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Anti ‑inflammatory effects of oxymatrine on rheumatoid arthritis in rats via regulating the imbalance between Treg and Th17 cells.
In conclusion, the present study demonstrated that OMT exhibited a protective effect on rheumatoid arthritis (RA) through the inhibition of inflammation and regulation of Treg/Th17 in the CIA rats, suggesting that OMT may be used as an immune suppressive and cartilage protective medicine in human RA. PMID: 28440447 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - April 27, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

High frequency ultrasonography of the hand versus anti-RA33 evaluation in early rheumatoid arthritis - a pilot study.
CONCLUSIONS: The current study shows that anti-RA33 antibodies might constitute an additional tool for diagnosing early RA patients and can help identify patients with mild disease and a low level of activesynovitis. PMID: 28440350 [PubMed - in process] (Source: Medical Ultrasonography)
Source: Medical Ultrasonography - April 27, 2017 Category: Radiology Tags: Med Ultrason Source Type: research

Correlations Between Sagittal Spinal Balance and Quality of Life in Rheumatoid Arthritis
Conclusions: Sagittal spinopelvic parameters were found to be significantly different in RA patients and normal controls. Correlation analysis revealed significant relationships between radiographic parameters and clinical outcomes. In particular, C7/SFD and SSA were found to be significant predictors of clinical outcomes in RA. (Source: Journal of Spinal Disorders and Techniques)
Source: Journal of Spinal Disorders and Techniques - April 27, 2017 Category: Surgery Tags: Spotlight on Deformity Source Type: research

Anti-rheumatoid arthritis effects of traditional Chinese herb couple in adjuvant-induced arthritis in rats
Conclusions To conclude, all results suggest that CN possesses evident anti-arthritic effects in AIA rats. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - April 27, 2017 Category: Drugs & Pharmacology Source Type: research

CpG-specific methylation at rheumatoid arthritis diagnosis as a marker of treatment response
Epigenomics Ahead of Print. (Source: Future Medicine: Epigenomics)
Source: Future Medicine: Epigenomics - April 27, 2017 Category: Genetics & Stem Cells Source Type: research

Calgizzarin (S100A11): a novel inflammatory mediator associated with disease activity of rheumatoid arthritis
Calgizzarin (S100A11) is a member of the S100 protein family that acts in different tumors by regulating a number of biologic functions. Recent data suggest its association with low-grade inflammation in osteo... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - April 26, 2017 Category: Rheumatology Authors: Lucie Andr és Cerezo, Barbora Šumová, Klára Prajzlerová, David Veigl, Dres Damgaard, Claus Henrik Nielsen, Karel Pavelka, Jiří Vencovský and Ladislav Šenolt Source Type: research

Doctors ’ preferences in de-escalating DMARDs in rheumatoid arthritis: a discrete choice experiment
Current guidelines suggest reduction of DMARDs can be considered in RA patients in remission. Objectives were (1) to estimate the relative importance of patient characteristics rheumatologists consider in thei... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - April 26, 2017 Category: Rheumatology Authors: T. Martijn Kuijper, Ri ëtte Folmer, Elly A. Stolk, Johanna M. W. Hazes and Jolanda J. Luime Source Type: research

Trends in Gout and Rheumatoid Arthritis Hospitalizations in Canada From 2000 to 2011
ConclusionOur findings indicate that hospitalization rates for gout have doubled over the past decade, while those for RA have decreased considerably. While these data provide an encouraging benchmark for RA care, they also highlight the critical need to improve gout management and prevention to mitigate its rising disease burden in Canada and beyond. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - April 26, 2017 Category: Rheumatology Authors: Sharan K. Rai, J. Antonio Avi ña‐Zubieta, Natalie McCormick, Mary A. de Vera, Diane Lacaille, Eric C. Sayre, Hyon K. Choi Tags: Brief Report Source Type: research

Withaferin-A, a steroidal lactone encapsulated mannose decorated liposomes ameliorates rheumatoid arthritis by intriguing the macrophage repolarization in adjuvant-induced arthritic rats
Publication date: 1 July 2017 Source:Colloids and Surfaces B: Biointerfaces, Volume 155 Author(s): Farhath Sultana, Manoj Kumar Neog, MahaboobKhan Rasool In order to develop a better therapeutic approach for the treatment of rheumatoid arthritis (RA), withaferin-A; a steroidal lactone incorporated with mannosylated liposomes (ML-WA) was administered to adjuvant induced arthritic rats in intent to target the synovial macrophages. The confocal microscopy studies showed a successful internalization of ML-WA in the primarily isolated synovial macrophages. Consequently, targeting synovial macrophages via ML-WA reduced the oxid...
Source: Colloids and Surfaces B: Biointerfaces - April 26, 2017 Category: Biochemistry Source Type: research

