Functional tricuspid regurgitation and efficacy of electrical cardioversion in patients with atrial fibrillation and atrial functional mitral regurgitation
CONCLUSIONS: The fTR frequently coexists with afMR and it significantly diminishes the effectiveness of CVE for treating AF. The degree of fTR does not appear to influence the efficacy of CVE.PMID:38587117 | DOI:10.5603/cj.96311 (Source: Cardiology Journal)
Source: Cardiology Journal - April 8, 2024 Category: Cardiology Authors: Katarzyna Klimek Micha ł Tworek Konrad Klocek Julia Do łęga Gabriela Majta Klaudia Marcinkiewicz Karolina Wrona-Kolasa Ma łgorzata Cichoń Katarzyna Mizia-Stec Source Type: research
Functional tricuspid regurgitation and efficacy of electrical cardioversion in patients with atrial fibrillation and atrial functional mitral regurgitation
CONCLUSIONS: The fTR frequently coexists with afMR and it significantly diminishes the effectiveness of CVE for treating AF. The degree of fTR does not appear to influence the efficacy of CVE.PMID:38587117 | DOI:10.5603/cj.96311 (Source: Cardiology Journal)
Source: Cardiology Journal - April 8, 2024 Category: Cardiology Authors: Katarzyna Klimek Micha ł Tworek Konrad Klocek Julia Do łęga Gabriela Majta Klaudia Marcinkiewicz Karolina Wrona-Kolasa Ma łgorzata Cichoń Katarzyna Mizia-Stec Source Type: research
The clinical relevance of heme detoxification by the macrophage heme oxygenase system
Front Immunol. 2024 Mar 22;15:1379967. doi: 10.3389/fimmu.2024.1379967. eCollection 2024.ABSTRACTHeme degradation by the heme oxygenase (HMOX) family of enzymes is critical for maintaining homeostasis and limiting heme-induced tissue damage. Macrophages express HMOX1 and 2 and are critical sites of heme degradation in healthy and diseased states. Here we review the functions of the macrophage heme oxygenase system and its clinical relevance in discrete groups of pathologies where heme has been demonstrated to play a driving role. HMOX1 function in macrophages is essential for limiting oxidative tissue damage in both acute ...
Source: Atherosclerosis - April 8, 2024 Category: Cardiology Authors: Scott Yeudall Clint M Upchurch Norbert Leitinger Source Type: research
Epidemiology of Diabetic Kidney Disease among US Veterans
(Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - April 8, 2024 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity Source Type: research
Exploring the Association of Metabolic Syndrome with In-Hospital Survival of Older Patients Hospitalized with COVID-19: Beyond Chronological Age
ConclusionsMetabolic syndrome measures are important individual predictors of COVID-19 outcomes. Building on prior examinations that metabolic syndrome is associated with death and ARDS across all ages, this analysis supports that metabolic syndrome criteria may be more relevant than chronological age as risk factors for poor outcomes attributed to COVID-19. (Source: Journal of General Internal Medicine)
Source: Journal of General Internal Medicine - April 8, 2024 Category: Internal Medicine Source Type: research
The Association Between the Triglyceride to High-Density Lipoprotein Cholesterol Ratio and the Incidence of Type 2 Diabetes Mellitus in the Japanese Population
Metabolic Syndrome and Related Disorders, Ahead of Print. (Source: Metabolic Syndrome and Related Disorders)
Source: Metabolic Syndrome and Related Disorders - April 8, 2024 Category: Endocrinology Authors: Guojuan Xu Jing Song Source Type: research
Dietary Total Polyphenol, Flavonoid, and Lignan Intakes Are Associated with Obesity and Diabetes-Related Traits: A Case-Control Study
Metabolic Syndrome and Related Disorders, Ahead of Print. (Source: Metabolic Syndrome and Related Disorders)
Source: Metabolic Syndrome and Related Disorders - April 8, 2024 Category: Endocrinology Authors: Busra Turan-Demirci Kubra Isgin-Atici Suleyman Nahit Sendur Deniz Yuce Tomris Erbas Zehra Buyuktuncer Source Type: research
Common Criticisms and Rebuttals of The BEST-CLI Trial
Peripheral artery disease (PAD) affects more than 230 million patients world-wide1 and its prevalence is increasing due to the aging world population and the epidemic of diabetes and metabolic syndrome. 2 Approximately 11% of those with PAD progress to chronic limb threatening ischemia (CLTI), the most severe form of chronic PAD3 that presents with non-healing wounds or ischemic rest pain4. Without revascularization, the rate of limb loss among those with CLTI is approximately 22% per year.5 In addition, patients with CLTI have a 2-year mortality rate as high as 40% and the risk of death is nearly 3-fold among those with m...
