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Enhanced therapeutic benefit of quercetin-loaded phytosome nanoparticles in ovariectomized rats
Publication date: Available online 29 April 2017 Source:Chemico-Biological Interactions Author(s): Abeer I. Abd El-Fattah, Mohamed M. Fathy, Zeinab Y. Ali, Abd El-Rahman A. El-Garawany, Ehsan K. Mohamed Quercetin, a dietary flavonol phytoestrogen, has many health benefits but it is poorly absorbed when administered orally. To improve its bioavailability, we prepared quercetin-loaded phytosome nanoparticles (QP) using the thin film hydration method. The prepared nano-formulations were characterized using different techniques. Transmission electron microscopy revealed the homogeneously spherical, well and uniformly disperse...
Source: Chemico Biological Interactions - April 29, 2017 Category: Biochemistry Source Type: research

Estradiol-loaded PLGA nanoparticles for improving low bone mineral density of cancellous bone caused by osteoporosis: Application of enhanced charged nanoparticles with iontophoresis
In this study, we have prepared E2-loaded poly(DL-lactide-co-glycolide) (PLGA) nanoparticles for osteoporosis by using a combination of an antisolvent diffusion method with preferential solvation. The average particle diameter of the nanoparticles was 110.0±41.0nm and the surface charge number density was 82 times higher than that of conventional E2-loaded PLGA nanoparticles. Therapeutic evaluation of E2-loaded PLGA nanoparticles was carried out using ovariectomized female rats. Therapeutic efficacy was evaluated to measure bone mineral density of cancellous bone using an X-ray CT system. When the E2-loaded PLGA nanoparti...
Source: Colloids and Surfaces B: Biointerfaces - April 24, 2017 Category: Biochemistry Source Type: research

Effects of hormone replacement therapy on ambulatory blood pressure and vascular responses in normotensive women.
Authors: Paul Manwaring Litsa Morfis Terence Diamond Laurence G Howes Abstract The effects of chronic oestrogen replacement therapy (ERT) (conjugated equine oestrogen 0.625 mg/day) and combined oestrogen and progestogen replacement therapy (HRT) (ERT plus continuous medroxyprogesterone acetate 5 mg/day) on 24-h ambulatory blood pressure recordings, forearm vascular resistance (FVR) and FVR responses to noradrenaline, angiotensin II, acetylcholine and nitroprusside were studied in 17 normotensive postmenopausal women in a 3-month randomized, double-blind, placebo-controlled crossover trial with 1 month of therapy in...
Source: Blood Pressure - April 23, 2017 Category: Hematology Tags: Blood Press Source Type: research

Use of Hormone Replacement in Females with Endocrine Disorders
Hormone replacement therapy (HRT) is necessary in adolescents with primary ovarian insufficiency (POI) in order to avoid estrogen deficiency. The goal of this minirewiew is to present the different types of estrogens (17 β-estradiol, estradiol valerate, ethinyl estradiol, and combined equine estrogens) as well as the different types of progestins available. In order to choose among the different types of HRTs, the features of each regimen are being discussed as well as their risks and their respective benefits. The differences between oral combined contraceptive pills and a dissociated regimen containing estrogen and prog...
Source: Hormone Research in Paediatrics - April 19, 2017 Category: Endocrinology Source Type: research

An unexpected diagnosis of primary omental endometrial stromal sarcoma in a patient with acute right abdominal pain: A case report and review of literature
Conclusion EESS can occur without endometriosis and HRT may be an aetiological factor. The condition can mimic a chronic or acute abdominal pathology and laparoscopic core biopsy is the best way to achieve a diagnosis and formulate management. (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - April 19, 2017 Category: Surgery Source Type: research

Clinical accuracy of preoperative breast MRI for breast cancer
ConclusionsBreast MRI provides greater accuracy for a third of patients undergoing preoperative MGM and U/S. Mammographic calcifications were associated with MRI clinical accuracy for patients with invasive cancer. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - April 13, 2017 Category: Cancer & Oncology Authors: Jennifer Tseng, Alexandra Kyrillos, Erik Liederbach, Georgia G. Spear, Jacob Ecanow, Chi ‐Hsiung Wang, Tom Czechura, Olga Kantor, Megan Miller, David J. Winchester, Catherine E. Pesce, Sarah Rabbitt, Katharine Yao Tags: RESEARCH ARTICLE Source Type: research

