Cheating death: How cancer cells escape
Cell death is fundamental to life and, thus, healthy aging. In the realm of cellular biology, ferroptosis (a form of programmed cell death) has emerged not only as a focal point of research for its potential in eliminating cancer cells, but also its role in a plethora of other diseases, including neurodegenerative diseases such as Alzheimer's disease, eye diseases such as Retinitis pigmentosa and age-related macular degeneration, as well as ischemia, cardiovascular disease, liver disease, acute kidney injury and inflammation. (Source: World Pharma News)
Source: World Pharma News - February 2, 2024 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news
How the 13-lined ground squirrel led an East Bay company to a potential half-billion-dollar drug deal
The Emeryville company is building out its own pipeline of potential drugs, including programs in lung-scarring pulmonary fibrosis and the genetic blinding disease retinitis pigmentosa. (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - December 21, 2023 Category: Pharmaceuticals Authors: Ron Leuty Source Type: news
Electrifying Results: Restoring Partial Color Vision In Retinitis Pigmentosa Patients With Retinal Implants
Retinal implants have recently gained attention as a potential treatment for RP-induced color blindness. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - December 16, 2023 Category: Pharmaceuticals Authors: William A. Haseltine, Contributor Tags: Healthcare /healthcare Innovation /innovation business pharma & standard Source Type: news
Opening Our Eyes To Stem Cells For Stargardt's Macular Dystrophy
Stem cell therapies are being studied in clinical trials to treat retinitis pigmentosa, a genetic disorder that causes vision loss. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - October 26, 2023 Category: Pharmaceuticals Authors: William A. Haseltine, Contributor Tags: Healthcare /healthcare Innovation /innovation business pharma & standard Source Type: news
Aldeyra reports positive mid-stage results for retinitis pigmentosa candidate
(Source: Reuters: Health)
Source: Reuters: Health - July 8, 2023 Category: Consumer Health News Source Type: news
The Road To CRISPR Vision
Stem cell therapies have been making significant progress in restoring vision loss. Here we describe recent advances that use CRISPR to treat retinitis pigmentosa. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - June 14, 2023 Category: Pharmaceuticals Authors: William A. Haseltine, Contributor Tags: Healthcare /healthcare Innovation /innovation business pharma & standard Source Type: news
Inspired by founder's daughter, East Bay startup Ray Therapeutics raises $100M to tackle eye diseases
The company is the second led by Paul Bresge, whose daughter Tamar was diagnosed with retinitis pigmentosa at 15. (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - May 16, 2023 Category: American Health Authors: Ron Leuty Source Type: news
Janssen to Highlight Innovation in Retinal Pipeline at the Association for Research in Vision and Ophthalmology (ARVO) 2023 Annual Meeting
Click to Access Audio Press ReleaseRARITAN, N.J., April 21, 2023 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that five company-sponsored presentations will be featured during the Association for Research in Vision and Ophthalmology (ARVO) 2023 Annual Meeting in New Orleans from April 23-27, 2023. Janssen presentations will include updates from the Phase 1/2 MGT009 trial for investigational gene therapy botaretigene sparoparvovec (bota-vec, formerly AAV-RPGR) in patients with the inherited retinal disease (IRD) X-linked retinitis pigmentosa (XLRP) associated with the retinitis pigmentos...
Source: Johnson and Johnson - April 21, 2023 Category: Pharmaceuticals Tags: Innovation Source Type: news
Being Diagnosed With Inherited Retinal Dystrophy
Being diagnosed with a hereditary vision disease is life-changing. Learn how someone with retinitis pigmentosa manages life with low vision. (Source: WebMD Health)
Source: WebMD Health - November 21, 2022 Category: Consumer Health News Source Type: news
'Bumping' into objects could be first sign of genetic eye condition retinitis pigmentosa
"Bumping" into objects that appear to "come out of nowhere" could be an early sign of retinitis pigmentosa, a sight condition. (Source: Daily Express - Health)
Source: Daily Express - Health - October 30, 2022 Category: Consumer Health News Source Type: news
Janssen Announces Late-Breaking Data from Two Gene Therapy Programs at the American Academy of Ophthalmology 2022 Annual Meeting
In this study, patients (n=17) were sequentially enrolled at a low, intermediate and high dose without steroid prophylaxis, and all three doses of JNJ-1887 met the primary endpoint of safety over the two-year follow-up period.6 In addition, the supportive efficacy measures, including evaluation of GA lesion growth rates, showed a continual decline in lesion growth over six-month increments.6 These results are the first shared from the Company's common eye disease portfolio and indicate further evaluation of this investigational gene therapy is warranted.6About the Phase 1/2 MGT009 Trial and Botaretigene SparoparvovecThe Ph...
Source: Johnson and Johnson - October 1, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news
A First: Blind Man's Sight Restored With Optogenetic Therapy A First: Blind Man's Sight Restored With Optogenetic Therapy
Combining gene therapy with light-stimulating goggles enabled a patient with a 40-year history of blindness caused by retinitis pigmentosa to regain partial sight.Medscape Medical News (Source: Medscape Emergency Medicine Headlines)
Source: Medscape Emergency Medicine Headlines - May 25, 2021 Category: Emergency Medicine Tags: Neurology & Neurosurgery News Source Type: news
Blind Patient Recovers Partial Vision with Optogenetics
After receiving an intraocular injection of the gene for a light-sensitive protein, a 58-year-old man diagnosed with the neurodegenerative eye disease retinitis pigmentosa was able to locate objects... (Source: The Scientist)
Source: The Scientist - May 24, 2021 Category: Science Tags: News & Opinion Source Type: news
A Blind Patient Regained Partial Sight in a Breakthrough Study, Offering Hope to Millions
The darkness descends slowly for people with retinitis pigmentosa (RP), a degenerative eye disease that affects 2 million people worldwide. The condition is typically diagnosed in childhood or adolescence, but it can take until middle age before a person’s vision has deteriorated severely enough that they are fully or effectively blind. When the lights finally do go out, however, they stay out.
Or that’s the way things used to be. In a breakthrough study published today in Nature Medicine, investigators report a relatively simple yet remarkably effective way to restore partial vision to RP patients—one th...
Source: TIME: Health - May 24, 2021 Category: Consumer Health News Authors: Jeffrey Kluger Tags: Uncategorized embargoed study Innovation Source Type: news
A Blind Patient Regained Partial Sight in a Breakthrough Study, Offering Hope to Millions
The darkness descends slowly for people with retinitis pigmentosa (RP), a degenerative eye disease that affects 2 million people worldwide. The condition is typically diagnosed in childhood or adolescence, but it can take until middle age before a person’s vision has deteriorated severely enough that they are fully or effectively blind. When the lights finally do go out, however, they stay out.
Or that’s the way things used to be. In a breakthrough study published today in Nature Medicine, investigators report a relatively simple yet remarkably effective way to restore partial vision to RP patients—one th...
Source: TIME: Science - May 24, 2021 Category: Science Authors: Jeffrey Kluger Tags: Uncategorized embargoed study Innovation Source Type: news
