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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 7.

Survival of macrovascular disease, chronic kidney disease, chronic respiratory disease, cancer and smoking in patients with type 2 diabetes: BioBank Japan cohort.
CONCLUSIONS: Diabetic patients with a past or current history of chronic kidney, macrovascular or respiratory diseases or smoking habit have exhibited the highest risk of mortality. Data were limited to those of survivors of comorbidities but we propose the need to improve comorbidities and terminate cigarette smoking for better prognosis in patients with diabetes. PMID: 28209242 [PubMed - as supplied by publisher] (Source: Journal of Epidemiology)
Source: Journal of Epidemiology - February 18, 2017 Category: Epidemiology Tags: J Epidemiol Source Type: research

Fulminant course in a case of malignant phyllodes tumor.
We present the case of a 31-year-old woman with an inflammatory and ulcerative malignant phyllodes tumor in her right breast. A right modified radical mastectomy and transverse rectus abdominis myocutaneous (TRAM) flap were performed. A month after the initial operation, several masses recurred at the superior margin and deep margin of the TRAM flap. Wide excision was performed, but masses recurred at the inferior margin and in both lung fields 2 weeks after the second operation. Six weeks after the second operation, the patient died due to progression of dyspnea and respiratory failure. PMID: 28203559 [PubMed] (Source...
Source: Annals of Surgical Treatment and Research - February 18, 2017 Category: Surgery Tags: Ann Surg Treat Res Source Type: research

How Much Does ICU Structure Account for Variation in Mobility Practices Between Acute Respiratory Distress Syndrome Network Hospitals?
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 18, 2017 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research

The Open Lung Approach Improves Pulmonary Vascular Mechanics in an Experimental Model of Acute Respiratory Distress Syndrome
Objective: To test whether positive end-expiratory pressure consistent with an open lung approach improves pulmonary vascular mechanics compared with higher or lower positive end-expiratory pressures in experimental acute respiratory distress syndrome. Design: Experimental study. Setting: Animal research laboratory. Subjects: Ten pigs, 35 ± 5.2 kg. Interventions: Acute respiratory distress syndrome was induced combining saline lung lavages with injurious mechanical ventilation. The positive end-expiratory pressure level resulting in highest compliance during a decremental positive end-expiratory pressure trial a...
Source: Critical Care Medicine - February 18, 2017 Category: Emergency Medicine Tags: Online Laboratory Investigation Source Type: research

Diagnostic Accuracy of the Inferior Vena Cava Collapsibility to Predict Fluid Responsiveness in Spontaneously Breathing Patients With Sepsis and Acute Circulatory Failure
Conclusions: The collapsibility index of the inferior vena cava during a deep standardized inspiration is a simple, noninvasive bedside predictor of fluid responsiveness in nonintubated patients with sepsis-related acute circulatory failure. (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 18, 2017 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

High-Flow Nasal Cannula Oxygenation in Immunocompromised Patients With Acute Hypoxemic Respiratory Failure: A Groupe de Recherche Respiratoire en Réanimation Onco-Hématologique Study
Conclusions: In immunocompromised patients with hypoxemic acute respiratory failure, high-flow nasal oxygen when compared with standard oxygen did not reduce intubation or survival rates. However, these results could be due to low statistical power or unknown confounders associated with the subgroup analysis. A randomized trial is needed. (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 18, 2017 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Skeletal Muscle Weakness Is Associated With Both Early and Late Mortality After Acute Respiratory Distress Syndrome*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 18, 2017 Category: Emergency Medicine Tags: Editorials Source Type: research

Exploring the Dark Side of the Moon: Pulmonary Vascular Dysfunction in Acute Respiratory Distress Syndrome*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 18, 2017 Category: Emergency Medicine Tags: Editorials Source Type: research

Muscle Weakness and 5-Year Survival in Acute Respiratory Distress Syndrome Survivors*
Conclusions: At hospital discharge, greater than one third of acute respiratory distress syndrome survivors had muscle weakness. Greater strength at discharge and throughout follow-up was associated with improved 5-year survival. In patients with post-ICU weakness, both persisting and resolving trajectories were commonly experienced and associated with worse survival during follow-up. (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 18, 2017 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research