240 The effect of female hormonal changes on psoriasis
While studies have noted improvement of psoriasis in most women during pregnancy with subsequent postpartum deterioration, there is little data on the impact of other hormonal events. Moreover, there have been changes in hormonally-based therapies in the last 20 years. We surveyed a large number and diversity of women on the effect that hormonal variations (menarche, menses, exposure to hormonal contraception, infertility therapy, pregnancy, menopause, and hormone replacement therapy) have had on their psoriasis. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 12, 2017 Category: Dermatology Authors: S. Feldstein, S. Admani, J. Proudfoot, W. Tom Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research

Menopause and Rheumatic Disease
Menopause occurs naturally in women at about 50 years of age. There is a wealth of data concerning the relationship of menopause to systemic lupus erythematosus, rheumatoid arthritis, and osteoarthritis; there are limited data concerning other rheumatic diseases. Age at menopause may affect the risk and course of rheumatic diseases. Osteoporosis, an integral part of inflammatory rheumatic diseases, is made worse by menopause. Hormone replacement therapy has been studied; its effects vary depending on the disease and even different manifestations within the same disease. Cyclophosphamide can induce early menopause, but ther...
Source: Rheumatic Disease Clinics of North America - April 11, 2017 Category: Rheumatology Authors: Mitali Talsania, Robert Hal Scofield Source Type: research

Common Causes of Postmenopausal Bleeding in Korean Women: 10-Year Outcomes from a Single Medical Center.
Abstract The common causes of postmenopausal bleeding (PMB), according to the data from the western world, are atrophy, hormone replacement therapy (HRT), endometrial cancer, etc. We conducted a retrospective study to assess whether the causes of PMB in Korean postmenopausal women are similar to those already known. This retrospective study used 10-year medical records (March 2005 to December 2014) of 792 PMB women in the Yonsei University Health System. The data were divided into 2 categories by 5-year intervals to compare the differences between the 2 periods. The most common cause of PMB in Korean women was atr...
Source: J Korean Med Sci - April 6, 2017 Category: Journals (General) Authors: Kim MK, Jung YS, Chon SJ, Yun BH, Cho S, Choi YS, Lee BS, Seo SK Tags: J Korean Med Sci Source Type: research

Lost in menopausal transition: the timing of atherosclerosis prevention in women.
Abstract Advanced atherosclerotic changes can often resist even to very aggressive treatment. Although basic mechanisms of its origin and development are known, some important steps in this process are still waiting for more detailed explanation. Therefore, in addition to already proved aggressive lowering of LDL cholesterol, appropriate timing of atherosclerosis treatment is of the essence. Revealing different stages of atherosclerotic process, less or more sensitive to treatment is of primary importance; however, its detection is complicated by several facts including not exactly identifiable periods of quiescen...
Source: Physiological Research - April 5, 2017 Category: Physiology Authors: Piťha J Tags: Physiol Res Source Type: research

Neurokinin 3 receptor antagonism as a novel treatment for menopausal hot flushes: a phase 2, randomised, double-blind, placebo-controlled trial
Publication date: Available online 3 April 2017 Source:The Lancet Author(s): Julia K Prague, Rachel E Roberts, Alexander N Comninos, Sophie Clarke, Channa N Jayasena, Zachary Nash, Chedie Doyle, Deborah A Papadopoulou, Stephen R Bloom, Pharis Mohideen, Nicholas Panay, Myra S Hunter, Johannes D Veldhuis, Lorraine C Webber, Les Huson, Waljit S Dhillo Background Hot flushes affect 70% of menopausal women and often severely impact physical, psychosocial, sexual, and overall wellbeing. Hormone replacement therapy is effective but is not without risk. Neurokinin B signalling is increased in menopausal women, and has been implic...
Source: The Lancet - April 4, 2017 Category: Journals (General) Source Type: research

