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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 9.

Individualized Multiplanar Electrical Impedance Tomography in Infants to Optimize Lung Monitoring.
PMID: 28199154 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 15, 2017 Category: Respiratory Medicine Authors: Miedema M, Waldmann A, McCall KE, Böhm SH, van Kaam AH, Tingay DG Tags: Am J Respir Crit Care Med Source Type: research

Taking It Off: New Insights into the Role of Tyrosine Phosphorylation-dependent Pathways in the Pathogenesis of Pulmonary Fibrosis.
PMID: 28199155 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 15, 2017 Category: Respiratory Medicine Authors: Downey GP, Aschner Y Tags: Am J Respir Crit Care Med Source Type: research

Reply: Software-assisted Computed Tomography Quantification of Airway Remodeling in the Normal Aging Process.
PMID: 28199156 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 15, 2017 Category: Respiratory Medicine Authors: Martinez CH, all the authors Tags: Am J Respir Crit Care Med Source Type: research

The Evolution of Bronchopulmonary Dysplasia after 50 Years.
PMID: 28199157 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 15, 2017 Category: Respiratory Medicine Authors: Abman SH, Bancalari E, Jobe A Tags: Am J Respir Crit Care Med Source Type: research

On a Collision Course: The Electronic Medical Record and Genetic Studies of Asthma.
PMID: 28199158 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 15, 2017 Category: Respiratory Medicine Authors: Ortega VE, Torgerson DG Tags: Am J Respir Crit Care Med Source Type: research

Prediction of Chronic Obstructive Pulmonary Disease Exacerbation Frequency. Clinical Parameters Are Still Better Than Biomarkers.
PMID: 28199159 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 15, 2017 Category: Respiratory Medicine Authors: Donaldson GC, Wedzicha JA Tags: Am J Respir Crit Care Med Source Type: research

Software-assisted Computed Tomography Quantification of Airway Remodeling in the Normal Aging Process.
PMID: 28199160 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 15, 2017 Category: Respiratory Medicine Authors: Bommart S, Kovacsik H, Vachier I, Molinari N, Bourdin A Tags: Am J Respir Crit Care Med Source Type: research

Reply: Acute Exacerbation of Idiopathic Pulmonary Fibrosis.
PMID: 28199161 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 15, 2017 Category: Respiratory Medicine Authors: Corte TJ, Ryerson CJ, Collard HR Tags: Am J Respir Crit Care Med Source Type: research

Mitochondrial Calcium Transport: A Potentially Prominent, Therapeutically Targetable Contributor to Pulmonary Arterial Hypertension Progression.
PMID: 28199162 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 15, 2017 Category: Respiratory Medicine Authors: Gupte SA, Wolin MS Tags: Am J Respir Crit Care Med Source Type: research

What is Tuberculosis (TB)?
Authors: PMID: 28199163 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 15, 2017 Category: Respiratory Medicine Tags: Am J Respir Crit Care Med Source Type: research

Acute Exacerbation of Idiopathic Pulmonary Fibrosis.
PMID: 28199164 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 15, 2017 Category: Respiratory Medicine Authors: Naccache JM, Cadranel J, Nunes H Tags: Am J Respir Crit Care Med Source Type: research

SNPing Away at the Genetic Risk for Acute Kidney Injury.
PMID: 28199165 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 15, 2017 Category: Respiratory Medicine Authors: Meyer NJ Tags: Am J Respir Crit Care Med Source Type: research

Consistency of T2 Gene Signatures in Severe Asthma. Key to Effective Treatments or Merely the Tip of the Iceberg?
PMID: 28199166 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 15, 2017 Category: Respiratory Medicine Authors: Modena BD, Wenzel SE Tags: Am J Respir Crit Care Med Source Type: research

Did Reduced Alveolar Delivery of Surfactant Contribute to Negative Results in Adults with Acute Respiratory Distress Syndrome?
PMID: 28199167 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 15, 2017 Category: Respiratory Medicine Authors: Grotberg JB, Filoche M, Willson DF, Raghavendran K, Notter RH Tags: Am J Respir Crit Care Med Source Type: research

