The accuracy and intra- and interobserver variability of PSMA PET/CT for the local staging of primary prostate cancer
ConclusionIn a large, multicentre study evaluating 600 patients with newly diagnosed intermediate and high-risk PCa, we showed that PSMA PET/CT may have a value in local tumour staging when pathological tumour stage in the radical prostatectomy specimen was used as the reference standard. The intra-observer and interobserver variability of assessment of tumour extent on PSMA PET/CT was moderate to substantial. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 24, 2024 Category: Nuclear Medicine Source Type: research
Clinical Pathology Conference: Case 4: An exophytic gingival mass of the right anterior mandible
An 83-year-old male presented to a community oral maxillofacial surgeon with a tender, pink, pedunculated exophytic tumor measuring 2 × 1.5 cm involving the right anterior mandible adjacent to tooth #27 (Figure 1A). His medical history was significant for hypertension, congestive heart failure, atrial fibrillation, and prostate cancer treated with radiation and androgen deprivation chemotherapy. The patient had been taking a miodarone, metoprolol, digoxin, rivaroxaban, furosemide, bicalutamide, and leuprorelin injections. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - April 24, 2024 Category: ENT & OMF Authors: Safia Durab, Ida A. Varghese, Laith Mahmood, Nadarajah Vigneswaran Source Type: research
Co-transcriptional R-loops-mediated epigenetic regulation drives growth retardation and docetaxel chemosensitivity enhancement in advanced prostate cancer
R-loops are prevalent three-stranded nucleic acid structures, comprising a DNA-RNA hybrid and a displaced single-stranded DNA, that frequently form during transcription and may be attributed to genomic stabili... (Source: Molecular Cancer)
Source: Molecular Cancer - April 24, 2024 Category: Cancer & Oncology Authors: Yufan Ying, Yuqing Wu, Fenghao Zhang, Yijie Tang, Jiahe Yi, Xueyou Ma, Jiangfeng Li, Danni Chen, Xiao Wang, Xiaoyan Liu, Ben Liu, Jindan Luo, Xiangyi Zheng and Liping Xie Tags: Research Source Type: research
Real-world treatment patterns and medical costs of prostate cancer patients in Switzerland – a claims data analysis
Prostate cancer (PC) is the most prevalent cancer in men in Switzerland. However, evidence on the real-world health care use of PC patients is scarce. The aim of this study is to describe health care utilization, treatment patterns, and medical costs in PC patients over a period of five years (2014-2018). (Source: European Journal of Cancer)
Source: European Journal of Cancer - April 24, 2024 Category: Cancer & Oncology Authors: Michael Stucki, Stephanie Dosch, Markus Gn ädinger, Sereina M. Graber, Carola A. Huber, Golda Lenzin, Räto T. Strebel, Daniel R. Zwahlen, Aurelius Omlin, Simon Wieser Tags: Original Research Source Type: research
Biparametric MRI in prostate cancer during active surveillance: is it safe?
AbstractActive surveillance (AS) is the preferred option for patients presenting with low-intermediate-risk prostate cancer. MRI now plays a crucial role for baseline assessment and ongoing monitoring of AS. The Prostate Cancer Radiological Estimation of Change in Sequential Evaluation (PRECISE) recommendations aid radiological assessment of progression; however, current guidelines do not advise on MRI protocols nor on frequency. Biparametric (bp) imaging without contrast administration offers advantages such as reduced costs and increased throughput, with similar outcomes to multiparametric (mp) MRI shown in the biopsy na...
Source: European Radiology - April 24, 2024 Category: Radiology Source Type: research
Nutritional supplement with fermented soy in men with an elevated risk of prostate cancer and negative prostate biopsies: General and oncological results from the prospective PRAECAP trial
To investigate the effect of a dietary supplement containing fermented soy on PSA, IPSS, changes in prostate volume and prostate cancer development after a 6-month challenge in men at increased risk of prostate cancer and negative previous biopsies. (Source: Urology)
Source: Urology - April 24, 2024 Category: Urology & Nephrology Authors: Hans Van Der Eecken, Bram Vansevenant, Ga ëtan Devos, Eduard Roussel, Alexander Giesen, Jochen Darras, Filip Ameye, Lodewijk Van Wynsberge, Lieven Goeman, Marc Claessens, Dieter Ost, Steven Joniau Source Type: research
Sophorin mitigate flutamide-induced hepatotoxicity in Wistar rats
In this study,sophorin was used at a dose of 100mg/kg body weight in purified water via oral route for 4 week daily whereas, flutamide was used at a dose of 100mg kg/b.wt for 4 weeks daily in 0.5% carboxy methyl cellulose (CMC) through the oral route for the induction of hepatotoxicity. Flutamide administration leads to enhanced reactive oxygen species (ROS) generation, an imbalance in redox homeostasis and peroxidation of lipid resulted in reduced natural antioxidant level in liver tissue. Our result demonstrated that sophorin significantly abrogate flutamide induced lipid peroxidation, protein carbonyl (PC), and also sig...
Source: Toxicon - April 23, 2024 Category: Toxicology Authors: Rishi Sharma Md Meraj Ansari Manzar Alam Mohammad Fareed Nemat Ali Anas Ahmad Sarwat Sultana Rehan Khan Source Type: research
Changes in Physiological Traits, Gene Expression and Phytochemical Profile of Mentha piperita in Response to Elicitor
The objective of this research is to investigate the expression of essential genes in the menthol pathway of Mentha piperita, including Pulegone reductase (Pr), Menthofuran synthase (Mfs), and limonene synthase (Ls) using qPCR, physiological analysis and essential oil composition in response to methyl jasmonate (MeJA) (0.5 mM) elicitation. Physiological analysis showed that 0.5 mM MeJA triggers defensive responsiveness in Mentha piperita by increasing superoxide dismutase (SOD) and Peroxidase (POD) enzymes activity. The highest transcript levels of Pr and Mfs genes were observed during 8 and 12 h after treatment respective...