Pulmonary Arterial Compliance in Acute Respiratory Distress Syndrome: Clinical Determinants and Association With Outcome From the Fluid and Catheter Treatment Trial Cohort*
Conclusions: Baseline measures of pulmonary arterial compliance and pulmonary vascular resistance predict mortality in acute respiratory distress syndrome, and pulmonary arterial compliance remains predictive even when pulmonary vascular resistance is normal. Pulmonary arterial compliance and right ventricular load improve over time in acute respiratory distress syndrome survivors. Future studies should assess the impact of right ventricular protective acute respiratory distress syndrome treatment on right ventricular afterload and outcome. (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 18, 2017 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research

Potency of parenteral antimicrobials including ceftolozane/tazobactam against nosocomial respiratory tract pathogens: considerations for empiric and directed therapy.
CONCLUSIONS: PSA was the predominant nosocomial respiratory pathogen; however, the Enterobacteriaceae comprised an additional 53% in this survey. When considering empiric β-lactam monotherapy therapy for the entire spectrum of pathogens C/T provided the highest (78%) %S followed by MEM, FEP and TZP. The addition of either TOB > CIP to these β-lactams enhances the likelihood that an active agent would be selected when considering empirical therapy choices for nosocomial respiratory tract infections. PMID: 28203427 [PubMed - in process] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - February 18, 2017 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Multiple cavitating pulmonary nodules: rare manifestation of benign metastatic leiomyoma.
Authors: Lee SR, Choi YI, Lee SJ, Shim SS, Lee JH, Kim YK, Sung SH Abstract Benign metastasizing leiomyoma (BML) is a rare disease of pathologically benign, but the tumor metastasizes to other organs. The most common organ involved in BML is lung. Pulmonary involvement usually manifested as multiple nodules on chest X-ray, however we experienced an interesting case of a 52-year-old premenopausal woman who presented with multiple bilateral lung cavitations and nodules on a chest X-ray without any respiratory symptoms. Chest computed-tomography identified multiple cavitary lesions of 5-12 mm in diameter and well-defi...
Source: Journal of Thoracic Disease - February 18, 2017 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Acute respiratory distress syndrome and chemical burns after exposure to chlorine-containing bleach: a case report.
We describe the case of a 74-year-old female who presented with shortness of breath and hemoptysis following accidental exposure to chlorine-containing bleach. She had second- to third-degree chemical burns on both buttocks and thighs, and received mechanical ventilation because of the development of ARDS. Mechanical ventilation was discontinued on day 6 of hospitalization because of the rapid improvement of hypoxemia, and the patient was transferred to another hospital for further management of the chemical burns on day 18. PMID: 28203432 [PubMed - in process] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - February 18, 2017 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Recent developments in the role of reactive oxygen species in allergic asthma.
Authors: Qu J, Li Y, Zhong W, Gao P, Hu C Abstract Allergic asthma has a global prevalence, morbidity, and mortality. Many environmental factors, such as pollutants and allergens, are highly relevant to allergic asthma. The most important pathological symptom of allergic asthma is airway inflammation. Accordingly, the unique role of reactive oxygen species (ROS) had been identified as a main reason for this respiratory inflammation. Many studies have shown that inhalation of different allergens can promote ROS generation. Recent studies have demonstrated that several pro-inflammatory mediators are responsible for t...
Source: Journal of Thoracic Disease - February 18, 2017 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Current concepts in severe adult tracheobronchomalacia: evaluation and treatment.
Authors: Buitrago DH, Wilson JL, Parikh M, Majid A, Gangadharan SP Abstract There is increasing recognition of tracheobronchomalacia (TBM) in patients with respiratory complaints, though its true incidence in the adult population remains unknown. Most of these patients have an acquired form of severe diffuse TBM of unclear etiology. The mainstays of diagnosis are dynamic (inspiratory and expiratory) airway computed tomography (CT) scan and dynamic flexible bronchoscopy with forced expiratory maneuvers. While the prevailing definition of TBM is 50% reduction in cross-sectional area, a high proportion of healthy volu...
Source: Journal of Thoracic Disease - February 18, 2017 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Evolutional trends in the management of tracheal and bronchial injuries.
Authors: Madden BP Abstract Tracheal and Bronchial injuries are potentially life threatening complications which require urgent diagnosis and therapeutic intervention. They typically occur in association with blunt and penetrating chest trauma although they are increasingly being encountered in patients following endobronchial intervention and percutaneous tracheostomy insertion. Their precise incidence is unknown. Presenting features include dyspnoea, stridor, respiratory and haemodynamic compromise, haemoptysis, surgical emphysema, pneumothorax and persistent significant airleak. There may be other additional inj...
Source: Journal of Thoracic Disease - February 18, 2017 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Clinical factors associated with weaning failure in patients requiring prolonged mechanical ventilation.
CONCLUSIONS: Respiratory causes of ICU admission and a high SOFA score on day 21 of MV could be predictive of weaning failure in patients requiring PMV. PMID: 28203417 [PubMed - in process] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - February 18, 2017 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Better perioperative outcomes in thoracoscopic-esophagectomy with two-lung ventilation in semi-prone position.
CONCLUSION: This study demonstrated that TLV intubation approach is superior to OLV approach during the thoracoscopic-esophagectomy in semi-prone position. According to this, TLV approach is a technically feasible, convenient and safe anesthesia induction approach for esophageal cancer surgery. PMID: 28203413 [PubMed - in process] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - February 18, 2017 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Antispasmodic and bronchorelaxant activities of Salsola imbricata are mediated through dual Ca(+2) antagonistic and β-adrenergic agonistic effects.
CONCLUSION: The results suggest that the spasmolytic and bronchorelaxant activities of S. imbricata are related to Ca(+2) antagonistic and β-adrenergic agonistic effects, thus justifying some of the traditional uses of the plant. PMID: 28209080 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - February 18, 2017 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Molecular characterization and clinical epidemiology of human respiratory syncytial virus (HRSV) A and B in hospitalized children, Southern Brazil
This study reports genetic variability and clinical profiles of HRSV‐infected patients from Southern Brazil. Seventy positive samples, 78% type A and 22% type B, were analyzed. Of the patients (median age, 6 months; interquartile range, 2–11 years) 16% had co‐morbidities and 17% developed severe disease. The ON1 HRSV genotype first appeared in 2012, and patients infected with this genotype showed an increased tendency to develop severe disease. This article is protected by copyright. All rights reserved (Source: Journal of Medical Virology)
Source: Journal of Medical Virology - February 18, 2017 Category: Virology Authors: FB Moreira, CS Rosario, JS Santos, VM Avanzi, MB Nogueira, LR Vidal, SM Raboni Tags: Short Communication Source Type: research

