Fight Aging! Newsletter, October 25th 2021
This study confirmed that the PSI could be a quantitative index of vascular aging and has potential for use in inferring arterial stiffness with an advantage over the rAIx. A Profile of Michael Greve and the Segment of the Longevity Industry that He Supports https://www.fightaging.org/archives/2021/10/a-profile-of-michael-greve-and-the-segment-of-the-longevity-industry-that-he-supports/ Would that the popular media produced more popular science articles about the longevity industry like this one. It is not just a profile of someone trying to make a difference in the world by advancing the state of medic...
Source: Fight Aging! - October 24, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

ELMO1 Inhibition as a Basis for Osteoporosis Therapies
Osteoporosis is the name given to the characteristic loss of bone mass and strength that takes place with age. Bone is constantly remodeled, and this condition is the consequence of a growing imbalance between the activity of osteoclasts, responsible for breaking down bone, and osteoblasts, responsible for building bone. Researchers here make the observation that osteoclasts perform functions related to bone construction even as they break down bone, meaning that therapies intended to limit osteoclast populations may not work as well as hoped. Instead, specifically dialing back only the breakdown of bone tissue by altering...
Source: Fight Aging! - October 21, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Thought experiment: Would therapists be out of a job if we could “ fix ” persistent pain?
Every few years someone, somewhere, announces that “it won’t be long before we have a treatment to rid the world of persistent pain.” And there’s a hiss and roar to celebrate this momentous finding, and much ado about how wonderful it will be. I’m still waiting. BUT I thought it might be an interesting thought experiment to wonder what might happen if a “cure” was available for fibromyalgia. As readers will know, I have lived with what eventually was named “fibromyalgia” since my early 20’s, and probably longer. I’ve dabbled in various treatments ove...
Source: HealthSkills Weblog - October 10, 2021 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Chronic pain Pain conditions Professional topics Research Science in practice biopsychosocial pain management Therapeutic approaches Source Type: blogs

Caregiving During Middle Age Inspired Author to Start Foundation to Help Caregivers
When people think about caregiving spouses, they often think of older adults. We only have to look at a young mother diagnosed with multiple sclerosis (MS), a young husband diagnosed with rheumatoid arthritis (RA), or in this case, a woman whose healthy husband had a sudden, massive stroke, to know differently. Kathi Koll, author of “Kick-Ass Kinda Girl: A Memoir of Life, Love, and Caregiving” knows the drill. She and her husband, Don, lived a life of glitz and glamour, working and playing alongside friends who were celebrities and politicians... Continue reading on HealthCentral for more about Kathi Koll's foundation:...
Source: Minding Our Elders - October 8, 2021 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

Future Treatment For Autoimmune Diseases
New digital health tech targeted to fight autoimmune diseases or their symptoms are diverse and creative. These often completely different illnesses, like type 1 diabetes, inflammatory bowel disease, rheumatoid arthritis, and multiple sclerosis, indicate an immune system dysfunction. Immune cells and mechanisms target the body’s own cells and structures, deconstructing it bit by bit and inducing inflammation. An estimated 24-50 million people in the US alone are living with autoimmune conditions. It affects their day-to-day life, but scientists suggest people living with chronic conditions could also be more suscepti...
Source: The Medical Futurist - July 29, 2021 Category: Information Technology Authors: szandra Tags: Biotechnology Future of Medicine Portable Medical Diagnostics Telemedicine & Smartphones chatbot diabetes digital health sleep optimization chronic pain chronic illness skin coronavirus autoimmune disease Source Type: blogs

Fight Aging! Newsletter, July 19th 2021
In this study, we developed the first epigenetic clock for domesticated sheep (Ovis aries), which can predict chronological age with a median absolute error of 5.1 months. We have discovered that castrated male sheep have a decelerated aging rate compared to intact males, mediated at least in part by the removal of androgens. Furthermore, we identified several androgen-sensitive CpG dinucleotides that become progressively hypomethylated with age in intact males, but remain stable in castrated males and females. Comparable sex-specific methylation differences in MKLN1 also exist in bat skin and a range of mouse tissu...
Source: Fight Aging! - July 18, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Dihomo- γ-linoleic Acid as a Basis for Senolytic Therapy
This interview with a researcher working on the biochemistry of senescent cells notes the exploration of dihomo-γ-linoleic acid and derived compounds as potential senotherapeutics, capable of reducing the burden of senescent cells in old animals. At the end of the day there will be a very large number of such approaches, as the animal data for rejuvenation resulting from the clearance of senescent cells is impressive enough to drive a considerable growth in funding and interest. A sizable number of biotech companies are working on drugs to selectively destroy senescent cells, and many more programs are in earlier stages i...
Source: Fight Aging! - July 14, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