Accuracy of Immunofluorescence in the Diagnosis of Primary Ciliary Dyskinesia.
Conclusions Immunofluorescence is a highly specific diagnostic test for PCD, and improves the speed and availability of diagnostic testing, however, sensitivity is limited and immunofluorescence is not suitable as a stand-alone test. PMID: 28199173 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 15, 2017 Category: Respiratory Medicine Authors: Shoemark A, Frost E, Dixon M, Ollosson S, Kilpin K, Patel M, Scully J, Rogers AV, Mitchison HM, Bush A, Hogg C Tags: Am J Respir Crit Care Med Source Type: research

Pulmonary Mucinous Cystadenocarcinoma Presenting as Extensive Multifocal Cystic Lesions.
PMID: 28199793 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 15, 2017 Category: Respiratory Medicine Authors: Shannon VR, Nanda AS, Middleton LP, Faiz SA Tags: Am J Respir Crit Care Med Source Type: research

Endobronchial Lesions of Mycobacterium abscessus Infection in an Immunocompromised Patient.
PMID: 28199133 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 15, 2017 Category: Respiratory Medicine Authors: Saeki K, Watanabe S, Waseda Y, Kasahara K Tags: Am J Respir Crit Care Med Source Type: research

SOX2 Drives Bronchial Dysplasia in a Novel Organotypic Model of Early Human Squamous Lung Cancer.
Conclusion In the appropriate genetic and microenvironmental context acute deregulation of SOX2 drives bronchial dysplasia. This confirms it's oncogenic potential in human cells and affords novel insights into the impact of SOX2 deregulation. This model can be used to test therapeutic agents aimed at chemoprevention. PMID: 28199128 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 15, 2017 Category: Respiratory Medicine Authors: Correia LL, Johnson JA, McErlean P, Bauer J, Farah H, Rassl DM, Rintoul RC, Sethi T, Lavender P, Rawlins EL, Littlewood TD, Evan GI, McCaughan FM Tags: Am J Respir Crit Care Med Source Type: research

Pulmonary MRI morphometry modeling of airspace enlargement in chronic obstructive pulmonary disease and alpha-1 antitrypsin deficiency.
CONCLUSIONS: Differences in airspace enlargement may be estimated using Lm and S/V, generated using MRI and a stretched-exponential or cylindrical model of the acinar ducts. Magn Reson Med, 2017. © 2017 International Society for Magnetic Resonance in Medicine. PMID: 28198571 [PubMed - as supplied by publisher] (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - February 15, 2017 Category: Radiology Authors: Ouriadov A, Lessard E, Sheikh K, Parraga G, Canadian Respiratory Research Network Tags: Magn Reson Med Source Type: research

Reply to letter to the editor of Gut by Dickson and Cox
Dear editor, We are thankful for the letter of Drs Dickson and Cox in response to our paper on the effect of the intestinal microbiota on host responses during pneumococcal pneumonia.1 We do agree that we cannot rule out that the antibiotics we used in our experiments could have influenced the microbiota in the airways and we do underwrite the importance of studying local host–microbe interactions within the respiratory tract during pneumonia. However, some points need to be addressed. The relative importance of the microbiota of the lower airways, the area where alveolar macrophages reside, is a matter of debate. A ...
Source: Gut - February 15, 2017 Category: Gastroenterology Authors: Lankelma, J. M., Schuijt, T. J., Wiersinga, W. J. Tags: PostScript Source Type: research

The Accuracy of the Bedside Swallowing Evaluation for Detecting Aspiration in Survivors of Acute Respiratory Failure
Dysphagia with subsequent aspiration occurs in up to 60% of acute respiratory failure (ARF) survivors. Accurate bedside tests for aspiration can reduce aspiration-related complications while minimizing delay of oral nutrition. In a cohort of ARF survivors, we determined the accuracy of the bedside swallowing evaluation (BSE) and its components for detecting aspiration. (Source: Journal of Critical Care)
Source: Journal of Critical Care - February 15, 2017 Category: Intensive Care Authors: Ylinne T Lynch, Brendan J Clark, Madison Macht, S. David White, Heather Taylor, Tim Wimbish, Marc Moss Source Type: research

