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Hormone replacement therapy for chronic tinnitus in menopausal women: our experience with 13 cases
This article is protected by copyright. All rights reserved. (Source: Clinical Otolaryngology)
Source: Clinical Otolaryngology - March 28, 2017 Category: ENT & OMF Authors: Jen ‐Tsung Lai, Chiung‐lin Liu, Tien‐Chen Liu Tags: Our Experience Source Type: research

A case of pituitary stalk interruption syndrome with intermittent seizures as the first presentation.
Authors: Abstract Pituitary stalk interruption syndrome (PSIS) is a congenital disease with isolated growth hormone deficiency (GHD) or multiple anterior pituitary hormone deficiencies (MPHD). The typical clinical manifestations of PSIS are growth retardation, hypoglycemia or delayed pubertal development. However, few reports showed cases of PSIS were diagnosed with acute epileptic seizures accompanied by hyponatremia. Here, we report an 18-year-old female presenting with episodes of intermittent seizures for 13 years. The electrolyte examination on many occasions has shown hyponatremia, even as low as 99.9 mmol/L...
Source: Neuroendocrinology Letters - March 25, 2017 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Breast Cancer in Saudi Arabia and its possible risk factors
Publication date: Available online 24 March 2017 Source:Journal of Cancer Policy Author(s): Bassam Ahmed Almutlaq, Rakan Fraih Almuazzi, Ahmed Abdullah Almuhayfir, Abdulrhman Mutlaq Alfouzan, Bandar Turqi Alshammari, Haitham Samear AlAnzi, Hussain Gadelkarim Ahmed Breast cancer is the commonest females’ cancer and the leading cause of cancer death worldwide. There is a substantial rise in the incidence of breast cancer in Saudi Arabia in recent years, particularly among younger females compared to affected females’ in western countries. There have been several factors implicated to the etiology of breast cancer, which...
Source: Journal of Cancer Policy - March 25, 2017 Category: Cancer & Oncology Source Type: research

Physiological and functional changes in the stratum corneum restored by oestrogen in an ovariectomized mice model of climacterium
This study objective was to evaluate structural and functional changes in the SC in ovariectomized mice model of menopause. Hydration of the SC, recovery of the permeability barrier function, integrity and cohesion of the SC, and irritant dermatitis were analysed in mice that underwent ovariectomy with or without replacement of 17ß‐estradiol. In ovariectomized mice, hydration of the SC was reduced, recovery of permeability barrier function after acute disruption was impaired, and integrity of the SC was weakened and was associated with increased cohesion and increased levels of irritant dermatitis. Oestrogen replacement...
Source: Experimental Dermatology - March 23, 2017 Category: Dermatology Authors: Yue Chen, Hiroo Yokozeki, Kazumoto Katagiri Tags: ORIGINAL ARTICLE Source Type: research

Therapeutic potential and outlook of alternative medicine for osteoporosis.
Abstract Osteoporosis, a bone disease resulting in loss of bone density and microstructure quality, is often associated with fragility fractures, and the latter imposes a great burden on the patient and society. Although there are several different treatments available for osteoporosis such as hormone replacement therapy, bisphosphonates, Denosumab, and parathyroid hormone some concern has been raised regarding the inherent side effects of their long term use. It would be of great relevance to search for alternative natural compounds, which could complementarily overcome the limitations of the currently available ...
Source: Current Drug Targets - March 21, 2017 Category: Drugs & Pharmacology Authors: Wang T, Liu Q, Tjhioe W, Zhao J, Lu A, Zhang G, Tan R, Zhou M, Xu J, Feng H Tags: Curr Drug Targets Source Type: research

Hypothyroidism
Publication date: Available online 20 March 2017 Source:The Lancet Author(s): Layal Chaker, Antonio C Bianco, Jacqueline Jonklaas, Robin P Peeters Hypothyroidism is a common condition of thyroid hormone deficiency, which is readily diagnosed and managed but potentially fatal in severe cases if untreated. The definition of hypothyroidism is based on statistical reference ranges of the relevant biochemical parameters and is increasingly a matter of debate. Clinical manifestations of hypothyroidism range from life threatening to no signs or symptoms. The most common symptoms in adults are fatigue, lethargy, cold intolerance,...
Source: The Lancet - March 20, 2017 Category: Journals (General) Source Type: research

