This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 5.
The impact of bitter taste receptor genetics on culturable bacteria in chronic rhinosinusitis.
CONCLUSION: Even in a small sample of patients with CRS, non-taster T2R38 genotype appears to predict the presence of culturable bacteria colonising the sinus cavity at the time of surgery for their condition. A genetic link to patients more likely to become infected is likely. PMID: 28214914 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - February 21, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research
Intratidal Overdistention and Derecruitment in the Injured Lung: A Simulation Study
Conclusion: Intratidal variations in lung mechanics may allow for optimization of ventila- or settings in patients with ARDS, by balancing lung recruitment against parenchymal overdistention. Significance: Titration of airway pressures based on variations in intratidal mechanics may mitigate processes associated with injurious ventilation. (Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - February 21, 2017 Category: Biomedical Engineering Source Type: research
Single Radial Haemolysis Compared to Hemagglutinin Inhibition and Microneutralization as a Correlate of Protection against Influenza A H3N2 in Children and Adolescents
ConclusionsSRH had the worst correlation with protection against seasonal H3N2 in children and adolescents compared to MN and HAI. SRH, HAI and MN titres were significantly correlated with each other. SRH was less sensitive than MN but more sensitive than HAI.This article is protected by copyright. All rights reserved. (Source: Influenza and Other Respiratory Viruses)
Source: Influenza and Other Respiratory Viruses - February 21, 2017 Category: Virology Authors: Biao Wang, Margaret L. Russell, Angela Brewer, Jennifer Newton, Pardeep Singh, Brian J. Ward, Mark Loeb Tags: Original Article Source Type: research
Mechanistic insights into the catalytic reaction of ferulic acid decarboxylase from Aspergillus niger: a QM/MM study
Phys. Chem. Chem. Phys., 2017, Accepted Manuscript DOI: 10.1039/C6CP08811B, PaperGe Tain, Yongjun Liu Ubiquinone plays a pivotal role in the aerobic cellular respiratory electron transport chain, whereas ferulic acid decarboxylase (FDC) is involved in the biosynthesis of ubiquinone precursor. Recently, a complete crystal... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Phys. Chem. Chem. Phys. latest articles)
Source: RSC - Phys. Chem. Chem. Phys. latest articles - February 21, 2017 Category: Chemistry Authors: Ge Tain Source Type: research
Gastro-intestinal manifestations in cystic fibrosis patients.
Authors: Van Biervliet S, de Clercq C, Declercq D, Van Braeckel E, Van Daele S, De Baets F, De Looze D Abstract Cystic fibrosis (CF) is a life-limiting disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR). This defective chloride channel, present in different organ systems such as respiratory system, gastrointestinal tract, reproductive system and sweat glands, disturbs the ion and water transport over the membranes leading to the well known CF symptoms. CF has outgrown paediatric care, as half of CF patients are currently adults. The CF gastrointestinal tract has its own p...
Source: Acta Gastro-Enterologica Belgica - February 21, 2017 Category: Gastroenterology Tags: Acta Gastroenterol Belg Source Type: research
Comparative mitogenomics indicates respiratory competence in parasitic Viscum despite loss of complex I and extreme sequence divergence, and reveals horizontal gene transfer and remarkable variation in genome size
Aerobically respiring eukaryotes usually contain four respiratory-chain complexes (complexes I-IV) and an ATP synthase (complex V). In several lineages of aerobic microbial eukaryotes, complex I has been lost,... (Source: BMC Plant Biology)
Source: BMC Plant Biology - February 21, 2017 Category: Biology Authors: Elizabeth Skippington, Todd J. Barkman, Danny W. Rice and Jeffrey D. Palmer Source Type: research
Birt –Hogg–Dubé syndrome: a literature review and case study of a Chinese woman presenting a novel FLCN mutation
The Birt –Hogg–Dubé (BHD) syndrome is a very rare autosomal dominant form of genodermatosis caused by germline mutations in the folliculin (FLCN) gene, which is mapped to the p11.2 region in chromosome 17. BHD com... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - February 21, 2017 Category: Respiratory Medicine Authors: Shengyu Hao, Fei Long, Fenglan Sun, Teng Liu, Daowei Li and Shujuan Jiang Source Type: research
Suspicion of respiratory tract infection with multidrug-resistant Enterobacteriaceae: epidemiology and risk factors from a Paediatric Intensive Care Unit