Through the looking glass of rheumatoid arthritis to study inflammation and high-density lipoprotein
Destruction of bone and soft tissue in rheumatoid arthritis (RA) occurs as a result of unchecked systemic inflammation. While swollen and deformed joints are easy to see, less obvious to the naked eye is the impact of this same inflammatory process on the cardiovascular (CV) system. Cardiovascular disease (CVD) is the leading cause of death in patients with RA. The mortality rate from CVD in RA is approximately 1.5 times that of individuals from the general population with the same age, sex and CV risk factors.1 The excess CV risk has been attributed to inflammation; however, the pathways and mechanisms linking inflammatio...
Source: Heart - April 26, 2017 Category: Cardiology Authors: Liao, K. P. Tags: Editorials Source Type: research

Anti-inflammatory treatment improves high-density lipoprotein function in rheumatoid arthritis
Conclusions HDL function can be improved with anti-inflammatory treatment in patients with RA. The M+I combination was superior to the M+P alone, suggesting that the tumour necrosis factor-α pathway may have a role in HDL vascular properties. (Source: Heart)
Source: Heart - April 26, 2017 Category: Cardiology Authors: O'Neill, F., Charakida, M., Topham, E., McLoughlin, E., Patel, N., Sutill, E., Kay, C. W. M., D'Aiuto, F., Landmesser, U., Taylor, P. C., Deanfield, J. Tags: Open access Aortic and vascular disease Source Type: research

“It’s so hard taking pills when you don’t know what they’re for”: a qualitative study of patients’ medicine taking behaviours and conceptualisation of medicines in the context of rheumatoid arthritis
Patients with chronic illnesses are often required to take lifelong medication to alleviate symptoms and prevent disease progression. Many patients find it difficult to adhere to prescribed medication for vari... (Source: BMC Health Services Research)
Source: BMC Health Services Research - April 26, 2017 Category: Journals (General) Authors: Boitshoko Kobue, Shirra Moch and Jennifer Watermeyer Source Type: research

Peficitinib, a JAK Inhibitor, in Combination With Limited Conventional Synthetic Disease ‐Modifying Antirheumatic Drugs in the Treatment of Moderate‐to‐Severe Rheumatoid Arthritis
ConclusionIn patients with moderate‐to‐severe RA, orally administered once‐daily peficitinib in combination with limited csDMARDs resulted in a dose‐dependent ACR20 response rate over 12 weeks with satisfactory tolerability. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - April 26, 2017 Category: Rheumatology Authors: Mark C. Genovese, Maria Greenwald, Christine Codding, Anna Zubrzycka ‐Sienkiewicz, Alan J. Kivitz, Annie Wang, Kathyjo Shay, Xuegong Wang, Jay P. Garg, Mario H. Cardiel Tags: Rheumatoid Arthritis Source Type: research

Effects of Baricitinib on Lipid, Apolipoprotein, and Lipoprotein Particle Profiles in a Phase IIb Study of Patients With Active Rheumatoid Arthritis
ConclusionBaricitinib‐associated increases in serum lipid levels were observed in this study. Increases in levels of HDL cholesterol correlated with improved clinical outcomes. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - April 26, 2017 Category: Rheumatology Authors: Joel M. Kremer, Mark C. Genovese, Edward Keystone, Peter C. Taylor, Steven H. Zuckerman, Giacomo Ruotolo, Douglas E. Schlichting, Victoria L. Crotzer, Eric Nantz, Scott D. Beattie, William L. Macias Tags: Rheumatoid Arthritis Source Type: research

High ‐Titer Rheumatoid Arthritis Antibodies Preferentially Bind Fibrinogen Citrullinated by Peptidylarginine Deiminase 4
ConclusionAt high titers, RA antibodies preferentially bind fibrinogen modified by PAD4, because intermittent citrullination offers a more diverse assortment of citrullinated epitopes. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - April 26, 2017 Category: Rheumatology Authors: Nathalie E. Blach ère, Salina Parveen, Mayu O. Frank, Brian D. Dill, Henrik Molina, Dana E. Orange Tags: Rheumatoid Arthritis Source Type: research