Clinical, behavioural and pharmacogenomic factors influencing the response to levothyroxine therapy in patients with primary hypothyroidism —protocol for a systematic review
DiscussionThis review will be the first systematic review of this nature. The evidence synthesised will be useful to general practitioners in their management of hypothyroidism. Findings will be disseminated at conferences and in professional and peer-reviewed journals.Systematic review registrationPROSPEROCRD42015027211 (Source: Systematic Reviews)
Source: Systematic Reviews - March 20, 2017 Category: Global & Universal Source Type: research

Management issues of congenital adrenal hyperplasia during the transition from pediatric to adult care.
Authors: Choi JH, Yoo HW Abstract Steroid 21-hydroxylase deficiency is the most prevalent form of congenital adrenal hyperplasia (CAH), accounting for approximately 95% of cases. With the advent of newborn screening and hormone replacement therapy, most children with CAH survive into adulthood. Adolescents and adults with CAH experience a number of complications, including short stature, obesity, infertility, tumor, osteoporosis, and reduced quality of life. Transition from pediatric to adult care and management of long-term complications are challenging for both patients and health-care providers. Psychosocial iss...
Source: Korean Journal of Pediatrics - March 18, 2017 Category: Pediatrics Tags: Korean J Pediatr Source Type: research

Endometriosis after menopause: physiopathology and management of an uncommon condition.
Abstract Endometriosis is a hormone-dependent inflammatory disease that is usually characterized by infertility and pain symptoms. This disease mainly occurs during the reproductive years and is rarely diagnosed after menopause. We discuss the physiopathology of this condition after menopause as well as treatment options and the risk of malignant transformation. Occurrence or progression of postmenopausal endometriosis lesions could be related to extra-ovarian production of estrogen by endometriosis lesions and adipose tissue, which becomes the major estrogen-producing tissue after menopause. Postmenopausal women ...
Source: Climacteric - March 15, 2017 Category: Geriatrics Authors: Streuli I, Gaitzsch H, Wenger JM, Petignat P Tags: Climacteric Source Type: research

Role of BMI and hormone therapy in melanoma risk: a case –control study
ConclusionsBeing overweight was significantly associated with CM risk, and this relationship was highly age-conditioned; the second finding was the protective effect of oestrogen therapies for women. Both findings may have a significant impact on melanoma prevention, as the prevalence of obesity and hormone therapy use is increasing worldwide. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - March 12, 2017 Category: Cancer & Oncology Source Type: research

The evidence base for HRT: what can we believe?
Abstract Prior to the unexpected early termination of the Women's Health Initiative (WHI) trial of continuous conjugated equine estrogens (CEE) and medroxyprogesterone acetate (MPA), the prevailing view was that hormone replacement therapy (HRT) was a low-risk intervention with immediate value for symptom relief in recently menopausal women, and that it probably conferred long-term protection against the major chronic diseases that affect women after menopause. Rather than replicating prior studies, the WHI was designed to test whether the beneficial associations consistently seen in women starting HRT near menopa...
Source: Climacteric - March 9, 2017 Category: Geriatrics Authors: Langer RD Tags: Climacteric Source Type: research

Prevalence of hypothyroidism in nondiabetic chronic kidney disease and effect of thyroxine replacement on estimated glomerular filtration rate
S Bajaj, N Purwar, A Gupta, P Gupta, A SrivastavaIndian Journal of Nephrology 2017 27(2):104-107Reduced T3 and free T4, elevated thyroid stimulating hormone, and hyporesponsiveness to thyrotropin releasing hormone raise questions about the presence of hypothyroidism in chronic kidney disease (CKD) and raise the possibility of benefit from thyroxine supplementation. A prospective cohort study was conducted on 73 nondiabetic CKD cases. Hypothyroid patients were started on levothyroxine and were reviewed after 3 and 6 months. The mean age of study population was 42.3 ± 16.8 years. Of the total population, 32 (43.8...
Source: Indian Journal of Nephrology - March 7, 2017 Category: Urology & Nephrology Authors: S Bajaj N Purwar A Gupta P Gupta A Srivastava Source Type: research

