Immuno-metabolic Reprogramming of T Cell: A New Frontier for Pharmacotherapy of Rheumatoid Arthritis
Immunopharmacol Immunotoxicol. 2024 Mar 13:1-32. doi: 10.1080/08923973.2024.2330636. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is a persistent autoimmune condition characterized by ongoing inflammation primarily affecting the synovial joint. This inflammation typically arises from an increase in immune cells such as neutrophils, macrophages, and T cells (TC). TC is recognised as a major player in RA pathogenesis. The involvement of HLA-DRB1 and PTPN-2 among RA patients confirms the TC involvement in RA. Metabolism of TC is maintained by various other factors like cytokines, mitochondrial proteins & other ...
Source: Immunopharmacology and Immunotoxicology - March 13, 2024 Category: Allergy & Immunology Authors: Sourav Mondal Sarthak Saha Debjeet Sur Source Type: research

T-Cell Metabolism in Rheumatoid Arthritis: Focus on Mitochondrial and Lysosomal Dysfunction
Immunopharmacol Immunotoxicol. 2024 Mar 13:1-10. doi: 10.1080/08923973.2024.2330645. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is a chronic inflammatory disease characterized by immune cell dysregulation, synovial hyperplasia, and progressive cartilage destruction. The loss of immunological self-tolerance against autoantigens is the crucial insult responsible for the pathogenesis of RA. These immune abnormalities are experienced many years before the onset of clinical arthritis. T-cells are identified as the primary initiators of immunological abnormalities in RA. These RA T-cells show a distinct metabolic pa...
Source: Immunopharmacology and Immunotoxicology - March 13, 2024 Category: Allergy & Immunology Authors: Asmita Parab Lokesh Kumar Bhatt Source Type: research

A case of filgrastim-induced neutrophilic dermatosis of the dorsal hands in a patient with Felty Syndrome
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329662999.ABSTRACTNeutrophilic dermatosis of the dorsal hands (NDDH) is a variant of Sweet syndrome that presents with erythematous bullae, papules/plaques, or pustules on the dorsal hands. It is most commonly associated with hematologic and solid organ malignancies, though cases of NDDH associated with inflammatory bowel disease, rheumatologic disorders, and medication exposure have also been described in the literature. Felty syndrome is a rare complication of long-standing rheumatoid arthritis characterized by neuropathy, splenomegaly, and neutropenia. Granulocyte colo...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Tejas P Joshi Yelena Dokic Gordana Verstovsek Theodore Rosen Source Type: research

Erythema elevatum diutinum in a patient with rheumatoid arthritis
We report a 65-year-old woman with painful and itchy lesions on her elbows, hands, knees, and foot for a year. Histopathologic examination confirmed the diagnosis of erythema elevatum diutinum and treatment with dapsone produced significant clinical improvement within few weeks. Erythema elevatum diutinum is a rare disease that should be considered in patients with violaceous nodular plaques located over the extensor regions of the limbs. Knowledge of this unusual pathology and its association helps to avoid misdiagnosis and late treatment.PMID:38478644 | DOI:10.5070/D329562408 (Source: Dermatol Online J)
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Maraya Semblano Bittencourt Tally Serruya Luana De Oliveira Loureiro Aline Dias Coelho De Souza Camilla Correa Neri Ana Thais Machado Moutinho Caren Dos Santos Lima Source Type: research

Role of Platelet/Lymphocyte, Neutrophil/Lymphocyte, and Interleukin-37/Interleukin-17 Ratios in the Occurrence and Treatment of Rheumatoid Arthritis
This study was designed to investigate the correlation of neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and interleukin (IL)-37/IL-17 ratio with the incidence/treatment of rheumatoid arthritis (RA). Firstly, fifty-eight patients with RA treated at the first affiliated hospital of Xinjiang Medical University from January 2018 to January 2019 were selected as the RA group; forty-nine healthy volunteers were enrolled in the control group. RA patients were treated with disease-modifying anti-rheumatic drugs (DMARDs). Next, the NLR, PLR, IL-37, IL-17 and 28-joint disease activity score using erythrocyte se...
Source: Immunological Investigations - March 13, 2024 Category: Allergy & Immunology Authors: Yan Meng Xuan-Lin Cai Shan Cong Jiao Sun Yong-Wei Hu Yan-Qin Gu Xiu-Min Ma Li Luo Source Type: research

