Impact of NMDA receptors block versus GABA-A receptors modulation on synaptic plasticity and brain electrical activity in metabolic syndrome
CONCLUSIONS: Both Allo and Memantine boosted the outcome parameters in the animal model of MetS. Allo markedly improved the anxiety-like behavior in the form of significantly decreased grooming frequency compared to the Memantine-treated groups. Both drugs were associated with increased hippocampal GFAP and BDNF expression, indicating an improvement in synaptic plasticity and so, cognition-related behaviors.PMID:38561071 | DOI:10.1016/j.advms.2024.03.008 (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - April 1, 2024 Category: Biomedical Science Authors: Shaimaa Nasr Amin Sherif Ahmed Shaltout Walaa Bayoumie El Gazzar Noha Samir Abdel Latif Ghada Al-Jussani Yasmeen Jamal Alabdallat Khaled Anwer Albakri Dalia Azmy Elberry Source Type: research
Intra-pancreatic fat deposition and its relation to obesity: a magnetic resonance imaging study
CONCLUSIONS: Pancreatic fat content was increased in obese individuals compared with lean controls and predominantly correlated with the amount of visceral adipose tissue. Pancreatic fat content was not clearly linked to measures of pancreatic fibrosis.PMID:38557425 | DOI:10.1080/00365521.2024.2333365 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 1, 2024 Category: Gastroenterology Authors: Mimoza Gjela Anders Askeland Maiken Mellergaard Asbj ørn Mohr Drewes Aase Handberg Jens Br øndum Frøkjær Source Type: research
Melatonin-mediated corrective changes in gut microbiota of experimentally chronodisrupted C57BL/6J mice
Chronobiol Int. 2024 Apr 1:1-13. doi: 10.1080/07420528.2024.2329205. Online ahead of print.ABSTRACTChronic consumption of a high-calorie diet coupled with an altered sleep-wake cycle causes disruption of circadian clock that can impact the gut microbiome leading to metabolic syndrome and associated diseases. Herein, we investigate the effects of a high fat high fructose diet (H) alone or in combination with photoperiodic shifts induced chronodisruption (CD) on gut microbiota of C57BL/6J male mice. Further, the merits of daily evening intraperitoneal administration of melatonin in restoring gut microbiota are studied herein...
Source: Chronobiology International - April 1, 2024 Category: Biology Authors: Aliasgar Vohra Rhydham Karnik Mansi Desai Hitarthi Vyas Shruti Kulshrestha Kapil Kumar Upadhyay Prakash Koringa Ranjitsinh Devkar Source Type: research
Intra-pancreatic fat deposition and its relation to obesity: a magnetic resonance imaging study
CONCLUSIONS: Pancreatic fat content was increased in obese individuals compared with lean controls and predominantly correlated with the amount of visceral adipose tissue. Pancreatic fat content was not clearly linked to measures of pancreatic fibrosis.PMID:38557425 | DOI:10.1080/00365521.2024.2333365 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 1, 2024 Category: Gastroenterology Authors: Mimoza Gjela Anders Askeland Maiken Mellergaard Asbj ørn Mohr Drewes Aase Handberg Jens Br øndum Frøkjær Source Type: research
Impact of NMDA receptors block versus GABA-A receptors modulation on synaptic plasticity and brain electrical activity in metabolic syndrome
CONCLUSIONS: Both Allo and Memantine boosted the outcome parameters in the animal model of MetS. Allo markedly improved the anxiety-like behavior in the form of significantly decreased grooming frequency compared to the Memantine-treated groups. Both drugs were associated with increased hippocampal GFAP and BDNF expression, indicating an improvement in synaptic plasticity and so, cognition-related behaviors.PMID:38561071 | DOI:10.1016/j.advms.2024.03.008 (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - April 1, 2024 Category: Biomedical Science Authors: Shaimaa Nasr Amin Sherif Ahmed Shaltout Walaa Bayoumie El Gazzar Noha Samir Abdel Latif Ghadah Nazar Al-Jussani Yasmeen Jamal Alabdallat Khaled Anwer Albakri Dalia Azmy Elberry Source Type: research
Melatonin-mediated corrective changes in gut microbiota of experimentally chronodisrupted C57BL/6J mice
Chronobiol Int. 2024 Apr 1:1-13. doi: 10.1080/07420528.2024.2329205. Online ahead of print.ABSTRACTChronic consumption of a high-calorie diet coupled with an altered sleep-wake cycle causes disruption of circadian clock that can impact the gut microbiome leading to metabolic syndrome and associated diseases. Herein, we investigate the effects of a high fat high fructose diet (H) alone or in combination with photoperiodic shifts induced chronodisruption (CD) on gut microbiota of C57BL/6J male mice. Further, the merits of daily evening intraperitoneal administration of melatonin in restoring gut microbiota are studied herein...