Rutoside and Hydrolytic Enzymes Do Not Attenuate Marathon-Induced Inflammation
Conclusion: Supplementation with rutoside and hydrolytic enzymes before and after a marathon race did not attenuate postrace inflammation or decrease URI incidence in nonelite male marathon runners. (Source: Medicine and Science in Sports and Exercise)
Source: Medicine and Science in Sports and Exercise - February 18, 2017 Category: Sports Medicine Tags: Clinical Sciences Source Type: research

Assessment of the Usefulness of Multiplex Real-Time PCR Tests in the Diagnostic and Therapeutic Process of Pneumonia in Hospitalized Children: A Single-Center Experience.
Conclusions. Our analysis demonstrated that the participation of viruses in causing severe lung infections is significant in children with comorbidities. Multiplex real-time PCR tests proved to be more useful in establishing the etiology of pneumonia in hospitalized children than the traditional microbiological examinations. PMID: 28182108 [PubMed - indexed for MEDLINE] (Source: Biomed Res)
Source: Biomed Res - February 18, 2017 Category: Research Authors: Gowin E, Bartkowska-Śniatkowska A, Jończyk-Potoczna K, Wysocka-Leszczyńska J, Bobkowski W, Fichna P, Sobkowiak P, Mazur-Melewska K, Bręborowicz A, Wysocki J, Januszkiewicz-Lewandowska D Tags: Biomed Res Int Source Type: research

