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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 3.

Fostering the exchange of real-life data across different countries to answer primary care research questions: a protocol for an UNLOCK study from the IPCRG
npj Primary Care Respiratory Medicine, Published online: 22 September 2016; doi:10.1038/npjpcrm.2016.48 (Source: npj Primary Care Respiratory Medicine)
Source: npj Primary Care Respiratory Medicine - September 22, 2016 Category: Primary Care Authors: Liza Cragg Si ân Williams Thys van der Molen Mike Thomas Jaime Correia de Sousa Niels H Chavannes Source Type: research

Development and Initial Validation of a Questionnaire to Measure Health-Related Quality of Life of Adults with Common Variable Immune Deficiency: The CVID_QoL Questionnaire
Conclusions This study provides evidence of the reliability and construct validity of the CVID_QoL to identify QoL issues in patients with CVID that may not be addressed by generic instruments. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 22, 2016 Category: Allergy & Immunology Source Type: research

Home Environmental Interventions for the Prevention or Control of Allergic and Respiratory Diseases: What Really Works
Publication date: Available online 21 September 2016 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): Pierre Le Cann, Hélène Paulus, Philippe Glorennec, Barbara Le Bot, Sophie Frain, Jean Pierre Gangneux Home health care workers interventions have been implemented in western countries to improve health status of patients with respiratory diseases especially asthma and allergic illnesses. Twenty-six controlled studies dealing with prevention and control of these diseases through home environmental interventions were reviewed. After a comprehensive description of the characteristics of these s...
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 22, 2016 Category: Allergy & Immunology Source Type: research

Prescription practices for non-malaria febrile illnesses among under-fives in the Lake Zone, Tanzania
Conclusions The proportion of clinicians prescribing antimalarial medications and over-prescribing antibiotics to malaria negative-tested under-fives in the Lake Zone is high, 11%, and as low as 14% of clinicians prescribed antibiotics correctly based on correct final diagnoses. Training of health care workers, health managers and regular supportive supervision may significantly improve prescription practices among clinicians attending under-fives. (Source: Asian Pacific Journal of Tropical Disease)
Source: Asian Pacific Journal of Tropical Disease - September 22, 2016 Category: Tropical Medicine Source Type: research

Detection of porcine reproductive and respiratory syndrome virus (PRRSV) and influenza A virus (IAV) in oral fluid of pigs
The objective of the study was to analyze porcine reproductive and respiratory syndrome virus (PRRSV) and influenza A virus (IAV) circulation in growing pigs from three Polish production farms, using Real Time PCR and ELISA testing of oral fluid and serum. Oral fluids were collected every 2weeks, in the same 3–4 pens of pigs aged between 5 and 17weeks. Additionally, blood samples were collected every 4weeks from 4 pigs corresponding to the same pens as oral fluid and tested for the presence of PRRSV nucleic acid (pooled by 4) and antibodies. In farm A no PRRSV circulation was detected and only maternal antibodies were pr...
Source: Research in Veterinary Science - September 22, 2016 Category: Veterinary Research Source Type: research

Safety of long-acting β2-agonists in asthma
Publication date: Available online 21 September 2016 Source:The Lancet Respiratory Medicine Author(s): Louise Rishton (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - September 22, 2016 Category: Respiratory Medicine Source Type: research

SAVE trial: no cardiovascular benefits for CPAP in OSA
Publication date: Available online 21 September 2016 Source:The Lancet Respiratory Medicine Author(s): Bryant Furlow (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - September 22, 2016 Category: Respiratory Medicine Source Type: research

Lung regeneration by fetal lung tissue implantation in a mouse pulmonary emphysema model.
Authors: Uyama K, Sakiyama S, Yoshida M, Kenzaki K, Toba H, Kawakami Y, Okumura K, Takizawa H, Kondo K, Tangoku A Abstract The mortality and morbidity of chronic obstructive pulmonary disease are high. However, no radical therapy has been developed to date. The purpose of this study was to evaluate whether fetal mouse lung tissue can grow and differentiate in the emphysematous lung. Fetal lung tissue from green fluorescent protein C57BL/6 mice at 16 days' gestation was used as donor material. Twelve-month-old pallid mice were used as recipients. Donor lungs were cut into small pieces and implanted into the recipien...
Source: Journal of Medical Investigation - September 21, 2016 Category: Journals (General) Tags: J Med Invest Source Type: research

