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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 3.

Cluster analysis of sputum cytokine-high profiles reveals diversity in T(h)2-high asthma patients
Asthma is characterized by a heterogeneous inflammatory profile and can be subdivided into T(h)2-high and T(h)2-low airway inflammation. Profiling of a broader panel of airway cytokines in large unselected pat... (Source: Respiratory Research)
Source: Respiratory Research - February 23, 2017 Category: Respiratory Medicine Authors: Sven F. Seys, Hans Scheers, Paul Van den Brande, Gudrun Marijsse, Ellen Dilissen, Annelies Van Den Bergh, Pieter C. Goeminne, Peter W Hellings, Jan L. Ceuppens, Lieven J Dupont and Dominique M. A. Bullens Source Type: research

CDKL5 deficiency entails sleep apneas in mice.
Abstract A recently discovered neurodevelopmental disorder caused by the mutation of the cyclin-dependent kinase-like 5 gene (CDKL5) entails complex autistic-like behaviours similar to Rett syndrome, but its impact upon physiological functions remains largely unexplored. Sleep-disordered breathing is common and potentially life-threatening in patients with Rett syndrome; however, evidence is limited in children with CDKL5 disorder, and is lacking altogether in adults. The aim of this study was to test whether the breathing pattern during sleep differs between adult Cdkl5 knockout (Cdkl5-KO) and wild-type (WT) mice...
Source: Journal of Sleep Research - February 23, 2017 Category: Sleep Medicine Authors: Lo Martire V, Alvente S, Bastianini S, Berteotti C, Silvani A, Valli A, Viggiano R, Ciani E, Zoccoli G Tags: J Sleep Res Source Type: research

An Unexpected Finding in SUDEP Involving a Child: Focal Myocardial Infarct Adjacent to Bundle of His.
We present a case of SUDEP where histopathologic examination of the cardiac conduction system revealed a focal myocardial infarct of the summit of the ventricular septum abutting the bundle of His, which potentially provides insight into the mechanism of SUDEP for this particular case, and suggests that routine examination of the cardiac conduction system in SUDEP may be beneficial. PMID: 28230913 [PubMed - as supplied by publisher] (Source: Journal of Forensic Sciences)
Source: Journal of Forensic Sciences - February 23, 2017 Category: Forensic Medicine Authors: Neff JL, Lin PT Tags: J Forensic Sci Source Type: research

[Impact of a Senso-Motoric Intervention in COPD-Patients Participating in an Outpatient Pulmonary Rehabilitation Program: A Randomized Controlled Trial].
Conclusion: Similarly to a conventional strength training improvements in exercise capacity could be achieved with a SMT during PR in COPD patients. Further studies are necessary to define the role of the SMT in regards to postural control. PMID: 28231596 [PubMed - as supplied by publisher] (Source: Die Rehabilitation)
Source: Die Rehabilitation - February 23, 2017 Category: Rehabilitation Authors: Spielmanns M, Müller K, Schott N, Winkler A, Polanski H, Nell C, Boeselt T, Koczulla AR, Storre JH, Windisch W, Magnet FS, Baum K Tags: Rehabilitation (Stuttg) Source Type: research

Pro-inflammatory Cytokines Impair Vitamin D-induced Host Defense in Cultured Airway Epithelial Cells.
Abstract Vitamin D is a regulator of host defense against infections and induces expression of the antimicrobial peptide hCAP18/LL-37. Vitamin D deficiency is associated with chronic inflammatory lung diseases and respiratory infections. However, it is incompletely understood if and how (chronic) airway inflammation affects vitamin D metabolism and action. We hypothesized that long-term exposure of primary bronchial epithelial cells (PBEC) to pro-inflammatory cytokines alters their vitamin D metabolism, antibacterial activity and expression of hCAP18/LL-37. To investigate this, PBEC were differentiated at the air-...
Source: Am J Respir Cell Mol... - February 23, 2017 Category: Respiratory Medicine Authors: Schrumpf JA, Amatngalim GD, Veldkamp JB, Verhoosel RM, Ninaber DK, Ordonez SR, van der Does AM, Haagsman HP, Hiemstra PS Tags: Am J Respir Cell Mol Biol Source Type: research

Reply to Coudroy et al. and Chertoff.
PMID: 28231018 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 23, 2017 Category: Respiratory Medicine Authors: Bellani G, Madotto F, Pham T, Fan E, Laffey JG Tags: Am J Respir Crit Care Med Source Type: research

