CO42 4P Care and Adjusting Therapy for Hypothyroidism – A Potential to Reduce Costs of Healthcare and Loss of Productivity
Hypothyroidism affects 25 million people in the US, causing health complications and increased healthcare utilization for many patients despite well-established hormone replacement therapy. A significant effort goes into understanding how personalized care for chronic patients can improve health outcomes, and reduce associated healthcare costs. We focused on two complications frequently affecting hypothyroid patients: (I) fatigue – known to increase workplace absenteeism and the economic burden on healthcare payers; (II) excessive body weight – known to increase the risk of health complications and total cost of care. ...
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: V. H ögqvist Tabor, M. Tarasova, G. Cohen-Skalli, F. Dubois, B. Curran, B. Candea, M. Murphy Source Type: research

EPH126 Gender-Affirming Hormone Therapy and Psychological Distress Among Transgender and Nonbinary People: Differences by Source of Hormones
Gender-affirming hormone replacement therapy (HRT) has been shown to be safe and is associated with positive health outcomes for transgender and nonbinary (TGNB) people. TGNB adults face many barriers to care which may lead to nonprescribed hormone (NPH) use. While studies have analyzed correlates of NPH use, less attention has been paid to health outcomes among TGNB adults who use NPHs. We seek to investigate psychological distress rating among TGNB adults by source of hormones. (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: A. Pandey, K. Seelman Source Type: research

Pregnancy prediction via ultrasound-detected endometrial blood for hormone replacement therapy-frozen embryo transfer: a prospective observational study
CONCLUSIONS: Endometrial blood flow perfusion during the peri-transplantation period of the HRT-FET cycle is a good indicator of pregnancy outcomes, suggesting that valuation of endometrial branches via power Doppler ultrasound is a simple and effective approach for achieving indicator measurements.PMID:38001517 | DOI:10.1186/s12958-023-01164-9 (Source: Reproductive Biology)
Source: Reproductive Biology - November 24, 2023 Category: Reproduction Medicine Authors: Xue Ke Xue-Fei Liang Yong-Hong Lin Fang Wang Source Type: research

Pregnancy prediction via ultrasound-detected endometrial blood for hormone replacement therapy-frozen embryo transfer: a prospective observational study
CONCLUSIONS: Endometrial blood flow perfusion during the peri-transplantation period of the HRT-FET cycle is a good indicator of pregnancy outcomes, suggesting that valuation of endometrial branches via power Doppler ultrasound is a simple and effective approach for achieving indicator measurements.PMID:38001517 | DOI:10.1186/s12958-023-01164-9 (Source: Reproductive Biology)
Source: Reproductive Biology - November 24, 2023 Category: Reproduction Medicine Authors: Xue Ke Xue-Fei Liang Yong-Hong Lin Fang Wang Source Type: research

The clinicopathological features, treatment outcomes and follow-up results of 47 ectopic thyroid gland cases: a single-center retrospective study
ConclusionETG is frequently observed in the head and neck, particularly in lingual. Accessory thyroid glands are commonly reported, with most cases being single ETG. Notably, these glands usually do not manifest specific clinical symptoms. Therefore, the appropriate and comprehensive examinations during the initial diagnosis are crucial to avoid misdiagnosis. Treatment should be individualized, and long-term follow-up is essential for managing ETG effectively. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - November 24, 2023 Category: Endocrinology Source Type: research

Pregnancy prediction via ultrasound-detected endometrial blood for hormone replacement therapy-frozen embryo transfer: a prospective observational study
This study aimed to assess the predictive value of endometrial blood flow branches on pregnancy outcomes after hormone replacement therapy-frozen embryo transfer (HRT-FET). (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - November 24, 2023 Category: Endocrinology Authors: Xue Ke, Xue-fei Liang, Yong-hong Lin and Fang Wang Tags: Research Source Type: research