Experiences and Psychosocial Impact of West Africa Ebola Deployment on US Health Care Volunteers
CONCLUSIONS The urge to do something to help in an international medical crisis is understandable and admirable, but the adverse impacts reported by participants here – at every stage of deployment, suggest that preparedness for these missions needs improvement and at the very least, high risk missions should be limited to more seasoned and well trained (for conditions in the field) personnel. While volunteering for a medical mission during a health crisis can be very rewarding, both professionally and personally, it can also be very disruptive and impactful. All volunteers for high risk missions must be made fully aware...
Source: PLOS Currents Outbreaks - September 21, 2016 Category: Epidemiology Authors: Robyn Gershon Source Type: research

Clinical characteristics of eosinophilic asthma exacerbations
ConclusionOur findings suggest that eosinophilic asthma exacerbations may be clinically more severe than NEEs, supporting the identification of these higher risk patients for specific interventions. (Source: Respirology)
Source: Respirology - September 21, 2016 Category: Respiratory Medicine Authors: Asger Bjerregaard, Ingrid A. Laing, Vibeke Backer, Markus Fally, Siew ‐Kim Khoo, Glenys Chidlow, Chisha Sikazwe, David W. Smith, Peter Le Souëf, Celeste Porsbjerg Tags: Original Article Source Type: research

Preservation of Cognitive Function by Lepidium meyenii (Maca) Is Associated with Improvement of Mitochondrial Activity and Upregulation of Autophagy-Related Proteins in Middle-Aged Mouse Cortex.
This study aimed to investigate if maca could improve cognitive function of middle-aged mice and if this effect was associated with improvement of mitochondrial activity and modulation of autophagy signaling in mouse cortex. Fourteen-month-old male ICR mice received maca powder administered by gavage for five weeks. Maca improved cognitive function, motor coordination, and endurance capacity in middle-aged mice, accompanied by increased mitochondrial respiratory function and upregulation of autophagy-related proteins in cortex. Our findings suggest that maca is a newly defined nutritional plant which can improve mitochondr...
Source: Evidence-based Complementary and Alternative Medicine - September 21, 2016 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Acute eosinophilic pneumonia following recent cigarette smoking.
In this report we describe the case of an 18 year old female who presented with fever, shortness of breath, and chest pain. Chest X-ray revealed diffuse bilateral infiltrates and eosinophilia was reported from her broncholaveolar lavage (BAL) fluid. She started smoking 3 weeks prior to the onset of symptoms and based on her clinical presentation, BAL findings and dramatic improvement, acute eosinophilic pneumonia (AEP) was diagnosed. PMID: 27642564 [PubMed] (Source: Respiratory Care)
Source: Respiratory Care - September 21, 2016 Category: Respiratory Medicine Authors: Thakur LK, Jha KK Tags: Respir Med Case Rep Source Type: research

Primary spontaneous pneumothorax due to high bleb burden.
We present a case report of a young, male, former-smoker and polysubstance abuser with no prior lung history that developed acute dyspnea at rest and was found to have a large right pneumothorax on chest x-ray. A pig-tail catheter was utilized, but his course was complicated by a recurrent tension pneumothorax. Chest computed tomography (CT) revealed a significant bleb burden and the patient underwent a lung wedge resection with mechanical pleurodesis. What made our case unique were the chest x-rays revealing blebs that could have predicted the patient's recurrent pneumothorax as well as the multiple potential risk factors...
Source: Respiratory Care - September 21, 2016 Category: Respiratory Medicine Authors: Segraves JM, Dulohery MM Tags: Respir Med Case Rep Source Type: research

Maternal allergic disease history affects childhood allergy development through impairment of neonatal regulatory T-cells.
CONCLUSION: Maternal allergy correlated with impaired Tregs in neonates, and this could enhance the susceptibility of offspring to allergic diseases in early childhood due to an imbalance of Th1 and Th2 cells. PMID: 27646403 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - September 21, 2016 Category: Respiratory Medicine Authors: Meng SS, Gao R, Yan BD, Ren J, Wu F, Chen P, Zhang J, Wang LF, Xiao YM, Liu J Tags: Respir Res Source Type: research

The genetics of the bitter taste receptor T2R38 in upper airway innate immunity and implications for chronic rhinosinusitis
ConclusionTaste receptors are emerging as critical components of early‐phase respiratory innate immunity, detecting molecules used by microbes to communicate and stimulating localized host defenses. Genetic polymorphisms are very common within the taste receptors, and recent linkage studies have demonstrated associations of taste receptor genetics with CRS. Lastly, ciliogenesis, which is often impacted in CRS, is critical for the functional expression of T2R38. Level of EvidenceN/A. Laryngoscope, 2016 (Source: The Laryngoscope)
Source: The Laryngoscope - September 21, 2016 Category: ENT & OMF Authors: Noam A. Cohen Tags: Allergy/Rhinology Source Type: research

