Spinal Delivery of Gene Therapy Promising for Neurodegenerative Disease
(MedPage Today) -- Gene therapy delivered for the first time via lumbar puncture showed promise of benefit in slowing progression of giant axonal neuropathy (GAN) in a phase I clinical trial.
The slope of change in motor function went from -7... (Source: MedPage Today Neurology)
Source: MedPage Today Neurology - March 21, 2024 Category: Neurology Source Type: news
University of Gothenburg Study Findings Affirm Accuracy of Clinical Laboratory Blood Test to Diagnose Alzheimer ’s Disease
Already-existing clinical laboratory blood test may be new standard for detecting Alzheimer’s biomarkers In Sweden, an independent study of an existing blood test for Alzheimer’s disease—called ALZpath—determined that this diagnostic assay appears to be “just as good as, if not surpass, lumbar punctures and expensive brain scans at detecting signs of Alzheimer’s in the brain,” […]
The post University of Gothenburg Study Findings Affirm Accuracy of Clinical Laboratory Blood Test to Diagnose Alzheimer’s Disease appeared first on Dark Daily. (Source: Dark Daily)
Source: Dark Daily - March 4, 2024 Category: Laboratory Medicine Authors: Jillia Schlingman Tags: International Laboratory News Laboratory Instruments & Laboratory Equipment Laboratory Management and Operations Laboratory Testing ACL AD Alzheimer’s Association Alzheimer’s disease Alzheimer’s Society ALZpath amyloid B (AB) a Source Type: news
Will new CPT codes spark utilization of quantitative MRI?
Efforts to bring quantitative MRI analysis into clinical practice received a boost with the availability of two new Category III Current Procedural Terminology (CPT) codes for brain MRI.
Effective January 1, 2024, the new codes, 0865T and 0866T, support the use of software to analyze brain MRI exams with comparison to prior studies. AI software would qualify under the Category III CPT codes, which are for new and emerging technology:
0865T -- qMRI analysis of the brain with comparison to prior MR study(ies), including lesion identification, characterization, and quantification, with brain volume(s) quantification and/o...
Source: AuntMinnie.com Headlines - January 30, 2024 Category: Radiology Authors: Liz Carey Tags: Artificial Intelligence SENL Source Type: news
A Blood Test for Alzheimer ’ s Disease Is Almost Here
As the world’s population ages, health experts are bracing for higher rates of age-related diseases, including Alzheimer’s.
Finding new ways to diagnose the condition is more of a priority than ever, since new treatments work best earlier in the course of disease. But currently, the two primary ways to diagnose Alzheimer’s—PET imaging or a lumbar puncture—are either too expensive or invasive for most people, leaving too many cases undiagnosed.
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In a study published in JAMA Neurology, researchers report on a promising, more accessible test usin...
Source: TIME: Health - January 24, 2024 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized healthscienceclimate Source Type: news
Are we FINALLY close to solving the Alzheimer's puzzle? After decades of failures in quest to beat cruel disease, scientists now have drugs AND tests - amid warnings rates could spiral in the coming years
Patients in the UK must undergo a swathe of tests, including scans and a lumbar puncture, with some facing waits of up to four years for their Alzheimer's diagnosis. (Source: the Mail online | Health)
Source: the Mail online | Health - January 23, 2024 Category: Consumer Health News Source Type: news
Blood test could revolutionise diagnosis of Alzheimer ’s, experts say
Study finds measuring levels of a protein could be just as good at detecting disease as lumbar puncturesA blood test for detecting Alzheimer ’s disease could be just as accurate as painful and invasive lumbar punctures and could revolutionise diagnosis of the condition, research suggests.Measuring levels of a protein called p-tau217 in the blood could be just as good as lumbar punctures at detecting the signs of Alzheimer ’s, and better than a range of other tests under development, experts say.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - January 23, 2024 Category: Science Authors: Jamie Grierson and agencies Tags: Alzheimer's Medical research Society Science Health Source Type: news
Groundbreaking Alzheimer's blood test can spot cruel disease 15 YEARS before symptoms emerge: Scientists believe breakthrough might lead to a national screening programme for all over-50s
The commercially available test is more accurate than a lumbar puncture - and could be used to track Alzheimer's progression, according to the results of an eight-year trial. (Source: the Mail online | Health)
Source: the Mail online | Health - January 22, 2024 Category: Consumer Health News Source Type: news
MRI reveals how football head injuries may lead to dementia
Thumbnail: From here https://www.auntminnie.com/clinical-news/molecular-imaging/article/15636058/pet-study-questions-equity-of-nfls-concussion-settlementSigns of injury to the brain's white matter called white matter hyperintensities, as seen on brain scans, may be tied more strongly to vascular risk factors, brain shrinkage, and other markers of dementia in former tackle football players than in those who did not play football.The results add to previous research that has evaluated the effect of repeated head injuries, senior author Michale Alosco, PhD, of Boston University said in a statement released by the journal. The...