First Metatarsal-Phalangeal Joint Arthrodesis
This article discusses the principles of first metatarsal-phalangeal joint arthrodesis in primary and revision situations, joint preparation, configurations of osteosynthesis, and common complications, including salvage of nonunion and revision of malunion with realignment osteotomy. (Source: Clinics in Podiatric Medicine and Surgery)
Source: Clinics in Podiatric Medicine and Surgery - April 26, 2017 Category: Podiatry Authors: Thomas S. Roukis Source Type: research

Increased galectin-3 may serve as a serologic signature of pre-rheumatoid arthritis while markers of synovitis and cartilage do not differ between early undifferentiated arthritis subsets
Undifferentiated arthritis (UA) is a label applied to patients with joint complaints which cannot be classified according to current criteria, which implies a need for precision diagnostic technologies. We stu... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - April 26, 2017 Category: Rheumatology Authors: Saida Farah Issa, Anne Duer, Mikkel Østergaard, Kim Hørslev-Petersen, Merete L. Hetland, Michael Sejer Hansen, Kirsten Junker, Hanne M. Lindegaard, Jakob M. Møller and Peter Junker Source Type: research

Dysregulated CD46 shedding interferes with Th1-contraction in systemic lupus erythematosus.
This article is protected by copyright. All rights reserved. PMID: 28444759 [PubMed - as supplied by publisher] (Source: European Journal of Immunology)
Source: European Journal of Immunology - April 26, 2017 Category: Allergy & Immunology Authors: Ellinghaus U, Cortini A, Pinder CL, Friec GL, Kemper C, Vyse TJ Tags: Eur J Immunol Source Type: research

Reconstruction and analysis of lncRNA-miRNA-mRNA network based on competitive endogenous RNA reveal functional lncRNAs in rheumatoid arthritis
Mol. BioSyst., 2017, Accepted Manuscript DOI: 10.1039/C7MB00094D, PaperHui Jiang, Rong Ma, Shubiao Zou, Zhuqing Li , Weiping Li Rheumatoid arthritis (RA) is an autoimmune disease with an unknown etiology, occurring in approximately 1.0% of general population. More and more studies have suggested that long non-coding RNAs (lncRNAs) could... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Molecular Biosystems)
Source: RSC - Molecular Biosystems - April 25, 2017 Category: Molecular Biology Authors: Hui Jiang Source Type: research

The correlation of serum bilirubin levels with disease activity in patients with rheumatoid arthritis
Conclusions Serum bilirubin concentrations are lower in patients with RA compared to controls and correlate with disease activity in patients with RA. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - April 25, 2017 Category: Laboratory Medicine Source Type: research

Anterior ST ‐elevation myocardial infarction induced by rituximab infusion: A case report and review of the literature
This report underlines previous published reports emphasizing the awareness of such an association. This communication also warrants the importance of screening for ischaemic heart disease in selected cases of patients treated with rituximab. Rituximab is a monoclonal antibody that is approved for treatment of certain malignancies and autoimmune diseases. Generally, Rituximab is well tolerated, nevertheless some patients develop adverse effects including infusion reactions. In this report, we investigated a patient who developed ST‐elevation myocardial infarction during the drug administration. Such complication albeit ...
Source: Journal of Clinical Pharmacy and Therapeutics - April 25, 2017 Category: Drugs & Pharmacology Authors: K. Sharif, A. Watad, N. L. Bragazzi, E. Asher, A. Abu Much, Y. Horowitz, M. Lidar, Y. Shoenfeld, H. Amital Tags: Case Report Source Type: research

Long-term mortality in patients with ST-segment elevation myocardial infarction is associated with anti –citrullinated protein antibodies
Cardiovascular (CV) mortality is higher in patients with rheumatoid arthritis (RA), in particular when anti –citrullinated protein antibodies (ACPA) are present. Recently, ACPA have also been described in a cohort of patients without RA, but with coronary artery disease (CAD). It is however unknown if ACPA can consistently be found in patients with CAD, and if ACPA are associated with mortality in these patients. The purpose of this study was to assess the relationship between ACPA and long-term outcomes including mortality in patients with ST-elevation myocardial infarction (STEMI) without RA. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 25, 2017 Category: Cardiology Authors: Maaike P.J. Hermans, Daniel van der Velden, Jos é M. Montero Cabezas, Hein Putter, Tom W.J. Huizinga, Johan Kuiper, Rene E.M. Toes, Martin J. Schalij, J. Wouter Jukema, Diane van der Woude Source Type: research