Discordant Genotypic Sex and Phenotype Variations in Two Spanish Siblings with 17 α-Hydroxylase/17,20-Lyase Deficiency Carrying the Most Prevalent Mutated CYP17A1 Alleles of Brazilian Patients.
In conclusion, one CYP17A1 mutation (p.Arg362Cys) may share a common ancestry in Brazilian and our present Spanish patients, while p.Trp406Arg may have arisen separately. The elder patient (46,XY) developed a more severe phenotype and a poorer response to estradiol replacement therapy. PMID: 28376482 [PubMed - as supplied by publisher] (Source: Sexual Development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation)
Source: Sexual Development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation - April 4, 2017 Category: Genetics & Stem Cells Authors: Fernández-Cancio M, García-García E, González-Cejudo C, Martínez-Maestre MA, Mangas-Cruz MA, Guerra-Junior G, Pandi de Mello M, Arnhold IJ, Nishi MY, Bilharinho Mendonça B, García-Arumí E, Audí L, Tizzano E, Carrascosa A Tags: Sex Dev Source Type: research

Discordant Genotypic Sex and Phenotype Variations in Two Spanish Siblings with 17 α-Hydroxylase/17,20-Lyase Deficiency Carrying the Most Prevalent Mutated < b > < i > CYP17A1 < /i > < /b > Alleles of Brazilian Patients
In conclusion, oneCYP17A1 mutation (p.Arg362Cys) may share a common ancestry in Brazilian and our present Spanish patients, while p.Trp406Arg may have arisen separately. The elder patient (46,XY) developed a more severe phenotype and a poorer response to estradiol replacement therapy.Sex Dev (Source: Sexual Development)
Source: Sexual Development - April 3, 2017 Category: Biology Source Type: research

Is the oral contraceptive or hormone replacement therapy a risk factor for cholelithiasis: A systematic review and meta-analysis
Conclusion: The HRT was positively associated with the cholelithiasis risk, and the OC will not increase the risk of cholelithiasis. (Source: Medicine)
Source: Medicine - April 1, 2017 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

Cholestasis caused by panhypopituitarism and acquired cytomegalovirus infection in a 2-month-old male infant: A case report
We report a case of SOD concurrent with acquired cytomegalovirus (CMV) infection, who presented with prolonged jaundice as the first clinical sign. Patient concerns: The patient was a 2-month-old male infant who presented with cholestasis, combined with fever and panhypopituitarism. Diagnoses: He was diagnosed with SOD and acquired CMV infection. Interventions: He was treated with hormone replacement therapy and ganciclovir. Outcomes: After correction of the pituitary hormone deficiency and ganciclovir treatment, significant improvements of cholestasis, retinal lesions, and growth rate were seen in our patient. Lesson...
Source: Medicine - April 1, 2017 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Dietary nitrite reverses features of postmenopausal metabolic syndrome induced by high-fat diet and ovariectomy in mice
We examined the effect of dietary nitrite in a mouse model with postmenopausal metabolic syndrome induced by ovariectomy (OVX) and a high fat diet (HF). C57BL/6 female mice were divided into five groups, sham+normal fat diet (NF), sham+ HF, OVX+HF with or without sodium nitrite (50 mg and 150 mg/l) in the drinking water. Daily food intake and weekly body weight were monitored for 18 wk. OVX and HF significantly reduced plasma levels of nitrate/nitrite (NOx), and mice developed obesity with visceral hypertrophic adipocytes and increased transcriptional levels of monocyte chemoattractant protein-1, TNF-α, and IL-6 in v...
Source: AJP: Endocrinology and Metabolism - April 1, 2017 Category: Endocrinology Authors: Ohtake, K., Ehara, N., Chiba, H., Nakano, G., Sonoda, K., Ito, J., Uchida, H., Kobayashi, J. Tags: Research Article Source Type: research

Gynecologic Health Issues in Patients With Turner Syndrome: A Survey Study
Adolescents with Turner Syndrome (TS) face almost certain premature ovarian failure which may result in increased risk of osteoporosis and in infertility. However, although hormone replacement therapy (HRT) is crucial for maintenance of bone mineral density (BMD) and osteoporosis prevention, women with Turner ’s syndrome may have variable knowledge of the importance of HRT and may have variable compliance. In addition, advances in assisted reproductive technology such as egg freezing and oocyte cryopreservation have now made fertility preservation an option for some adolescents with TS. (Source: Journal of Pediatric and ...
Source: Journal of Pediatric and Adolescent Gynecology - April 1, 2017 Category: OBGYN Authors: Tazim Dowlut-McElroy, Karen B. Williams, Julie L. Strickland Source Type: research