Pathological Findings and Prognosis in a Large Prospective Cohort of Chronic Hypersensitivity Pneumonitis.
CONCLUSIONS: Histopathologic patterns of c-NSIP and PI-PFG had a better transplant-free survival than UIP, f-NSIP and BF patterns. Presence of fibroblast foci or dense collagen fibrosis correlated with progression to death or lung transplantation. Identification of fibroblast foci on biopsies, regardless of the underlying histopathologic pattern, may be a clinically useful predictor of survival in HP patients. PMID: 28223152 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - February 18, 2017 Category: Respiratory Medicine Authors: Wang P, Jones KD, Urisman A, Elicker BM, Urbania T, Johannson KA, Assayag D, Lee J, Wolters PJ, Collard HR, Koth LL Tags: Chest Source Type: research

Evaluations of Implementation at Early-adopting Lung Cancer Screening Programs: Lessons Learned.
CONCLUSION: Lung cancer screening implementation is a complex undertaking requiring coordination at many levels. The insight gained from evaluation of these early-adopting programs may inform subsequent design and implementation of lung cancer screening programs. PMID: 28223153 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - February 18, 2017 Category: Respiratory Medicine Authors: Gesthalter YB, Koppelman E, Bolton R, Slatore CG, Yoon SH, Cain HC, Tanner NT, Au DH, Clark JA, Wiener RS Tags: Chest Source Type: research

Idiopathic and Systemic Sclerosis associated Pulmonary Arterial Hypertension: A Comparison of Demographic, Haemodynamic and Magnetic Resonance Imaging Characteristics and Outcomes.
CONCLUSION: The reasons for poorer outcomes in SSc-PAH are likely to be multifactorial including, but not limited to, older age and reduced gas transfer. PMID: 28223154 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - February 18, 2017 Category: Respiratory Medicine Authors: Ramjug S, Hussain N, Hurdman J, Billings C, Charampopoulos A, Elliot CA, Kiely DG, Sabroe I, Rajaram S, Swift AJ, Condliffe R Tags: Chest Source Type: research

Nanoconjugate-bound adenosine A1 receptor antagonist enhances recovery of breathing following acute cervical spinal cord injury.
The objective of the present study was to test the hypothesis that intradiaphragmatic administration of nanoconjugate-bound DPCPX, enhances recovery of ventilation following SCI in the unanesthetized rat. To that end, Sprague-Dawley rats underwent C2 spinal cord hemisection (C2Hx) on day 0 and received either: (i) 0.15μg/kg of nanoconjugate-bound DPCPX or (ii) vehicle control (50μl distilled water). To assess ventilation, unrestrained whole body plethysmography (WBP) was performed on day 0 (immediately before the surgery) and 3, 7, 14, 21 and 28days following the SCI. Frequency, tidal volume, and minute ventilation data ...
Source: Experimental Neurology - February 18, 2017 Category: Neurology Authors: Minic Z, Wilson S, Liu F, Sankari A, Mao G, Goshgarian H Tags: Exp Neurol Source Type: research

Antiprotozoal, antimycobacterial, and anti-inflammatory evaluation of Cnidoscolus chayamansa (Mc Vaugh) extract and the isolated compounds.
Abstract Cnidoscolus chayamansa is a medicinal and edible plant known as Chaya, is commonly used as an anti-inflammatory, antiprotozoal, antibacterial agent and as a remedy for respiratory illness, gastrointestinal disorders, and vaginal infections related with the inflammation process. In this paper, we describe the plant's phytochemical analysis and biological activities (antimycobacterial, antibacterial, antiprotozoal, and anti-inflammatory properties) of the CHCl3:MeOH (1:1) leaves extract and isolated compounds, as well as the acute and sub-acute toxic effects. Chemical identification of isolated compounds wa...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 18, 2017 Category: Drugs & Pharmacology Authors: Pérez-González MZ, Gutiérrez-Rebolledo GA, Yépez-Mulia L, Rojas-Tomé IS, Luna-Herrera J, Jiménez-Arellanes MA Tags: Biomed Pharmacother Source Type: research