Risk of pulmonary embolism and deep venous thrombosis in patients with asthma: a nationwide case-control study from Sweden
Asthma is associated with an increased risk of pulmonary embolism (PE) but little is known about whether asthma is associated with an increased risk of deep venous thrombosis (DVT). The aim in this study was to determine the risk of the first event of PE, DVT or a combination of PE and DVT in patients with asthma. We conducted this nationwide case–control study using data from Swedish nationwide registries. We included 114 366 Swedish-born patients with a first hospital diagnosis of PE, 76 494 patients with DVT and 6854 patients with both PE and DVT in Sweden between 1981 and 2010. We also included five age-, sex- an...
Source: European Respiratory Journal - February 15, 2017 Category: Respiratory Medicine Authors: Zöller, B., Pirouzifard, M., Memon, A. A., Sundquist, J., Sundquist, K. Tags: Original Articles: Pulmonary vascular diseases Source Type: research

Measurement of tidal breathing flows in infants using impedance pneumography
Tidal breathing flow volume (TBFV) profiles have been used to characterise altered lung function. Impedance pneumography (IP) is a novel option for assessing TBFV curves noninvasively. The aim of this study was to extend the application of IP for infants and to estimate the agreement between IP and direct pneumotachograph (PNT) measurements in assessing tidal airflow and flow-derived indices. Tidal flow profiles were recorded for 1 min simultaneously with PNT and uncalibrated IP at baseline in 44 symptomatic infants, and after methacholine-induced bronchoconstriction in a subgroup (n=20). The agreement expressed as th...
Source: European Respiratory Journal - February 15, 2017 Category: Respiratory Medicine Authors: Malmberg, L. P., Seppä, V.-P., Kotaniemi-Syrjänen, A., Malmström, K., Kajosaari, M., Pelkonen, A. S., Viik, J., Mäkelä, M. J. Tags: Paediatric pulmonology Original Articles: Paediatric pulmonology Source Type: research

A two-year evaluation of the ‘real life’ impact of COPD on patients in Germany: The DACCORD observational study
DACCORD is an observational, non-interventional study being conducted in German primary and secondary care centres. The study aims to describe the impact of disease (including exacerbations) and treatments over 2 years on ‘real-life’ patients with chronic obstructive pulmonary disease (COPD). (Source: Respiratory Medicine)
Source: Respiratory Medicine - February 15, 2017 Category: Respiratory Medicine Authors: Peter Kardos, Claus Vogelmeier, Heinrich Worth, Roland Buhl, Nadine S. Lossi, Claudia Mail änder, Carl-Peter Criée Tags: Clinical Trial Paper Source Type: research

A randomised double-blind, placebo-controlled, long-term extension study of the efficacy, safety and tolerability of fixed-dose combinations of aclidinium/formoterol or monotherapy in the treatment of chronic obstructive pulmonary disease
Aclidinium bromide/formoterol fumarate (AB/FF) 400/12  μg efficacy and safety was demonstrated in two 6-month Phase III studies (AUGMENT and ACLIFORM) and a 12-month study in patients with moderate to severe chronic obstructive pulmonary disease (COPD). This Phase III, double-blind, placebo-controlled, 6-month AUGMENT extension investigated the long- term safety and tolerability of AB/FF 400/12 μg (NCT01572792). (Source: Respiratory Medicine)
Source: Respiratory Medicine - February 15, 2017 Category: Respiratory Medicine Authors: Anthony D'Urzo, Stephen Rennard, Edward Kerwin, James F. Donohue, Alejhandra Lei, Eduard Molins, Anne Leselbaum Source Type: research

Airway dynamics in COPD patients by within-breath impedance tracking: effects of continuous positive airway pressure
Tracking of the within-breath changes of respiratory mechanics using the forced oscillation technique may provide outcomes that characterise the dynamic behaviour of the airways during normal breathing. We measured respiratory resistance (Rrs) and reactance (Xrs) at 8 Hz in 55 chronic obstructive pulmonary disease (COPD) patients and 20 healthy controls, and evaluated Rrs and Xrs as functions of gas flow (V') and volume (V) during normal breathing cycles. In 12 COPD patients, additional measurements were made at continuous positive airway pressure (CPAP) levels of 4, 8, 14 and 20 hPa. The Rrs and Xrs versus V' an...
Source: European Respiratory Journal - February 15, 2017 Category: Respiratory Medicine Authors: Lorx, A., Czövek, D., Gingl, Z., Makan, G., Radics, B., Bartusek, D., Szigeti, S., Gal, J., Losonczy, G., Sly, P. D., Hantos, Z. Tags: Lung structure and function Original Articles: COPD and lung function Source Type: research