Progesterone Increased β-endorphin Innervation of the Locus Coeruleus, but Ovarian Steroids had no Effect on Noradrenergic Neurodegeneration.
In conclusion, we found that HRT increases the inhibitory influence of β-endorphin in the LC, which could, in turn, contribute to reduce anxiety and increase stress resilience. In addition, we did not find compelling evidence of neurodegeneration or neuroprotection by HRT in the LC of Rhesus monkeys. PMID: 28284896 [PubMed - as supplied by publisher] (Source: Brain Research)
Source: Brain Research - March 7, 2017 Category: Neurology Authors: Lima FB, Leite CM, Bethea CL, Anselmo-Franci JA Tags: Brain Res Source Type: research

Estrone Sulfate Transport and Steroid Sulfatase Activity in Colorectal Cancer: Implications for Hormone Replacement Therapy
Lorna C. Gilligan, Ali Gondal, Vivien Tang, Maryam T. Hussain, Anastasia Arvaniti, Anne-Marie Hewitt, Paul A. Foster (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 7, 2017 Category: Drugs & Pharmacology Source Type: research

Prevalence of right atrial non-pulmonary vein triggers in atrial fibrillation patients treated with thyroid hormone replacement therapy
ConclusionsRight atrial non-PV triggers were more prevalent in AF patients treated with THR. Elimination of non-PV triggers provided better arrhythmia-free survival in the non-THR group. (Source: Journal of Interventional Cardiac Electrophysiology)
Source: Journal of Interventional Cardiac Electrophysiology - March 6, 2017 Category: Cardiology Source Type: research

Primary Ovarian Insufficiency: Current Concepts.
Authors: Collins G, Patel B, Thakore S, Liu J Abstract A potential consequence of chemotherapy is the destruction of oocytes, resulting in primary ovarian insufficiency (POI) in young patients; this often results in secondary amenorrhea and necessitates hormone replacement therapy. Regardless of the etiology of POI, the chance of pregnancy is low in this patient population. Given the extent to which oocyte depletion or dysfunction is variable, there is the possibility of spontaneous ovulation on hormone replacement therapy and subsequent pregnancy, however. If pregnancy is not desired, contraception always should b...
Source: Southern Medical Journal - March 4, 2017 Category: Journals (General) Tags: South Med J Source Type: research

The Deterioration of the Glycemic Profile during Hormone Replacement Therapy in a Patient with Fulminant Type 1 Diabetes.
Authors: Tanaka S, Hishiki M, Ogasawara J, Sorimachi E, Nakayama M Abstract Although most women with type 1 diabetes experience the normal transition to menopause, there is little information about the impact of hormone replacement therapy on their glycemic profiles. A 54-year-old postmenopausal woman with fulminant type 1 diabetes was admitted to our hospital due to diabetic ketoacidosis. She was treated with fluid replacement and a continuous insulin infusion. Thereafter, her glycemic profile was well maintained by daily multiple insulin injections. However, her glycemic profiles immediately deteriorated followin...
Source: Internal Medicine - March 4, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research

Sleeve gastrectomy leads to easy management of hormone replacement therapy and good weight loss in patients treated for craniopharyngioma
AbstractThe aim of this study is to investigate the effects of sleeve gastrectomy on hormone replacement therapy and on hypothalamic obesity in patients affected by craniopharyngioma with post-surgical pan-hypopituitarism. A retrospective review of three patients, treated for hypothalamic obesity with laparoscopic sleeve gastrectomy, who have previously undergone surgery for craniopharyngioma in their childhood, was done. Patients ’ mean age and BMI were 22.3 years (range 21–24) and 49.2 kg/m2 (range 41.6 –58.1), respectively. The mean time of delay between neurosurgery and bariatric surgery was 12.3 years (range ...
Source: Updates in Surgery - March 3, 2017 Category: Surgery Source Type: research

The Impact of Bariatric Surgery on Thyroid Function and Medication Use in Patients with Hypothyroidism
ConclusionsThere is a favorable effect of BS on the hypothyroid bariatric population. This includes improvement of thyroid function and reduction of thyroid medication dosages. Further studies are required to evaluate an influence of THR absorption and compare different types of bariatric surgeries. (Source: Obesity Surgery)
Source: Obesity Surgery - March 1, 2017 Category: Surgery Source Type: research