Could NIV Failure Rates Be Underestimated in the LUNG SAFE Study?
PMID: 28231020 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 23, 2017 Category: Respiratory Medicine Authors: Coudroy R, Frat JP, Thille AW Tags: Am J Respir Crit Care Med Source Type: research

Caution Regarding Catheter-Directed Thrombolysis: CTEPH Mistaken for Acute Submassive PE.
PMID: 28231022 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 23, 2017 Category: Respiratory Medicine Authors: Fernandes TM, Pretorius VG, Kim NH Tags: Am J Respir Crit Care Med Source Type: research

High-Flow Oxygen, PEEP, and the Berlin Definition of ARDS: Are They Mutually Exclusive?
PMID: 28231028 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 23, 2017 Category: Respiratory Medicine Authors: Chertoff J Tags: Am J Respir Crit Care Med Source Type: research

Effects of Retinoids on Augmentation of Club Cell Secretory Protein.
PMID: 28231434 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 23, 2017 Category: Respiratory Medicine Authors: Chen Y, Vasquez MM, Zhu L, Lizarraga RE, Krutzsch M, Einspahr J, Alberts DS, Di PY, Martinez FD, Guerra S Tags: Am J Respir Crit Care Med Source Type: research

Bronchoscopic lung volume reduction procedures for chronic obstructive pulmonary disease.
CONCLUSIONS: Results for selected BLVR procedures indicate they can provide significant and clinically meaningful short-term (up to one year) improvements in health outcomes, but this was at the expense of increased adverse events. The currently available evidence is not sufficient to assess the effect of BLVR procedures on mortality. These findings are limited by the lack of long-term follow-up data, limited availability of cost-effectiveness data, significant heterogeneity in results, presence of skew and high CIs, and the open-label character of a number of the studies. PMID: 28230230 [PubMed - as supplied by publi...
Source: Cochrane Database of Systematic Reviews - February 23, 2017 Category: Journals (General) Authors: van Agteren JE, Hnin K, Grosser D, Carson KV, Smith BJ Tags: Cochrane Database Syst Rev Source Type: research

Relative Abundance of Human Bocaviruses in Urban Sewage in Greater Cairo, Egypt
AbstractHuman bocavirus (HBoV) is predominantly found in the respiratory tract infections and in the stool of patients with gastroenteritis symptoms. However, data on the prevalence of HBoV genotypes in environmental samples are limited. Here we addressed the prevalence of HBoV in sewage collected from three different wastewater treatment plants in Egypt. HBoV-1, HBoV-2, and HBoV-3 were detected, whereas none of the samples were positive for HBoV-4. The median concentration of HBoV in influent samples was 8.5  × 103 GC/l for HBoV-1, 3.0  × 104 GC/l for HBoV-2, and 2.5  × 104 GC/l for HBoV-3. The concentration was ...
Source: Food and Environmental Virology - February 23, 2017 Category: Virology Source Type: research

Likelihood of Immediate Food Challenge Reactions Varies by Age, History, Allergens, and Levels of Sensitization
Pediatric Allergy, Immunology, and Pulmonology , Vol. 0, No. 0. (Source: Pediatric, Allergy, Immunology, and Pulmonology)
Source: Pediatric, Allergy, Immunology, and Pulmonology - February 23, 2017 Category: Respiratory Medicine Source Type: research

Rare respiratory diseases are ready for primetime: from Rare Disease Day to the European Reference Networks
Rare diseases are life-threatening or chronically debilitating conditions which are of such low prevalence (fewer than 1 in 2000 people) that special combined efforts are needed to address them [1]. Launched in 2008 by Rare Diseases Europe (EURORDIS), a non-governmental patient-driven alliance representing 733 rare disease patient organisations in 64 countries, Rare Disease Day (figure 1) takes place on the last day of February each year. The main objective of Rare Disease Day is to raise awareness amongst the general public and decision-makers about rare diseases and their impact on patients' lives [2]. In 2017, Rare Dise...
Source: European Respiratory Journal - February 23, 2017 Category: Respiratory Medicine Authors: Humbert, M., Wagner, T. O. Tags: Editorials Source Type: research