Physical and social characteristics and support needs of adult female childhood cancer survivors who underwent hormone replacement therapy
ConclusionsAlthough the subjects of this survey exhibited good social adjustment regardless of whether or not they underwent HRT, they were anxious about fertility. It is important to understand the concerns and anxieties unique to female childhood cancer survivors and to enhance psychological support in addition to providing educational support so that HRT can be administered. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 31, 2017 Category: Cancer & Oncology Source Type: research

Abstract 226: Strokes Worse in Women at 24 hours but Severity Reduced in Younger Women With Hormone Therapy [Session Title: Poster Session II]
Conclusion: Women in this study had more severe 24 hour AIS outcomes than men but this improved with HRT use in women younger than 80 years. This cannot be fully explained by age differences as there could be other underlying factors. Improving 24 hour NIHSS may correctly predict later outcomes following AIS. Further study of HRT use in AIS outcomes is justified. (Source: Circulation: Cardiovascular Quality and Outcomes)
Source: Circulation: Cardiovascular Quality and Outcomes - March 31, 2017 Category: Cardiology Authors: Brown, A., Onteddu, S., Joiner, R., Benton, T., Culp, W., Lowery, C. Tags: Session Title: Poster Session II Source Type: research

(115) Protective role of progesterone against allodynia in rats with persistent temporomandibular joint inflammation
Temporomandibular joint disorder (TMD), caused by injury, stress, or systemic disorders, is associated with pain and inflammation in the joint (TMJ) and muscles involved in mastication. TMD affects men and women, but is more prevalent in woman from the onset of puberty until post-menopause when symptoms diminish. After menopause, some women undergo hormone replacement therapy (HRT), which has been linked to the reemergence of TMD pain. Progesterone attenuates inflammation through reduced expression of pro-inflammatory genes and attenuates allodynia in rodent pain models. (Source: The Journal of Pain)
Source: The Journal of Pain - March 29, 2017 Category: Materials Science Authors: R. Hornung, W. Benton, S. Tongkhuya, L. Uphouse, D. Averitt Source Type: research

Hormone replacement therapy for chronic tinnitus in menopausal women: our experience with 13 cases
This article is protected by copyright. All rights reserved. (Source: Clinical Otolaryngology)
Source: Clinical Otolaryngology - March 28, 2017 Category: ENT & OMF Authors: Jen ‐Tsung Lai, Chiung‐lin Liu, Tien‐Chen Liu Tags: Our Experience Source Type: research

A case of pituitary stalk interruption syndrome with intermittent seizures as the first presentation.
Authors: Abstract Pituitary stalk interruption syndrome (PSIS) is a congenital disease with isolated growth hormone deficiency (GHD) or multiple anterior pituitary hormone deficiencies (MPHD). The typical clinical manifestations of PSIS are growth retardation, hypoglycemia or delayed pubertal development. However, few reports showed cases of PSIS were diagnosed with acute epileptic seizures accompanied by hyponatremia. Here, we report an 18-year-old female presenting with episodes of intermittent seizures for 13 years. The electrolyte examination on many occasions has shown hyponatremia, even as low as 99.9 mmol/L...
Source: Neuroendocrinology Letters - March 25, 2017 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Breast Cancer in Saudi Arabia and its possible risk factors
Publication date: Available online 24 March 2017 Source:Journal of Cancer Policy Author(s): Bassam Ahmed Almutlaq, Rakan Fraih Almuazzi, Ahmed Abdullah Almuhayfir, Abdulrhman Mutlaq Alfouzan, Bandar Turqi Alshammari, Haitham Samear AlAnzi, Hussain Gadelkarim Ahmed Breast cancer is the commonest females’ cancer and the leading cause of cancer death worldwide. There is a substantial rise in the incidence of breast cancer in Saudi Arabia in recent years, particularly among younger females compared to affected females’ in western countries. There have been several factors implicated to the etiology of breast cancer, which...
Source: Journal of Cancer Policy - March 25, 2017 Category: Cancer & Oncology Source Type: research

Physiological and functional changes in the stratum corneum restored by oestrogen in an ovariectomized mice model of climacterium
This study objective was to evaluate structural and functional changes in the SC in ovariectomized mice model of menopause. Hydration of the SC, recovery of the permeability barrier function, integrity and cohesion of the SC, and irritant dermatitis were analysed in mice that underwent ovariectomy with or without replacement of 17ß‐estradiol. In ovariectomized mice, hydration of the SC was reduced, recovery of permeability barrier function after acute disruption was impaired, and integrity of the SC was weakened and was associated with increased cohesion and increased levels of irritant dermatitis. Oestrogen replacement...
Source: Experimental Dermatology - March 23, 2017 Category: Dermatology Authors: Yue Chen, Hiroo Yokozeki, Kazumoto Katagiri Tags: ORIGINAL ARTICLE Source Type: research