Multidrug-resistant (MDR) infections are a serious concern for children admitted to the Paediatric Intensive Care Unit (PICU). Tracheal colonization with MDR Enterobacteriaceae predisposes to respiratory infec... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - February 21, 2017 Category: Infectious Diseases Authors: Hanna Renk, Lenja Stoll, Felix Neunhoeffer, Florian H ölzl, Matthias Kumpf, Michael Hofbeck and Dominik Hartl Source Type: research
Dibutyryl-cAMP attenuates pulmonary fibrosis by blocking myofibroblast differentiation via PKA/CREB/CBP signaling in rats with silicosis
Myofibroblasts play a major role in the synthesis of extracellular matrix (ECM) and the stimulation of these cells is thought to play an important role in the development of silicosis. The present study was un... (Source: Respiratory Research)
Source: Respiratory Research - February 21, 2017 Category: Respiratory Medicine Authors: Yan Liu, Hong Xu, Yucong Geng, Dingjie Xu, Lijuan Zhang, Yi Yang, Zhongqiu Wei, Bonan Zhang, Shifeng Li, Xuemin Gao, Ruimin Wang, Xianghong Zhang, Darrell Brann and Fang Yang Source Type: research
Complexity Analysis of Respiratory Dynamics.
PMID: 28222267 [PubMed - as supplied by publisher] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - February 21, 2017 Category: Intensive Care Authors: Raoufy MR, Ghafari T, Mani AR Tags: Am J Respir Crit Care Med Source Type: research
Reply to Complexity Analysis of Respiratory Dynamics.
PMID: 28222268 [PubMed - as supplied by publisher] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - February 21, 2017 Category: Intensive Care Authors: Thamrin C, Frey U, Kaminsky DA, Reddel HK, Seely AJ, Suki B, Sterk PJ Tags: Am J Respir Crit Care Med Source Type: research
Bordetella PlrSR regulatory system controls BvgAS activity and virulence in the lower respiratory tract [Microbiology]
Bacterial pathogens coordinate virulence using two-component regulatory systems (TCS). The Bordetella virulence gene (BvgAS) phosphorelay-type TCS controls expression of all known protein virulence factor-encoding genes and is considered the “master virulence regulator” in Bordetella pertussis, the causal agent of pertussis, and related organisms, including the broad host range pathogen Bordetella... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 21, 2017 Category: Science Authors: M. Ashley Bone, Aaron J. Wilk, Andrew I. Perault, Sara A. Marlatt, Erich V. Scheller, Rebecca Anthouard, Qing Chen, Scott Stibitz, Peggy A. Cotter, Steven M. Julio Tags: PNAS Plus Source Type: research
Counterpoint: Too little care or too little collaboration: Approaches to treatment refusal in CF
The CF treatment paradigm focuses on aggressive intervention and management of multi-system CF manifestations with the goal of decreasing the frequency of pulmonary exacerbations, improving nutritional status, and reducing the rate of disease progression. As a result, CF treatment complexity and burden is high during childhood and continues to increase over the life-span; adults with CF are often burdened with over 2h of recommended daily therapies as standard of care [1,2]. It is no surprise, therefore, that adherence to chronic therapies poses an enormous challenge to individuals with CF, their caregivers, and their heal...
Source: Journal of Cystic Fibrosis - February 21, 2017 Category: Respiratory Medicine Authors: Gregory S. Sawicki, Kristin A. Riekert Source Type: research
Life Expectancy and Cause-Specific Mortality in Type 2 Diabetes: A Population-Based Cohort Study Quantifying Relationships in Ethnic Subgroups
CONCLUSIONS Type 2 diabetes was associated with more years of life lost among whites than among South Asians or blacks, with older South Asians experiencing longer life expectancy compared with South Asians without diabetes. The findings support optimized cardiovascular disease risk factor management, especially in whites with type 2 diabetes. (Source: Diabetes Care)
Source: Diabetes Care - February 21, 2017 Category: Endocrinology Authors: Wright, A. K.; Kontopantelis, E.; Emsley, R.; Buchan, I.; Sattar, N.; Rutter, M. K.; Ashcroft, D. M. Tags: Epidemiology/Health Services Research Source Type: research
Development of TaqMan RT-qPCR for the detection of type a human respiratory syncytial virus
In this study RT-qPCR using TaqMan hydrolysis probe based on the F gene detection was developed to identify and quantify hRSV in clinical samples. The assay was validated by comparing the results with a commercially available RT-qPCR kit. The newly developed assay was sensitive in detecting hRSV positive samples (59/126) which were equivalent to those detected by the commercial kit (57/126) with a detection limit of 1 × 102 copies/mL. A high correlation was found between the results of the newly developed assay and the commercial one. It was concluded that the newly developed RT-qPCR assay can be used as a sensitive det...