Immunology proves a great success for treating systemic autoimmune diseases – a perspective on immunopharmacology: IUPHAR Review 23
Abstract Recent advances in the bioengineering of monoclonal antibodies (mAbs) have revolutionized the treatment of several immunological and rheumatic diseases. mAbs exhibit high specificity and affinity, and are very effective targeting agents, associated with minimal off‐target adverse effects. Of several relevant immunological diseases, rheumatoid arthritis was the condition initially treated with mAbs, with great success. Currently, many immunological disorders are targeted and successfully treated using such novel approaches; these include inflammatory bowel diseases, multiple sclerosis, lupus and psoriasis. Today,...
Source: British Journal of Pharmacology - April 24, 2017 Category: Drugs & Pharmacology Authors: Masaru Ishii Tags: IUPHAR REVIEW Source Type: research

Prediction of successful dose reduction or discontinuation of adalimumab, etanercept, or infliximab in rheumatoid arthritis patients using serum drug levels and antidrug antibody measurement
. (Source: Expert Opinion on Drug Metabolism and Toxicology)
Source: Expert Opinion on Drug Metabolism and Toxicology - April 24, 2017 Category: Drugs & Pharmacology Authors: CAM Bouman N van Herwaarden FHJ van den Hoogen A van der Maas BJF van den Bemt AA den Broeder Source Type: research

Pain Sensitization is Associated with Disease Activity in Rheumatoid Arthritis Patients: A Cross ‐Sectional Study
Conclusion. High pain sensitization is associated with elevations in disease activity measures. Longitudinal studies are underway to elucidate the cause‐effect relationships between pain sensitization and inflammatory disease activity in RA. This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - April 24, 2017 Category: Rheumatology Authors: Yvonne C. Lee, Clifton O. Bingham, Robert R. Edwards, Wendy Marder, Kristine Phillips, Marcy B. Bolster, Daniel J. Clauw, Larry W. Moreland, Bing Lu, Alyssa Wohlfahrt, Zhi Zhang, Tuhina Neogi Tags: Original Article Source Type: research

How Are Behavioral Theories Used in Interventions to Promote Physical Activity in Rheumatoid Arthritis? A systematic review
Conclusions: Findings indicate PA intervention studies claiming the use of BTs use theory to a small extent. We suggest expanding theory use in design, evaluation and interpretation of PA intervention results. Further, we recommend future studies evaluate the most salient BTs, interventions components, and delivery modes in RA populations. This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - April 24, 2017 Category: Rheumatology Authors: Ingrid Demmelmaier, Maura D. Iversen Tags: Original Article Source Type: research

Underuse of Methotrexate in the Treatment of Rheumatoid Arthritis: A National Analysis of Prescribing Practices in the US
ConclusionMTX is underutilized in the treatment of RA with suboptimal dosing, inadequate duration of therapy, and failure to use SC administration. The comparison of MTX use between the 2009 and the 2012 cohorts demonstrates only a marginal increase in the dose of oral MTX and the use of SC MTX. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - April 24, 2017 Category: Rheumatology Authors: Melanie K. Rohr, Ted R. Mikuls, Stanley B. Cohen, J. Carter Thorne, James R. O'Dell Tags: Original Article Source Type: research

Knowledge and perception of cardiovascular disease risk among patients with rheumatoid arthritis
This study demonstrated the rheumatoid arthritis patients’ lack of knowledge about the effects of physical inactivity and anti-inflammatory medications on the development of cardiovascular disease, and their misperception of cardiovascular risk was common. As a preventive measure, educational programs about cardiovascular disease should be tailored specifically for patients with rheumatoid arthritis, and behavioral interventions, including routine exercise, should be made available at the time of diagnosis. (Source: PLoS One)
Source: PLoS One - April 24, 2017 Category: Biomedical Science Authors: Sunjoo Boo Source Type: research

Enhanced liver fibrosis test in patients with psoriasis, psoriatic arthritis and rheumatoid arthritis: a cross ‐sectional comparison with procollagen‐3 N‐terminal peptide (P3NP)
ConclusionsELF score and P3NP are elevated in PSO, PsA and RA. ELF may be superior to P3NP alone, but further research should be done to validate the ELF test in determining susceptibility for developing liver fibrosis in PSO, PsA and RA. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - April 24, 2017 Category: Dermatology Authors: E.A.M. Voort, M. Wakkee, P. Veldt ‐Kok, S. Darwish Murad, T. Nijsten Tags: Medical Dermatology Source Type: research