Therapeutic potential and outlook of alternative medicine for osteoporosis.
Abstract Osteoporosis, a bone disease resulting in loss of bone density and microstructure quality, is often associated with fragility fractures, and the latter imposes a great burden on the patient and society. Although there are several different treatments available for osteoporosis such as hormone replacement therapy, bisphosphonates, Denosumab, and parathyroid hormone some concern has been raised regarding the inherent side effects of their long term use. It would be of great relevance to search for alternative natural compounds, which could complementarily overcome the limitations of the currently available ...
Source: Current Drug Targets - March 21, 2017 Category: Drugs & Pharmacology Authors: Wang T, Liu Q, Tjhioe W, Zhao J, Lu A, Zhang G, Tan R, Zhou M, Xu J, Feng H Tags: Curr Drug Targets Source Type: research

Publication date: Available online 20 March 2017 Source:The Lancet Author(s): Layal Chaker, Antonio C Bianco, Jacqueline Jonklaas, Robin P Peeters Hypothyroidism is a common condition of thyroid hormone deficiency, which is readily diagnosed and managed but potentially fatal in severe cases if untreated. The definition of hypothyroidism is based on statistical reference ranges of the relevant biochemical parameters and is increasingly a matter of debate. Clinical manifestations of hypothyroidism range from life threatening to no signs or symptoms. The most common symptoms in adults are fatigue, lethargy, cold intolerance,...
Source: The Lancet - March 20, 2017 Category: Journals (General) Source Type: research

Clinical, behavioural and pharmacogenomic factors influencing the response to levothyroxine therapy in patients with primary hypothyroidism —protocol for a systematic review
DiscussionThis review will be the first systematic review of this nature. The evidence synthesised will be useful to general practitioners in their management of hypothyroidism. Findings will be disseminated at conferences and in professional and peer-reviewed journals.Systematic review registrationPROSPEROCRD42015027211 (Source: Systematic Reviews)
Source: Systematic Reviews - March 20, 2017 Category: Global & Universal Source Type: research

Management issues of congenital adrenal hyperplasia during the transition from pediatric to adult care.
Authors: Choi JH, Yoo HW Abstract Steroid 21-hydroxylase deficiency is the most prevalent form of congenital adrenal hyperplasia (CAH), accounting for approximately 95% of cases. With the advent of newborn screening and hormone replacement therapy, most children with CAH survive into adulthood. Adolescents and adults with CAH experience a number of complications, including short stature, obesity, infertility, tumor, osteoporosis, and reduced quality of life. Transition from pediatric to adult care and management of long-term complications are challenging for both patients and health-care providers. Psychosocial iss...
Source: Korean Journal of Pediatrics - March 18, 2017 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

Endometriosis after menopause: physiopathology and management of an uncommon condition.
Abstract Endometriosis is a hormone-dependent inflammatory disease that is usually characterized by infertility and pain symptoms. This disease mainly occurs during the reproductive years and is rarely diagnosed after menopause. We discuss the physiopathology of this condition after menopause as well as treatment options and the risk of malignant transformation. Occurrence or progression of postmenopausal endometriosis lesions could be related to extra-ovarian production of estrogen by endometriosis lesions and adipose tissue, which becomes the major estrogen-producing tissue after menopause. Postmenopausal women ...
Source: Climacteric - March 15, 2017 Category: Geriatrics Authors: Streuli I, Gaitzsch H, Wenger JM, Petignat P Tags: Climacteric Source Type: research

Role of BMI and hormone therapy in melanoma risk: a case –control study
ConclusionsBeing overweight was significantly associated with CM risk, and this relationship was highly age-conditioned; the second finding was the protective effect of oestrogen therapies for women. Both findings may have a significant impact on melanoma prevention, as the prevalence of obesity and hormone therapy use is increasing worldwide. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - March 12, 2017 Category: Cancer & Oncology Source Type: research