Chronic obstructive pulmonary disease exacerbation and inhaler device handling: real-life assessment of 2935 patients
Acute exacerbations of chronic obstructive pulmonary disease (COPD) can be prevented by inhaled treatment. Errors in inhaler handling, not taken into account in clinical trials, could impact drug delivery and minimise treatment benefit. We aimed to assess real-life inhaler device handling in COPD patients and its association with COPD exacerbations. To this end, 212 general practitioners and 50 pulmonologists assessed the handling of 3393 devices used for continuous treatment of COPD in 2935 patients. Handling errors were observed in over 50% of handlings, regardless of the device used. Critical errors compromising drug de...
Source: European Respiratory Journal - February 15, 2017 Category: Respiratory Medicine Authors: Molimard, M., Raherison, C., Lignot, S., Balestra, A., Lamarque, S., Chartier, A., Droz-Perroteau, C., Lassalle, R., Moore, N., Girodet, P.-O. Tags: COPD and smoking Original Articles: COPD Source Type: research

Poor adherence to management guidelines in nontuberculous mycobacterial pulmonary diseases
Nontuberculous mycobacterial pulmonary diseases (NTM-PD) are increasingly recognised as opportunistic infections of humans. Nodular/bronchiectatic disease and fibrocavitary disease are the most frequent manifestations [1]. Although guidelines have been published [1], there are few data on diagnostic and treatment practices outside of reference clinics. A recent survey in the USA suggested limited adherence to guidelines for diagnosis and treatment of NTM-PD [2]. (Source: European Respiratory Journal)
Source: European Respiratory Journal - February 15, 2017 Category: Respiratory Medicine Authors: van Ingen, J., Wagner, D., Gallagher, J., Morimoto, K., Lange, C., Haworth, C. S., Floto, R. A., Adjemian, J., Prevots, D. R., Griffith, D. E., for the NTM-NET Tags: Respiratory infections and tuberculosis Original Articles: Research letters Source Type: research

Chronic intermittent hypoxia mimicking sleep apnoea increases spontaneous tumorigenesis in mice
Obstructive sleep apnoea (OSA) is a very prevalent disorder with well proven mid- and long-term deleterious consequences, such as increased risk of cardiovascular, metabolic and neurocognitive diseases [1]. Recently, considerable data from both animal models and patient studies also suggest that OSA increases the risk of cancer incidence and mortality [2]. Some of these studies indicate that nocturnal hypoxic events experienced by OSA patients as a consequence of recurrent upper airway obstructions may be a main challenge driving tumour progression [3, 4]. Although the clinical and experimental data available do not undoub...
Source: European Respiratory Journal - February 15, 2017 Category: Respiratory Medicine Authors: Gallego-Martin, T., Farre, R., Almendros, I., Gonzalez-Obeso, E., Obeso, A. Tags: Original Articles: Research letters Source Type: research

Inhaler device handling: have we really started to address the problem?
How big a problem is inhaler technique and how important is it? In this issue of the European Respiratory Journal we are presented with a "real-life" study exploring the inhaler technique of almost 3000 patients with chronic obstructive pulmonary disease (COPD) and the relationship between inhaler device handling and disease control. This observational, cross-sectional study, conducted by Molimard et al. [1], assesses the handling of devices by patients visiting general practitioners and pulmonologists and in so doing determines two key findings. 1) Over 50% of patients with COPD are not able to use their devices corr...
Source: European Respiratory Journal - February 15, 2017 Category: Respiratory Medicine Authors: Bosnic-Anticevich, S. Z. Tags: COPD and smoking, Asthma and allergy Editorials Source Type: research

Application of SOFA score as a predict tool for mortality of delayed admission to ICU on patients with acute respiratory failure
The article by Chih-Chia Hsieh et al. is indeed interesting [1]. We agree that a delayed ICU admission is a strong determinant of mortality for patients with acute respiratory failure (ARF) who required mechanical ventilation support and intensive care. Unfortunately, delayed ICU admission is an increasing problem widely because of Emergency Department overcrowding or shortage of medical resources [1-3]. We have to select the most valuable patients based on both the severity of acute illness and the waiting time for ICU. (Source: The American Journal of Emergency Medicine)
Source: The American Journal of Emergency Medicine - February 15, 2017 Category: Emergency Medicine Authors: Hai Hu, Xinmiao Du, Yarong He, Cao Yu Source Type: research