Source: AuntMinnie.com Headlines - December 22, 2023 Category: Radiology Authors: Kate Madden Yee Tags: Subspecialties Neuroradiology Source Type: news
When Should We Consider A Rickettsial Disease?
Discussion
Rickettsioses are “small, obligate intracellular, gram-negative, aerobic coccobacillary α-proeobacteria” from the genuses Rickettsia, Anaplasma, Coxiella, Ehrlichia, and Orientia genuses. Often they cause limited health problems but can cause severe disease and death. They present with a fever and other non-specific signs and symptoms, usually with a rash and lymphadenopathy. Other problems can include:
Cardiac – endocarditis, myocarditis, pericarditis
Gastrointestinal – abdominal pain, acute abdomen, cholecystitis, hepatitis, pancreatitis
Heme/Lymph – hemophagocytosis, lymph...
Source: PediatricEducation.org - December 18, 2023 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news
Do young children with known cannabis intoxication benefit from further neurological-based testing or imaging? - Dupont AS, Walsh PS.
BACKGROUND: Recent work has demonstrated that children with unintentional cannabis ingestions often undergo extensive ancillary testing such as head imaging or lumbar puncture. To better understand the yield of these tests, our objective was to describe th... (Source: SafetyLit)
Source: SafetyLit - November 13, 2023 Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
Simple blood tests for dementia to be trialled in NHS
£5m project launched with aim of having reliable tests within five years to provide quick diagnosisScientists are to begin piloting simple blood tests for dementia that could revolutionise detection of the disease and within five years lead to people being diagnosed in seconds by the NHS.Currently, getting a formal diagnosis in the UK relies on mental ability tests, brain scans or invasive and painful lumbar punctures, where a sample of cerebrospinal fluid is drawn from the lower back.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - November 9, 2023 Category: Science Authors: Andrew Gregory Health editor Tags: Dementia Alzheimer's NHS Medical research Health Society Science UK news Source Type: news
CMS lifts limit on amyloid PET coverage
The U.S. Centers for Medicare and Medicaid Services (CMS) announced on October 13 that it has lifted its coverage limit of one beta-amyloid PET scan per lifetime for patients with Alzheimer’s disease.The decision, which removes the previous national coverage determination and ends coverage with evidence development for beta-amyloid PET, comes in the wake of recent U.S. Food and Drug Administration (FDA) approvals of the first drugs to treat the disease – monoclonal antibodies that target brain amyloid plaque deposits. Medicare coverage decisions for amyloid PET scans will now be made by local Medicare Administrative ...
Source: AuntMinnie.com Headlines - October 13, 2023 Category: Radiology Authors: Will Morton Tags: Molecular Imaging Source Type: news
Third with dementia never receive a formal diagnosis so won't receive new 'miracle' drugs
Alzheimer's Research UK said proven diagnosis techniques, such as lumbar punctures, were scarcely used with just 2 per cent of people suspected of having the disease given one. (Source: the Mail online | Health)
Source: the Mail online | Health - August 31, 2023 Category: Consumer Health News Source Type: news
Health-related quality of life and functional status following intensive neurorehabilitation in a patient after severe head injury with spinal epidural hematoma: a case report - Gnus J, Druszcz A, Mi ś M, Ślósarz L.
Spinal epidural hematoma (SEH) is a very rare condition associated with trauma or occurring as a complication of lumbar puncture and can appear spontaneously. It manifests with acute pain and neurological deficits, leading to severe and permanent complicat... (Source: SafetyLit)
Source: SafetyLit - May 3, 2023 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
What Are the Classifications of Perinatal Stroke?
Discussion
Perinatal stroke occurs in about 1:1000 live births and is a “focal vascular injury from the fetal period to 28 days postnatal age.” Perinatal stroke is the most common cause of hemiparetic cerebral palsy and causes other significant morbidity including cognitive deficits, learning disabilities, motor problems, sensory problems including visual and hearing disorders, epilepsy, and behavioral and psychological problems. Family members are also affected because of the potential anxiety and guilt feelings that having a child with a stroke presents, along with the care that may be needed over the child&#...
Source: PediatricEducation.org - May 1, 2023 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news
