Potential impact of underlying diseases influencing ADME in nonclinical safety assessment
Food Chem Toxicol. 2024 Apr 4:114636. doi: 10.1016/j.fct.2024.114636. Online ahead of print.ABSTRACTNonclinical studies involve in vitro, in silico, and in vivo experiments to assess the toxicokinetics, toxicology, and safety pharmacology of drugs according to regulatory requirements by a national or international authority. In this review, we summarize the potential effects of various underlying diseases governing the absorption, distribution, metabolism, and excretion (ADME) of drugs to consider the use of animal models of diseases in nonclinical trials. Obesity models showed alterations in hepatic metabolizing enzymes, ...
Source: Food and Chemical Toxicology - April 6, 2024 Category: Food Science Authors: Sumin Cho Harin Jo Yeon Jeong Hwang Changuk Kim Yong Hyeon Jo Jun-Won Yun Source Type: research
Short-Term Changes in Weight, Body Composition, and Metabolic Biomarkers After Laparoscopic Sleeve Gastrectomy in Patients with Obesity: A Comparative Prospective Study
ConclusionLGS significantly improves weight, body composition, and metabolic biomarkers in populations with obesity, regardless of whether they have MS. Among the body composition, VFA and LF were the most significantly improved body composition measurements.Graphical Abstract (Source: Obesity Surgery)
Source: Obesity Surgery - April 6, 2024 Category: Surgery Source Type: research
Impact of postpartum weight change on metabolic syndrome and its components among women with recent gestational diabetes mellitus
While postpartum weight changes may affect the levels of metabolic parameters, the direct effects of weight changes in the postpartum period on changes in the prevalence rates of metabolic syndrome and its com... (Source: Reproductive Health)
Source: Reproductive Health - April 6, 2024 Category: OBGYN Authors: Chadakarn Phaloprakarn, Sasiwan Suthasmalee and Siriwan Tangjitgamol Tags: Research Source Type: research
Longitudinal association between fitness and metabolic syndrome: a population-based study over 29 years follow-up
To examine the longitudinal associations between fitness and metabolic syndrome (MetS) in community-dwelling adults over 29 years of follow-up. (Source: BMC Public Health)
Source: BMC Public Health - April 6, 2024 Category: Consumer Health News Authors: Johannes Wiemann, Janina Krell-Roesch, Alexander Woll and Klaus Boes Tags: Research Source Type: research
Identification of herbal drug extracts that promote growth of Akkermansia muciniphila in high-fat diet fed mice
In this study, we screened herbal drug extracts that promoted the growth ofA.muciniphila. Among the 123 herbal drugs, five herbal drug extracts significantly increasedA.muciniphila DNA levels compared with that in controls. In particular, Dioscoreae rhizoma extract increased the growth ofA.muciniphila in the intestines of mice fed a high-fat diet and improved obesity. It significantly reduced body weight gain, improved glucose tolerance even when the administration was initiated after the induction of dietary obesity. These results suggest that herbal drug extracts, such as Dioscoreae rhizome, that increaseA.muciniphila co...
Source: Diabetology International - April 6, 2024 Category: Endocrinology Source Type: research
DR10627, a Novel Dual Glucagon ‑like Peptide‑1 and Gastric Inhibitory Polypeptide Receptor Agonist for the Treatment of Obesity and Type 2 Diabetes Mellitus
(Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - April 5, 2024 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity Source Type: research
A Nomogram Including Total Cerebral Small Vessel Disease Burden Score for Predicting Mild Vascular Cognitive Impairment in Patients with Type 2 Diabetes Mellitus
(Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - April 5, 2024 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity Source Type: research
Update in lean metabolic dysfunction-associated steatotic liver disease
CONCLUSION: MASLD is a complex disease comprising epigenetic, genetic, and metabolic factors in its pathogenesis. Results vary across populations, gender, and age. Limited data exists on clinical practice guidelines for lean patients. Future studies employing this new nomenclature can contribute to standardizing and generalizing results among lean patients with steatotic liver disease.PMID:38577539 | PMC:PMC10989317 | DOI:10.4254/wjh.v16.i3.452 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - April 5, 2024 Category: Gastroenterology Authors: Karina Sato-Espinoza Perapa Chotiprasidhi Mariella R Huaman Javier D íaz-Ferrer Source Type: research
Cardiovascular-Kidney-Metabolic Syndrome: Association with Adverse Events After Major Noncardiac Surgery