Bacterial N ‐formyl Peptides Reduce PMA‐ and E.coli‐induced Neutrophil Respiratory Burst in Term Neonates and Adults
This article is protected by copyright. All rights reserved. (Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - February 15, 2017 Category: Allergy & Immunology Authors: Maria E. St ålhammar, Lena Douhan Håkansson, Richard Sindelar Tags: Regular Article Source Type: research

Pharmacological postconditioning with sevoflurane activates PI3K/AKT signaling and attenuates cardiopulmonary bypass-induced lung injury in dog
Publication date: Available online 14 February 2017 Source:Life Sciences Author(s): Yu Zhang, Dongdong Li, Junli Luo, Song Chen, Xuejiao Dou, Ming Han, Hong Zhang Aims Sevoflurane, a widely used inhaled anesthetic, showed valid protective effect against ischemia reperfusion injury in lung, however, the underlying molecular mechanisms has yet to be explained. Materials and methods Dogs were divided into four groups: control group, cardiopulmonary bypass (CPB) group, sevoflurane postconditioning group and wortmannin group. Arterial blood was obtained from each group to test the respiratory index and oxygenation index and pu...
Source: Life Sciences - February 15, 2017 Category: Biology Source Type: research

Temperature sensitivity of substrate-use efficiency can result from altered microbial physiology without change to community composition
Publication date: June 2017 Source:Soil Biology and Biochemistry, Volume 109 Author(s): Tobias Bölscher, Eric Paterson, Thomas Freitag, Barry Thornton, Anke M. Herrmann Mechanisms controlling carbon stabilisation in soil and its feedback to climate change are of considerable importance. Microbial substrate-use efficiency is an important property during decomposition of soil organic matter. It determines the allocation of substrate towards biosynthetic stabilisation of carbon and for respiratory losses into the atmosphere. Previously, it was observed that substrate-use efficiency declines with an increase in temperature a...
Source: Soil Biology and Biochemistry - February 15, 2017 Category: Biology Source Type: research

Early immune responses and development of pathogenesis of avian infectious bronchitis viruses with different virulence profiles
This study compared the expression profile of genes related to immune responses in tracheal samples after challenge with two Brazilian field isolates (A and B) of IBV from the same genotype, associating these responses with viral replication and with pathological changes in trachea and kidney. We detected a suppressive effect on the early activation of TLR7 pathway, followed by lower expression levels of inflammatory related genes induced by challenge with the IBV B isolate when compared to the challenge with to the IBV A isolate. Cell-mediated immune (CMI) related genes presented also lower levels of expression in trachea...
Source: PLoS One - February 15, 2017 Category: Biomedical Science Authors: Cintia Hiromi Okino Source Type: research

< i > Mycoplasma pneumoniae < /i > CARDS toxin elicits a functional IgE response in Balb/c mice
by Jorge L. Medina, Edward G. Brooks, Adriana Chaparro, Peter H. DubeMycoplasma pneumoniae is strongly associated with new onset asthma and asthma exacerbations. Until recently, the molecular mechanisms utilized byM.pneumoniae to influence asthma symptoms were unknown. However, we recently reported that an ADP-ribosylating and vacuolating toxin called the Community Acquired Respiratory Distress Syndrome toxin, CARDS toxin, produced byM.pneumoniae was sufficient to promote allergic inflammation and asthma-like disease in mice. A mouse model of CARDS toxin exposure was used to evaluate total and CARDS-toxin specific serum Ig...
Source: PLoS One - February 15, 2017 Category: Biomedical Science Authors: Jorge L. Medina Source Type: research

No room for hyperoxia or hypertonic saline in septic shock
Publication date: Available online 15 February 2017 Source:The Lancet Respiratory Medicine Author(s): Jean-Louis Vincent (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - February 15, 2017 Category: Respiratory Medicine Source Type: research

Palivizumab prophylaxis in preterm infants
Publication date: Available online 15 February 2017 Source:The Lancet Respiratory Medicine Author(s): Paul Kiet Tang (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - February 15, 2017 Category: Respiratory Medicine Source Type: research

