Blood Urea Nitrogen to Serum Albumin Ratio as a New Indicator of Disease Severity and Prognosis in Idiopathic Pulmonary Artery Hypertension
This study investigated the associations between BAR and functional status, echocardiographic findings, hemodynamics, and long-term outcomes among patients with IPAH. (Source: Respiratory Medicine)
Source: Respiratory Medicine - April 22, 2024 Category: Respiratory Medicine Authors: Sicheng Zhang, Luyang Gao, Zhihui Zhao, Qing Zhao, Tao Yang, Qixian Zeng, Yi Zhang, Xin Li, Zhihua Huang, Anqi Duan, Qin Luo, Zhihong Liu Source Type: research
Progress of Mitochondrial Function Regulation in Cardiac Regeneration
This article reviews mitochondria's multifaceted role in cardiac regeneration, particularly in myocardial infarction and heart failure models. Understanding mitochondrial function in cardiac regeneration aims to enhance myocardial infarction and heart failure treatment methods and insights.Graphical Abstract (Source: Journal of Cardiovascular Translational Research)
Source: Journal of Cardiovascular Translational Research - April 22, 2024 Category: Cardiology Source Type: research
Disentangling Knots of Misfolded Proteins: Do We Really Know the Prognostic Implications of the Pathogenic V122I TTR Variant?
The valine to isoleucine replacement at position 122 (V122I) of the transthyretin (TTR) protein destabilizes its tertiary structure and is the rate-limiting step towards TTR amyloidogenesis. This variant is virtually exclusive to those of African ancestry with a carrier frequency of ∼3-4% (1) and is the most common cause of hereditary transthyretin cardiac amyloidosis (ATTR-CA) in the world (1, 2). However, because the vast majority of individuals with V122I TTR variant ATTR cardiac amyloidosis (V122I ATTRv) are Black, a population with disparately worse heart failure outcome s than white individuals, more clarity is nee...
Source: The American Journal of Cardiology - April 22, 2024 Category: Cardiology Authors: Anas Jawaid, Isabel Wees, Justin L. Grodin Tags: Editorial Source Type: research
The neutrophil-to-apolipoprotein A1 ratio is associated with adverse outcomes in patients with acute decompensated heart failure at different glucose metabolic states: a retrospective cohort study
The present study was performed to assess the association between the neutrophil-to-apolipoprotein A1 ratio (NAR) and outcomes in patients with acute decompensated heart failure (ADHF) at different glucose met... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - April 22, 2024 Category: Lipidology Authors: Weimeng Cheng, Tianyue Li, Xiaohan Wang, Tingting Xu, Ying Zhang, Jianzhou Chen and Zhonghai Wei Tags: Research Source Type: research
CD8+ T cell-mediated rejection of allogenic human induced pluripotent stem cell-derived cardiomyocyte sheets in human PBMC-transferred NOG MHC double knockout mice
Transplantation of human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) has emerged as a promising therapy to treat end-stage heart failure. However, immunogenicity of hiPS-CMs in transplanted patients has not been fully elucidated. Thus, in vivo models are required to estimate immune responses against hiPS-CMs in transplant recipients. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 22, 2024 Category: Transplant Surgery Authors: Ryu Matsumoto, Yin Enzhi, Kazuyoshi Takeda, Kodai Morimoto, Kyoko Yogo, Masaki Harada, Koji Tokushige, Yui Maehara, Saori Hirota, Yuko Kojima, Mamoru Ito, Nagako Sougawa, Shigeru Miyagawa, Yoshiki Sawa, Ko Okumura, Koichiro Uchida Tags: Original Translational Science Source Type: research
Outcomes of combined left bundle branch area pacing with atrioventricular nodal ablation in patients with atrial fibrillation and pulmonary disease
ConclusionThis small, retrospective cohort study suggests concomitant LBBAP with AV nodal ablation may be safe and efficacious for management of atrial fibrillation in patients with advanced pulmonary disease. (Source: Pacing and Clinical Electrophysiology : PACE)
Source: Pacing and Clinical Electrophysiology : PACE - April 21, 2024 Category: Cardiology Authors: Christopher Sefton,
Christine Tanaka ‐Esposito,
Thomas Dresing,
Justin Lee,
Roy Chung Tags: ORIGINAL ARTICLE Source Type: research
The Role and Mechanism of circAMOTL1 in Hypertensive Heart Failure
(Source: Journal of Biomedical Nanotechnology)
Source: Journal of Biomedical Nanotechnology - April 20, 2024 Category: Nanotechnology Authors: Mou, Yanhong Fan, Xin Sun, Runmin Zhang, Xiaowei Yu, Jing Tags: research-article Source Type: research
Prognostic value of growth differentiation factor ‐15 in heart failure among whole ejection fraction phenotypes
ConclusionsGDF-15 is identified as an independent risk factor for adverse outcomes in HF patients across the entire EF spectrum in the context of CHD. Integrating GDF-15 into the MAGGIC risk score-based model enhances its prognostic capability for adverse outcomes in the general HF population. This incremental prognostic effect was observed specifically in the HFpEF subgroup and not in other subgroups. (Source: ESC Heart Failure)