CONCLUSION: The newly defined CKM syndrome is associated with increased morbidity and mortality after non-cardiac surgery. Thus, cardiovascular, renal, and metabolic disorders should be regarded in mutual context in this setting.PMID:38578871 | DOI:10.1213/ANE.0000000000006975 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 5, 2024 Category: Anesthesiology Authors: Sebastian Roth Ren é M'Pembele Purificaci ón Matute Katarzyna Kotfis Jan Larmann Giovanna Lurati Buse Source Type: research
Cardiovascular-Kidney-Metabolic Syndrome: Association with Adverse Events After Major Noncardiac Surgery
CONCLUSION: The newly defined CKM syndrome is associated with increased morbidity and mortality after non-cardiac surgery. Thus, cardiovascular, renal, and metabolic disorders should be regarded in mutual context in this setting.PMID:38578871 | DOI:10.1213/ANE.0000000000006975 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 5, 2024 Category: Anesthesiology Authors: Sebastian Roth Ren é M'Pembele Purificaci ón Matute Katarzyna Kotfis Jan Larmann Giovanna Lurati Buse Source Type: research
Update in lean metabolic dysfunction-associated steatotic liver disease
CONCLUSION: MASLD is a complex disease comprising epigenetic, genetic, and metabolic factors in its pathogenesis. Results vary across populations, gender, and age. Limited data exists on clinical practice guidelines for lean patients. Future studies employing this new nomenclature can contribute to standardizing and generalizing results among lean patients with steatotic liver disease.PMID:38577539 | PMC:PMC10989317 | DOI:10.4254/wjh.v16.i3.452 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - April 5, 2024 Category: Gastroenterology Authors: Karina Sato-Espinoza Perapa Chotiprasidhi Mariella R Huaman Javier D íaz-Ferrer Source Type: research
Cardiovascular-Kidney-Metabolic Syndrome: Association with Adverse Events After Major Noncardiac Surgery
CONCLUSION: The newly defined CKM syndrome is associated with increased morbidity and mortality after non-cardiac surgery. Thus, cardiovascular, renal, and metabolic disorders should be regarded in mutual context in this setting.PMID:38578871 | DOI:10.1213/ANE.0000000000006975 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 5, 2024 Category: Anesthesiology Authors: Sebastian Roth Ren é M'Pembele Purificaci ón Matute Katarzyna Kotfis Jan Larmann Giovanna Lurati Buse Source Type: research
Obesity: An Impact with Cardiovascular and Cerebrovascular Diseases
Indian J Clin Biochem. 2024 Apr;39(2):168-178. doi: 10.1007/s12291-023-01157-w. Epub 2023 Oct 13.ABSTRACTThe authors sought to correlate the complex sequel of obesity with various parameters known to develop metabolic syndrome viz. insulin resistance, dyslipidemia, hypertension etc., as these anomalies are linked to vascular atherosclerosis and outbreak of cardiovascular and cerebrovascular diseases. A comprehensive online survey using MEDLINE, Scopus, PubMed and Google Scholar was conducted for relevant journals from 1970 till present time (2023) with key search terms like: 'obesity', 'leptin', type-2 diabetes', 'atherosc...
Source: Atherosclerosis - April 5, 2024 Category: Cardiology Authors: Savi Dutta A K Singhal Varsha Suryan Nimai Chand Chandra Source Type: research
The Effects of Fermented Rice Drink With < em > Lactiplantibacillus plantarum < /em > JSA22 in Overweight Irritable Bowel Syndrome Patients: A Randomized, Double-blind, Placebo-controlled Study
CONCLUSIONS: The fermented rice drink with L. plantarum JSA22 showed a beneficial effect in reducing abdominal distension in IBS patients. Bacteria that reduce visceral fat accumulation increased in the stool and saliva of patients who consumed fermented rice drinks.PMID:38576369 | PMC:PMC10999840 | DOI:10.5056/jnm23184 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 5, 2024 Category: Gastroenterology Authors: Nam-Hee Kim Hye Sun Choi Moon Young Lee Hyunbin Seong Nam Soo Han Hae-Jin Hu Yong Sung Kim Jung Ho Park Source Type: research
The Effects of Fermented Rice Drink With < em > Lactiplantibacillus plantarum < /em > JSA22 in Overweight Irritable Bowel Syndrome Patients: A Randomized, Double-blind, Placebo-controlled Study
CONCLUSIONS: The fermented rice drink with L. plantarum JSA22 showed a beneficial effect in reducing abdominal distension in IBS patients. Bacteria that reduce visceral fat accumulation increased in the stool and saliva of patients who consumed fermented rice drinks.PMID:38576369 | DOI:10.5056/jnm23184 (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - April 5, 2024 Category: Gastroenterology Authors: Nam-Hee Kim Hye Sun Choi Moon Young Lee Hyunbin Seong Nam Soo Han Hae-Jin Hu Yong Sung Kim Jung Ho Park Source Type: research