Source: Chronobiology International - April 1, 2024 Category: Biology Authors: Aliasgar Vohra Rhydham Karnik Mansi Desai Hitarthi Vyas Shruti Kulshrestha Kapil Kumar Upadhyay Prakash Koringa Ranjitsinh Devkar Source Type: research
Breast adiposity: Menopausal status impact and its influence on glycemic and anthropometric metabolic parameters
CONCLUSION: The BA was related to different adverse body composition and metabolic factors in women in postmenopause. The results suggest that there might be a relevant BrAT endocrine role during menopause, whose mechanisms are yet to be clarified, which thus opens up research perspectives on the subject as well as on clinical settings.PMID:38558168 | DOI:10.1210/clinem/dgae205 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 1, 2024 Category: Endocrinology Authors: Barbara Limberger Nedel Michelle Garcia Madure Silvia Guaresi Maria Elisa Soares Machado Marcelo Madrid de Bittencourt Nathalia Nobrega Chagas Fernando Gerchman Source Type: research
Melatonin-mediated corrective changes in gut microbiota of experimentally chronodisrupted C57BL/6J mice
Chronobiol Int. 2024 Apr 1:1-13. doi: 10.1080/07420528.2024.2329205. Online ahead of print.ABSTRACTChronic consumption of a high-calorie diet coupled with an altered sleep-wake cycle causes disruption of circadian clock that can impact the gut microbiome leading to metabolic syndrome and associated diseases. Herein, we investigate the effects of a high fat high fructose diet (H) alone or in combination with photoperiodic shifts induced chronodisruption (CD) on gut microbiota of C57BL/6J male mice. Further, the merits of daily evening intraperitoneal administration of melatonin in restoring gut microbiota are studied herein...
Source: Chronobiology International - April 1, 2024 Category: Biology Authors: Aliasgar Vohra Rhydham Karnik Mansi Desai Hitarthi Vyas Shruti Kulshrestha Kapil Kumar Upadhyay Prakash Koringa Ranjitsinh Devkar Source Type: research
A Review: Cytochrome P450 in Alcoholic and Non-Alcoholic Fatty Liver Disease
(Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - April 1, 2024 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity Source Type: research
Type 2 diabetes mellitus and cardiometabolic outcomes in metabolic dysfunction-associated steatotic liver disease population
The metabolic syndrome is a constellation of epidemics, involving type 2 diabetes mellitus (T2DM), hypertension, hyperlipidemia, and obesity, that share common biological and societal pathways.[1 –4] This pathological metabolic milieu collectively increases the individual’s risk of cardiovascular diseases, including coronary heart disease and heart failure.[3,5,6] More recently, metabolic dysfunction-associated steatotic liver disease (MASLD) has been increasingly recognized as a key man ifestation of this systemic metabolic disease. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 1, 2024 Category: Endocrinology Authors: Nicholas W.S. Chew, Xin Hui Pan, Bryan Chong, Chanchal Chandramouli, Mark Muthiah, Carolyn S.P. Lam Source Type: research
High systemic inflammation as a novel cardiovascular risk factor and target for anti-cytokine therapy: comment regarding the triglyceride glucose index
AbstractIn the last century, there has been more than enough research that proved the association of high lipid and glucose levels with cardiovascular disease, thus establishing the current well-known traditional cardiovascular risk factors such as dyslipidemia, diabetes, and metabolic syndrome. Hence, these cardiovascular risk factors are target therapy for glucose and lipid-lowering agents to prevent adverse cardiovascular events. However, despite controlling the lipid and glucose levels, some studies demonstrated the subclinical atherosclerosis suggesting that these cardiovascular risk factors alone cannot account for t...