Source: Annals of Vascular Surgery - April 7, 2024 Category: Surgery Authors: Olivia D ’Angelo, Matthew T. Menard, Alik Farber Source Type: research
Chronic unpredictable mild stress increases serum aldosterone without affecting corticosterone levels and induces hepatic steatosis and renal injury in young adult male rats
AbstractStress is often associated with anxiety and depressive symptoms in adolescents. Stress is associated with components of metabolic syndrome and inflammation. The present study hypothesizes that aldosterone, more than corticosterone, promotes chronic stress-hepatic steatosis and fibrosis, as well as renal inflammation and fibrosis in young adult rats. Thirty-two young adult male Wistar rats of 51 days old were divided into four groups (n = 8 per group): Control (C), chronic unpredictable mild stress (CUMS), control plus vehicle (C plus veh), CUMS plus eplerenone, a selective aldosterone blocker (CUMS plus EP). On...
Source: Journal of Molecular Histology - April 7, 2024 Category: Laboratory Medicine Source Type: research
Potential impact of underlying diseases influencing ADME in nonclinical safety assessment
Food Chem Toxicol. 2024 Apr 4:114636. doi: 10.1016/j.fct.2024.114636. Online ahead of print.ABSTRACTNonclinical studies involve in vitro, in silico, and in vivo experiments to assess the toxicokinetics, toxicology, and safety pharmacology of drugs according to regulatory requirements by a national or international authority. In this review, we summarize the potential effects of various underlying diseases governing the absorption, distribution, metabolism, and excretion (ADME) of drugs to consider the use of animal models of diseases in nonclinical trials. Obesity models showed alterations in hepatic metabolizing enzymes, ...
Source: Food and Chemical Toxicology - April 6, 2024 Category: Food Science Authors: Sumin Cho Harin Jo Yeon Jeong Hwang Changuk Kim Yong Hyeon Jo Jun-Won Yun Source Type: research
Potential impact of underlying diseases influencing ADME in nonclinical safety assessment
Food Chem Toxicol. 2024 Apr 4:114636. doi: 10.1016/j.fct.2024.114636. Online ahead of print.ABSTRACTNonclinical studies involve in vitro, in silico, and in vivo experiments to assess the toxicokinetics, toxicology, and safety pharmacology of drugs according to regulatory requirements by a national or international authority. In this review, we summarize the potential effects of various underlying diseases governing the absorption, distribution, metabolism, and excretion (ADME) of drugs to consider the use of animal models of diseases in nonclinical trials. Obesity models showed alterations in hepatic metabolizing enzymes, ...
Source: Food and Chemical Toxicology - April 6, 2024 Category: Food Science Authors: Sumin Cho Harin Jo Yeon Jeong Hwang Changuk Kim Yong Hyeon Jo Jun-Won Yun Source Type: research
Longitudinal association between fitness and metabolic syndrome: a population-based study over 29 years follow-up
To examine the longitudinal associations between fitness and metabolic syndrome (MetS) in community-dwelling adults over 29 years of follow-up. (Source: BMC Public Health)
Source: BMC Public Health - April 6, 2024 Category: Consumer Health News Authors: Johannes Wiemann, Janina Krell-Roesch, Alexander Woll and Klaus Boes Tags: Research Source Type: research
Impact of postpartum weight change on metabolic syndrome and its components among women with recent gestational diabetes mellitus
While postpartum weight changes may affect the levels of metabolic parameters, the direct effects of weight changes in the postpartum period on changes in the prevalence rates of metabolic syndrome and its com... (Source: Reproductive Health)
Source: Reproductive Health - April 6, 2024 Category: OBGYN Authors: Chadakarn Phaloprakarn, Sasiwan Suthasmalee and Siriwan Tangjitgamol Tags: Research Source Type: research
Identification of herbal drug extracts that promote growth of Akkermansia muciniphila in high-fat diet fed mice
In this study, we screened herbal drug extracts that promoted the growth ofA.muciniphila. Among the 123 herbal drugs, five herbal drug extracts significantly increasedA.muciniphila DNA levels compared with that in controls. In particular, Dioscoreae rhizoma extract increased the growth ofA.muciniphila in the intestines of mice fed a high-fat diet and improved obesity. It significantly reduced body weight gain, improved glucose tolerance even when the administration was initiated after the induction of dietary obesity. These results suggest that herbal drug extracts, such as Dioscoreae rhizome, that increaseA.muciniphila co...
Source: Diabetology International - April 6, 2024 Category: Endocrinology Source Type: research
Short-Term Changes in Weight, Body Composition, and Metabolic Biomarkers After Laparoscopic Sleeve Gastrectomy in Patients with Obesity: A Comparative Prospective Study
ConclusionLGS significantly improves weight, body composition, and metabolic biomarkers in populations with obesity, regardless of whether they have MS. Among the body composition, VFA and LF were the most significantly improved body composition measurements.Graphical Abstract (Source: Obesity Surgery)
Source: Obesity Surgery - April 6, 2024 Category: Surgery Source Type: research