Recombinant beta interferon could clear the low-dose infected porcine reproductive and respiratory syndrome virus (PRRSV) in MARC-145 cells.
Abstract Porcine reproductive and respiratory syndrome virus (PRRSV) causes one of the most economically devastating and pandemic porcine diseases. Previous study has shown that MARC-145 cells pretreated with recombinant IFN-β (rIFN-β) couldn't develop cytopathic effect (CPE) of PRRSV. However, up to date, it is not clear whether MARC-145 cells post-treated with rIFN-β could develop CPE of PRRSV. The present work showed that the MARC-145 cells didn't develop the CPE at 120 hr post-infection (p.i.) with low-dose of PRRSV when the cells were pre-treated with rIFN-β (Group 1), post-treated with rIFN-β at 4 hr p....
Source: Acta Virologica - September 21, 2016 Category: Infectious Diseases Authors: Shi X, Zhang X, Wang L, Li W, Jiang B, Deng R, Wang A, Zhang G Tags: Acta Virol Source Type: research

Vitamin D and allergic airway disease shape the murine lung microbiome in a sex-specific manner
Vitamin D is under scrutiny as a potential regulator of the development of respiratory diseases characterised by chronic lung inflammation, including asthma and chronic obstructive pulmonary disease. It has an... (Source: Respiratory Research)
Source: Respiratory Research - September 21, 2016 Category: Respiratory Medicine Authors: Michael Roggenbuck, Denise Anderson, Kenneth Klingenberg Barfod, Martin Feelisch, Sian Geldenhuys, S øren J. Sørensen, Clare E. Weeden, Prue H. Hart and Shelley Gorman Source Type: research

The Use of Polymerase Chain Reaction Amplification for the Detection of Viruses and Bacteria in Severe Community-Acquired Pneumonia
Conclusions: Viruses and bacteria were detected in 7 of 10 patients with severe CAP with the aid of PCR amplification. Viral infection appears to be independently associated with lower mortality.Respiration (Source: Respiration)
Source: Respiration - September 21, 2016 Category: Respiratory Medicine Source Type: research

Relationships Among Maternal Stress and Depression, Type 2 Responses, and Recurrent Wheezing at Age 3 Years in Low Income Urban Families.
CONCLUSIONS: In urban children at high risk for asthma, maternal perceived stress and depression were significantly associated with recurrent wheezing, but not increased atopy or reduced antiviral responses. PMID: 27654103 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 21, 2016 Category: Respiratory Medicine Authors: Ramratnam SK, Visness CM, Jaffee KF, Bloomberg GR, Kattan M, Sandel MT, Wood RA, Gern JE, Wright RJ Tags: Am J Respir Crit Care Med Source Type: research

Physical Activity, Air Pollution and the Risk of Asthma and Chronic Obstructive Pulmonary Disease.
CONCLUSIONS: Increased exposure to air pollution during exercise does not outweigh beneficial effects of physical activity on the risk of asthma and COPD. PMID: 27653737 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 21, 2016 Category: Respiratory Medicine Authors: Fisher JE, Loft S, Ulrik CS, Raaschou-Nielsen O, Hertel O, Tjønneland A, Overvad K, Nieuwenhuijsen MJ, Andersen ZJ Tags: Am J Respir Crit Care Med Source Type: research

Comparison of Echocardiographic Indices Used to Predict Fluid Responsiveness in Ventilated Patients.
CONCLUSIONS: ∆VmaxAo had the best sensitivity and ∆SVC the best specificity in predicting fluid responsiveness. ∆SVC had a greater diagnostic accuracy than ∆IVC and ∆PP but its measurement requires transesophageal echocardiography. PMID: 27653798 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 21, 2016 Category: Respiratory Medicine Authors: Vignon P, Repessé X, Bégot E, Léger J, Jacob C, Bouferrache K, Slama M, Prat G, Vieillard-Baron A Tags: Am J Respir Crit Care Med Source Type: research

Environment, Global Climate Change, and Cardiopulmonary Health.
Abstract There is widespread agreement among scientists that climate change, primarily due to greenhouse gas (GHG) production from human activities, is causing significant global health impacts.The focus of this Pulmonary Perspective is to highlight emerging evidence for cardio-respiratory health impacts related to climate change, and to suggest possible strategies for individual and collective responses to this threat. Adaptation and mitigation strategies, along with co-benefits of these actions, are also discussed. The association between heat stress and cardiopulmonary mortality is well established. Hot and dri...
Source: American Journal of Respiratory and Critical Care Medicine - September 21, 2016 Category: Respiratory Medicine Authors: Bayram H, Bauer AK, Abdalati W, Carlsten C, Pinkerton KE, Thurston GD, Balmes JR, Takaro TK Tags: Am J Respir Crit Care Med Source Type: research