Rathke cleft cyst masquerading as pituitary abscess: A case report
Conclusion: Through this rare case, we aim to emphasize that the differential diagnosis of sellar lesions requires constant vigilance and that RCC may lead to clinical and radiological changes similar with pituitary abscess. (Source: Medicine)
Source: Medicine - March 1, 2017 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Bias from depletion of susceptibles: the example of hormone replacement therapy and the risk of venous thromboembolism
ConclusionThe phenomenon of depletion of susceptibles should be considered in cohort studies evaluating acute side effects of medications. This can be achieved by estimating the risk as a function not only of current use but also of duration of use. Copyright © 2017 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety)
Source: Pharmacoepidemiology and Drug Safety - March 1, 2017 Category: Drugs & Pharmacology Authors: Christel Renoux, Sophie Dell'Aniello, Benjamin Brenner, Samy Suissa Tags: Original Report Source Type: research

Conventional or Natural Pharmacotherapy and the Prevalence of Anxiety and Depression During Menopause.
Conclusions • The best method of treatment with the smallest risk of adverse effects together with a high level of patient satisfaction was found to be the phytoestrogen therapy. The women themselves believed that the therapies were effective and largely helped them to stay mentally fit. PMID: 28323624 [PubMed - in process] (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 1, 2017 Category: Complementary Medicine Authors: Kopciuch D, Paczkowska A, Zaprutko T, Michalak M, Nowakowska E Tags: Altern Ther Health Med Source Type: research

Dietary inflammatory index and risk of renal cancer in the Iowa Women ’s Health Study
ConclusionPro-inflammatory diet, as indicated by higher DII scores, was associated with increased renal cancer risk. (Source: European Journal of Nutrition)
Source: European Journal of Nutrition - February 28, 2017 Category: Nutrition Source Type: research

Abstract P3-01-05: Influence of hormone replacement therapy following bilateral salpingo-oophorectomy on mammographic breast density in women newly diagnosed with breast cancer
Background: Studies have demonstrated that use of hormone replacement therapy (HRT) in post-menopausal women results in increased breast density. This is associated with increased risk of breast cancer and reduced sensitivity of mammography. The purpose of the present study was to compare breast densities of women following surgical menopause with and without use of HRT to women who had natural menopause without use of HRT.Methods: Our institutional Database was queried for post-menopausal women newly diagnosed with breast cancer from 01/2010 to 01/2016. Patients were divided into following groups: 1) natural menopause wit...
Source: Cancer Research - February 28, 2017 Category: Cancer & Oncology Authors: S Pivo, S Schwartz, J Chun, A Guth, D Axelrod, R Shapiro, F Schnabel Tags: Poster Session Abstracts Source Type: research

Effects of sex hormone treatment on white matter microstructure in individuals with gender dysphoria
This study investigated the effects of transgender hormone replacement therapy on white matter microstructure using diffusion tensor imaging. Female-to-male and male-to-female transgender participants were measured at baseline, four weeks and four months past treatment start and compared to female and male controls. We observed androgenization-related reductions in mean diffusivity and increases in fractional anisotropy. We also observed feminization-related increases in mean diffusivity and reductions in fractional anisotropy. In both transgender participants and controls, hormonal fluctuations were correlated with change...
Source: NeuroImage - February 20, 2017 Category: Neuroscience Source Type: research

Therapeutic role of Punica granatum (pomegranate) seed oil extract on bone turnover and resorption induced in ovariectomized rats
ConclusionThe results of this study show that SOE has therapeutic effects on osteoporosis, while it has no adverse effects on lipid profile, uric acid, liver and kidney functions when compared to HRT. SOE offers a promising alternative in the design of new strategies in nutritional management of age-related bone complications. (Source: The Journal of Nutrition, Health and Aging)
Source: The Journal of Nutrition, Health and Aging - February 19, 2017 Category: Nutrition Source Type: research

Radical resection of a craniopharyngioma via the extradural anterior temporal approach with zygomatic arch osteotomy.
CONCLUSION: EDATA with zygomatic osteotomy ensures sufficient mobility of the internal carotid artery, and provides a good lateral and look up operative view. Hence, it can be used effectively for radical resection of craniopharyngiomas through the opticocarotid space and retrocarotid space. PMID: 28194297 [PubMed - in process] (Source: Surgical Neurology International)
Source: Surgical Neurology International - February 16, 2017 Category: Neurosurgery Tags: Surg Neurol Int Source Type: research

The effect of hormone replacement therapy and tibolone on lipoprotein (a) concentrations in postmenopausal women: A systematic review and meta-analysis
(Source: Maturitas)
Source: Maturitas - February 15, 2017 Category: Primary Care Authors: Panagiotis Anagnostis, Petros Galanis, Vasileia Chatzistergiou, John C. Stevenson, Ian F. Godsland, Irene Lambrinoudaki, Mamas Theodorou, Dimitrios G. Goulis Tags: Review article Source Type: research