Source: Molecular and Cellular Probes - February 21, 2017 Category: Molecular Biology Source Type: research
Micro-NMR elucidates altered metabolites in the Parkinson ’s disease-related catp-6 genotype of Caenorhabditis elegans
ConclusionsIf the effect of thecatp-6 mutation inC. elegans at the level of metabolites is correlated to the metabolic dysfunction in the humanPARK9 ortholog, then it may be possible to uncover the molecular mechanism behind Parkinsonism and theKufor-Rakeb syndrome. (Source: Metabolomics)
Source: Metabolomics - February 21, 2017 Category: Biology Source Type: research
Searching for the low affinity ubiquinone binding site in cytochrome bo3 from Escherichia coli
Publication date: Available online 21 February 2017 Source:Biochimica et Biophysica Acta (BBA) - Bioenergetics Author(s): Sylvia K. Choi, Myat T. Lin, Hanlin Ouyang, Robert B. Gennis The cytochrome bo3 ubiquinol oxidase is one of three respiratory oxygen reductases in the aerobic respiratory chain of Escherichia coli. The generally accepted model of catalysis assumes that cyt bo3 contains two distinct ubiquinol binding sites: (i) a low affinity (QL) site which is the traditional substrate binding site; and (ii) a high affinity (QH) site where a “permanently” bound quinone acts as a cofactor, taking two electrons from ...
Source: Biochimica et Biophysica Acta (BBA) Bioenergetics - February 21, 2017 Category: Biochemistry Source Type: research
ANLN truncation causes a familial fatal acute respiratory distress syndrome in Dalmatian dogs
by Saila Holopainen, Marjo K. Hyt önen, Pernilla Syrjä, Meharji Arumilli, Anna-Kaisa Järvinen, Minna Rajamäki, Hannes Lohi Acute respiratory distress syndrome (ARDS) is the leading cause of death in critical care medicine. The syndrome is typified by an exaggerated inflammatory response within the lungs. ARDS has been reported in many species, including dogs. We have previously reported a fatal familial juvenile respi ratory disease accompanied by occasional unilateral renal aplasia and hydrocephalus, in Dalmatian dogs. The condition with a suggested recessive mode of inheritance resembles acute exacerbation of usual ...