The evidence base for HRT: what can we believe?
Abstract Prior to the unexpected early termination of the Women's Health Initiative (WHI) trial of continuous conjugated equine estrogens (CEE) and medroxyprogesterone acetate (MPA), the prevailing view was that hormone replacement therapy (HRT) was a low-risk intervention with immediate value for symptom relief in recently menopausal women, and that it probably conferred long-term protection against the major chronic diseases that affect women after menopause. Rather than replicating prior studies, the WHI was designed to test whether the beneficial associations consistently seen in women starting HRT near menopa...
Source: Climacteric - March 9, 2017 Category: Geriatrics Authors: Langer RD Tags: Climacteric Source Type: research

Prevalence of hypothyroidism in nondiabetic chronic kidney disease and effect of thyroxine replacement on estimated glomerular filtration rate
S Bajaj, N Purwar, A Gupta, P Gupta, A SrivastavaIndian Journal of Nephrology 2017 27(2):104-107Reduced T3 and free T4, elevated thyroid stimulating hormone, and hyporesponsiveness to thyrotropin releasing hormone raise questions about the presence of hypothyroidism in chronic kidney disease (CKD) and raise the possibility of benefit from thyroxine supplementation. A prospective cohort study was conducted on 73 nondiabetic CKD cases. Hypothyroid patients were started on levothyroxine and were reviewed after 3 and 6 months. The mean age of study population was 42.3 &#177; 16.8 years. Of the total population, 32 (43.8...
Source: Indian Journal of Nephrology - March 7, 2017 Category: Urology & Nephrology Authors: S Bajaj N Purwar A Gupta P Gupta A Srivastava Source Type: research

Progesterone Increased β-endorphin Innervation of the Locus Coeruleus, but Ovarian Steroids had no Effect on Noradrenergic Neurodegeneration.
In conclusion, we found that HRT increases the inhibitory influence of β-endorphin in the LC, which could, in turn, contribute to reduce anxiety and increase stress resilience. In addition, we did not find compelling evidence of neurodegeneration or neuroprotection by HRT in the LC of Rhesus monkeys. PMID: 28284896 [PubMed - as supplied by publisher] (Source: Brain Research)
Source: Brain Research - March 7, 2017 Category: Neurology Authors: Lima FB, Leite CM, Bethea CL, Anselmo-Franci JA Tags: Brain Res Source Type: research

Estrone Sulfate Transport and Steroid Sulfatase Activity in Colorectal Cancer: Implications for Hormone Replacement Therapy
Lorna C. Gilligan, Ali Gondal, Vivien Tang, Maryam T. Hussain, Anastasia Arvaniti, Anne-Marie Hewitt, Paul A. Foster (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 7, 2017 Category: Drugs & Pharmacology Source Type: research

Prevalence of right atrial non-pulmonary vein triggers in atrial fibrillation patients treated with thyroid hormone replacement therapy
ConclusionsRight atrial non-PV triggers were more prevalent in AF patients treated with THR. Elimination of non-PV triggers provided better arrhythmia-free survival in the non-THR group. (Source: Journal of Interventional Cardiac Electrophysiology)
Source: Journal of Interventional Cardiac Electrophysiology - March 6, 2017 Category: Cardiology Source Type: research

Primary Ovarian Insufficiency: Current Concepts.
Authors: Collins G, Patel B, Thakore S, Liu J Abstract A potential consequence of chemotherapy is the destruction of oocytes, resulting in primary ovarian insufficiency (POI) in young patients; this often results in secondary amenorrhea and necessitates hormone replacement therapy. Regardless of the etiology of POI, the chance of pregnancy is low in this patient population. Given the extent to which oocyte depletion or dysfunction is variable, there is the possibility of spontaneous ovulation on hormone replacement therapy and subsequent pregnancy, however. If pregnancy is not desired, contraception always should b...
Source: Southern Medical Journal - March 4, 2017 Category: Journals (General) Tags: South Med J Source Type: research

The Deterioration of the Glycemic Profile during Hormone Replacement Therapy in a Patient with Fulminant Type 1 Diabetes.
Authors: Tanaka S, Hishiki M, Ogasawara J, Sorimachi E, Nakayama M Abstract Although most women with type 1 diabetes experience the normal transition to menopause, there is little information about the impact of hormone replacement therapy on their glycemic profiles. A 54-year-old postmenopausal woman with fulminant type 1 diabetes was admitted to our hospital due to diabetic ketoacidosis. She was treated with fluid replacement and a continuous insulin infusion. Thereafter, her glycemic profile was well maintained by daily multiple insulin injections. However, her glycemic profiles immediately deteriorated followin...
Source: Internal Medicine - March 4, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research