Source: The International Journal of Cardiovascular Imaging - April 1, 2024 Category: Radiology Source Type: research
Impact of a Mindfulness Mobile Application on Weight Loss and Eating Behavior in People with Metabolic Syndrome: a Pilot Randomized Controlled Trial
ConclusionsThis study found that CLI plus MMA was highly feasible and moderately acceptable. There were no significant differences in weight loss between the groups, but the CLI + MMA group showed an increase in restrained eating. Further large-scale studies are needed.Trial RegistrationJapanese University Hospital Medical Information Network (UMIN-ICDR). Clinical Trial identifier number UMIN000042626. (Source: International Journal of Behavioral Medicine)
Source: International Journal of Behavioral Medicine - April 1, 2024 Category: Psychiatry Source Type: research
52-week mid-term efficacy of tildrakizumab in moderate-to-severe psoriasis: a real-life multicenter experience
Actas Dermosifiliogr. 2024 Mar 29:S0001-7310(24)00276-X. doi: 10.1016/j.ad.2023.08.019. Online ahead of print.ABSTRACTTildrakizumab is an IL-23-inhibitor that has been approved to treat plaque psoriasis. However, few reports have become available on its efficacy profile in the real-world. Our objective was to study the mid-term efficacy of tildrakizumab in patients with moderate-to-severe psoriasis in the Spanish routine clinical practice setting. This was a retrospective multicenter study that included a total of 91 psoriatic patients on tildrakizumab. The mean Psoriasis Area and Severity Index (PASI) was 9.09 (SD, 5.30)....
Source: Actas Dermo-Sifiliograficas - March 31, 2024 Category: Dermatology Authors: F J Melgosa Ramos A Mateu Puchades J Mat áix Díaz L Schneller Pavelescu I Belinch ón Romero S Santos Alarc ón Source Type: research
52-week mid-term efficacy of tildrakizumab in moderate-to-severe psoriasis: a real-life multicenter experience
Actas Dermosifiliogr. 2024 Mar 29:S0001-7310(24)00276-X. doi: 10.1016/j.ad.2023.08.019. Online ahead of print.ABSTRACTTildrakizumab is an IL-23-inhibitor that has been approved to treat plaque psoriasis. However, few reports have become available on its efficacy profile in the real-world. Our objective was to study the mid-term efficacy of tildrakizumab in patients with moderate-to-severe psoriasis in the Spanish routine clinical practice setting. This was a retrospective multicenter study that included a total of 91 psoriatic patients on tildrakizumab. The mean Psoriasis Area and Severity Index (PASI) was 9.09 (SD, 5.30)....
Source: Actas Dermo-Sifiliograficas - March 31, 2024 Category: Dermatology Authors: F J Melgosa Ramos A Mateu Puchades J Mat áix Díaz L Schneller Pavelescu I Belinch ón Romero S Santos Alarc ón Source Type: research
52-week mid-term efficacy of tildrakizumab in moderate-to-severe psoriasis: a real-life multicenter experience
Actas Dermosifiliogr. 2024 Mar 29:S0001-7310(24)00276-X. doi: 10.1016/j.ad.2023.08.019. Online ahead of print.ABSTRACTTildrakizumab is an IL-23-inhibitor that has been approved to treat plaque psoriasis. However, few reports have become available on its efficacy profile in the real-world. Our objective was to study the mid-term efficacy of tildrakizumab in patients with moderate-to-severe psoriasis in the Spanish routine clinical practice setting. This was a retrospective multicenter study that included a total of 91 psoriatic patients on tildrakizumab. The mean Psoriasis Area and Severity Index (PASI) was 9.09 (SD, 5.30)....
Source: Actas Dermo-Sifiliograficas - March 31, 2024 Category: Dermatology Authors: F J Melgosa Ramos A Mateu Puchades J Mat áix Díaz L Schneller Pavelescu I Belinch ón Romero S Santos Alarc ón Source Type: research