Prediction of successful dose reduction or discontinuation of adalimumab, etanercept, or infliximab in rheumatoid arthritis patients using serum drug levels and antidrug antibody measurement
. (Source: Expert Opinion on Drug Metabolism and Toxicology)
Source: Expert Opinion on Drug Metabolism and Toxicology - April 24, 2017 Category: Drugs & Pharmacology Authors: CAM Bouman N van Herwaarden FHJ van den Hoogen A van der Maas BJF van den Bemt AA den Broeder Source Type: research

Physical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews.
CONCLUSIONS: The quality of the evidence examining physical activity and exercise for chronic pain is low. This is largely due to small sample sizes and potentially underpowered studies. A number of studies had adequately long interventions, but planned follow-up was limited to less than one year in all but six reviews.There were some favourable effects in reduction in pain severity and improved physical function, though these were mostly of small-to-moderate effect, and were not consistent across the reviews. There were variable effects for psychological function and quality of life.The available evidence suggests physica...
Source: Cochrane Database of Systematic Reviews - April 24, 2017 Category: Journals (General) Authors: Geneen LJ, Moore RA, Clarke C, Martin D, Colvin LA, Smith BH Tags: Cochrane Database Syst Rev Source Type: research

Serum Tartrate-resistant Acid Phosphatase-5b Levels are Associated with the Severity and Extent of Coronary Atherosclerosis in Patients with Coronary Artery Disease.
CONCLUSIONS: These data indicate that the TRACP-5b level is significantly associated with the OPG level and with the severity and extent of coronary atherosclerosis in CAD patients. PMID: 28428481 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 23, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Clinical Characteristics of Rheumatoid Arthritis Patients Achieving Functional Remission with Six Months of Biological DMARDs Treatment.
Conclusion These findings suggested that RA patients with lower HAQ-DI and lower depression scores at baseline were more likely to achieve functional remission using bDMARDs treatment than those without these variables. PMID: 28420837 [PubMed - in process] (Source: Internal Medicine)
Source: Internal Medicine - April 22, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research

Cardiovascular disease in rheumatoid arthritis: medications and risk factors in China
This study aims to assess the risk factors of cardiovascular disease (CVD) and to determine the association of traditional and biologic disease-modifying anti-rheumatic drugs (DMARDs) with risk for CVD in Chinese rheumatoid arthritis (RA) patients. A cross-sectional cohort of 2013 RA patients from 21 hospitals around China was established. Medical history of CVD was documented. The patients ’ social background, clinical manifestations, comorbidities, and medications were also collected. Of the 2013 patients, 256 had CVD with an incidence of 12.7%. Compared with non-CVD controls, RA patients with CVD had a significantly a...
Source: Clinical Rheumatology - April 22, 2017 Category: Rheumatology Source Type: research

Protective Effect of Pinitol Against Inflammatory Mediators of Rheumatoid Arthritis via Inhibition of Protein Tyrosine Phosphatase Non-Receptor Type 22 (PTPN22).
CONCLUSIONS Pinitol showed anti-arthritic effects via reduction of proinflammatory cytokines and inflammatory mediators via inhibition of PTPN22. PMID: 28430763 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 22, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Role of ultrasound disease activity score in assessing inflammatory disease activity in rheumatoid arthritis patients
Conclusion US DAS is a feasible scoring system for use in daily rheumatologic practice. US DAS may reflect disease activity and disability. The association between US DAS and USEC with radiologic scoring reflects their ability to detect structural joint damage. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - April 22, 2017 Category: Rheumatology Source Type: research

Enhanced anti-rheumatic activity of methotrexate-entrapped ultradeformable liposomal gel in adjuvant-induced arthritis rat model
In conclusion, the developed MTX-UDLs-gel has a great potential for effective delivery of MTX into the inflamed joints in rheumatoid arthritis. Graphical abstract (Source: International Journal of Pharmaceutics)
Source: International Journal of Pharmaceutics - April 22, 2017 Category: Drugs & Pharmacology Source Type: research