Source: Biochemical Genetics - April 23, 2024 Category: Genetics & Stem Cells Authors: Soheila Afkar Ghasem Karimzadeh Source Type: research
Knockdown of growth differentiation factor-15 restrains prostate cancer through regulating MAPK/ERK signaling pathway
This study investigates the regulatory function of GDF15 in prostate cancer. To explore GDF15's impact, we established GDF15 knockdown and overexpression models in prostate cancer cells. We quantified mRNA and protein levels using RT-PCR and Western blotting. Functional assays, including CCK8, Transwell, wound healing, and flow cytometry, were employed to evaluate cell proliferation, invasion, migration, and apoptosis. Additionally, the effect of GDF15 on tumor growth was assessed using a metastatic tumor model in nude mice. Elevated GDF15 expression was identified in prostate cancer tissues and cells. The knockdown of GDF...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Minggen Yang Miaolin Guo Chenqiang Su Weiping Hao Zhenqiang Xu Source Type: research
Research of the unrecognised functions of miR-375 in prostate cancer cells
In conclusion, miR-375 has anti-proliferative and cell migration inhibitory effects in prostate cancer. However, studies demonstrate that miR-375 may have tumor suppressor and oncogenic effects when considering cell molecular differences.PMID:38650131 | DOI:10.14715/cmb/2024.70.3.32 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Merve Goztepe Onur Eroglu Source Type: research
Reducing False-Positives Due to Urinary Stagnation in the Prostatic Urethra on 18F-DCFPyL PSMA PET/CT With MRI
CONCLUSIONS: Stagnated urine within the prostatic urethra is a potential confounding factor on PSMA PET scans. Integrating PET imaging with T2W MRI can mitigate false-positive calls, especially as PSMA PET/CT continues to gain traction in diagnosing localized prostate cancer.PMID:38651785 | DOI:10.1097/RLU.0000000000005220 (Source: Cancer Control)
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: David G Gelikman Esther Mena Liza Lindenberg William S Azar Nityam Rathi Enis C Yilmaz Stephanie A Harmon Kyle C Schuppe Jessica Y Hsueh Hannah Huth Bradford J Wood Sandeep Gurram Peter L Choyke Peter A Pinto Baris Turkbey Source Type: research
Salvage Reirradiation for Locally Recurrent Prostate Cancer: Results From a Prospective Study With 7.2 Years of Follow-Up
CONCLUSION: Reirradiation with EBRT for locally recurrent PCa after primary curative radiation therapy is clinically feasible and demonstrated a favorable outcome with acceptable toxicity in this prospective study with long-term follow-up.PMID:38652872 | DOI:10.1200/JCO.23.01391 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Christian Ekanger Svein Inge Helle Lars Reis æter Liv Bolstad Hysing Rune Kv åle Alfred Honor é Karsten Gravdal Sara Pilskog Olav Dahl Source Type: research
Reducing False-Positives Due to Urinary Stagnation in the Prostatic Urethra on 18F-DCFPyL PSMA PET/CT With MRI
CONCLUSIONS: Stagnated urine within the prostatic urethra is a potential confounding factor on PSMA PET scans. Integrating PET imaging with T2W MRI can mitigate false-positive calls, especially as PSMA PET/CT continues to gain traction in diagnosing localized prostate cancer.PMID:38651785 | DOI:10.1097/RLU.0000000000005220 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 23, 2024 Category: Cancer & Oncology Authors: David G Gelikman Esther Mena Liza Lindenberg William S Azar Nityam Rathi Enis C Yilmaz Stephanie A Harmon Kyle C Schuppe Jessica Y Hsueh Hannah Huth Bradford J Wood Sandeep Gurram Peter L Choyke Peter A Pinto Baris Turkbey Source Type: research
GSE149226 Prognostic classifier for predicting biochemical recurrence in localized prostate cancer patients after radical prostatectomy
Contributors : L Mengual ; J J Lozano ; A AlcarazSeries Type : Expression profiling by arrayOrganism : Homo sapiensAccurate estimation of recurrence risk is needed for optimal treatment of clinically localized prostate cancer (PCa) patients. We combined classical clinicopathological predictors of biochemical recurrence (BCR) and molecular markers into a new risk score for predicting BCR after radical prostatectomy (RP). A retrospective study which included 122 PCa patients who attended our department between 2000 and 2007 was conducted. Total RNA was isolated from formalin-fixed paraffin embedded PCa tissue. Gene express...
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Radiomic nomogram based on bi-parametric MRI to predict the International Society of Urological Pathology (ISUP) grading ≥ 3 prostate cancer: a multicenter study
To create a reliable radiomic nomogram for the prediction of the International Society of Urological Pathology (ISUP) grading ≥ 3 PCa patients. (Source: Clinical Radiology)
Source: Clinical Radiology - April 23, 2024 Category: Radiology Authors: Yongsheng Zhang, Zhiping Li, Chen Gao, Liqing Zhang, Yasheng Huang, Hua Qu, Chang Shu, Yuguo Wei, Maosheng Xu, Feng Cui Source Type: research