Sleeve gastrectomy leads to easy management of hormone replacement therapy and good weight loss in patients treated for craniopharyngioma
AbstractThe aim of this study is to investigate the effects of sleeve gastrectomy on hormone replacement therapy and on hypothalamic obesity in patients affected by craniopharyngioma with post-surgical pan-hypopituitarism. A retrospective review of three patients, treated for hypothalamic obesity with laparoscopic sleeve gastrectomy, who have previously undergone surgery for craniopharyngioma in their childhood, was done. Patients ’ mean age and BMI were 22.3 years (range 21–24) and 49.2 kg/m2 (range 41.6 –58.1), respectively. The mean time of delay between neurosurgery and bariatric surgery was 12.3 years (range ...
Source: Updates in Surgery - March 3, 2017 Category: Surgery Source Type: research

The Impact of Bariatric Surgery on Thyroid Function and Medication Use in Patients with Hypothyroidism
ConclusionsThere is a favorable effect of BS on the hypothyroid bariatric population. This includes improvement of thyroid function and reduction of thyroid medication dosages. Further studies are required to evaluate an influence of THR absorption and compare different types of bariatric surgeries. (Source: Obesity Surgery)
Source: Obesity Surgery - March 1, 2017 Category: Surgery Source Type: research

Rathke cleft cyst masquerading as pituitary abscess: A case report
Conclusion: Through this rare case, we aim to emphasize that the differential diagnosis of sellar lesions requires constant vigilance and that RCC may lead to clinical and radiological changes similar with pituitary abscess. (Source: Medicine)
Source: Medicine - March 1, 2017 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Bias from depletion of susceptibles: the example of hormone replacement therapy and the risk of venous thromboembolism
ConclusionThe phenomenon of depletion of susceptibles should be considered in cohort studies evaluating acute side effects of medications. This can be achieved by estimating the risk as a function not only of current use but also of duration of use. Copyright © 2017 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety)
Source: Pharmacoepidemiology and Drug Safety - March 1, 2017 Category: Drugs & Pharmacology Authors: Christel Renoux, Sophie Dell'Aniello, Benjamin Brenner, Samy Suissa Tags: Original Report Source Type: research

Conventional or Natural Pharmacotherapy and the Prevalence of Anxiety and Depression During Menopause.
Conclusions • The best method of treatment with the smallest risk of adverse effects together with a high level of patient satisfaction was found to be the phytoestrogen therapy. The women themselves believed that the therapies were effective and largely helped them to stay mentally fit. PMID: 28323624 [PubMed - in process] (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 1, 2017 Category: Complementary Medicine Authors: Kopciuch D, Paczkowska A, Zaprutko T, Michalak M, Nowakowska E Tags: Altern Ther Health Med Source Type: research

Dietary inflammatory index and risk of renal cancer in the Iowa Women ’s Health Study
ConclusionPro-inflammatory diet, as indicated by higher DII scores, was associated with increased renal cancer risk. (Source: European Journal of Nutrition)
Source: European Journal of Nutrition - February 28, 2017 Category: Nutrition Source Type: research

Abstract P3-01-05: Influence of hormone replacement therapy following bilateral salpingo-oophorectomy on mammographic breast density in women newly diagnosed with breast cancer
Background: Studies have demonstrated that use of hormone replacement therapy (HRT) in post-menopausal women results in increased breast density. This is associated with increased risk of breast cancer and reduced sensitivity of mammography. The purpose of the present study was to compare breast densities of women following surgical menopause with and without use of HRT to women who had natural menopause without use of HRT.Methods: Our institutional Database was queried for post-menopausal women newly diagnosed with breast cancer from 01/2010 to 01/2016. Patients were divided into following groups: 1) natural menopause wit...
Source: Cancer Research - February 28, 2017 Category: Cancer & Oncology Authors: S Pivo, S Schwartz, J Chun, A Guth, D Axelrod, R Shapiro, F Schnabel Tags: Poster Session Abstracts Source Type: research