The influence of radical trachelectomy on endometrial thickness in in vitro fertilization-embryo transfer
CONCLUSIONS: Our data revealed that RT influenced endometrial thickness in IVF-ET. This was not affected by the background of the patients or perioperative management in this study. We could not reveal the underlying mechanism, but it is postulated that the transient postoperative uterine blood flow status and postoperative infections may have some effect on the endometrium. To resolve these issues, accumulation of evidences are required. We recommend informing patients about the impact of RT on IVF-ET before starting assisted reproductive technology (ART).PMID:37994299 | DOI:10.1111/jog.15841 (Source: Cancer Control)
Source: Cancer Control - November 23, 2023 Category: Cancer & Oncology Authors: Atsushi Yabuki Ayako Muraoka Satoshi Tamauchi Tomomi Seki Takehiko Takeda Reina Sonehara Natsuki Miyake Tomoko Nakamura Satoko Osuka Hiroaki Kajiyama Source Type: research

A mini-review of the evidence for cerebrovascular changes following gender-affirming hormone replacement therapy and a call for increased focus on cerebrovascular transgender health
Gender-affirming hormone replacement therapy (gaHRT) is an important step for many in the gender diverse community, associated with increased quality-of-life and lower self-reported scores of depression and anxiety. However, considering the interactions that the involved sex hormones have on vasculature (with oestrogen and testosterone demonstrating vasodilatory and vasoconstricting properties, respectively), it is important for transgender healthcare research to examine how the manipulation of these hormones interact with cerebrovascular structure and functioning. There is a stark lack of research in this area. This mini-...
Source: Frontiers in Human Neuroscience - November 22, 2023 Category: Neuroscience Source Type: research

Cancers, Vol. 15, Pages 5491: Lobular Carcinoma of the Breast: A Comprehensive Review with Translational Insights
iela Raso The second most common breast carcinoma, invasive lobular carcinoma, accounts for approximately 15% of tumors of breast origin. Its incidence has increased in recent times due in part to hormone replacement therapy and improvement in diagnostic modalities. Although believed to arise from the same cell type as their ductal counterpart, invasive lobular carcinomas (ILCs) are a distinct entity with different regulating genetic pathways, characteristic histologies, and different biology. The features most unique to lobular carcinomas include loss of E-Cadherin leading to discohesion and formation of a characteris...
Source: Cancers - November 20, 2023 Category: Cancer & Oncology Authors: Harsh Batra Jason Aboudi Mouabbi Qingqing Ding Aysegul A. Sahin Maria Gabriela Raso Tags: Review Source Type: research

Menstrual blood-derived endometrial stem cell, a unique and promising alternative in the stem cell-based therapy for chemotherapy-induced premature ovarian insufficiency
Stem Cell Res Ther. 2023 Nov 13;14(1):327. doi: 10.1186/s13287-023-03551-w.ABSTRACTChemotherapy can cause ovarian dysfunction and infertility since the ovary is extremely sensitive to chemotherapeutic drugs. Apart from the indispensable role of the ovary in the overall hormonal milieu, ovarian dysfunction also affects many other organ systems and functions including sexuality, bones, the cardiovascular system, and neurocognitive function. Although conventional hormone replacement therapy can partly relieve the adverse symptoms of premature ovarian insufficiency (POI), the treatment cannot fundamentally prevent deterioratio...
Source: Cell Research - November 14, 2023 Category: Cytology Authors: Shenghui Zhang Badrul Hisham Yahaya Ying Pan Yanli Liu Juntang Lin Source Type: research

Reproductive outcomes with delayed blastocyst development: the clinical value of day 7 euploid blastocysts in frozen embryo transfer cycles
Zygote. 2023 Nov 13:1-8. doi: 10.1017/S0967199423000485. Online ahead of print.ABSTRACTEmbryos of optimal development reach blastocyst stage 116 ± 2 h after insemination. Usable D7 blastocysts represent nearly 5% of embryos in IVF with acceptable pregnancy and live birth rates, however data are still limited. Therefore, this study aimed to analyze the ongoing pregnancy rate (OPR) of D7 blastocysts in single euploid frozen embryo transfer (FET) cycles. An observational study was performed including 1527 FET cycles with blastocysts biopsied on D5 (N = 855), D6 (N = 636) and D7 (N = 36). Blastocysts were classified as good (...
Source: Zygote - November 13, 2023 Category: Reproduction Medicine Authors: Andrea Abdala Ibrahim Elkhatib A şina Bayram Ahmed El-Damen Laura Melado Daniela Nogueira Barbara Lawrenz Human M Fatemi Source Type: research