Immuno-metabolic Reprogramming of T Cell: A New Frontier for Pharmacotherapy of Rheumatoid Arthritis
Immunopharmacol Immunotoxicol. 2024 Mar 13:1-32. doi: 10.1080/08923973.2024.2330636. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is a persistent autoimmune condition characterized by ongoing inflammation primarily affecting the synovial joint. This inflammation typically arises from an increase in immune cells such as neutrophils, macrophages, and T cells (TC). TC is recognised as a major player in RA pathogenesis. The involvement of HLA-DRB1 and PTPN-2 among RA patients confirms the TC involvement in RA. Metabolism of TC is maintained by various other factors like cytokines, mitochondrial proteins & other ...
Source: Immunopharmacology and Immunotoxicology - March 13, 2024 Category: Allergy & Immunology Authors: Sourav Mondal Sarthak Saha Debjeet Sur Source Type: research

T-cell metabolism in rheumatoid arthritis: focus on mitochondrial and lysosomal dysfunction
Discussion: T-cells are identified as the primary initiators of immunological abnormalities in RA. These RA T-cells show a distinct metabolic pattern compared to the healthy individuals. Dampened glycolytic flux, poor ATP production, and shifting of glucose to the pentose phosphate pathway resulting in increased NADPH and decreased ROS levels are the common metabolic patterns observed in RA T-cells. Defective mtDNA due to lack of MRE11A gene, a key molecular actor for resection, and inefficient lysosomal function due to misplacement of AMPK on the lysosomal surface were found to be responsible for mitochondrial and lysosom...
Source: Immunopharmacology and Immunotoxicology - March 13, 2024 Category: Allergy & Immunology Authors: Asmita Parab Lokesh Kumar Bhatt Source Type: research

A case of filgrastim-induced neutrophilic dermatosis of the dorsal hands in a patient with Felty Syndrome
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329662999.ABSTRACTNeutrophilic dermatosis of the dorsal hands (NDDH) is a variant of Sweet syndrome that presents with erythematous bullae, papules/plaques, or pustules on the dorsal hands. It is most commonly associated with hematologic and solid organ malignancies, though cases of NDDH associated with inflammatory bowel disease, rheumatologic disorders, and medication exposure have also been described in the literature. Felty syndrome is a rare complication of long-standing rheumatoid arthritis characterized by neuropathy, splenomegaly, and neutropenia. Granulocyte colo...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Tejas P Joshi Yelena Dokic Gordana Verstovsek Theodore Rosen Source Type: research

Erythema elevatum diutinum in a patient with rheumatoid arthritis
We report a 65-year-old woman with painful and itchy lesions on her elbows, hands, knees, and foot for a year. Histopathologic examination confirmed the diagnosis of erythema elevatum diutinum and treatment with dapsone produced significant clinical improvement within few weeks. Erythema elevatum diutinum is a rare disease that should be considered in patients with violaceous nodular plaques located over the extensor regions of the limbs. Knowledge of this unusual pathology and its association helps to avoid misdiagnosis and late treatment.PMID:38478644 | DOI:10.5070/D329562408 (Source: Dermatol Online J)
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Maraya Semblano Bittencourt Tally Serruya Luana De Oliveira Loureiro Aline Dias Coelho De Souza Camilla Correa Neri Ana Thais Machado Moutinho Caren Dos Santos Lima Source Type: research

Role of Platelet/Lymphocyte, Neutrophil/Lymphocyte, and Interleukin-37/Interleukin-17 Ratios in the Occurrence and Treatment of Rheumatoid Arthritis
This study was designed to investigate the correlation of neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and interleukin (IL)-37/IL-17 ratio with the incidence/treatment of rheumatoid arthritis (RA). Firstly, fifty-eight patients with RA treated at the first affiliated hospital of Xinjiang Medical University from January 2018 to January 2019 were selected as the RA group; forty-nine healthy volunteers were enrolled in the control group. RA patients were treated with disease-modifying anti-rheumatic drugs (DMARDs). Next, the NLR, PLR, IL-37, IL-17 and 28-joint disease activity score using erythrocyte se...
Source: Immunological Investigations - March 13, 2024 Category: Allergy & Immunology Authors: Yan Meng Xuan-Lin Cai Shan Cong Jiao Sun Yong-Wei Hu Yan-Qin Gu Xiu-Min Ma Li Luo Source Type: research