Source: PLoS Genetics - February 21, 2017 Category: Genetics & Stem Cells Authors: Saila Holopainen Source Type: research
The near-infrared spectroscopy-derived deoxygenated haemoglobin breaking-point is a repeatable measure that demarcates exercise intensity domains
Conclusions The [HHb]BP is a repeatable measure that consistently occurs towards the end of a RI test. The association between the [HHb]BP and the RCP reinforces the idea that these parameters may share similar mechanistic basis. (Source: Journal of Science and Medicine in Sport)
Source: Journal of Science and Medicine in Sport - February 21, 2017 Category: Sports Medicine Source Type: research
Decrease in Small Pulmonary Vessels on Chest Computed Tomography in Light Smokers Without COPD: An Early Change, but Correlated with Smoking Index
ConclusionsThe percentage of total CSA of the lung made up of small pulmonary vessels in light smokers without COPD significantly decreases with increasing amount of smoking, in contrast to emphysema measurements. This suggests that small pulmonary vessels might have been injured or might have degenerated because of smoking, and might represent an initial stage in the development of COPD. (Source: Lung)
Source: Lung - February 21, 2017 Category: Respiratory Medicine Source Type: research
High ‐sensitivity cardiac troponin T predicts mortality after hospitalization for community‐acquired pneumonia
ConclusionElevated cTnT level on admission is a strong predictor of short‐ and long‐term mortalities in patients hospitalized with CAP. (Source: Respirology)
Source: Respirology - February 21, 2017 Category: Respiratory Medicine Authors: Stefan M.T. Vestjens, Simone M.C. Spoorenberg, Ger T. Rijkers, Jan C. Grutters, Jurri ën M. Ten Berg, Peter G. Noordzij, Ewoudt M.W. Van de Garde, Willem Jan W. Bos, Tags: Original Article Source Type: research
The impact of anaemia and iron deficiency in chronic obstructive pulmonary disease: A clinical overview
Conclusions Anaemia and iron deficiency continue to be undervalued in most COPD clinical settings, despite affecting up to one-third of patients and having negative impact on prognosis. Special efforts should be made to improve clinical management of anaemia and iron deficiency in COPD patients as a means of achieving better patient care. (Source: Revista Portuguesa de Pneumologia)
Source: Revista Portuguesa de Pneumologia - February 21, 2017 Category: Respiratory Medicine Source Type: research
Respiratory responses to progesterone and allopregnanolone following chronic caffeine treatment in newborn female rats
Publication date: Available online 20 February 2017 Source:Respiratory Physiology & Neurobiology Author(s): NagaPraveena Uppari, Vincent Joseph, Aida Bairam We recently showed that in 12-day-old male rats exposed to caffeine for 10 consecutive days, progesterone inhibits the respiratory response to hypoxia and increases apnea frequency (Uppari et al., 2016 J Physiol, 594(2), 373-389). This was partly due to a higher inhibitory response of GABAa receptor to allopregnanolone, the neuroactive metabolite of progesterone. In the present study, we addressed whether similar effects occur in females. We used newborn femal...
Source: Respiratory Physiology and Neurobiology - February 21, 2017 Category: Respiratory Medicine Source Type: research
Expiratory Flow Limitation and Operating Lung Volumes during Exercise in Older and Younger Adults
Publication date: Available online 20 February 2017 Source:Respiratory Physiology & Neurobiology Author(s): Joshua R. Smith, Stephanie P. Kurti, Kayla Meskimen, Craig A. Harms We determined the effect of aging on expiratory flow limitation (EFL) and operating lung volumes when matched for lung size. We hypothesized that older adults will exhibit greater EFL and increases in EELV during exercise compared to younger controls. Ten older (5M/5W;>60years old) and nineteen height-matched young adults (10M/9W) were recruited. Young adults were matched for %predicted forced vital capacity (FVC) (Y-matched %Pred FVC...
Source: Respiratory Physiology and Neurobiology - February 21, 2017 Category: Respiratory Medicine Source Type: research
Cerebral and lung effects of a new generation synthetic surfactant with SP ‐B and SP‐C analogs in preterm lambs
CONCLUSIONIntratracheal administration of a bolus of CHF5633 improves pulmonary status in preterm lambs with severe RDS, obtaining better lung and brain injury scores than controls and favorable cerebral hemodynamics, comparable to those with gold standard Curosurf treatment. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - February 21, 2017 Category: Respiratory Medicine Authors: Carmen Rey ‐Santano, Victoria E. Mielgo, Xabier Murgia, Miguel Angel Gomez‐Solaetxe, Fabrizio Salomone, Federico Bianco, Nicola Pelizzi, Begoña Loureiro, Jon López de Heredia y Goya Tags: ORIGINAL ARTICLE: NEONATAL LUNG DISEASE Source Type: research
Esogastric pressure measurement to assist noninvasive ventilation indication and settings in infants with hypercapnic respiratory failure: A pilot study
CONCLUSIONSPES and PGAS measurements may be useful for the indication and optimal setting of NIV in a selected group of infants with hypercapnic respiratory failure. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - February 21, 2017 Category: Respiratory Medicine Authors: Guillaume Mortamet, Sonia Khirani, Alessandro Amaddeo, Guillaume Emeriaud, Sylvain Renolleau, Brigitte Fauroux Tags: ORIGINAL ARTICLE: PULMONARY PHYSIOLOGY Source Type: research
Complications of acromegaly: cardiovascular, respiratory and metabolic comorbidities
AbstractAcromegaly is associated with an enhanced mortality, with cardiovascular and respiratory complications representing not only the most frequent comorbidities but also two of the main causes of deaths, whereas a minor role is played by metabolic complications, and particularly diabetes mellitus. The most prevalent cardiovascular complications of acromegaly include a cardiomyopathy, characterized by cardiac hypertrophy and diastolic and systolic dysfunction together with arterial hypertension, cardiac rhythm disorders and valve diseases, as well as vascular endothelial dysfunction. Biochemical control of acromeg...