Effects of sex hormone treatment on white matter microstructure in individuals with gender dysphoria
This study investigated the effects of transgender hormone replacement therapy on white matter microstructure using diffusion tensor imaging. Female-to-male and male-to-female transgender participants were measured at baseline, four weeks and four months past treatment start and compared to female and male controls. We observed androgenization-related reductions in mean diffusivity and increases in fractional anisotropy. We also observed feminization-related increases in mean diffusivity and reductions in fractional anisotropy. In both transgender participants and controls, hormonal fluctuations were correlated with change...
Source: NeuroImage - February 20, 2017 Category: Neuroscience Source Type: research

Therapeutic role of Punica granatum (pomegranate) seed oil extract on bone turnover and resorption induced in ovariectomized rats
ConclusionThe results of this study show that SOE has therapeutic effects on osteoporosis, while it has no adverse effects on lipid profile, uric acid, liver and kidney functions when compared to HRT. SOE offers a promising alternative in the design of new strategies in nutritional management of age-related bone complications. (Source: The Journal of Nutrition, Health and Aging)
Source: The Journal of Nutrition, Health and Aging - February 19, 2017 Category: Nutrition Source Type: research

Radical resection of a craniopharyngioma via the extradural anterior temporal approach with zygomatic arch osteotomy.
CONCLUSION: EDATA with zygomatic osteotomy ensures sufficient mobility of the internal carotid artery, and provides a good lateral and look up operative view. Hence, it can be used effectively for radical resection of craniopharyngiomas through the opticocarotid space and retrocarotid space. PMID: 28194297 [PubMed - in process] (Source: Surgical Neurology International)
Source: Surgical Neurology International - February 16, 2017 Category: Neurosurgery Tags: Surg Neurol Int Source Type: research

The effect of hormone replacement therapy and tibolone on lipoprotein (a) concentrations in postmenopausal women: A systematic review and meta-analysis
(Source: Maturitas)
Source: Maturitas - February 15, 2017 Category: Primary Care Authors: Panagiotis Anagnostis, Petros Galanis, Vasileia Chatzistergiou, John C. Stevenson, Ian F. Godsland, Irene Lambrinoudaki, Mamas Theodorou, Dimitrios G. Goulis Tags: Review article Source Type: research

Leukocyte and Skeletal Muscle Telomere Length and Body Composition in Monozygotic Twin Pairs Discordant for Long-term Hormone Replacement Therapy.
Abstract Estrogen-based hormone replacement therapy (HRT) may be associated with deceleration of cellular aging. We investigated whether long-term HRT has effects on leukocyte (LTL) or mean and minimum skeletal muscle telomere length (SMTL) in a design that controls for genotype and childhood environment. Associations between telomeres, body composition, and physical performance were also examined. Eleven monozygotic twin pairs (age 57.6 ± 1.8 years) discordant for HRT were studied. Mean duration of HRT use was 7.3 ± 3.7 years in the user sister, while their co-twins had never used HRT. LTL was measured by qPCR ...
Source: Twin Research and Human Genetics - February 13, 2017 Category: Genetics & Stem Cells Authors: Sillanpää E, Niskala P, Laakkonen EK, Ponsot E, Alén M, Kaprio J, Kadi F, Kovanen V, Sipilä S Tags: Twin Res Hum Genet Source Type: research

Dietary nitrite reverses features of postmenopausal metabolic syndrome induced by high fat diet and ovariectomy in mice.
We examined the effect of dietary nitrite on mice model with postmenopausal metabolic syndrome induced by ovariectomy (OVX) with high fat diet (HF). C57BL/6 female mice were divided into five groups, sham+normal fat diet (NF), sham+ HF, OVX+HF without or with sodium nitrite (50mg and 150mg/L) in drinking water. Daily food intake and weekly body weight were monitored for 18 weeks. OVX and HF significantly reduced plasma levels of nitrate/nitrite (NOx), and developed obesity with visceral hypertrophic adipocytes, and increased transcriptional levels of monocyte chemoattractant protein-1 (MCP-1), tumor necrotizing factor-α (...
Source: Am J Physiol Endocri... - February 13, 2017 Category: Endocrinology Authors: Ohtake K, Ehara N, Chiba H, Nakano G, Sonoda K, Ito J, Uchida H, Kobayashi J Tags: Am J Physiol Endocrinol Metab Source Type: research