Leukocyte and Skeletal Muscle Telomere Length and Body Composition in Monozygotic Twin Pairs Discordant for Long-term Hormone Replacement Therapy.
Abstract Estrogen-based hormone replacement therapy (HRT) may be associated with deceleration of cellular aging. We investigated whether long-term HRT has effects on leukocyte (LTL) or mean and minimum skeletal muscle telomere length (SMTL) in a design that controls for genotype and childhood environment. Associations between telomeres, body composition, and physical performance were also examined. Eleven monozygotic twin pairs (age 57.6 ± 1.8 years) discordant for HRT were studied. Mean duration of HRT use was 7.3 ± 3.7 years in the user sister, while their co-twins had never used HRT. LTL was measured by qPCR ...
Source: Twin Research and Human Genetics - February 13, 2017 Category: Genetics & Stem Cells Authors: Sillanpää E, Niskala P, Laakkonen EK, Ponsot E, Alén M, Kaprio J, Kadi F, Kovanen V, Sipilä S Tags: Twin Res Hum Genet Source Type: research

Dietary nitrite reverses features of postmenopausal metabolic syndrome induced by high fat diet and ovariectomy in mice.
We examined the effect of dietary nitrite on mice model with postmenopausal metabolic syndrome induced by ovariectomy (OVX) with high fat diet (HF). C57BL/6 female mice were divided into five groups, sham+normal fat diet (NF), sham+ HF, OVX+HF without or with sodium nitrite (50mg and 150mg/L) in drinking water. Daily food intake and weekly body weight were monitored for 18 weeks. OVX and HF significantly reduced plasma levels of nitrate/nitrite (NOx), and developed obesity with visceral hypertrophic adipocytes, and increased transcriptional levels of monocyte chemoattractant protein-1 (MCP-1), tumor necrotizing factor-α (...
Source: Am J Physiol Endocri... - February 13, 2017 Category: Endocrinology Authors: Ohtake K, Ehara N, Chiba H, Nakano G, Sonoda K, Ito J, Uchida H, Kobayashi J Tags: Am J Physiol Endocrinol Metab Source Type: research

Abstract P3-04-19: Inhibition of ER-positive breast cancer progression with duavee, a new form of hormone replacement therapy
Conclusions: Our results strongly support s-triglycerides as an important biomarker for breast cancer outcomes among triple negative breast cancer patients.canres;77/4_Supplement/P3-04-19/table1T1Table 1: Multivariable adjusted Hazard Ratios (HRs) for incidence breast cancer recurrence or breast cancer specific death, and incidence overall mortality by pre-diagnostic serum-triglycerides among non-triple negative breast cancer (TNBC) and TNBC patientsNon-TNBC, n=488TNBC, n=87Recurrence or breast cancer specific death (n=90)Overall mortality (n=104)Recurrence or breast cancer specific death (n=24)Overall mortality (n=33)nHR ...
Source: Cancer Research - February 13, 2017 Category: Cancer & Oncology Authors: AG Dembo, E Aledort, GL Greene Tags: Poster Session Abstracts Source Type: research

Abstract P3-08-01: TruRisk(R) based next-generation sequencing in BRCA1/2-negative breast and ovarian cancer families reveal high mutation prevalence in additional risk genes
Background: Studies have demonstrated that use of hormone replacement therapy (HRT) in post-menopausal women results in increased breast density. This is associated with increased risk of breast cancer and reduced sensitivity of mammography. The purpose of the present study was to compare breast densities of women following surgical menopause with and without use of HRT to women who had natural menopause without use of HRT.Methods: Our institutional Database was queried for post-menopausal women newly diagnosed with breast cancer from 01/2010 to 01/2016. Patients were divided into following groups: 1) natural menopause wit...
Source: Cancer Research - February 13, 2017 Category: Cancer & Oncology Authors: K Keupp, L Richters, L Bulow, S Krober, C Ernst, B Blumcke, B Versmold, A Waha, J Driesen, A Baasner, J Altmuller, H Thiele, P Nuernberg, B Wappenschmidt, G Neidhardt, K Rhiem, R Schmutzler, E Hahnen, J Hauke Tags: Poster Session Abstracts Source Type: research