Immuno-metabolic Reprogramming of T Cell: A New Frontier for Pharmacotherapy of Rheumatoid Arthritis
Immunopharmacol Immunotoxicol. 2024 Mar 13:1-32. doi: 10.1080/08923973.2024.2330636. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is a persistent autoimmune condition characterized by ongoing inflammation primarily affecting the synovial joint. This inflammation typically arises from an increase in immune cells such as neutrophils, macrophages, and T cells (TC). TC is recognised as a major player in RA pathogenesis. The involvement of HLA-DRB1 and PTPN-2 among RA patients confirms the TC involvement in RA. Metabolism of TC is maintained by various other factors like cytokines, mitochondrial proteins & other ...
Source: Immunopharmacology and Immunotoxicology - March 13, 2024 Category: Allergy & Immunology Authors: Sourav Mondal Sarthak Saha Debjeet Sur Source Type: research

T-cell metabolism in rheumatoid arthritis: focus on mitochondrial and lysosomal dysfunction
Discussion: T-cells are identified as the primary initiators of immunological abnormalities in RA. These RA T-cells show a distinct metabolic pattern compared to the healthy individuals. Dampened glycolytic flux, poor ATP production, and shifting of glucose to the pentose phosphate pathway resulting in increased NADPH and decreased ROS levels are the common metabolic patterns observed in RA T-cells. Defective mtDNA due to lack of MRE11A gene, a key molecular actor for resection, and inefficient lysosomal function due to misplacement of AMPK on the lysosomal surface were found to be responsible for mitochondrial and lysosom...
Source: Immunopharmacology and Immunotoxicology - March 13, 2024 Category: Allergy & Immunology Authors: Asmita Parab Lokesh Kumar Bhatt Source Type: research

A case of filgrastim-induced neutrophilic dermatosis of the dorsal hands in a patient with Felty Syndrome
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329662999.ABSTRACTNeutrophilic dermatosis of the dorsal hands (NDDH) is a variant of Sweet syndrome that presents with erythematous bullae, papules/plaques, or pustules on the dorsal hands. It is most commonly associated with hematologic and solid organ malignancies, though cases of NDDH associated with inflammatory bowel disease, rheumatologic disorders, and medication exposure have also been described in the literature. Felty syndrome is a rare complication of long-standing rheumatoid arthritis characterized by neuropathy, splenomegaly, and neutropenia. Granulocyte colo...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Tejas P Joshi Yelena Dokic Gordana Verstovsek Theodore Rosen Source Type: research

Erythema elevatum diutinum in a patient with rheumatoid arthritis
We report a 65-year-old woman with painful and itchy lesions on her elbows, hands, knees, and foot for a year. Histopathologic examination confirmed the diagnosis of erythema elevatum diutinum and treatment with dapsone produced significant clinical improvement within few weeks. Erythema elevatum diutinum is a rare disease that should be considered in patients with violaceous nodular plaques located over the extensor regions of the limbs. Knowledge of this unusual pathology and its association helps to avoid misdiagnosis and late treatment.PMID:38478644 | DOI:10.5070/D329562408 (Source: Dermatol Online J)
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Maraya Semblano Bittencourt Tally Serruya Luana De Oliveira Loureiro Aline Dias Coelho De Souza Camilla Correa Neri Ana Thais Machado Moutinho Caren Dos Santos Lima Source Type: research

Immuno-metabolic Reprogramming of T Cell: A New Frontier for Pharmacotherapy of Rheumatoid Arthritis
Immunopharmacol Immunotoxicol. 2024 Mar 13:1-32. doi: 10.1080/08923973.2024.2330636. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is a persistent autoimmune condition characterized by ongoing inflammation primarily affecting the synovial joint. This inflammation typically arises from an increase in immune cells such as neutrophils, macrophages, and T cells (TC). TC is recognised as a major player in RA pathogenesis. The involvement of HLA-DRB1 and PTPN-2 among RA patients confirms the TC involvement in RA. Metabolism of TC is maintained by various other factors like cytokines, mitochondrial proteins & other ...
Source: Immunopharmacology and Immunotoxicology - March 13, 2024 Category: Allergy & Immunology Authors: Sourav Mondal Sarthak Saha Debjeet Sur Source Type: research