Reproductive outcomes with delayed blastocyst development: the clinical value of day 7 euploid blastocysts in frozen embryo transfer cycles
Zygote. 2023 Nov 13:1-8. doi: 10.1017/S0967199423000485. Online ahead of print.ABSTRACTEmbryos of optimal development reach blastocyst stage 116 ± 2 h after insemination. Usable D7 blastocysts represent nearly 5% of embryos in IVF with acceptable pregnancy and live birth rates, however data are still limited. Therefore, this study aimed to analyze the ongoing pregnancy rate (OPR) of D7 blastocysts in single euploid frozen embryo transfer (FET) cycles. An observational study was performed including 1527 FET cycles with blastocysts biopsied on D5 (N = 855), D6 (N = 636) and D7 (N = 36). Blastocysts were classified as good (...
Source: Zygote - November 13, 2023 Category: Reproduction Medicine Authors: Andrea Abdala Ibrahim Elkhatib A şina Bayram Ahmed El-Damen Laura Melado Daniela Nogueira Barbara Lawrenz Human M Fatemi Source Type: research

Reproductive outcomes with delayed blastocyst development: the clinical value of day 7 euploid blastocysts in frozen embryo transfer cycles
Zygote. 2023 Nov 13:1-8. doi: 10.1017/S0967199423000485. Online ahead of print.ABSTRACTEmbryos of optimal development reach blastocyst stage 116 ± 2 h after insemination. Usable D7 blastocysts represent nearly 5% of embryos in IVF with acceptable pregnancy and live birth rates, however data are still limited. Therefore, this study aimed to analyze the ongoing pregnancy rate (OPR) of D7 blastocysts in single euploid frozen embryo transfer (FET) cycles. An observational study was performed including 1527 FET cycles with blastocysts biopsied on D5 (N = 855), D6 (N = 636) and D7 (N = 36). Blastocysts were classified as good (...
Source: Zygote - November 13, 2023 Category: Reproduction Medicine Authors: Andrea Abdala Ibrahim Elkhatib A şina Bayram Ahmed El-Damen Laura Melado Daniela Nogueira Barbara Lawrenz Human M Fatemi Source Type: research

Efficiency and safety of acupuncture for women with premature ovarian insufficiency: study protocol for a randomized controlled trial
J Tradit Chin Med. 2023 Oct;43(6):1268-1274. doi: 10.19852/j.cnki.jtcm.20230214.002.ABSTRACTAcupuncture has been widely used as an alternative and complementary therapy for premature ovarian insufficiency (POI) in China. However, research to date has not shown that acupuncture is effective for POI compared with hormone replacement therapy (HRT). We will conduct a randomized, controlled, and outcome assessor-blind trial to evaluate the efficacy and safety of acupuncture on POI. Seventy-six patients with POI will be randomly assigned to two groups. The treatment group will receive twenty-eight one-hour sessions of acupunctur...
Source: Journal of Traditional Chinese Medicine - November 10, 2023 Category: Complementary Medicine Authors: X U Yani Zhang Yutong H E Weile Dai Linglin Tang Ding Wang Jialing Zhang Xufen Chen Qin Chen Lifang Wang Zhanglian Zhan Mingjie Source Type: research

Efficiency and safety of acupuncture for women with premature ovarian insufficiency: study protocol for a randomized controlled trial
J Tradit Chin Med. 2023 Oct;43(6):1268-1274. doi: 10.19852/j.cnki.jtcm.20230214.002.ABSTRACTAcupuncture has been widely used as an alternative and complementary therapy for premature ovarian insufficiency (POI) in China. However, research to date has not shown that acupuncture is effective for POI compared with hormone replacement therapy (HRT). We will conduct a randomized, controlled, and outcome assessor-blind trial to evaluate the efficacy and safety of acupuncture on POI. Seventy-six patients with POI will be randomly assigned to two groups. The treatment group will receive twenty-eight one-hour sessions of acupunctur...
Source: Journal of Traditional Chinese Medicine - November 10, 2023 Category: Complementary Medicine Authors: X U Yani Zhang Yutong H E Weile Dai Linglin Tang Ding Wang Jialing Zhang Xufen Chen Qin Chen Lifang Wang Zhanglian Zhan Mingjie Source Type: research