Efficacy of golimumab in Belgian patients with active rheumatoid arthritis despite treatment with non-biologic disease-modifying anti-rheumatic drugs: sub-analysis of the GO-MORE study
. (Source: Acta Clinica Belgica)
Source: Acta Clinica Belgica - April 22, 2017 Category: Journals (General) Authors: Patrick Durez Marie Vanthuyne Muhammad S. Soyfoo Ilse Hoffman Michel Malaise Piet Geusens Source Type: research

The performance of the GAP model in patients with rheumatoid arthritis associated interstitial lung disease
Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is associated with significant morbidity and mortality. Similarities have been observed between patients with idiopathic pulmonary fibrosis (IPF) and the UIP (usual interstitial pneumonia) form of RA-ILD. The GAP (gender, age, physiology) model has been shown to predict mortality in patients with IPF, but its ability to predict mortality in RA-ILD is not known. (Source: Respiratory Medicine)
Source: Respiratory Medicine - April 22, 2017 Category: Respiratory Medicine Authors: Julie Morisset, Eric Vittinghoff, Bo Young Lee, Roberto Tonelli, Xiaowen Hu, Brett M. Elicker, Jay H. Ryu, Kirk D. Jones, Stefania Cerri, Andreina Manfredi, Marco Sebastiani, Andrew J. Gross, Brett Ley, Paul J. Wolters, Talmadge E. King, Dong Soon Kim, Ha Source Type: research

Glucocorticoid resistance as a major drive in sepsis pathology
Since the first application of hydrocortisone in the suppression of rheumatoid arthritis in 1948 [1], multiple other compounds with glucocorticoid (GC) activity have been applied, in numerous formulations, for the treatment of inflammatory disorders, such as asthma, allergy, septic shock, multiple sclerosis and inflammatory bowel disease [2 –5]. GCs belong to the most prescribed drugs in the world. The fraction of the population in the USA using GCs is estimated to be 1.2% [6]. GC act via binding to their intracellular receptor, the glucocorticoid receptor (GR). (Source: Cytokine and Growth Factor Reviews)
Source: Cytokine and Growth Factor Reviews - April 22, 2017 Category: Molecular Biology Authors: Karen Dendoncker, Claude Libert Tags: Mini review Source Type: research

Calprotectin levels in rheumatoid arthritis and their correlation with disease activity: a meta-analysis.
CONCLUSIONS: Our meta-analysis demonstrates that circulating and synovial fluid calprotectin levels are high in patients with RA, and that circulating calprotectin levels positively correlate with RA activity. PMID: 28425837 [PubMed - as supplied by publisher] (Source: Postgraduate Medicine)
Source: Postgraduate Medicine - April 21, 2017 Category: Internal Medicine Tags: Postgrad Med Source Type: research

Endoscopic Manifestations and Clinical Characteristics of Cytomegalovirus Infection in the Upper Gastrointestinal Tract.
In conclusion, physicians must recall the relevance of CMV infection when any mucosal alterations exist in the upper gastrointestinal tract of immunosuppressed patients. PMID: 28420890 [PubMed - in process] (Source: Acta Medica Okayama)
Source: Acta Medica Okayama - April 21, 2017 Category: Journals (General) Tags: Acta Med Okayama Source Type: research

A tailored-guided internet-based cognitive-behavioral intervention for patients with rheumatoid arthritis as an adjunct to standard rheumatological care: results of a randomized controlled trial
Abstract: For patients with chronic pain conditions such as rheumatoid arthritis (RA), who experience elevated levels of distress, tailored-guided internet-based cognitive-behavioral treatment may be effective in improving psychological and physical functioning, and reducing the impact of RA on daily life. A multicenter, randomized controlled trial was conducted for RA patients with elevated levels of distress as assessed by a disease-specific measure. The control group (n = 71) received standard care and the intervention group (n = 62) additionally received an internet-based tailored cognitive-behavioral intervention. Mai...
Source: Pain - April 21, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Recommendations by the Spanish Rheumatology Society for the Management of Patients Diagnosed With Rheumatoid Arthritis who Cannot Be Treated With Methotrexate
Publication date: Available online 20 April 2017 Source:Reumatología Clínica (English Edition) Author(s): Rosario García-Vicuña, María Auxiliadora Martín-Martínez, María Rosa Gonzalez-Crespo, Jesús Tornero-Molina, Antonio Fernández-Nebro, Francisco Javier Blanco-García, Ricardo Blanco-Alonso, Sara Marsal-Barril To establish a set of recommendations for the management of patients diagnosed with rheumatoid arthritis (RA) who cannot be treated with methotrexate (MTX) due to contraindications, drug toxicity or lack of adherence, and to establish therapeutic strategies more effective and safer in these RA patients. ...
Source: Reumatologia Clinica - April 21, 2017 Category: Rheumatology Source Type: research