Source: Pituitary - February 21, 2017 Category: Endocrinology Source Type: research
Respiratory Muscles and Chemoreflex Sensitivity in Heart Failure: A Breath of Fresh Air
Publication date: Available online 20 February 2017 Source:Canadian Journal of Cardiology Author(s): Richard Severin, Shane A. Phillips (Source: Canadian Journal of Cardiology)
Source: Canadian Journal of Cardiology - February 21, 2017 Category: Cardiology Source Type: research
Cover Image, Volume 114, Number 4, April 2017
Cover Legend The cover image, by Dong‐Feng Liu et al., is based on the Article Anaerobic reduction of 2,6‐dinitrotoluene by Shewanella oneidensis MR‐1: Roles of Mtr respiratory pathway and NfnB, DOI: 10.1002/bit.26212. (Source: Biotechnology and Bioengineering)
Source: Biotechnology and Bioengineering - February 21, 2017 Category: Biomedical Science Authors: Dong ‐Feng Liu, Di Min, Lei Cheng, Feng Zhang, Dao‐Bo Li, Xiang Xiao, Guo‐Ping Sheng, Han‐Qing Yu Tags: Cover Source Type: research
One-day nasogastric tube decompression after distal gastrectomy: a prospective randomized study
ConclusionConsidering the physical discomfort caused by the NGT, we believe that routine 1-day NGT decompression is unnecessary after distal gastrectomy. (Source: Surgery Today)
Source: Surgery Today - February 21, 2017 Category: Surgery Source Type: research
Methacholine challenge tests to demonstrate therapeutic equivalence of terbutaline sulfate via different Turbuhaler ® devices in patients with mild to moderate asthma: Appraisal of a four-way crossover design
Conclusions Bronchoprotection using a standardised methacholine challenge model proved to be an effective design to elucidate therapeutic equivalence between devices in patients with mild-to-moderate asthma. The findings indicate that patients may switch from one type of Turbuhaler® to the other without adjustment of therapy. Moreover, they show the robustness and utility of this study design and its suitability for investigating therapeutic equivalence. EudraCT Number 2014-001457-16. Clinicaltrials.gov identifier NCT02322788. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - February 21, 2017 Category: Respiratory Medicine Source Type: research
Ethnicity impacts the cystic fibrosis diagnosis: A note of caution
The diagnosis of Cystic Fibrosis (CF) is by consensus based on the same parameters in all patients, yet the influence of ethnicity has only scarcely been studied. We aimed at elucidating the impact of Asian descent on the diagnosis of CF. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - February 21, 2017 Category: Respiratory Medicine Authors: Barbara Bosch, Diana Bilton, Patrick Sosnay, Karen S. Raraigh, Denise Y.F. Mak, Hiroshi Ishiguro, Vincent Gulmans, Muriel Thomas, Harry Cuppens, Margarida Amaral, Kris De Boeck Tags: Short Communication Source Type: research
A letter of thanks to the founding editors of Sleep and Breathing
(Source: Sleep and Breathing)
Source: Sleep and Breathing - February 21, 2017 Category: Respiratory Medicine Source Type: research
Cytomegalovirus pneumonitis complicated by a central peribronchial pattern of organising pneumonia
We present five cases of cytomegalovirus (CMV) pneumonitis occurring in patients after recent T cell deplete allogeneic stem cell transplantation (AlloHSCT). These cases were complicated by an organising pneumonia (during the recovery period) with a predominantly central peribronchial pattern. All patients presented with evidence of active CMV pneumonitis which was treated successfully with anti-viral therapy but was followed by persistent severe dyspnoea, cough and hypoxia. High resolution computed tomography (HRCT) imaging showed widespread central peribronchial consolidation with traction bronchiectasis. There was a mar...
Source: Respiratory Medicine Case Reports - February 21, 2017 Category: Respiratory Medicine Source Type: research
Pulmonary outcomes following specialized respiratory management for acute cervical spinal cord injury: a retrospective analysis
L McKenna (Source: Spinal Cord)
Source: Spinal Cord - February 21, 2017 Category: Research Authors: E C Zakrasek J L Nielson J J Kosarchuk J D Crew A R Ferguson S L McKenna Source Type: research
Maternal Chorioamnionitis and Postneonatal Respiratory Tract Infection in Ex-Preterm Infants
To assess whether exposure to histologically confirmed chorioamnionitis (ie, histologic chorioamnionitis [HCA]) is associated with altered risk of infection-related hospitalization (IRH) during the first 24 months of life in very preterm infants. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 21, 2017 Category: Pediatrics Authors: David P. Burgner, Dorota Doherty, James Humphreys, Andrew Currie, Karen Simmer, Adrian Charles, Tobias Strunk Tags: Original Articles Source Type: research
Estimating Energy Expenditure in Critically Ill Children: Still Shooting in the Dark?
Nutrient use in humans requires a cellular process of combustion that consumes oxygen and produces heat that is required for life. Carbon dioxide is also produced as a waste product of this process and is carried to the respiratory system, where it is eliminated. Thus, energy metabolism can be determined directly by measuring heat production (direct calorimetry), although this is not practical for clinical application. In the early twentieth century, an indirect method of measurement was introduced where gases associated with substrate combustion were measured and energy expenditure was derived from back calculation. (Sour...
Source: The Journal of Pediatrics - February 21, 2017 Category: Pediatrics Authors: Craig D. Smallwood, Nilesh M. Mehta Tags: Editorials Source Type: research
Current Care and Investigational Therapies in Achondroplasia
AbstractPurpose of ReviewThe goal of this review is to evaluate the management options for achondroplasia, the most common non-lethal skeletal dysplasia. This disease is characterized by short stature and a variety of complications, some of which can be quite severe.Recent FindingsDespite several attempts to standardize care, there is still no widely accepted consensus. This is in part due to absence of concrete data on the incidence of sudden unexplained death in infants with achondroplasia and the best investigation for ascertaining which individuals could benefit from foramen magnum decompression surgery.SummaryIn this ...
Source: Current Osteoporosis Reports - February 21, 2017 Category: Orthopaedics Source Type: research
Erratum to: Using respiratory sinus arrhythmia to detect obstructive sleep apnea
(Source: Health and Technology)
Source: Health and Technology - February 21, 2017 Category: Information Technology Source Type: research
Clinical Mimics: An Emergency Medicine –Focused Review of Asthma Mimics
Asthma is a common diagnosis or preexisting condition, and many patients with acute asthma exacerbation may present to the emergency department with wheezing and respiratory distress. However, many conditions may mimic this presentation. (Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - February 21, 2017 Category: Emergency Medicine Authors: Kristen Kann, Brit Long, Alex Koyfman Tags: Clinical Reviews Source Type: research
Clinical value of the new International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification of lung adenocarcinoma
ConclusionPatients with exon 19 mutations obtained greater benefits from targeted therapy. In the new classification, EGFR mutation rates are higher in lepidic cases and in cases without the solid subtype. The micropapillary subtype of adenocarcinoma has the worst prognosis, while the lepidic subtype has the best. (Source: Thoracic Cancer)
Source: Thoracic Cancer - February 21, 2017 Category: Cancer & Oncology Authors: Ziwei Guo, Fumei Yi, Wencheng Yin, Yu Zhang, Qian Li, Yangchun Gu, Yu Xiao, Baoshan Cao, Liwen Ma, Li Liang Tags: ORIGINAL ARTICLE Source Type: research
Effector mechanisms of humoral immunity to porcine reproductive and respiratory syndrome virus
Publication date: Available online 20 February 2017 Source:Veterinary Immunology and Immunopathology Author(s): Michael C. Rahe, Michael P. Murtaugh Porcine reproductive and respiratory syndrome virus (PRRSV) continues to afflict swine nearly 30 years after it was first discovered as the causative agent of “mystery swine disease”. Immunological tools of vaccination and exposure to virulent viruses have not succeeded in achieving control and prevention of PRRSV. Humoral immunity, mediated by antibodies, is a hallmark of anti-viral immunity, but little is known about the effector mechanisms of humoral immunity against P...