The Burden of Respiratory Disease in Very-Low-Birth-Weight Infants: Changes in Perinatal Care and Outcomes in a Decade in Spain.
CONCLUSIONS: Enhanced adherence to international recommendations in perinatal care and a significant reduction in mortality were found during the second period. Survival without BPD increased only among the most immature. Further investigation is needed to optimize the strategies to prevent and manage respiratory disease in this group of patients. PMID: 28214832 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - February 18, 2017 Category: Perinatology & Neonatology Authors: García-Muñoz Rodrigo F, Losada Martínez A, Elorza Fernández MD, Moreno Hernando J, Figueras Aloy J, Vento Torres M Tags: Neonatology Source Type: research

Vitamin D administration during pregnancy as prevention for pregnancy, neonatal and postnatal complications.
Abstract Pregnancy represents a time of rapid bodily change, which includes physical proportions, physiology and responsibility. At this context, maternal vitamin D stores have been the objective of extensive scientific research during the last decades, focusing on their potential effects on maternal an neonatal health. A growing body of observational studies indicated that maternal hypovitaminosis D (as defined by maternal 25-hydroxyvitamin D [25(OH)D] levels <20 ng/ml or <50 nmol/l) is a significant risk factor for adverse neonatal outcomes including asthma, multiple sclerosis and other neurological disord...
Source: ENDOCR REV - February 18, 2017 Category: Endocrinology Authors: Wagner CL, Hollis BW, Kotsa K, Fakhoury H, Karras SN Tags: Rev Endocr Metab Disord Source Type: research

Missed Opportunities in Neonatal Deaths in Rwanda: Applying the Three Delays Model in a Cross-Sectional Analysis of Neonatal Death
Conclusion Delays for women in seeking obstetrical care is a critical factor associated with the main causes of neonatal death in Rwanda. Improving obstetrical care quality could reduce neonatal deaths due to asphyxia. Likewise, reducing all three delays could reduce neonatal deaths due to LRTI. (Source: Maternal and Child Health Journal)
Source: Maternal and Child Health Journal - February 18, 2017 Category: Health Management Source Type: research

No mediating effects of glycemic control and inflammation on the association between vitamin D and lung function in the general population
Vitamin D deficiency is discussed to be associated with lung health. While former studies focused on subjects suffering from pulmonary diseases, we aimed to investigate the association of 25-hydroxy vitamin D [25(OH)D] with lung function in the general population and examined whether mediating effects of inflammation, glycemic control or renal function exist. (Source: Respiratory Medicine)
Source: Respiratory Medicine - February 18, 2017 Category: Respiratory Medicine Authors: Anne Kaul, Sven Gl äser, Anke Hannemann, Beate Stubbe, Stefan B. Felix, Matthias Nauck, Ralf Ewert, Nele Friedrich Source Type: research

Structure-activity relationship for toxicity of α-pyrrolidinophenones in human aortic endothelial cells
In this study, we found that exposure of 20  μM α-pyrrolidinooctanophenone (α-POP), a new synthetic cathinone, time- and dose-dependently reduced viability of human aortic endothelial (HAE) cells, and the 50% lethal concentration (LC50) for α-POP in its 48-h treatment was 15.6 μM. In addition, the LC50 comparison of α-POP and α-pyrrolidinoheptanophenone (α-PHPP) toxicity against ten human cells exhibited that vascular (HAE and human aortic smooth muscle) and bronchial epithelial BEAS-2B cells were more susceptible to the cytotoxicity than neuronal (SK-N-SH and A172), gastrointestinal (DLD1 and MKN45), hepati c He...
Source: Forensic Toxicology - February 18, 2017 Category: Forensic Medicine Source Type: research