Corneal melting in rheumatoid arthritis patients treated with a tectonic reinforcing corneolimbal graft: an interventional case series
ConclusionFresh-tissue full-thickness corneolimbal grafts may be used to cover emergency corneal melting and perforations secondary to rheumatoid arthritis. (Source: International Ophthalmology)
Source: International Ophthalmology - April 21, 2017 Category: Opthalmology Source Type: research

Immunomodulation of autoimmune arthritis by pro-inflammatory cytokines.
Abstract Pro-inflammatory cytokines promote autoimmune inflammation and tissue damage, while anti-inflammatory cytokines help resolve inflammation and facilitate tissue repair. Over the past few decades, this general feature of cytokine-mediated events has offered a broad framework to comprehend the pathogenesis of autoimmune and other immune-mediated diseases, and to successfully develop therapeutic approaches for diseases such as rheumatoid arthritis (RA). Anti-tumor necrosis factor-α (TNF-α) therapy is a testimony in support of this endeavor. However, many patients with RA fail to respond to this or other bio...
Source: Cytokine - April 21, 2017 Category: Molecular Biology Authors: Kim EY, Moudgil KD Tags: Cytokine Source Type: research

Selfie: Autoimmunity.
Authors: Ahsan H Abstract The immune system provides protection to tissues damaged by infectious microrganisms or physical damage. In autoimmune diseases, the immune system recognizes and attacks its own tissues i.e., self-destruction. Various agents such as genetic factors and environmental triggers are thought to play a major role in the development of autoimmune diseases. A common feature of all autoimmune diseases is the presence of autoantibodies and inflammation, including mononuclear phagocytes, autoreactive T lymphocytes and autoantibody producing B cells (plasma cells). It has long been known that B cells ...
Source: Journal of Immunoassay and Immunochemistry - April 20, 2017 Category: Biochemistry Tags: J Immunoassay Immunochem Source Type: research

Obesity does not diminish the efficacy of IL-6 signalling blockade in mice with collagen-induced arthritis.
CONCLUSIONS: These results suggested that a high-fat diet induces inflammatory changes in the synovium. We demonstrated that IL-6 signalling blockade by an anti-IL-6 receptor antibody can be effective in treating arthritis, even with obesity. PMID: 28421996 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 20, 2017 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Multiple cavities with halo sign in a case of invasive pulmonary aspergillosis during therapy for drug-induced hypersensitivity syndrome
Publication date: Available online 19 April 2017 Source:Respiratory Medicine Case Reports Author(s): Tomoo Ikari, Katsura Nagai, Masashi Ohe, Toshiyuki Harada, Yasushi Akiyama A 67-year-old female with rheumatoid arthritis and asthma-chronic obstructive pulmonary disease overlap syndrome was admitted for drug-induced hypersensitivity syndrome (DIHS) caused by salazosulfapyridine. Human herpes virus 6 (HHV-6) variant B was strongly positive on peripheral blood. Multiple cavities with ground grass opacities rapidly emerged predominantly in the upper and middle lobes. She was diagnosed with invasive pulmonary aspergillosis (...
Source: Respiratory Medicine Case Reports - April 20, 2017 Category: Respiratory Medicine Source Type: research

Periarticular bone loss in arthritis is induced by autoantibodies against citrullinated vimentin
This study investigated whether autoimmunity against citrullinated proteins is causally involved in triggering periarticular bone loss. Periarticular bone loss was studied in the standard antigen induced arthritis (AIA) mouse model with methylated bovine serum albumin (mBSA) as well as modified model with mutated citrullinated vimentin (MCV) alone or in combination with mBSA. Periarticular bone loss, subchondral osteoclastogenesis as well as local expression of cytokines, osteoclast genes and PAD enzymes were assessed after arthritis induction. Immune cell and osteoclast precursor infiltration were detected in the periarti...
Source: Journal of Bone and Mineral Research - April 20, 2017 Category: Orthopaedics Authors: Cecilia Engdahl, Holger Bang, Katharina Dietel, Stefanie C Lang, Ulrike Harre, Georg Schett Tags: Original Article Source Type: research