort
Patients with rheumatoid arthritis (RA) are considered to be at increased risk of severe infections. We here describe the clinical characteristics, course and outcome of RA patients with Staphylococcus aureus bacteremia (SAB). (Source: Journal of Infection)
Source: Journal of Infection - March 17, 2017 Category: Infectious Diseases Authors: Insa Joost, Achim Kaasch, Christine Pausch, Gabriele Peyerl-Hoffmann, Christian Schneider, Reinhard E. Voll, Harald Seifert, Winfried V. Kern, Siegbert Rieg Source Type: research

Cost-effectiveness of sequenced treatment of rheumatoid arthritis with targeted immune modulators.
CONCLUSIONS: bDMARD treatment sequences are cost-effective from a US societal perspective. PMID: 28294642 [PubMed - as supplied by publisher] (Source: Journal of Medical Economics)
Source: Journal of Medical Economics - March 17, 2017 Category: Health Management Tags: J Med Econ Source Type: research

[Editorial] Managing arthritis in the USA
On March 7, the Centers for Disease Control and Prevention (CDC) issued new data on the prevalence of arthritis in the USA. More than 54 million adults (23%) in the USA report arthritis diagnosed by a doctor, and almost 60% are of working age (18 –64 years old). 24 million adults with arthritis report that the disease limits their daily activities, which represents an increase of about 20% since 2002. Most have osteoarthritis, but rheumatoid arthritis, gout, lupus, and fibromyalgia are other common diagnoses in the report. (Source: LANCET)
Source: LANCET - March 17, 2017 Category: Journals (General) Authors: The Lancet Tags: Editorial Source Type: research

GSE73254 Identification of genetic variants affecting vitamin D receptor binding and associations with autoimmune disease
Contributors : Giuseppe Gallone ; Wilfried Haerty ; Giulio Disanto ; Sreeram Ramagopalan ; Chris P Ponting ; Antonio J Berlanga-TaylorSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensLarge numbers of statistically significant associations between sentinel SNPs and case-control status have been replicated by genome-wide association studies (GWAS). Nevertheless, currently few underlying molecular mechanisms of complex disease are known. Our approach has been to investigate whether variation in binding of a transcription factor, the vitamin D receptor (VDR) whose activating ...
Source: GEO: Gene Expression Omnibus - March 17, 2017 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research

Def6 Restrains Osteoclastogenesis and Inflammatory Bone Resorption.
In this study, we identify the immunoregulator differentially expressed in FDCP 6 homolog (Def6) as a novel inhibitor of osteoclastogenesis in physiological and inflammatory conditions. Def6 deficiency in Def6(-/-) mice enhanced the sensitivity of osteoclast precursors to the physiological osteoclastogenic inducer receptor activator for NF-κB ligand, and Def6(-/-) osteoclasts formed actin rings. Furthermore, Def6 deficiency markedly increased TNF-α-induced osteoclastogenesis in vitro and in vivo and enhanced bone resorption in an inflammatory osteolysis mouse model. TNF-α serum levels correlated negatively with Def6 exp...
Source: Journal of Immunology - March 17, 2017 Category: Allergy & Immunology Authors: Binder N, Miller C, Yoshida M, Inoue K, Nakano S, Hu X, Ivashkiv LB, Schett G, Pernis A, Goldring SR, Ross FP, Zhao B Tags: J Immunol Source Type: research