Source: Veterinary Immunology and Immunopathology - February 21, 2017 Category: Veterinary Research Source Type: research
Electricity generation by Pyrococcus furiosus in microbial fuel cells operated at 90 °C
This article is protected by copyright. All rights reserved (Source: Biotechnology and Bioengineering)
Source: Biotechnology and Bioengineering - February 20, 2017 Category: Biomedical Science Authors: Narendran Sekar, Chang ‐Hao Wu, Michael W. W. Adams, Ramaraja P. Ramasamy Tags: Article Source Type: research
Radiopathological Features and Identification of Mycobacterial Infections in Granulomatous Nodules Resected from the Lung
Conclusion: The most frequent cause of granulomatous lesions was mycobacterial infection. It seemed that the culture result was associated with nodule size and that the results ofIS6110 were associated with18F-FDG-uptake.Respiration (Source: Respiration)
Source: Respiration - February 20, 2017 Category: Respiratory Medicine Source Type: research
[Adult immunisation: General points, hot topics and perspectives].
Authors: Loubet P, Launay O Abstract Vaccination in immunocompetent adult mainly concerns booster vaccination against diphtheria, tetanus, polio and pertussis. Some chronic diseases may also require the achievement of pneumococcal and influenza vaccines. In addition, from the age of 65, annual influenza vaccination as well as one dose of a live attenuated shingles vaccine between 64 and 75 years are recommended. Immunocompromised adults, due to the increased risk of serious infections responsible of significant morbidity and mortality, are particularly concerned by vaccination. Main issues in this population are th...
Source: Revue de Medecine Interne - February 20, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research
[Contribution of the Xpert MTB/RIF to the etiological diagnosis of tuberculous pleurisy].
CONCLUSION: Gene amplification by Xpert MTB/RIF of the pleural liquid is much less effective in establishing the diagnosis of tuberculous pleurisy than pleural biopsy, which remains the gold standard. PMID: 28214065 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - February 20, 2017 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
The influencing factors on procalcitonin values in newborns with noninfectious conditions during the first week of life.
CONCLUSION: In newborns without bacterial infection, increased PCT level was significantly associated with lower gestational age and respiratory difficulty during the first week of life. Further studies are needed for clinical applications. PMID: 28203255 [PubMed - in process] (Source: Korean Journal of Pediatrics)
Source: Korean Journal of Pediatrics - February 20, 2017 Category: Pediatrics Tags: Korean J Pediatr Source Type: research
Characteristics and longitudinal progression of chronic obstructive pulmonary disease in GOLD B patients
The characteristics and natural history of GOLD B COPD patients are not well described. The clinical characteristics and natural history of GOLD B patients over 1 year in a multicentre cohort of COPD patients ... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - February 20, 2017 Category: Respiratory Medicine Authors: Philip J. Lawrence, Umme Kolsum, Vandana Gupta, Gavin Donaldson, Richa Singh, Bethan Barker, Leena George, Adam Webb, Anthony J. Brookes, Christopher Brightling, Jadwiga Wedzicha and Dave Singh Source Type: research
Clarithromycin attenuates IL-13 –induced periostin production in human lung fibroblasts
Periostin is a biomarker indicating the presence of type 2 inflammation and submucosal fibrosis; serum periostin levels have been associated with asthma severity. Macrolides have immunomodulatory effects and a... (Source: Respiratory Research)
Source: Respiratory Research - February 20, 2017 Category: Respiratory Medicine Authors: Kosaku Komiya, Shoichiro Ohta, Kazuhiko Arima, Masahiro Ogawa, Shoichi Suzuki, Yasutaka Mitamura, Satoshi Nunomura, Yasuhiro Nanri, Tomohito Yoshihara, Atsushi Kawaguchi, Jun-ichi Kadota, Bruce K. Rubin and Kenji Izuhara Source Type: research