Microfilaruria by Dirofilaria immitis in a dog: a rare clinical pathological finding
AbstractA 6-year-old Labrador with history of hyperpnea, respiratory distress, ascites and paraparesis, presentedDirofilaria immitis microfilariae in the blood smear, cytology of the abdominal fluid and urine. The positive samples were confirmed by multiplex-PCR (COI gene) and sequencing, and presented 98% homology toD. immitis (GenBank accession nos. KC107805.1, EU159111.1, EU163945.1, DQ358815.1, and AJ537512-1). Based on the presented results and the physiopathology of the heartworm disease, molecular techniques may be helpful and accurate in the diagnosis of the disease in vertebrates, and microfilaruria, even uncommon...
Source: Journal of Parasitic Diseases - February 18, 2017 Category: Parasitology Source Type: research

Chitayat syndrome: hyperphalangism, characteristic facies, hallux valgus and bronchomalacia results from a recurrent c.266A>G p.(Tyr89Cys) variant in the ERF gene
Conclusions We report the molecular aetiology of Chitayat syndrome and discuss potential mechanisms for this distinctive phenotype associated with the p.Tyr89Cys substitution in ERF. (Source: Journal of Medical Genetics)
Source: Journal of Medical Genetics - February 18, 2017 Category: Genetics & Stem Cells Authors: Balasubramanian, M., Lord, H., Levesque, S., Guturu, H., Thuriot, F., Sillon, G., Wenger, A. M., Sureka, D. L., Lester, T., Johnson, D. S., Bowen, J., Calhoun, A. R., Viskochil, D. H., DDD Study, Bejerano, G., Bernstein, J. A., Chitayat, D. Tags: Calcium and bone Developmental defects Source Type: research

Do cystic fibrosis patients on azithromycin need electrocardiogram monitoring?
Publication date: Available online 17 February 2017 Source:Pulmonary Pharmacology &amp; Therapeutics Author(s): Rachel Sharpton, Mario Cazzola (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - February 18, 2017 Category: Respiratory Medicine Source Type: research

Is pulmonary diffusion capacity for nitric oxide (DL,NO) likely to become a routine pulmonary function test?
Publication date: Available online 17 February 2017 Source:Respiratory Physiology &amp; Neurobiology Author(s): Irene Steenbruggen, Frans de Jongh DL,CO measurements are often used to evaluate and monitor lung diseases as well as cardiovascular diseases. Whether the combination of DL,CO and DL,NO will improve the management of cardiovascular diseases needs to be investigated. It is hoped that the standardization of the DL,NO measurement will facilitate research. Scientific evidence that DL,NO can provide more accurate information than DL,CO alone, can take away the barriers that prevents DL,NO to become a routine test...
Source: Respiratory Physiology and Neurobiology - February 18, 2017 Category: Respiratory Medicine Source Type: research

Vitamin D administration during pregnancy as prevention for pregnancy, neonatal and postnatal complications
AbstractPregnancy represents a time of rapid bodily change, which includes physical proportions, physiology and responsibility. At this context, maternal vitamin D stores have been the objective of extensive scientific research during the last decades, focusing on their potential effects on maternal an neonatal health. A growing body of observational studies indicated that maternal hypovitaminosis D (as defined by maternal 25-hydroxyvitamin D [25(OH)D] levels<20 ng/ml or<50 nmol/l) is a significant risk factor for adverse neonatal outcomes including asthma, multiple sclerosis and other neurological disorders. On that...
Source: Reviews in Endocrine and Metabolic Disorders - February 18, 2017 Category: Endocrinology Source Type: research