Hyperoxia and hypertonic saline in patients with septic shock (HYPERS2S): a two-by-two factorial, multicentre, randomised, clinical trial
This study was registered with ClinicalTrials.gov, number NCT01722422. Findings Between Nov 3, 2012, and June 13, 2014, 442 patients were recruited and assigned to a treatment group (normoxia [n=223] or hyperoxia [n=219]; isotonic [n=224] or hypertonic [n=218]). The trial was stopped prematurely for safety reasons. 28 day mortality was recorded for 434 patients; 93 (43%) of 217 patients had died in the hyperoxia group versus 77 (35%) of 217 patients in the normoxia group (hazard ratio [HR] 1·27, 95% CI 0·94–1·72; p=0·12). 89 (42%) of 214 patients had died in the hypertonic group versus 81 (37%) of 220 patients in the...
Source: The Lancet Respiratory Medicine - February 15, 2017 Category: Respiratory Medicine Source Type: research

The PATH to smoking cessation in the USA
Publication date: Available online 15 February 2017 Source:The Lancet Respiratory Medicine Author(s): Aaron van Dorn (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - February 15, 2017 Category: Respiratory Medicine Source Type: research

Validation of a quantitative method to measure neural respiratory drive in children during sleep
Conclusion NRD in children during sleep as assessed by sEMGdi can be quantified in a reliable and reproducible fashion. (Source: Respiratory Physiology and Neurobiology)
Source: Respiratory Physiology and Neurobiology - February 15, 2017 Category: Respiratory Medicine Source Type: research

Each day is a new beginning
(Source: Multidisciplinary Respiratory Medicine)
Source: Multidisciplinary Respiratory Medicine - February 15, 2017 Category: Respiratory Medicine Source Type: research

Professor Neil Pride
Professor Neil Blair Pride MD, FRCP, FERS: born Croydon 29 July 1931, died Ealing 12 November 2016. Neil Pride, Emeritus Professor of Respiratory Medicine at Imperial College London, died on 12 November 2016, aged 85 years. He was a world-renowned respiratory physician and physiologist who made enormous contributions to our understanding of common lung diseases. He was an active member of the British Thoracic Society (BTS) and served as President from 1992 to 1993. Neil was born in Croydon to a general practitioner father and educated at Bryanston School, Dorset. He studied preclinical medicine at Christ's College, Ca...
Source: Thorax - February 15, 2017 Category: Respiratory Medicine Authors: Barnes, P. J., Hughes, M. Tags: Chest clinic Source Type: research

The pressure-dependent air leak after partial lung resection
Case report A 72-year-old man with a right middle lobe lung adenocarcinoma underwent lobectomy with removal of tube thoracostomy 3 days after the thoracic surgery. He presented approximately 3 weeks after surgery with increasing dyspnoea. A chest X-ray (CXR) revealed a moderately large, loculated basilar pneumothorax (figure 1A). A small bore tube thoracostomy was placed with reduction of the pneumothorax. However, a moderate-sized pneumothorax with a persistent air leak persisted for approximately 2 weeks after chest tube placement requiring ongoing hospitalisation (figure 1B). Pleural manometry was perform...
Source: Thorax - February 15, 2017 Category: Respiratory Medicine Authors: Chopra, A., Doelken, P., Judson, M. A., Huggins, T. Tags: Images in Thorax, Health policy, Epidemiologic studies, Lung cancer (oncology), Screening (oncology), Lung cancer (respiratory medicine), Cardiothoracic surgery, Radiology (diagnostics), Health service research Chest clinic Source Type: research

Large airways nodularity secondary to tracheobronchopathia osteochondroplastica
A 74-year-old retired librarian was referred for assessment after a full-body CT, performed to investigate a 3-month history of persistent nausea and weight loss, incidentally identified a 10 mm left lower lobe nodule alongside small volume nodularity seen throughout the trachea and proximal main bronchi (figure 1). There was no previous thoracic imaging for comparison. She had a five pack-year smoking history and reported no preceding respiratory disease or symptoms. Her medical background was otherwise unremarkable. She appeared well in clinic; physical examination, basic spirometry (FEV1 131%, FVC 133% predicted) a...
Source: Thorax - February 15, 2017 Category: Respiratory Medicine Authors: Corcoran, J. P., Wrightson, J. M., Moore, A. J., Gleeson, F. V., Sykes, A. Tags: Images in Thorax, Hemoptysis, Cardiothoracic surgery, Health education, Smoking, Tobacco use Chest clinic Source Type: research