Abstract P3-10-11: Influence of winter season, driving distance, and time on receipt of breast conserving therapy among Iowa urban and rural patients
Menopause occurs in all women between the ages of 45 and 55 and often results in undesirable vasomotor symptoms. Hormone replacement therapy (HRT) can alleviate these symptoms, including hot flashes, difficulty sleeping, fatigue, and vaginal atrophy, and also prevents osteoporosis. PremPro, a HRT formulation that combines conjugated equine estrogens (CE) with medroxyprogesterone acetate, was found to increase the risk of breast cancer in the Women's Health Initiative (WHI) trial. Due to the perceived risk based largely on the results of the WHI trial, the number of women taking HRT has dramatically decreased. Studies sugge...
Source: Cancer Research - February 13, 2017 Category: Cancer & Oncology Authors: CL Wolf, D Frankova, J Franko Tags: Poster Session Abstracts Source Type: research

Abstract P3-13-24: Non-liposuctive endoscopic axillary lymph node dissection in breast conservative surgery
Invasive lobular carcinoma (ILC) is the second most common type of breast cancer after invasive ductal carcinoma (IDC), accounting for approximately 10-15% of all breast tumors. ILC is characterized by inactivation of E-Cadherin and neoplastic cells that invade the stroma in a "single-file" pattern. Women with ILC are usually older, have used hormone replacement therapy and are more likely to have hormone receptor–positive disease. ILCs have similar survival to IDCs at both five and 10 years, but despite this, the clinical course is distinct: ILCs are three times more likely to metastasize to the peritoneum, gastrointest...
Source: Cancer Research - February 13, 2017 Category: Cancer & Oncology Authors: W Yang, H Zhang, H Wang Tags: Poster Session Abstracts Source Type: research

Abstract P4-03-16: FAP{alpha} (fibroblast activation protein-{alpha}) analysis in breast tumor cells and stroma after neoadȷuvant treatment
Conclusions. Our model includes three mammographic features that could easily be derived from clinically available software. By adding information on some few established risk factors it is possible to improve clinical care by identifying women in need of additional examination procedures. At the same time there is a substantial proportion of women that will have very little benefit from mammography screening due to their low risk of breast cancer.canres;77/4_Supplement/P4-03-16/table1T1Table 1. Absolute 2-year risk of breast cancer in women stratified in to risk categories based on the NICE guidelinesAbsolute 2-year risk ...
Source: Cancer Research - February 13, 2017 Category: Cancer & Oncology Authors: I Calvo, M Prieto, A Suarez–Gauthier, FJ Perez, E Hernandez, D Acosta, JM Cardenas, F Lopez–Rios, LG Estevez Tags: Poster Session Abstracts Source Type: research

Osteoprotegerin and uremic osteoporosis in chronic hemodialysis patients
ConclusionsOPG levels had directly correlated with bone mineral density parameters. Our study further confirms the critical role of OPG in the pathogenesis of uremic osteoporosis in ESRD. Whether the increased circulant OPG protect against bone loss in patients undergoing HD remains to be established. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - February 3, 2017 Category: Urology & Nephrology Source Type: research

A longitudinal online interprofessional education experience involving family nurse practitioner students and pharmacy students.
This article describes the implementation of a 21-month prospective cohort study pilot programme for the Master of Science in nursing family nurse practitioner (FNP) and doctor of pharmacy (PharmD) students at a private university in the United States. This IPE experience utilised a blended approach for the learning activities; these students had initial and final sessions where they met face-to-face, with asynchronous online activities between these two sessions. The online assignments, discussions, and quizzes during the pilot programme involved topics such as antimicrobial stewardship, hormone replacement therapy, human...
Source: Journal of Interprofessional Care - February 1, 2017 Category: Health Management Tags: J Interprof Care Source Type: research

Use of hormone replacement therapy after risk ‐reducing salpingo‐oophorectomy
ConclusionsAmong the RRSO women and BSO controls ≤ 52 years without a history of breast cancer, relatively few were current users. If no contraindications, these women would benefit from systemic HRT. Additionally, almost 40% of the BSO controls > 52 years used systemic HRT. Doctors should be aware of this practice, and prescribe systemic HRT when indicated.This article is protected by copyright. All rights reserved. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - January 31, 2017 Category: OBGYN Authors: Nora Johansen, Astrid H. Liavaag, Ole ‐Erik Iversen, Anne Dørum, Tonje Braaten, Trond M. Michelsen Tags: Original Research Article Source Type: research