Opioids and the immune system ‐ friend or foe
Abstract Systemically administered opioids are among the most powerful analgesics for treating severe pain. Several negative side‐effects (respiratory depression, addiction, nausea, confusion) and the risk of opioid‐induced hyperalgesia accompany opioid administration. One other side effect is the potential of opioids to suppress the immune response and thereby to increase the vulnerability for infections. Several studies have investigated the link between opioids and immunosuppression in vitro, in vivo as well as in patients with divergent results: Exogenous opioids such as morphine and fentanyl can impair macrophage ...
Source: British Journal of Pharmacology - February 18, 2017 Category: Drugs & Pharmacology Authors: Lisanne Mirja Plein, Heike L. Rittner Tags: REVIEW ARTICLE THEMED ISSUE Source Type: research

Association of rhinovirus with exacerbations in young children affected by cystic fibrosis: Preliminary data
This article is protected by copyright. All rights reserved (Source: Journal of Medical Virology)
Source: Journal of Medical Virology - February 18, 2017 Category: Virology Authors: Sacha Stelzer ‐Braid, Nancy Liu, Michael Doumit, Russell D'Cunha, Yvonne Belessis, Adam Jaffe, William D. Rawlinson Tags: Short Communication Source Type: research

Lab ‐in‐a‐tube: Real‐time molecular point‐of‐care diagnostics for influenza A and B using the cobas® Liat® system
ConclusionThe cobas® Liat® Influenza A/B assay is a useful tool for accurate, rapid, and sensitive detection of influenza A and B, offering timely and personalized patient management and infection control when implemented at the point‐of‐care. This article is protected by copyright. All rights reserved (Source: Journal of Medical Virology)
Source: Journal of Medical Virology - February 18, 2017 Category: Virology Authors: Willem JG Melchers, Judith Kuijpers, Joanna Sickler, Janette Rahamat ‐Langendoen Tags: Research Article Source Type: research

Analysis of significantly mutated genes as a clinical tool for the diagnosis in a case of lung cancer
Publication date: Available online 17 February 2017 Source:Respiratory Medicine Case Reports Author(s): Yoshihiro Miyashita, Yosuke Hirotsu, Toshiharu Tsutsui, Seishi Higashi, Yusuke Sogami, Yumiko Kakizaki, Taichiro Goto, Kenji Amemiya, Toshio Oyama, Masao Omata Bronchoendoscopic examination is not necessarily comfortable procedure and limited by its sensitivity, depending on the location and size of the tumor lesion. Patients with a non-diagnostic bronchoendoscopic examination often undergo further invasive examinations. Non-invasive diagnostic tool of lung cancer is desired. A 72-year-old man had a 3.0 cm × 2.5 cm...
Source: Respiratory Medicine Case Reports - February 18, 2017 Category: Respiratory Medicine Source Type: research

Electric Muscle Stimulation for Weaning from Mechanical Ventilation in Elder Patients with Severe Sepsis and Acute Respiratory Failure – A Pilot Study
Conclusion EMS did not help critical-ill septic elderly to reduce the duration of mechanical ventilation in our pilot study. Further larger study is warranted with adequate study power and identical weaning strategy to test the EMS benefits. (Source: International Journal of Gerontology)
Source: International Journal of Gerontology - February 18, 2017 Category: Geriatrics Source Type: research

Surgical Treatment Results of Burn-Related Oesophageal Strictures
ConclusionsThe use of colonic and gastric conduit is an effective and safe method for restoring the continuity of the gastrointestinal tract, with an acceptable rate of post-operative complications. Patients who undergo oesophageal resection for post-burn stricture require post-operative systematic endoscopic control. (Source: World Journal of Surgery)
Source: World Journal of Surgery - February 17, 2017 Category: Surgery Source Type: research

The Role of Epithelial-Mesenchymal Transition in Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a major cause of mortality worldwide, and there is currently no treatment that can halt the progression of the disease. Over the last decade there has been increasing interest in the idea that epithelial-mesenchymal transition (EMT) may be active in COPD. Here we review the evidence for EMT in COPD as well as the current progress being made on understanding the drivers and mechanisms involved. Finally, we discuss the potential benefits that understanding EMT may bring to the field of chronic respiratory disease.Cells Tissues Organs 2017;203:99-104 (Source: Cells Tissues Organs)
Source: Cells Tissues Organs - February 17, 2017 Category: Cytology Source Type: research