Impact of pulmonary vascular volume on mortality in IPF: is it time to reconsider the role of vasculature in disease pathogenesis and progression?
We were pleased to read the letter from E. Puxeddu and co-workers, written in response to our observation that an increased pulmonary vessel volume, derived using quantitative computed tomography (CT) analysis, strongly predicts mortality in patients with idiopathic pulmonary fibrosis (IPF) [1]. E. Puxeddu and his team highlight a selection of studies that have identified pulmonary vascular alterations in IPF, similar to those seen in pulmonary venous occlusive disease (PVOD) and pulmonary capillary haemangiomatosis (PCH) [2–4]. They suggest that when considered in the light of these previous reports, our findings ad...
Source: European Respiratory Journal - February 23, 2017 Category: Respiratory Medicine Authors: Jacob, J., Nicholson, A. G., Wells, A. U., Hansell, D. M. Tags: Interstitial and orphan lung disease Original Articles: Correspondence Source Type: research

Evaluation of the incidence of rare diseases: difficulties and uncertainties, the example of chronic thromboembolic pulmonary hypertension
Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare form of pulmonary hypertension, classified as group 4 in the present clinical classification [1, 2]. CTEPH is generally considered a late complication of one or multiple episodes of acute pulmonary embolism that have not resolved despite at least 3 months of therapeutic anticoagulation. Haemodynamically, CTEPH is characterised by a mean pulmonary arterial pressure of at least 25 mmHg at rest, measured during right heart catheterisation. (Source: European Respiratory Journal)
Source: European Respiratory Journal - February 23, 2017 Category: Respiratory Medicine Authors: Simonneau, G., Hoeper, M. M. Tags: Pulmonary vascular disease Editorials Source Type: research

Hypertonic saline in patients with primary ciliary dyskinesia: on the road to evidence-based treatment for a rare lung disease
The study of Paff et al. [1], published in this issue of the European Respiratory Journal on Rare Disease Day 2017, describes the first randomised clinical trial of inhaled hypertonic saline on quality of life and other outcomes in patients with primary ciliary dyskinesia (PCD). Although the results were negative, the study is a major step towards evidence-based treatment of PCD. (Source: European Respiratory Journal)
Source: European Respiratory Journal - February 23, 2017 Category: Respiratory Medicine Authors: Kuehni, C. E., Goutaki, M., Kobbernagel, H. E. Tags: Interstitial and orphan lung disease, CF and non-CF bronchiectasis Editorials Source Type: research

Impact of pulmonary vascular volume on mortality in IPF: is it time to reconsider the role of vasculature in disease pathogenesis and progression?
The article by Jacob et al. [1], reporting a computer-based computed tomography (CT) approach able to provide a precise quantification of disease extension in idiopathic publmonary fibrosis (IPF) patients by means of specific computer algorithm, CALIPER, is very interesting. (Source: European Respiratory Journal)
Source: European Respiratory Journal - February 23, 2017 Category: Respiratory Medicine Authors: Puxeddu, E., Cavalli, F., Pezzuto, G., Teodori, E., Rogliani, P. Tags: Interstitial and orphan lung disease Original Articles: Correspondence Source Type: research

The yin and yang of idiopathic pulmonary fibrosis
125 years ago, Osler [1] summarised in his medical textbook for the first time the knowledge at that time on "chronic interstitial pneumonia" as pulmonary diseases with fibroid changes, easy to diagnose but difficult to classify. In his very detailed report (recommended reading for everyone interested in interstitial lung diseases (ILDs), although it probably did not correspond to idiopathic pulmonary fibrosis (IPF), as discussed elsewhere [2]), he mentioned aetiology, histopathology and clinical characteristics, and finally about treatment stated that "nothing can be done for the condition itself ". Typical for this ...
Source: European Respiratory Journal - February 23, 2017 Category: Respiratory Medicine Authors: Kreuter, M., Cottin, V. Tags: Interstitial and orphan lung disease Editorials Source Type: research

Clinical relevance of pulmonary amyloidosis: an analysis of 76 autopsy-derived cases
Amyloidosis refers to a group of diseases characterised by the extracellular tissue deposition of insoluble misfolded proteins that disrupt the function of the involved organs [1]. The principal types of systemic amyloidosis include immunoglobulin light-chain amyloidosis (AL) due to an underlying monoclonal B-lymphocyte/plasma cell disorder, serum amyloid A amyloidosis (AA) due to chronic inflammatory diseases, and transthyretin amyloidosis (ATTR) from variations (mutations) in the transthyretin gene (mut-ATTR) or acquired form, i.e. wild-type ATTR (wt-ATTR) [1]. (Source: European Respiratory Journal)
Source: European Respiratory Journal - February 23, 2017 Category: Respiratory Medicine Authors: Ussavarungsi, K., Yi, E. S., Maleszewski, J. J., Kurtin, P. J., Dasari, S., Theis, J. D., Dispenzieri, A., Ryu, J. H. Tags: Interstitial and orphan lung disease Original Articles: Research letters Source Type: research