Placental transmogrification of the lung presenting as progressive symptomatic bullous emphysema
In 2015, a 63-year-old non-smoking male with a history of bullous emphysema, for which a wedge resection of the right lower lobe had been performed in 1972, presented with progressive dyspnoea on exertion and coughing. Pulmonary function tests demonstrated a moderate obstructive pattern with normal diffusion capacity (FEV1: 61%, FVC: 64%, TLco: 86%). CT of the thorax revealed localised bullous–cystic changes in the right lower lobe with displacement of the mediastinum to the contralateral side (figure 1). Due to the patient’s increasing respiratory distress, a right lower lobectomy was performed. Grossly, the s...
Source: Thorax - February 15, 2017 Category: Respiratory Medicine Authors: Brüstle, K., Lema, S., Komminoth, P., Weder, W., Vrugt, B., Jungraithmayr, W. Tags: Images in Thorax, Pneumonia (infectious disease), TB and other respiratory infections, Pneumonia (respiratory medicine) Chest clinic Source Type: research

Histologist's original opinion compared with multidisciplinary team in determining diagnosis in interstitial lung disease
Guidelines recommend that multidisciplinary interstitial lung disease meeting (ILD MDT) decisions become the gold standard for diagnosis, replacing the histologist from this position, and identify this as requiring supportive evidence. We have compared diagnoses from lung biopsy material made by expert histologists with the subsequent consensus opinion from a properly constituted ILD MDT in 71 consecutive patients referred to a regional thoracic unit. MDT changed the original histological diagnoses in 30% (95% CI 19.3% to 41.6%) and strengthened the diagnoses from probable to confident in a further 17% (95% CI 9.1% to 27.7...
Source: Thorax - February 15, 2017 Category: Respiratory Medicine Authors: Burge, P., Reynolds, J., Trotter, S., Burge, G., Walters, G., Djearaman, Hussain, Hoey, Langman, Payyappilly, Naidoo, Kalkat, Steyn, Rajesh, Bishay, Naidu, Ghani, Petkova, Robertson, Jayakumar Tags: Pneumonia (infectious disease), TB and other respiratory infections, Interstitial lung disease, Pneumonia (respiratory medicine) Research letter Source Type: research

Endobronchial valves for patients with heterogeneous emphysema and without interlobar collateral ventilation: open label treatment following the BeLieVeR-HIFi study
Outcomes in early trials of bronchoscopic lung volume reduction using endobronchial valves for the treatment of patients with advanced emphysema were inconsistent. However improvements in patient selection with focus on excluding those with interlobar collateral ventilation and homogeneous emphysema resulted in significant benefits in the BeLieVeR-HIFi study compared with sham treated controls. In this manuscript we present data from the control patients in the BeLieVeR-HIFi study who went on to have open label endobronchial valve treatment after completion of the clinical trial (n=12), combined with data from those in the...
Source: Thorax - February 15, 2017 Category: Respiratory Medicine Authors: Zoumot, Z., Davey, C., Jordan, S., McNulty, W. H., Carr, D. H., Hind, M. D., Polkey, M. I., Shah, P. L., Hopkinson, N. S. Tags: Open access Research letter Source Type: research

{beta}-Blockers, heart disease and COPD: current controversies and uncertainties
Treating people with cardiovascular disease and COPD causes significant clinician anxiety. β-Blockers save lives in people with heart disease, specifically postinfarction and heart failure. COPD and heart disease frequently coexist and people with both disorders have particularly high cardiovascular mortality. There are concerns about giving β-blockers to people with concomitant COPD that include reduced basal lung function, diminished effectiveness of emergency β-agonist treatments, reduced benefit of long-acting β-agonist treatment and difficulty in discriminating between asthma and COPD. β-Block...
Source: Thorax - February 15, 2017 Category: Respiratory Medicine Authors: Baker, J. G., Wilcox, R. G. Tags: State of the art review Source Type: research

The effect of diabetes control status on treatment response in pulmonary tuberculosis: a prospective study
Conclusions Uncontrolled diabetes is an independent risk factor for poor treatment response in PTB. (Source: Thorax)
Source: Thorax - February 15, 2017 Category: Respiratory Medicine Authors: Yoon, Y. S., Jung, J.-W., Jeon, E. J., Seo, H., Ryu, Y. J., Yim, J.-J., Kim, Y. H., Lee, B.-H., Park, Y. B., Lee, B. J., Kang, H., Choi, J. C. Tags: TB and other respiratory infections, Tuberculosis Source Type: research