The Burden of Respiratory Disease in Very-Low-Birth-Weight Infants: Changes in Perinatal Care and Outcomes in a Decade in Spain
Background: Advances in perinatal care have led to a significant reduction in morbidity and mortality among very-low-birth-weight (VLBW) infants. Much of this progress is related to the prevention and management of respiratory disease.Objectives: To evaluate changes in perinatal care and its influence on respiratory morbidity and mortality among VLBW infants in Spain in 2 consecutive periods (2002-2006 and 2007-2011).Methods: This is a retrospective analysis of data prospectively collected of all VLBW infants included in the Spanish SEN1500 network. Patients with major congenital anomalies, those who died in the delivery r...
Source: Neonatology - February 17, 2017 Category: Perinatology & Neonatology Source Type: research

Editorial Board EOV.
Authors: PMID: 28199141 [PubMed - in process] (Source: Journal of Asthma)
Source: Journal of Asthma - February 17, 2017 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Targeted therapy for chronic respiratory disease: a new paradigm.
Authors: Gibson PG, Peters MJ, Wainwright CE Abstract Targeted therapy has emerged as a highly effective treatment approach for chronic respiratory diseases. Many of these conditions have dismal outcomes; however, targeted therapy shows great results for the subgroup who respond. This represents a new way to approach these conditions and offers great promise as a future treatment direction. In severe eosinophilic asthma, therapy that targets the interleukin-5 pathway with monoclonal antibodies leads to a 50% reduction in asthma exacerbations in previously refractory disease. In cystic fibrosis, lung function improv...
Source: Medical Journal of Australia - February 17, 2017 Category: Journals (General) Tags: Med J Aust Source Type: research

Azithromycin for Acute Exacerbations of Asthma: The AZALEA Randomized Clinical Trial
Asthma exacerbations are a common presentation in the emergency department. Often times, these exacerbations can be attributed to respiratory infections, both viral and bacterial in etiology. It is known that people with asthma are susceptible to developing more severe bacterial and viral infections because of an impairment in asthmatics' innate immune responses. Macrolide antibiotics such as azithromycin have been shown to provide anti-inflammatory, anti-microbial as well as anti-viral properties. (Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - February 17, 2017 Category: Emergency Medicine Authors: Alexa Camarena-Michel Tags: Abstract Source Type: research

The Predictive Value of Plasma Galectin-3 for Ards Severity and Clinical Outcome
Background: Galectin-3 is a β-galactoside-binding lectin implicated as a mediator in a variety of inflammatory and fibrotic diseases. However, information about galectin-3 release in patients with acute respiratory distress syndrome (ARDS) is very limited. We sought to determine whether plasma galectin-3 levels were increased in ARDS patients and were associated with disease severity. Methods: Patients admitted to intensive care unit (ICU) within 48 h and diagnosed with ARDS were identified. In addition, healthy subjects were assigned to a control group. Plasma samples were collected from patients within 48 h after I...
Source: Shock - February 17, 2017 Category: Emergency Medicine Tags: Clinical Aspects Source Type: research

Practice Guidelines for the Prevention, Detection, and Management of Respiratory Depression Associated With Neuraxialn Opioid Administration: An Updated Report by the American Society of Anesthesiologists Task Force on Neuraxial Opioids and the American Society of Regional Anesthesia and Pain Medicine
(Anesthesiology. 2016;124:535–552) Practice guidelines are systematically developed recommendations that enable the practitioner and the patient to make informed health care decisions. They may be adopted, modified, or rejected based on clinical needs and constraints, and are subject to revision as necessitated by the advancement of medical knowledge, technology, and practice. This review is an update of the American Society of Anesthesiologists guidelines for the prevention, detection, and management of respiratory depression associated with neuraxial opioid administration. The purpose of these updated guidelines was t...
Source: Obstetric Anesthesia Digest - February 17, 2017 Category: Anesthesiology Tags: Editorials and Reviews Source Type: research