Heat shock protein: a hot topic in idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a progressive disease of the lung parenchyma, causing significant morbidity and mortality [1, 2]. The therapeutic options in IPF are limited to only two recently approved drugs, pirfenidone and nintedanib, which have been shown to slow progression but are not able to stop or reverse the disease [3, 4]. Better pathophysiological knowledge is needed to develop new therapeutic strategies in IPF. The current understanding of the disease is that fibroblastic foci, characterised by accumulation of myofibroblasts and overlying "activated" epithelium, represent "hot zones" of the disease and ...
Source: European Respiratory Journal - February 23, 2017 Category: Respiratory Medicine Authors: Bonniaud, P., Bellaye, P.-S., Burgy, O., Kolb, M. Tags: Lung biology and experimental studies, Interstitial and orphan lung disease Editorials Source Type: research

Within-day test-retest reliability of the 6-min walk test in patients with pulmonary fibrosis
Interstitial lung diseases (ILDs) are a group of more than 150 different disorders characterized by inflammation of the lung parenchyma, or interstitium, often followed by the occurrence of pulmonary fibrosis. Patients with pulmonary fibrosis complain about exertional dyspnoea, exercise intolerance and reduced quality of life [1]. Poor exercise tolerance and oxygen desaturation during exercise are associated with poor survival [2]. Therefore, measuring exercise capacity in patients with pulmonary fibrosis is an important element of clinical management. The 6-min walk test (6MWT) is one of the most widely used clinical test...
Source: European Respiratory Journal - February 23, 2017 Category: Respiratory Medicine Authors: Bloem, A. E. M., Veltkamp, M., Custers, J. W. H., Dolk, H. M., Grutters, J. C., Spruit, M. A. Tags: Interstitial and orphan lung disease Original Articles: Research letters Source Type: research

Volatolomics of breath as an emerging frontier in pulmonary arterial hypertension
There is accumulating evidence in support of the significant improvement in survival rates and clinical outcomes when pulmonary arterial hypertension (PAH) is diagnosed at early stages. Nevertheless, it remains a major clinical challenge and the outcomes are dependent on invasive right heart catheterisation. Resulting from pathophysiological processes and detectable in exhaled breath, volatile organic compounds (VOCs) have been proposed as noninvasive biomarkers for PAH. Studies have confirmed significant alterations of the exhaled VOCs among PAH patients when compared to controls and/or patients with other respiratory dis...
Source: European Respiratory Journal - February 23, 2017 Category: Respiratory Medicine Authors: Nakhleh, M. K., Haick, H., Humbert, M., Cohen-Kaminsky, S. Tags: Review Source Type: research

Incidence of chronic thromboembolic pulmonary hypertension after acute pulmonary embolism: a contemporary view of the published literature
The incidence of chronic thromboembolic pulmonary hypertension (CTEPH) after pulmonary embolism (PE) is relevant for management decisions but is currently unknown. We performed a meta-analysis of studies including consecutive PE patients followed for CTEPH. Study cohorts were predefined as "all comers", "survivors" or "survivors without major comorbidities". CTEPH incidences were calculated using random effects models. We selected 16 studies totalling 4047 PE patients who were mostly followed up for >2-years. In 1186 all comers (two studies), the pooled CTEPH incidence was 0.56% (95% CI 0.1–1.0). In 999 survivors ...
Source: European Respiratory Journal - February 23, 2017 Category: Respiratory Medicine Authors: Ende-Verhaar, Y. M., Cannegieter, S. C., Vonk Noordegraaf, A., Delcroix, M., Pruszczyk, P., Mairuhu, A. T. A., Huisman, M. V., Klok, F. A. Tags: Original Articles: Pulmonary vascular diseases Source Type: research

A randomised controlled trial on the effect of inhaled hypertonic saline on quality of life in primary ciliary dyskinesia
This study found little evidence to support the hypothesis that hypertonic saline improves QoL in PCD patients. We advise the use of disease-specific outcome measures in future trials. (Source: European Respiratory Journal)
Source: European Respiratory Journal - February 23, 2017 Category: Respiratory Medicine Authors: Paff, T., Daniels, J. M. A., Weersink, E. J., Lutter, R., Vonk Noordegraaf, A., Haarman, E. G. Tags: Original Articles: Primary ciliary dyskinesia Source Type: research