Abstract PR06: Interactions between nonsteroidal anti-inflammatory drugs and other risk factors on colorectal cancer risk
Background: Long-term use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) has been shown to be protective against colorectal cancer (CRC). While aspirin is recommended to prevent cardiovascular disease and colorectal cancer in certain subgroups, a broad recommendation is not in place due to concerns about side effects. Evidence from clinical trials among patients with colorectal adenomas suggested stronger effect of aspirin among non-smokers, compared to current smokers; but the effect has not been evaluated for CRC risk.Methods: Using 11,894 cases and 15,999 controls from the Genetics and Epidemiology o...
Source: Cancer Research - January 30, 2017 Category: Cancer & Oncology Authors: Xiaoliang Wang, Andrew T. Chan, Martha L. Slattery, Jenny Chang Claude, John D. Potter, Steven Gallinger, Caan Bette, Johanna W. Lampe, Polly A. Newcomb, Niha Zubair, Li Hsu, Robert E. Schoen, Hermann Brenner, Loic Le Marchand, Ulrike Peters, Emily White Tags: Prevention Source Type: research

Abstract IA27: Understanding more about risk and prognostic factors: Lessons from the Colon Cancer Family Registry
Conclusions: The CCFR has shed light on many environmental factors, genetics and tumor characteristics that are related to both incidence and survival. Information gained from studies using this resource provides insight into the biology of this common cancer and importantly may help target messaging on prevention, inform the development of interventions, or tailor recommendations for CRC survivorship care. The greater scientific community has access to this rich resource.Citation Format: Polly A. Newcomb. Understanding more about risk and prognostic factors: Lessons from the Colon Cancer Family Registry. [abstract]. In: P...
Source: Cancer Research - January 30, 2017 Category: Cancer & Oncology Authors: Polly A. Newcomb Tags: Outcomes, Survivorship, and Health Disparities Source Type: research

Case of drug-induced acute pancreatitis produced by horsetail infusions.
We report the case of a 56-year-old woman with a history of bilateral adrenalectomy on hormone replacement therapy with corticosteroids, who has recurrent episodes of mild acute pancreatitis with an etiologic study (laboratory and imaging tests) without significant findings. A drug-induced etiology was suspected, so corticosteroids were removed and antihypertensive treatment was modified, but the clinical manifestations persisted. Later regular consumption of horsetail infusions was detected, and after their suspension the patient became asymptomatic and has not presented new episodes. DISCUSSION: The drug-induced acut...
Source: Revista Espanola de Enfermedades Digestivas - January 26, 2017 Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research

New insights into the tonifying kidney-yin herbs and formulas for the treatment of osteoporosis
AbstractOsteoporosis is characterized by an increasing osseous fragility and fracture resulting from the low mass and deteriorated microarchitecture in the bone tissue. The hormone replacement therapy and alendronate were frequently used to treat osteoporosis as the primary therapeutic strategy, but their adverse effects have severely limited their extensive clinical application, therefore, it is urgent to develop alternative or complementary therapeutic agents for anti-osteoporosis. Interestingly, with more people focusing on the complementary and alternative medicine, traditional Chinese herbs and formulas are being grad...
Source: Archives of Orthopaedic and Trauma Surgery - January 25, 2017 Category: Orthopaedics Source Type: research

Recurrence risk of venous thromboembolism and hormone use in women from England: a cohort study using clinical practice research datalink
In conclusion, having a hormone‐associated VTE is associated with a lower recurrence risk than one that is unprovoked after discontinuation of the hormone‐containing preparation. Prolonged anticoagulation may therefore be unjustified in such women. (Source: British Journal of Haematology)
Source: British Journal of Haematology - January 19, 2017 Category: Hematology Authors: Sylvia Kiconco, Alyshah Abdul Sultan, Matthew J. Grainge Tags: Research Paper Source Type: research

Does endogenous serum oestrogen play a role in meibomian gland dysfunction in postmenopausal women with dry eye?
Conclusion Serum oestrogen appears to be a key factor in MG signs. Although serum hormone levels did not contribute significantly to dry eye symptoms in this study, it is possible that oestrogen plays a role through its effect on meibum secretion. These findings suggest that MG dysfunction underpins dry eye symptoms in non-Sjögren's dry eye in postmenopausal women. Trial registration number ACTRN12612000281897. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 19, 2017 Category: Opthalmology Authors: Golebiowski, B., Badarudin, N., Eden, J., You, J., Hampel, U., Stapleton, F. Tags: Original articles - Clinical science Source Type: research