Source: ESC Heart Failure - April 20, 2024 Category: Cardiology Authors: Lyu Lyu,
Juan Xu,
Cui Xv,
Hunan Xiao,
Zhenzhen Liu,
Yanru He,
Weiyang Gao,
Benchuan Hao,
Hongbin Liu Tags: Original Article Source Type: research
Role of stiff atrium in elucidating diastolic dysfunction in Fontan circulation. Letter regarding the article ‘Exercise catheterization in adults post‐Fontan with normal and abnormal haemodynamic criteria: Insights into normal Fontan physiology’
(Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - April 20, 2024 Category: Cardiology Authors: Makoto Takei Tags: Letter to Editor Source Type: research
Association of Ultraprocessed Food Consumption with Risk of Cardiovascular Disease Among Individuals with Type 2 Diabetes: Findings from the UK Biobank
ConclusionHigher UPF intakes are associated with increased hazards of CVD among individuals with T2D, and the association is partly mediated through worsening biomarkers of renal function, lipid metabolism, inflammation, and body weight. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - April 20, 2024 Category: Food Science Authors: Yue Li,
Yuwei Lai,
Tingting Geng,
Peng ‐Fei Xia,
Jun‐Xiang Chen,
Zhou‐Zheng Tu,
Kun Yang,
Yun‐Fei Liao,
Gang Liu,
An Pan Tags: Research Article Source Type: research
GSE263965 Deubiquitinase USP29 Ameliorates Pathological Cardiac Hypertrophy Through Inhibiting TAK1
In this study, we elucidated the role of Ubiquitin-specific protease 29 (USP29), a deubiquitinase, in pressure overload-induced cardiac hypertrophy. Genetic knockout of USP29 in mice significantly exacerbated TAC-induced heart hypertrophy, dysfunction, and fibrosis; whereas overexpression of USP29 in cardiomyocytes attenuated the hypertrophic response. Similarly, USP29 markedly alleviated PE-induced hypertrophy of primary neonatal rat cardiomyocytes. Mechanistically, the cardio-protective effects mediated by USP29 were attributed to its suppression of transforming growth factor β-activated kinase 1 (TAK1)-JNK/P38 signal...
Source: GEO: Gene Expression Omnibus - April 20, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Role of NT-proBNP and lung ultrasound in diagnosing and classifying heart failure in a hospitalized oldest-old population: a cross-sectional study
Diagnosing and classifying heart failure (HF) in the oldest-old patients has technical and interpretation issues, especially in the acute setting. We assessed the usefulness of both N-terminal pro-brain natriu... (Source: BMC Geriatrics)
Source: BMC Geriatrics - April 20, 2024 Category: Geriatrics Authors: Matteo Landolfo, Francesco Spannella, Federico Giulietti, Chiara Di Pentima, Piero Giordano, Elisabetta Borioni, Laura Landi, Mirko Di Rosa, Roberta Galeazzi and Riccardo Sarzani Tags: Research Source Type: research
Epicardial Adipose Tissue Thickness and Preserved Ejection Fraction Heart Failure
AbstractPurpose of the ReviewPreserved ejection fraction heart failure and obesity frequently coexist. Whether obesity plays a consistent role in the pathogenesis of preserved ejection fraction heart failure is unclear. Accumulation of visceral adiposity underlies the pathogenic aftermaths of obesity. However, visceral adiposity imaging is assessed by computed tomography or magnetic resonance and thus not routinely available. In contrast, epicardial adiposity thickness is assessed by echocardiography and thus routinely available. We review the rationale for assessing epicardial adiposity thickness in patients with preserve...
Source: Current Hypertension Reports - April 20, 2024 Category: Primary Care Source Type: research
The redox-active defensive Selenoprotein T as a novel stress sensor protein playing a key role in the pathophysiology of heart failure
Maladaptive cardiac hypertrophy contributes to the development of heart failure (HF). The oxidoreductase Selenoprotein T (SELENOT) emerged as a key regulator during rat cardiogenesis and acute cardiac protecti... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 20, 2024 Category: Research Authors: Anna De Bartolo, Teresa Pasqua, Naomi Romeo, Vittoria Rago, Ida Perrotta, Francesca Giordano, Maria Concetta Granieri, Alessandro Marrone, Rosa Mazza, Maria Carmela Cerra, Benjamin Lefranc, J érôme Leprince, Youssef Anouar, Tommaso Angelone and Carmine Tags: Research Source Type: research
Outcomes of Percutaneous Revascularization in Severe Ischemic Left Ventricular Dysfunction
This article presents a comprehensive review of coronary revascularization versus optimal medical therapy (OMT) in patients with severe ischemic left ventricular dysfunction.Recent FindingsThe REVIVED-BCIS2 trial randomized 700 patients with extensive coronary artery disease and left ventricular (LV) ejection fraction (LVEF) ≤ 35% and viability in more than four dysfunctional myocardial segments to percutaneous coronary intervention (PCI) plus OMT versus OMT alone. Over a median duration of 41 months, there was no difference in the composite of all-cause mortality, heart failure hospitalization, or improvement i n ...
Source: Current Cardiology Reports - April 20, 2024 Category: Cardiology Source Type: research