Baseline characteristics of idiopathic pulmonary fibrosis: analysis from the Australian Idiopathic Pulmonary Fibrosis Registry
7The prevalence of idiopathic pulmonary fibrosis (IPF), a fatal and progressive lung disease, is estimated at 1.25–63 out of 100 000, making large population studies difficult. Recently, the need for large longitudinal registries to study IPF has been recognised. The Australian IPF Registry (AIPFR) is a national registry collating comprehensive longitudinal data of IPF patients across Australia. We explored the characteristics of this IPF cohort and the effect of demographic and physiological parameters and specific management on mortality. Participants in the AIPFR (n=647, mean age 70.9±8.5 years, 67.7% ...
Source: European Respiratory Journal - February 23, 2017 Category: Respiratory Medicine Authors: Jo, H. E., Glaspole, I., Grainge, C., Goh, N., Hopkins, P. M. A., Moodley, Y., Reynolds, P. N., Chapman, S., Walters, E. H., Zappala, C., Allan, H., Keir, G. J., Hayen, A., Cooper, W. A., Mahar, A. M., Ellis, S., Macansh, S., Corte, T. J. Tags: Interstitial and orphan lung disease Original Articles: Interstitial lung diseases Source Type: research

Secondary pulmonary alveolar proteinosis after lung transplantation: a single-centre series
Pulmonary alveolar proteinosis (PAP) is a rare disease characterized by accumulation of surfactant in alveolar space related to alveolar macrophage dysfunction. PAP occurs in three clinically distinct forms: autoimmune PAP (90% of cases), secondary PAP and genetic PAP [1]. Secondary PAP may be related to immunosuppressive disorders, with few cases associated with solid-organ transplant [1]. Indeed, to our knowledge, only five cases of symptomatic PAP secondary to lung transplantation have been reported [2–4]. (Source: European Respiratory Journal)
Source: European Respiratory Journal - February 23, 2017 Category: Respiratory Medicine Authors: Philippot, Q., Cazes, A., Borie, R., Debray, M.-P., Danel, C., Hurtado Nedelec, M., Boudjemaa, S., Sroussi, D., Dupin, C., Mal, H., Dauriat, G., Jean-Baptiste, S., Jebrak, G., Castier, Y., Mordant, P., Thabut, G., Brugiere, O. Tags: Interstitial and orphan lung disease Original Articles: Research letters Source Type: research

Risk of cardiovascular disease among patients with sarcoidosis: a population-based retrospective cohort study, 1976-2013
In this study, 345 patients with incident sarcoidosis in Olmsted County (Minnesota, USA) during 1976–2013 were identified based on comprehensive medical record review. 345 sex- and age-matched comparators were also identified from the same underlying population. Medical records were individually reviewed for CVD, including coronary artery disease, congestive heart failure, atrial fibrillation, cerebrovascular accident, transient ischaemic attack, peripheral arterial disease and abdominal aortic aneurysm. Cox proportional hazards models with adjustment for age, sex, calendar year and cardiovascular risk factors were u...
Source: European Respiratory Journal - February 23, 2017 Category: Respiratory Medicine Authors: Ungprasert, P., Crowson, C. S., Matteson, E. L. Tags: Interstitial and orphan lung disease Original Articles: Sarcoidosis Source Type: research

"Can health status questionnaires be used as a measure of physical activity in COPD patients?" Heleen Demeyer, Ivan Duenas-Espin, Corina De Jong, Zafeiris Louvaris, Miek Hornikx, Elena Gimeno-Santos, Matthias Loeckx, Ioannis Vogiatzis, Wim Janssens, Nicholas S. Hopkinson, Roberto A. Rabinovich, Niklas Karlsson, Judith Garcia-Aymerich and Thierry Troosters, on behalf of the PROactive consortium. Eur Respir J 2016; 47: 1565-1568.
(Source: European Respiratory Journal)
Source: European Respiratory Journal - February 23, 2017 Category: Respiratory Medicine Tags: Author correction Source Type: research

Amplified canonical transforming growth factor-{beta} signalling via heat shock protein 90 in pulmonary fibrosis
In conclusion, this is the first study to demonstrate that HSP90 inhibition blocks pulmonary fibroblast activation and ameliorates bleomycin-induced pulmonary fibrosis in mice. (Source: European Respiratory Journal)
Source: European Respiratory Journal - February 23, 2017 Category: Respiratory Medicine Authors: Sibinska, Z., Tian, X., Korfei, M., Kojonazarov, B., Kolb, J. S., Klepetko, W., Kosanovic, D., Wygrecka, M., Ghofrani, H. A., Weissmann, N., Grimminger, F., Seeger, W., Guenther, A., Schermuly, R. T. Tags: Lung biology and experimental studies, Interstitial and orphan lung disease Original Articles: Interstitial lung diseases Source Type: research

Serum YKL-40 as predictor of outcome in hypersensitivity pneumonitis
YKL-40, a chitinase-like protein mainly secreted by macrophages, neutrophils and epithelial cells, is increased in patients with idiopathic interstitial pneumonia and sarcoidosis. We aimed to investigate the role of YKL-40 as a biomarker in hypersensitivity pneumonitis (HP). 72 HP patients, 100 interstitial lung disease (ILD) controls and 60 healthy controls were studied. YKL-40 was measured by ELISA in serum and bronchoalveolar lavage fluid (BALF) at baseline and follow-up. The relationship between YKL-40 levels, clinical variables and disease outcome was evaluated. Baseline serum YKL-40 levels were significantly higher i...
Source: European Respiratory Journal - February 23, 2017 Category: Respiratory Medicine Authors: Long, X., He, X., Ohshimo, S., Griese, M., Sarria, R., Guzman, J., Costabel, U., Bonella, F. Tags: Interstitial and orphan lung disease Original Articles: Interstitial lung diseases Source Type: research

Hormone deprivation alters mitochondrial function and lipid profile in the hippocampus
In conclusion, chronic ovarian hormone deprivation induces mitochondrial dysfunction and changes in the mitochondrial membrane lipid profile comparable to an aging phenotype. Our study provides insights into ovarian hormone loss-induced early lipidomic changes with bioenergetic deficits in the hippocampus that may contribute to the increased risk of Alzheimer’s disease and other age-associated disorders observed in postmenopause. (Source: Journal of Endocrinology)
Source: Journal of Endocrinology - February 23, 2017 Category: Endocrinology Authors: Zarate, S., Astiz, M., Magnani, N., Imsen, M., Merino, F., Alvarez, S., Reines, A., Seilicovich, A. Tags: Research Source Type: research

TControl: a Mobile App to Follow up Tobacco-Quitting Patients
Tobacco smoking is a major risk factor for active and passive smokers in certain respiratory [1] and circulatory diseases [2] as well as in some types of cancer[3,4] and infections [5], among other diseases. Because of this, both public and private medical institutions in an increasing number of countries provide services for people who want stop smoking. (Source: Computer Methods and Programs in Biomedicine)
Source: Computer Methods and Programs in Biomedicine - February 23, 2017 Category: Bioinformatics Authors: Marc Pifarr é, Adrián Carrera, Jordi Vilaplana, Josep Cuadrado, Sara Solsona, Francesc Abella, Francesc Solsona, Rui Alves Source Type: research

The Effect of Birth Order on Neonatal Morbidity and Mortality in Very Preterm Twins
Conclusion Thus, while second-born twins had reduced odds of mortality, they also had increased odds of RDS and ROP. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - February 23, 2017 Category: Perinatology & Neonatology Authors: Mei-Dan, Elad Shah, Jyotsna Lee, Shoo Shah, Prakesh S. Murphy, Kellie E. Tags: Original Article Source Type: research

4D dose simulation in volumetric arc therapy: Accuracy and affecting parameters
by Thilo Sothmann, Tobias Gauer, Ren é Werner Radiotherapy of lung and liver lesions has changed from normofractioned 3D-CRT to stereotactic treatment in a single or few fractions, often employing volumetric arc therapy (VMAT)-based techniques. Potential unintended interference of respiratory target motion and dynamically changing beam parame ters during VMAT dose delivery motivates establishing 4D quality assurance (4D QA) procedures to assess appropriateness of generated VMAT treatment plans when taking into account patient-specific motion characteristics. Current approaches are motion phantom-based 4D QA and image-bas...
Source: PLoS One - February 23, 2017 Category: Biomedical Science Authors: Thilo Sothmann Source Type: research

Breastfeeding and the risk of respiratory tract infections after infancy: The Generation R Study
This study was embedded in The Generation R study, a Dutch population-based prospective cohort study from fetal life until young adulthood. Information on breastfeeding duration (never; (Source: PLoS One)
Source: PLoS One - February 23, 2017 Category: Biomedical Science Authors: Ilse Tromp Source Type: research