Response to commentary to Gonadal dysgenesis in disorders of sex development (DSD): Diagnosis and surgical management'
We acknowledge that gonadal management of DSD patients, like many other DSD-related issues, is controversial. Bilateral gonadectomy in children with DSD conditions with known high germ cell cancer (GCC) risk is indeed a safe option, but at a significant price in terms of need for puberty induction and subsequent hormone replacement therapy, and definite loss of fertility. For patient and parent counseling procedures it is regrettable that reliable figures on gonadal GCC risk in many DSD conditions are either lacking or at best roughly known. (Source: Journal of Pediatric Urology)
Source: Journal of Pediatric Urology - January 18, 2017 Category: Urology & Nephrology Authors: Katja Wolffenbuttel, Leendert Looijenga Tags: Letter to the Editor Source Type: research

Response to commentary to ‘Gonadal dysgenesis in disorders of sex development (DSD): Diagnosis and surgical management’
We acknowledge that gonadal management of DSD patients, like many other DSD-related issues, is controversial. Bilateral gonadectomy in children with DSD conditions with known high germ cell cancer (GCC) risk is indeed a safe option, but at a significant price in terms of need for puberty induction and subsequent hormone replacement therapy, and definite loss of fertility. For patient and parent counseling procedures it is regrettable that reliable figures on gonadal GCC risk in many DSD conditions are either lacking or at best roughly known. (Source: Journal of Pediatric Urology)
Source: Journal of Pediatric Urology - January 18, 2017 Category: Urology & Nephrology Authors: Katja Wolffenbuttel, Leendert Looijenga Tags: Letter to the Editor Source Type: research

Perinatal Exposure to Bisphenol A or Diethylstilbestrol Increases the Susceptibility to Develop Mammary Gland Lesions After Estrogen Replacement Therapy in Middle-Aged Rats
AbstractThe development of the mammary gland is a hormone-regulated event. Several factors can dysregulate its growth and make the gland more susceptible to cellular transformation. Among these factors, perinatal exposure to xenoestrogens and hormone replacement therapy has been associated with increased risk of developing breast cancer. Here, we assessed the effects induced by estrogen replacement therapy (ERT) in ovariectomized (OVX) middle-aged rats and whether perinatal exposure to diethylstilbestrol (DES) or bisphenol A (BPA) modified these effects in the mammary gland. Pregnant rats were orally exposed to vehicle, 5 ...
Source: Hormones and Cancer - January 10, 2017 Category: Cancer & Oncology Source Type: research

Establishing the risk related to hormone replacement therapy and cardiovascular disease in women
Abstract Hormone replacement therapy (HRT) has a profound impact on the cardiovascular system in postmenopausal women, achieved through its effects on metabolic risk factors for coronary heart disease (CHD) and on arterial function. Observational studies have consistently shown an association between postmenopausal HRT use and a reduced incidence of CHD. However, the largest randomised trial initially reported no overall benefit on CHD risk. Subsequent analyses ... (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - January 10, 2017 Category: Drugs & Pharmacology Source Type: research

Statin use and risk of endometrial cancer: a nationwide registry ‐based case–control study
ConclusionsIn our nationwide case–control study, we found no association between statin use and risk of endometrial cancer. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - January 6, 2017 Category: OBGYN Authors: Cecilie D. Sperling, Freija Verdoodt, S øren Friis, Christian Dehlendorff, Susanne K. Kjaer Tags: Original Research Article Source Type: research

Association between asthma and female sex hormones.
CONCLUSIONS:: The associations between asthma and female sex hormones remain obscure. We speculate that estrogen fluctuations are responsible for asthma exacerbations that occur in women. Because of the anti-inflammatory action of estrogen, it decreases TNF-α production, interferon-γ expression and NK cell activity. We suggest that further studies that highlight the underlying physiopathological mechanisms contributing towards these interactions should be conducted. PMID: 28076614 [PubMed - as supplied by publisher] (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - January 4, 2017 Category: Journals (General) Authors: Baldaçara RP, Silva I Tags: Sao Paulo Med J Source Type: research