3D Printing in Medicine And Healthcare – The Ultimate List In 2021
3D printing has demonstrated huge potential for the future of medicine in the previous years, and its development is unstoppable. Just look at the impressive list of 3D printed healthcare materials and medical equipment below! How does 3D printing in medicine work? 3D printing in medicine is part of the innovative process called additive manufacturing, which means producing three-dimensional solid objects from a digital file. How the technology works, we explained the technology in our article on bioprinting here. As technology evolves, researchers work on various solutions. For example, engineers from the University of B...
Source: The Medical Futurist - July 13, 2021 Category: Information Technology Authors: berci.mesko Tags: 3D Printing Biotechnology Future of Medicine Healthcare Design Medical Education Personalized Medicine bioprinting Innovation Video GC1 3d printed biomaterial tissue engineering Source Type: blogs

Fight Aging! Newsletter, April 26th 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - April 25, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A Nanomaterial Incorporating TNF Epitopes Reduces Inflammation
The inflammatory cytokine TNF is the target of many efforts to find ways to reduce inflammation in conditions characterized by excessive inflammatory activity of the immune system, such as autoimmune diseases. It is a blunt approach, as it reduces not only inappropriate activity, but also the needed activity of the immune system, such as defense against pathogens and destruction of potentially cancerous and senescent cells. The methods of targeting TNF are becoming ever more sophisticated, as this example demonstrates. It is nonetheless the case that better and different classes of treatment will be needed in order to avoi...
Source: Fight Aging! - April 22, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Acute aortic regurgitation
Clinical scenario of acute aortic regurgitation is quite different from familiar finding in chronic aortic regurgitation. Due to the atypical findings, it may be difficult to diagnose acute aortic regurgitation. All the same, it is not a stable condition like chronic aortic regurgitation. Acute regurgitation can rapidly progress to heart failure and early mortality if left untreated. Important causes of acute aortic regurgitation are infective endocarditis, aortic dissection, and rarely trauma [1]. Rare causes reported are necrotizing granulomatous inflammation of the aortic valve in rheumatoid arthritis [2] and avulsion...
Source: Cardiophile MD - April 13, 2021 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs

Why Journaling as a Practice is the Best Gift You Can Give Yourself
Fill your paper, with the breathings of your heart'- William Wordsworth. I had made a new pal over the last few years. She's resilient against stress, cheap, accommodating, trusting, and takes my nasties all the time. She's ready to be my punching bag, therapist, friend, and priest all rolled in one. She has no judgment or opinion and accepts me as I am, the good, bad, and ugly- and that, friends, is my Penzu app. The first time I heard about it, I knew I reached kingdom come. It is an online diary journal with dates and is free for the most part. In Penzu, I write my deepest darkest thoughts and fe...
Source: PickTheBrain | Motivation and Self Improvement - April 1, 2021 Category: Consumer Health News Authors: Lana Tags: creativity featured happiness self-improvement writing tips Source Type: blogs

It Is A Pity That We Don ’t See More Balanced Views On Clinical Software Errors.
This appeared las week: Medical software blamed for fatal anticoagulant double-dosing error Hospital doctors relying on the Cerner system accidentally prescribed an additional dose of apixaban 11th March 2021 By Antony Scholefield A hospital software system has been blamed for a fatal anticoagulant double-dosing error after it displayed a prescribing icon so small that it could not be seen on a standard computer screen.  In 2019, Ian Fraser was admitted to the Sunshine Hospital in Melbourne with an exacerbation of his congestive cardiac failure as well as community-acquired pneumonia. He had a comp...
Source: Australian Health Information Technology - March 17, 2021 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

Fight Aging! Newsletter, March 15th 2021
In conclusion, PLG attenuates high calcium/phosphate-induced vascular calcification by upregulating P53/PTEN signaling in VSMCs. Tsimane and Moseten Hunter-Gatherers Exhibit Minimal Levels of Atrial Fibrillation https://www.fightaging.org/archives/2021/03/tsimane-and-moseten-hunter-gatherers-exhibit-minimal-levels-of-atrial-fibrillation/ Epidemiological data for the Tsimane and Moseten populations in Bolivia shows that they suffer very little cardiovascular disease in later life, despite a presumably greater lifetime burden of infectious disease (and consequent inflammation) than is the case for people ...
Source: Fight Aging! - March 14, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Age-Associated B Cells Contribute to Autoimmunity and Chronic Inflammation
The immune system becomes disordered and dysfunctional with age in numerous different ways. The B cell component accumulates inflammatory and problematic cells that are known as age-associated B cells. Here, researchers show that these errant B cells produce antibodies that provoke autoimmunity. B cell aging is a problem with a solution demonstrated in animal models: just destroy all B cells. Mammals can get by without B cells for at least a short period of time, and the B cell population regenerates quite rapidly following clearance even in later life. The newly replaced B cells do not exhibit the problems of their destro...
Source: Fight Aging! - March 11, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs