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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 9.

Etiology of Influenza-Like Illnesses from Sentinel Network Practitioners in R éunion Island, 2011-2012
In conclusion, this study highlights a substantial circulation of multiple respiratory pathogens in Réunion Is land throughout the year. It shows that ILI are not only attributable to influenza and underlines the need for biological surveillance. As the use of multiplex RT-PCR showed its efficacy, it is now used routinely in the surveillance of ILI. (Source: PLoS One)
Source: PLoS One - September 21, 2016 Category: Biomedical Science Authors: Elise Brottet Source Type: research

Isolation of yeast complex IV in native lipid nanodiscs
Publication date: December 2016 Source:Biochimica et Biophysica Acta (BBA) - Biomembranes, Volume 1858, Issue 12 Author(s): Irina A. Smirnova, Dan Sjöstrand, Fei Li, Markus Björck, Jacob Schäfer, Henrik Östbye, Martin Högbom, Christoph von Ballmoos, Gabriel C. Lander, Pia Ädelroth, Peter Brzezinski We used the amphipathic styrene maleic acid (SMA) co-polymer to extract cytochrome c oxidase (CytcO) in its native lipid environment from S. cerevisiae mitochondria. Native nanodiscs containing one CytcO per disc were purified using affinity chromatography. The longest cross-sections of the native nanodiscs were 11nm×14n...
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - September 21, 2016 Category: Biochemistry Source Type: research

Characterization of a Mouse Model of Oral Potassium Cyanide Intoxication
Potassium cyanide (KCN) is an inhibitor of cytochrome C oxidase causing rapid death due to hypoxia. A well-characterized model of oral KCN intoxication is needed to test new therapeutics under the Food and Drug Administration Animal Rule. Clinical signs, plasma pH and lactate concentrations, biomarkers, histopathology, and cyanide and thiocyanate toxicokinetics were used to characterize the pathology of KCN intoxication in adult and juvenile mice. The acute oral LD50s were determined to be 11.8, 11.0, 10.9, and 9.9 mg/kg in water for adult male, adult female, juvenile male, and juvenile female mice, respectively. The time ...
Source: International Journal of Toxicology - September 21, 2016 Category: Toxicology Authors: Sabourin, P. J., Kobs, C. L., Gibbs, S. T., Hong, P., Matthews, C. M., Patton, K. M., Sabourin, C. L., Wakayama, E. J. Tags: Regular Articles Source Type: research

The asthma-anxiety connection
The literature reports a significant association between various mental disorders and asthma, in particular depression and/or anxiety, with some more robust data regarding anxiety disorders. However, the nature of this association remains largely unclear. (Source: Respiratory Medicine)
Source: Respiratory Medicine - September 21, 2016 Category: Respiratory Medicine Authors: Stefano R. Del Giacco, Alessandra Cappai, Luisanna Gambula, Stefano Cabras, Silvia Perra, Paolo Emilio Manconi, Bernardo Carpiniello, Federica Pinna Source Type: research

The architecture of respiratory supercomplexes
Nature advance online publication 21 September 2016. doi:10.1038/nature19774 Authors: James A. Letts, Karol Fiedorczuk & Leonid A. Sazanov (Source: Nature AOP)
Source: Nature AOP - September 21, 2016 Category: Research Authors: James A. Letts Karol Fiedorczuk Leonid A. Sazanov Tags: Article Source Type: research

Systematic literature review on effectiveness of self ‐management support interventions in patients with chronic conditions and low socio‐economic status
ConclusionLimited evidence was found for the effectiveness of self‐management support interventions in chronic ill patients with low socio‐economic status. Essential characteristics and component(s) of effective self‐management support interventions for these patients could not be detected. Rigorous reporting on development and underlying theories of health behavioural components in the intervention is recommended.This article is protected by copyright. All rights reserved. (Source: Journal of Advanced Nursing)
Source: Journal of Advanced Nursing - September 21, 2016 Category: Nursing Authors: A Van Hecke, M Heinen, P Fern ández‐Ortega, M Graue, J Hendriks, B Høy, S Köpke, M Lithner, B van Gaal Tags: Review Source Type: research

Respiratory variation in tricuspid valve regurgitant orifice: a three-dimensional transthoracic echocardiographic perspective
(Source: European Journal of Echocardiography)
Source: European Journal of Echocardiography - September 21, 2016 Category: Cardiology Authors: Agmon, Y., Caspi, O. Tags: Image Focus Source Type: research

Postoperative pain management of liver transplantation in cystic fibrosis: Is it time to start US-guided neuraxial blocks ?
We report the first case of continuous thoracic epidural analgesia after pediatric liver transplantation in a 10-year-old boy affected with CF with macronodular cirrhosis. Despite a challenging coagulation profile, the echo-assisted procedure was safely performed and allowed extubation in the odds ratio, postoperative awakening and comfort, and quick resumption of respiratory physiotherapy. (Source: Saudi Journal of Anaesthesia)
Source: Saudi Journal of Anaesthesia - September 21, 2016 Category: Anesthesiology Authors: M Piazza G Martucci A Arcadipane Source Type: research

European Consensus Guidelines on the Management of Respiratory Distress Syndrome - 2016 Update.
We report the third update of the European Guidelines for the Management of RDS by a European panel of expert neonatologists including input from an expert perinatal obstetrician based on available literature up to the beginning of 2016. Optimizing the outcome for babies with RDS includes consideration of when to use antenatal steroids, and good obstetric practice includes methods of predicting the risk of preterm delivery and also consideration of whether transfer to a perinatal centre is necessary and safe. Methods for optimal delivery room management have become more evidence based, and protocols for lung protection, in...
Source: Neonatology - September 21, 2016 Category: Perinatology & Neonatology Authors: Sweet DG, Carnielli V, Greisen G, Hallman M, Ozek E, Plavka R, Saugstad OD, Simeoni U, Speer CP, Vento M, Visser GH, Halliday HL Tags: Neonatology Source Type: research

Strategies to broaden the cross-protective efficacy of vaccines against porcine reproductive and respiratory syndrome virus
This article summarizes the impediments for the development of a highly protective PRRS vaccine and reviews the vaccinology approaches that have been attempted to overcome one of the most formidable challenges, which is the substantial genetic variation among PRRSV isolates, to broaden the antigenic coverage of PRRS vaccines. (Source: Veterinary Microbiology)
Source: Veterinary Microbiology - September 21, 2016 Category: Veterinary Research Source Type: research

Rapid detection of viral antibodies based on multifunctional Staphylococcus aureus nanobioprobes
In this study, a simple way to conjugate antigens to the S. aureus nanobioparticles was developed by utilizing a cell wall binding domain (CBD) from a bacteriophage lysin PlyV12. Based on this novel design, simple agglutination tests of the IgG antibodies of Ebola virus (EBOV) nucleoprotein (NP) and Middle East Respiratory Virus (MERS) NP in rabbit sera were successfully developed by conjugating the S. aureus nanobioparticles with two fusion proteins EBOV NP- CBD and MERS NP-CBD, respectively. The conjugation was done easily by just mixing the fusion proteins with the S. aureus nanoparticles. The detection time was within ...
Source: Enzyme and Microbial Technology - September 21, 2016 Category: Biotechnology Source Type: research

The differential effects of azithromycin on the airway epithelium in  vitro and in vivo
Abstract Macrolides including azithromycin (AZM) can improve clinical symptoms in asthma regardless of infection status. The mechanisms underlying these beneficial effects are yet to be elucidated. The aim of this study was to determine the effect of AZM on the airway epithelial barrier both in an in vitro model and in patients with asthma. Primary human bronchial epithelial cells (HBEC) were grown at air liquid interface (ALI) and challenged using lipopolysaccharides from Pseudomonas aeruginosa. AZM was added at various stages and barrier integrity assessed using transepithelial electrical resistance (TEER) and permeabil...
Source: Physiological Reports - September 21, 2016 Category: Physiology Authors: Mariel Slater, Elizabeth Torr, Tim Harrison, Doug Forrester, Alan Knox, Dominick Shaw, Ian Sayers Tags: Original Research Source Type: research

Structural and functional characterisation of the cyanobacterial PetC3 Rieske protein family
Publication date: Available online 20 September 2016 Source:Biochimica et Biophysica Acta (BBA) - Bioenergetics Author(s): Sebastian Veit, Kazuki Takeda, Yuichi Tsunoyama, Frauke Baymann, Reinat Nevo, Ziv Reich, Matthias Rögner, Kunio Miki, Sascha Rexroth The cyanobacterium Synechocystis PCC 6803 possesses three Rieske isoforms: PetC1, PetC2 and PetC3. While PetC1 and PetC2 have been identified as alternative subunits of the cytochrome b 6 f complex (b 6 f), PetC3 was localized exclusively within the plasma membrane. The spatial separation of PetC3 from the photosynthetic and respiratory protein complexes raises doubt in...
Source: Biochimica et Biophysica Acta (BBA) Bioenergetics - September 21, 2016 Category: Biochemistry Source Type: research

Doxycycline poudrage: An old agent for a new technique
Conclusion Doxycycline, as an old agent, when poudraged during medical thoracoscopy proved to be safe and effective agent for pleurodesis in symptomatic malignant pleural effusion. (Source: Egyptian Journal of Chest Diseases and Tuberculosis)
Source: Egyptian Journal of Chest Diseases and Tuberculosis - September 21, 2016 Category: Respiratory Medicine Source Type: research

Defining morphology of periodic leg movements in sleep: an evidence-based definition of a minimum window of sustained activity
ConclusionAn added criterion requiring 0.5  s of high EMG activity within a valid CLM improves the accuracy of automatic scoring algorithms in relation to the gold standard of expert visual scorers. Our results suggest that this rule is an accurate representation of the morphology feature used by experts. This new rule has the potential to improve consistency and accuracy of visual and automatic scoring of PLM. (Source: Sleep and Breathing)
Source: Sleep and Breathing - September 21, 2016 Category: Respiratory Medicine Source Type: research

Effect of Maternal Influenza Vaccination on Hospitalization for Respiratory Infections in Newborns: A Retrospective Cohort Study
Conclusions: Maternal influenza vaccination was associated with a reduction in the incidence of hospital admission for acute respiratory illness among infants (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - September 20, 2016 Category: Infectious Diseases Tags: Original Studies Source Type: research

Limited Evidence on the Management of Respiratory Tract Infections in Down’s Syndrome: A Systematic Review
Conclusions: The evidence base for the management of RTIs in people with Down’s syndrome is incomplete; current studies included children only and carry a moderate to serious risk of bias. Methodologic rigorous studies are warranted to guide clinicians in how best to prevent and treat RTIs in children with Down’s syndrome. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - September 20, 2016 Category: Infectious Diseases Tags: Original Studies Source Type: research

Rhinovirus Infections and Associated Respiratory Morbidity in Infants: A Prospective Cohort Study
Conclusions: RVs are highly prevalent during the first year of life, and most infections are asymptomatic. Frequency of RV infections is associated with environmental factors, while respiratory symptoms during RV infections are linked to host determinants like infant age, maternal atopy or premorbid lung function. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - September 20, 2016 Category: Infectious Diseases Tags: Original Studies Source Type: research

Spatial and Temporal Spread of Acute Viral Respiratory Infections in Young Children Living in High-altitude Rural Communities: A Prospective Household-based Study
We examined the spatial and temporal spread of viral ARI among young children in rural Peruvian highland communities. Previous studies have described intense social interactions in those communities, which could influence the transmission of viral infections. Methods: We enrolled and followed children (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - September 20, 2016 Category: Infectious Diseases Tags: Original Studies Source Type: research

Splenectomy Versus Sham Splenectomy in a Swine Model of Controlled Hemorrhagic Shock
Introduction: Splenectomy is controversial in acute hemorrhagic shock models. Objective: To compare splenectomized (SP) versus sham-splenectomized (SSP) swine during acute controlled hemorrhage. Methods: Twenty-six male Landrace White swine (mean body weight ± standard deviation, 33.8 ± 2.9 kg) were used. Ethics approval was obtained. Landrace swine underwent splenectomy (n = 13) or sham-splenectomy (n = 13), were bled to mean arterial blood pressure (MAP) of 40 mm Hg, which was held for 60 min, given 125 mL IV RescueFlow, held for a further 60 min, given whole blood, and held for a final 60 min. Ti...
Source: Shock - September 20, 2016 Category: Emergency Medicine Tags: Basic Science Aspects Source Type: research

Neutralization of Osteopontin Ameliorates Acute Lung Injury Induced by Intestinal Ischemia-Reperfusion
In conclusion, we have demonstrated beneficial outcomes of anti-OPN Ab treatment in protecting against ALI, implicating a novel therapeutic potential in intestinal I/R. (Source: Shock)
Source: Shock - September 20, 2016 Category: Emergency Medicine Tags: Basic Science Aspects Source Type: research

Toll-Like Receptor-9 (TLR9) is Requisite for Acute Inflammatory Response and Injury Following Lung Contusion
ABSTRACT: Lung contusion (LC) is a significant risk factor for the development of acute respiratory distress syndrome. Toll-like receptor 9 (TLR9) recognizes specific unmethylated CpG motifs, which are prevalent in microbial but not vertebrate genomic DNA, leading to innate and acquired immune responses. TLR9 signaling has recently been implicated as a critical component of the inflammatory response following lung injury. The aim of the present study was to evaluate the contribution of TLR9 signaling to the acute physiologic changes following LC. Nonlethal unilateral closed-chest LC was induced in TLR9 (-/-) and wild-type ...
Source: Shock - September 20, 2016 Category: Emergency Medicine Tags: Basic Science Aspects Source Type: research

High Levels of Methylarginines Were Associated With Increased Mortality in Patients With Severe Sepsis
Conclusions: High levels of ADMA and SDMA in plasma were associated with increased 90-day mortality in patients with severe sepsis or septic shock. Interfering with the methylarginine-NO systems may be a novel target in these patients. (Source: Shock)
Source: Shock - September 20, 2016 Category: Emergency Medicine Tags: Clinical Aspects Source Type: research

Pulmonary Vascular Dysfunction and Cor Pulmonale During Acute Respiratory Distress Syndrome in Sicklers
The objective of this study was to evaluate the prevalence and prognosis of PVD and ACP during ACS-ARDS. Patients and Methods: This was a retrospective analysis over a 10-year period of patients with moderate-to-severe ARDS. PVD and ACP were assessed by echocardiography. ARDS episodes were assigned to ACS-ARDS or nonACS-ARDS group according to whether the clinical insult was ACS or not, respectively. To evaluate independent factors associated with ACP, significant univariable risk factors were examined using logistic regression and propensity score analyses. Results: A total of 362 patients were analyzed, including 24 AC...
Source: Shock - September 20, 2016 Category: Emergency Medicine Tags: Clinical Aspects Source Type: research

Nondepolarizing Neuromuscular Blocking Agents, Reversal, and Risk of Postoperative Pneumonia
Conclusions Intraoperative use of intermediate nondepolarizing NMBAs is associated with developing pneumonia after surgery. Among patients who receive these agents, nonreversal is associated with an increased risk of postoperative pneumonia. (Source: Anesthesiology)
Source: Anesthesiology - September 20, 2016 Category: Anesthesiology Source Type: research

Paracetamol does not worsen lung function of children with asthma
When used during respiratory illness in children, paracetamol is not associated with a higher risk of asthma exacerbations than ibuprofen. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - September 20, 2016 Category: Drugs & Pharmacology Source Type: research

Codeine is Not Safe for Kids
The drug has been linked to life-threatening or fatal respiratory problems in children -- Read more on ScientificAmerican.com (Source: Scientific American)
Source: Scientific American - September 20, 2016 Category: Science Tags: Health Medicine Source Type: research

European Consensus Guidelines on the Management of Respiratory Distress Syndrome - 2016 Update
We report the third update of the European Guidelines for the Management of RDS by a European panel of expert neonatologists including input from an expert perinatal obstetrician based on available literature up to the beginning of 2016. Optimizing the outcome for babies with RDS includes consideration of when to use antenatal steroids, and good obstetric practice includes methods of predicting the risk of preterm delivery and also consideration of whether transfer to a perinatal centre is necessary and safe. Methods for optimal delivery room management have become more evidence based, and protocols for lung protection, in...
Source: Neonatology - September 20, 2016 Category: Perinatology & Neonatology Source Type: research

Assessment and predictors of physical functioning post-hospital discharge in survivors of critical illness
Prior studies of physical functioning after critical illness have been mostly limited to survivors of acute respiratory distress syndrome. The purpose of this study was to objectively assess muscle strength an... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - September 20, 2016 Category: Intensive Care Authors: Kevin J. Solverson, Christopher Grant and Christopher J. Doig Source Type: research

Human extraintestinal pathogenic Escherichia coli strains differ in prevalence of virulence factors, phylogroups, and bacteriocin determinants
The study used a set of 407 human extraintestinal pathogenic E. coli strains (ExPEC) isolated from (1) skin and soft tissue infections, (2) respiratory infections, (3) intra-abdominal infections, and (4) genital ... (Source: BMC Microbiology)
Source: BMC Microbiology - September 20, 2016 Category: Microbiology Authors: Lenka Micenkov á, Juraj Bosák, Martin Vrba, Alena Ševčíková and David Šmajs Source Type: research

Transpulmonary and pleural pressure in a respiratory system model with an elastic recoiling lung and an expanding chest wall
We have shown in acute lung injury patients that lung elastance can be determined by a positive end-expiratory pressure (PEEP) step procedure and proposed that this is explained by the spring-out force of the ... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - September 20, 2016 Category: Surgery Authors: Per Persson, Stefan Lundin and Ola Stenqvist Source Type: research

Maternal allergic disease history affects childhood allergy development through impairment of neonatal regulatory T-cells
Maternal allergic disease history and impaired regulatory T-cells (Tregs) are critical risk factors for allergy development in children. However, the mechanisms that underlie these risk factors remain poorly d... (Source: Respiratory Research)
Source: Respiratory Research - September 20, 2016 Category: Respiratory Medicine Authors: Shan-shan Meng, Rong Gao, Bing-di Yan, Jin Ren, Fei Wu, Peng Chen, Jie Zhang, Li-fang Wang, Yuan-ming Xiao and Jing Liu Source Type: research

Respiratory symptoms, sleep-disordered breathing and biomarkers in nocturnal gastroesophageal reflux
Nocturnal gastroesophageal reflux (nGER) is associated with respiratory symptoms and sleep-disordered breathing (SDB), but the pathogenesis is unclear. We aimed to investigate the association between nGER and ... (Source: Respiratory Research)
Source: Respiratory Research - September 20, 2016 Category: Respiratory Medicine Authors: Össur Ingi Emilsson, Bryndís Benediktsdóttir, Ísleifur Ólafsson, Elizabeth Cook, Sigurður Júlíusson, Einar Stefán Björnsson, Sunna Guðlaugsdóttir, Anna Soffía Guðmundsdóttir, Ekaterina Mirgorodskaya, Evert Ljungström, Erna Sif Arnardóttir Source Type: research

Kratom Products Seized
Federal marshals seized more than 100 cases of a potentially addictive botanical supplement that has been linked with respiratory depression, vomiting, nervousness, weight loss, and constipation. (Source: JAMA)
Source: JAMA - September 20, 2016 Category: Journals (General) Source Type: research

Tidal Volume Delivery and Endotracheal Tube Leak during Cardiopulmonary Resuscitation in Intubated Newborn Piglets with Hypoxic Cardiac Arrest Exposed to Different Modes of Ventilatory Support
Conclusions: There is interaction between lung inflations and CC affecting leak and delivery of tidal volume, which may be influenced by the mode/device used for respiratory support. Leak is larger in the presence of PEEP. However, CC cause additional tidal volume which is larger in the presence of PEEP.Neonatology 2017;111:100-106 (Source: Neonatology)
Source: Neonatology - September 20, 2016 Category: Perinatology & Neonatology Source Type: research

Mono- and quadri-subtype virus-like particles (VLPs) containing H10 subtype elicit protective immunity to H10 influenza in a ferret challenge model.
In this study, we evaluated H10 VLPs containing hemagglutinin from H10N8 virus as an experimental vaccine in a ferret challenge model. In addition, we evaluated quadri-subtype VLPs co-localizing H5, H7, H9 and H10 subtypes. Both vaccines elicited serum antibody that reacted with the homologous H10 derived from H10N8 virus and cross-reacted with the heterologous H10N1 virus. Quadri-subtype vaccine also elicited serum antibody to the homologous H5, H7, and H9 antigens and cross-reacted with multiple clades of H5N1 virus. After heterologous challenge with the H10N1 virus, all vaccinated ferrets showed significantly reduced ti...
Source: Vaccine - September 20, 2016 Category: Allergy & Immunology Authors: Pushko P, Sun X, Tretyakova I, Hidajat R, Pulit-Penaloza JA, Belser JA, Maines TR, Tumpey TM Tags: Vaccine Source Type: research

Porcine reproductive and respiratory syndrome virus (PRRSV) induces IL-12p40 production through JNK-AP-1 and NF- κB signaling pathways.
Porcine reproductive and respiratory syndrome virus (PRRSV) induces IL-12p40 production through JNK-AP-1 and NF-κB signaling pathways. Virus Res. 2016 Sep 20; Authors: Yu Z, Huang C, Zhang Q, Feng WH Abstract Porcine reproductive and respiratory syndrome virus (PRRSV) mainly infects monocyte/macrophage cells and modulates cytokine production to regulate host immune response. IL-12p40 is the basic subunit of IL-12, a heterodimeric cytokine, which plays key roles in the cell-mediated immune response. In the present study, we demonstrated that PRRSV infection induced IL-12p40 production in vitro and in ...
Source: Virus Research - September 20, 2016 Category: Virology Authors: Yu Z, Huang C, Zhang Q, Feng WH Tags: Virus Res Source Type: research

RIFM fragrance ingredient safety assessment, 3,7-dimethyl-1,6-nonadien-3-ol, CAS Registry Number 10339-55-6.
Abstract The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the suitable read across analog linalool (CAS # 78-70-6) show that this material is not genotoxic nor does it have skin sensitization potential and also provided a MOE > 100 for the local respiratory endpoint. The repeated dose, developmental and reproductive toxicity endpoints were...
Source: Food and Chemical Toxicology - September 20, 2016 Category: Food Science Authors: Api AM, Belsito D, Bhatia S, Bruze M, Calow P, Dagli ML, Dekant W, Fryer AD, Kromidas L, La Cava S, Lalko JF, Lapczynski A, Liebler DC, Miyachi Y, Politano VT, Ritacco G, Salvito D, Schultz TW, Shen J, Sipes IG, Wall B, Wilcox DK Tags: Food Chem Toxicol Source Type: research

Clinical predictors of hospital mortality differ between direct and indirect acute respiratory distress syndrome.
CONCLUSIONS: Despite lower severity of illness and fewer organ failures, patients with direct ARDS had similar mortality to patients with indirect ARDS. Factors previously associated with mortality during ARDS were only associated with mortality in direct ARDS. These findings suggest that direct and indirect ARDS have distinct features that may differentially affect risk prediction and clinical outcomes. PMID: 27663180 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - September 20, 2016 Category: Respiratory Medicine Authors: Luo L, Shaver CM, Zhao Z, Koyama T, Calfee CS, Bastarache JA, Ware LB Tags: Chest Source Type: research

Neuropeptide Y in the brain of Euphlyctus cyanophlyctus tadpoles responds to hypoxic stress.
Abstract Neuropeptide Y (NPY) has emerged as a novel peptide to antagonize various physiological consequences of stress within a mammalian brain. Hypoxia induced neuropeptide Y release in mammalian systems is well established. However, the possible role of NPY in regulating the effects of oxygen variation in lower vertebrates has not been investigated. We have studied the distribution and neuro-anatomical expression of NPY in the brain of Euphlyctus cyanophlyctus tadpoles, exposed to normal and reduced oxygen levels using immunohistochemistry. Animals exposed to hypoxia (<2mg/ml) exhibited a significant amplifi...
Source: General and Comparative Endocrinology - September 20, 2016 Category: Endocrinology Authors: Ali I, Bhargava S Tags: Gen Comp Endocrinol Source Type: research

Lutibacter oceani sp. nov., isolated from marine sediment in South Korea.
Abstract A novel Gram-negative, non-motile, non-spore forming, facultatively anaerobic and short-rod shaped bacterial strain, designated as 325-5(T), was isolated from marine sediment obtained from a coastal region in South Korea. Phylogenetic analysis based on the 16S rRNA gene sequence of strain 325-5(T) showed close similarity to Lutibacter crassostreae (97.8 %). The novel isolate was found to grow optimally at 25 °C and pH 7.0. The major fatty acids identified in the strain were iso C15:0 and iso C15:0 3OH, which supports the affiliation of strain 325-5(T) to the genus Lutibacter. Menaquinone (MK-6) was ide...
Source: Antonie van Leeuwenhoek - September 20, 2016 Category: Microbiology Authors: Sundararaman A, Lee SS Tags: Antonie Van Leeuwenhoek Source Type: research

Effects of continuous positive airway pressure and isocapnic-hypoxia on cerebral autoregulation in patients with obstructive sleep apnea.
In conclusion, CA is altered in the more severe OSA patients during normoxia but not during isocapnic-hypoxia and CPAP treatment does not impact CA. This article is protected by copyright. All rights reserved. PMID: 27644162 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - September 20, 2016 Category: Physiology Authors: Waltz X, Beaudin AE, Hanly PJ, Mitsis GD, Poulin MJ Tags: J Physiol Source Type: research

Long-Chain Acyl-CoA Synthetase 6 regulates lipid synthesis and mitochondrial oxidative capacity in human and rat skeletal muscle.
In conclusion, ACSL6 drives acyl-CoA toward lipid synthesis and its downregulation improves mitochondrial biogenesis, respiratory capacity and lipid oxidation. These outcomes are associated with the activation of the AMPK/PGC1-α pathway. This article is protected by copyright. All rights reserved. PMID: 27647415 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - September 20, 2016 Category: Physiology Authors: Teodoro BG, Sampaio IH, Bomfim LH, Queiroz AL, Silveira LR, Souza AO, Fernandes AM, Eberlin MN, Huang TY, Zheng D, Neufer PD, Cortright RN, Alberici LC Tags: J Physiol Source Type: research

Tidal Volume Delivery and Endotracheal Tube Leak during Cardiopulmonary Resuscitation in Intubated Newborn Piglets with Hypoxic Cardiac Arrest Exposed to Different Modes of Ventilatory Support.
CONCLUSIONS: There is interaction between lung inflations and CC affecting leak and delivery of tidal volume, which may be influenced by the mode/device used for respiratory support. Leak is larger in the presence of PEEP. However, CC cause additional tidal volume which is larger in the presence of PEEP. PMID: 27643857 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - September 20, 2016 Category: Perinatology & Neonatology Authors: Mendler MR, Weber C, Hassan MA, Huang L, Mayer B, Hummler HD Tags: Neonatology Source Type: research

miR-138 and miR-25 Downregulate MCU, Causing Pulmonary Arterial Hypertension's Cancer Phenotype.
CONCLUSIONS: These results highlight miR-mediated MCUC dysfunction as a unifying mechanism in PAH that can be therapeutically targeted. PMID: 27648837 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 20, 2016 Category: Respiratory Medicine Authors: Hong Z, Chen KH, DasGupta A, Potus F, Dunham-Snary K, Bonnet S, Tian L, Fu J, Breuils-Bonnet S, Provencher S, Wu D, Mewburn J, Ormiston ML, Archer SL Tags: Am J Respir Crit Care Med Source Type: research

Translating MicroRNA Biology in Pulmonary Hypertension: It Will Take More Than "miR" Words.
Abstract Pulmonary hypertension (PH) is an enigmatic vascular disease with complex molecular origins, leading to right ventricular failure and often death. Recent studies have implicated the pervasive actions of microRNAs in the pulmonary vasculature and the right ventricle as essential to the development of PH. MicroRNAs are small, non-protein coding RNA molecules that negative regulate gene expression. Because greater than 5,500 microRNA molecules have been predicted or verified to be encoded by the human genome, we are still at the inception of our mechanistic understanding of how all of these factors, either s...
Source: American Journal of Respiratory and Critical Care Medicine - September 20, 2016 Category: Respiratory Medicine Authors: Chun HJ, Bonnet S, Chan SY Tags: Am J Respir Crit Care Med Source Type: research

qSOFA, SIRS, and Early Warning Scores for Detecting Clinical Deterioration in Infected Patients Outside the ICU.
CONCLUSIONS: Commonly used early warning scores are more accurate than the qSOFA score for predicting death and ICU transfer in non-ICU patients. These results suggest that the qSOFA score should not replace general early warning scores when risk-stratifying patients with suspected infection. PMID: 27649072 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 20, 2016 Category: Respiratory Medicine Authors: Churpek MM, Snyder A, Han X, Sokol S, Pettit N, Howell MD, Edelson DP Tags: Am J Respir Crit Care Med Source Type: research

Translating Research into Improved Patient Care in Pulmonary Arterial Hypertension.
Abstract Despite important advances in its therapeutic management, pulmonary arterial hypertension (PAH) remains an incurable disease. Although numerous drugs exhibited beneficial effects in preclinical settings, only few have reached clinical trial phases, highlighting the challenges of translating preclinical investigations into clinical trials. Potential reasons for delayed PAH drug development may include the inherent limitations of the currently available animal and in vitro models, potential lack of appropriate standardization of the experimental design, regulatory agencies requirements, competing clinical t...
Source: American Journal of Respiratory and Critical Care Medicine - September 20, 2016 Category: Respiratory Medicine Authors: Bonnet S, Provencher S, Guignabert C, Perros F, Boucherat O, Schermuly RT, Hassoun PM, Rabinovitch M, Nicolls MR, Humbert M Tags: Am J Respir Crit Care Med Source Type: research

Sing Your Lungs Out: a qualitative study of a community singing group for people with chronic obstructive pulmonary disease (COPD)
Conclusions This study helps us to better understand how participation in a community singing group can benefit the health and well-being of patients with COPD. Trial registration number ACTRN12615000736549; Results. (Source: BMJ Open)
Source: BMJ Open - September 20, 2016 Category: Journals (General) Authors: McNaughton, A., Aldington, S., Williams, G., Levack, W. M. M. Tags: Open access, Qualitative research, Rehabilitation medicine, Respiratory medicine Source Type: research

Long-Term Oxygen Therapy 24 vs 15 h/day and Mortality in Chronic Obstructive Pulmonary Disease
by Zainab Ahmadi, Josefin Sundh, Anna Bornefalk-Hermansson, Magnus Ekstr öm Long-term oxygen therapy (LTOT) ≥ 15 h/day improves survival in hypoxemic chronic obstructive pulmonary disease (COPD). LTOT 24 h/day is often recommended but may pose an unnecessary burden with no clear survival benefit compared with LTOT 15 h/day. The aim was to test the hypothesis that LTOT 2 4 h/day decreases all-cause, respiratory, and cardiovascular mortality compared to LTOT 15 h/day in hypoxemic COPD. This was a prospective, observational, population-based study of COPD patients starting LTOT between October 1, 2005 and June 30, 2009 in...
Source: PLoS One - September 20, 2016 Category: Biomedical Science Authors: Zainab Ahmadi Source Type: research