IJERPH, Vol. 14, Pages 226: The Association between Ambient Air Pollution and Allergic Rhinitis: Further Epidemiological Evidence from Changchun, Northeastern China
With the continuous rapid urbanization process over the last three decades, outdoors air pollution has become a progressively more serious public health hazard in China. To investigate the possible associations, lag effects and seasonal differences of urban air quality on respiratory health (allergic rhinitis) in Changchun, a city in Northeastern China, we carried out a time-series analysis of the incidents of allergic rhinitis (AR) from 2013 to 2015. Environmental monitoring showed that PM2.5 and PM10 were the major air pollutants in Changchun, followed by SO2, NO2 and O3. The results also demonstrated that the daily conc...
Source: International Journal of Environmental Research and Public Health - February 23, 2017 Category: Environmental Health Authors: Bo Teng Xuelei Zhang Chunhui Yi Yan Zhang Shufeng Ye Yafang Wang Daniel Tong Binfeng Lu Tags: Article Source Type: research

IJERPH, Vol. 14, Pages 223: Simultaneous Detection of Nine Key Bacterial Respiratory Pathogens Using Luminex xTAG® Technology
In conclusion, MPLT is a high-throughput, labor-saving and reliable method with high sensitivity and specificity for identifying nine respiratory pathogens responsible for LRTIs. Indeed, this assay may be a promising supplement to conventional methods used to diagnose LRTIs. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - February 23, 2017 Category: Environmental Health Authors: Luxi Jiang Hongyu Ren Haijian Zhou Tian Qin Yu Chen Tags: Article Source Type: research

Esophagopericardial fistula, septic shock and intracranial hemorrhage with hydrocephalus after lung transplantation
Publication date: Available online 23 February 2017 Source:Revista Portuguesa de Pneumologia (English Edition) Author(s): M.M. Schuurmans, C. Benden, C. Moehrlen, C. Gubler, M. Wilhelm, W. Weder, I. Inci A 57-year old woman underwent lung transplantation for non-specific interstitial pneumonia. Primary graft dysfunction was diagnosed requiring continued use of extracorporeal membrane oxygenation (ECMO). Within three days she developed recurring hemothoraces requiring two surgical evacuations. After ECMO removal a series of complications occurred within four months: femoral thrombosis, persisting tachycardic atrial fibrill...
Source: Revista Portuguesa de Pneumologia - February 23, 2017 Category: Respiratory Medicine Source Type: research

CT-guided transthoracic lung diagnostic procedures: A 5 year experience
Publication date: Available online 23 February 2017 Source:Revista Portuguesa de Pneumologia (English Edition) Author(s): C. Dias, R. Reis, C. Oliveira, I. Candelária, T. Couto, A. Estevão (Source: Revista Portuguesa de Pneumologia)
Source: Revista Portuguesa de Pneumologia - February 23, 2017 Category: Respiratory Medicine Source Type: research

Time for a paradigm shift: Assessing for anxiety in patients receiving mechanical ventilation
Publication date: Available online 23 February 2017 Source:Heart & Lung: The Journal of Acute and Critical Care Author(s): Glen Au, Jaclynn R. Johnson, Linda L. Chlan (Source: Heart and Lung: The Journal of Acute and Critical Care)
Source: Heart and Lung: The Journal of Acute and Critical Care - February 23, 2017 Category: Respiratory Medicine Source Type: research

Sex differences in leptin modulate ventilation in heart failure
Conclusion Men have significantly lower circulating leptin concentration and increased ventilatory drive during exercise than women with comparable HF. In men with HF, lower leptin concentration may account for an increased ventilatory drive. (Source: Heart and Lung: The Journal of Acute and Critical Care)
Source: Heart and Lung: The Journal of Acute and Critical Care - February 23, 2017 Category: Respiratory Medicine Source Type: research

Design and characterization of a cough simulator
Expiratory droplets from human coughing have always been considered as potential carriers of pathogens, responsible for respiratory infectious disease transmission. To study the transmission of disease by human coughing, a transient repeatable cough simulator has been designed and built. Cough droplets are generated by different mechanisms, such as the breaking of mucus, condensation and high-speed atomization from different depths of the respiratory tract. These mechanisms in coughing produce droplets of different sizes, represented by a bimodal distribution of ‘fine’ and ‘coarse’ droplets. A cough simulator...
Source: Journal of Breath Research - February 23, 2017 Category: Respiratory Medicine Authors: Bo Zhang, Chao Zhu, Zhiming Ji and Chao-Hsin Lin Source Type: research

Reducing socioeconomic inequalities in COPD care in the hospital outpatient setting - A nationwide initiative
We examined socioeconomic differences in the quality of COPD outpatient care and the potential of a systematic quality improvement initiative in reducing potential socioeconomic differences. (Source: Respiratory Medicine)
Source: Respiratory Medicine - February 23, 2017 Category: Respiratory Medicine Authors: Sandra S. T øttenborg, Peter Lange, Reimar W. Thomsen, Henrik Nielsen, Søren P. Johnsen Source Type: research

Obstructive sleep apnoea and the role of tongue reduction surgery in children with Beckwith-Wiedemann syndrome
Beckwith-Wiedemann syndrome (BWS) is a rare paediatric overgrowth disorder. Associated macroglossia is a feature of many children with BWS and is felt to be a risk factor for obstructive sleep apnoea (OSA). Sleep-disordered breathing is highly variable in this population. The relationship between degree of macroglossia or other genotypic or phenotypic factors and OSA severity has not been established. The natural history of OSA in this population is unknown; a variety of conservative and surgical therapies have been used to treat OSA in children with BWS but none have been studied systematically. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - February 23, 2017 Category: Respiratory Medicine Authors: Christopher M. Cielo, Kelly A. Duffy, Aesha Vyas, Jesse A. Taylor, Jennifer M. Kalish Tags: Review Source Type: research

Epidemiological characteristics of seven respiratory viruses among pediatric patients with acute respiratory tract infections from 2011 to 2015 in Dongguan, Southern China
Publication date: Available online 23 February 2017 Source:The Brazilian Journal of Infectious Diseases Author(s): Mingyu Xie, Qiang Ma, Xiuying Chen, Xiaomei Lu, Baimao Zhong (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - February 23, 2017 Category: Infectious Diseases Source Type: research

Intravenous Buprenorphine: A Substitute for Naloxone in Methadone-Overdosed Patients?
We present a 20-year-old morphine-addicted man who presented with methadone-induced respiratory depression and responded safely and effectively to intravenous administration of buprenorphine. Buprenorphine may be a useful alternative opioid reversal agent for opioid-dependent patients. (Source: Annals of Emergency Medicine)
Source: Annals of Emergency Medicine - February 23, 2017 Category: Emergency Medicine Source Type: research

Fiber optic bronchoscopy and remifentanil target-controlled infusion in critically ill patients with acute hypoxaemic respiratory failure: A descriptive study
Conclusion Sedation with remifentanil-TCI during FOB with prior failure under topical anaesthesia alone was effective and acceptably safe in non-intubated hypoxaemic thoracic surgery patients. (Source: Anaesthesia, Critical Care and Pain Medicine)
Source: Anaesthesia, Critical Care and Pain Medicine - February 23, 2017 Category: Anesthesiology Source Type: research

Recurrent Respiratory Papillomatosis in a Parturient Presenting for Cesarean Delivery
Recurrent respiratory papillomatosis (RRP) is a human papilloma virus (HPV)-mediated disease characterized by multiple benign squamous papillomas of the respiratory tract, principally within the larynx.1 Involvement of the tracheobronchial tree and rarely the lungs ( (Source: International Journal of Obstetric Anesthesia)
Source: International Journal of Obstetric Anesthesia - February 23, 2017 Category: Anesthesiology Authors: K.G. Segna, S.L. Huffnagle, J. Huffnagle, M.M. Mele, J.T. Wenzel, J.R. Spiegel Tags: Correspondence Source Type: research

Ambiguous presentation of Mycobacterium avium complex ‐associated Rasmussen aneurysm
A 77‐year‐old man with a progressively dry cough (two months duration) was admitted with hemoptysis. Chest computed tomography (CT) revealed left lingular lobe consolidation and one thick‐walled cavity lesion over the left lower lobe, which was accompanied by satellite micro‐nodules in a tree‐in‐bud pattern. CT‐guided biopsy confirmed mycobacterial infection, and subsequent culture yielded Mycobacterium avium complex (MAC). Unremitting hemoptysis was present despite treatment (14 days) with ethambutol, rifampin, clarithromycin, and streptomycin. Initial CT angiography (CTA) to determine the source of the he...
Source: Respirology Case Reports - February 23, 2017 Category: Respiratory Medicine Authors: Hsin ‐Wei Chiu, Shu‐Hung Kuo, Ruay‐Sheng Lai, Ming‐Ting Wu, Hsiu‐Fu Wu Tags: Case Report Source Type: research