Translational Aspects of the Human Respiratory Virome.
Abstract Despite the dominant role of community acquired respiratory viruses (CARV) as etiological agents of disease, there has been little focus to date on the translation of rapidly developing diagnostic modalities, such as next generation sequencing techniques (NGS) in the examination of lower respiratory tract samples. When applied, these techniques should inform strategies to both understand the nexus between health and disease states of the respiratory virome, and drive a paradigm shift in how the practicing pulmonologist views the conceptual framework of respiratory infections. The lower respiratory tract w...
Source: American Journal of Respiratory and Critical Care Medicine - September 21, 2016 Category: Respiratory Medicine Authors: Mitchell AB, Oliver BG, Glanville AR Tags: Am J Respir Crit Care Med Source Type: research

Adverse Childhood Experiences and Autonomic Regulation in Response to Acute Stress: the Role of the Sympathetic and Parasympathetic Nervous Systems.
CONCLUSIONS: ACEs were associated with down-regulation in a measure of sympathetic but no alteration in a measure of parasympathetic cardiovascular stress reactivity in adulthood. Future research will need to clarify whether this indicates increased risk for negative health outcomes or stress resistance and resilience. PMID: 27653030 [PubMed - as supplied by publisher] (Source: Anxiety, Stress, and Coping)
Source: Anxiety, Stress, and Coping - September 21, 2016 Category: Psychiatry & Psychology Authors: Winzeler K, Voellmin A, Hug E, Kirmse U, Helmig S, Princip M, Cajochen C, Bader K, Wilhelm FH Tags: Anxiety Stress Coping Source Type: research

Highlights of the 11th International Bordetella Symposium: from Basic Biology to Vaccine Development.
Abstract Pertussis is a severe respiratory disease caused by infection with the bacterial pathogen Bordetella pertussis The disease affects individuals of all ages but is particularly severe and sometimes fatal in unvaccinated young infants. Other Bordetella species cause diseases in humans, animals and birds. Scientific, clinical, public health, vaccine company and regulatory agency experts on these pathogens and diseases gathered in Buenos Aires, Argentina from 5 to 8 April 2016 for the 11th International Bordetella Symposium to discuss recent advances in our understanding of the biology of these organisms, the ...
Source: Clinical and Vaccine Immunology - September 21, 2016 Category: Allergy & Immunology Authors: Carbonetti NH, Wirsing von König CH, Lan R, Jacob-Dubuisson F, Cotter PA, Deora R, Merkel TJ, van Els CA, Locht C, Hozbor D, Rodriguez ME Tags: Clin Vaccine Immunol Source Type: research

Pulmonary Manifestations of Acute Lung Injury: More Than Just Diffuse Alveolar Damage.
Conclusions .- Acute pulmonary injury is a significant cause of morbidity and mortality. In addition to diffuse alveolar damage, pathologists should be aware of alternate histologic patterns of lung disease that may present with a similar clinical presentation because this may impact treatment decisions and disease outcome. PMID: 27652982 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - September 21, 2016 Category: Laboratory Medicine Authors: Hughes KT, Beasley MB Tags: Arch Pathol Lab Med Source Type: research

ESAT-6 Drives MMP-10 Gene Expression and Secretion in Tuberculosis.
Abstract Tuberculosis (TB) causes disease worldwide and multi-drug resistance is an increasing problem. Matrix metalloproteinases (MMPs), particularly the collagenase MMP-1, cause lung extracellular matrix destruction which drives disease transmission and morbidity. The role in such tissue damage of the stromelysin MMP-10, a key activator of the collagenase MMP-1, was investigated in direct Mycobacterium tuberculosis (Mtb) infected macrophages and in conditioned medium from Mtb infected monocytes (CoMtb)-stimulated cells. Mtb infection increased MMP-10 secretion from primary human macrophages 29-fold, while CoMtb ...
Source: American Journal of Respiratory Cell and Molecular Biology - September 21, 2016 Category: Molecular Biology Authors: Brilha S, Sathyamoorthy T, Stuttaford LH, Walker NF, Wilkinson RJ, Singh S, Moores RC, Elkington PT, Friedland JS Tags: Am J Respir Cell Mol Biol Source Type: research

Immunotherapy Added to Antibiotic Treatment Reduces Relapse of Disease in a Mouse Model of Tuberculosis.
CONCLUSIONS: We demonstrate in a mouse model of pulmonary tuberculosis that immunotherapy consisting of three clinically approved drugs can improve the therapeutic efficacy of standard antibiotic treatment. PMID: 27654457 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - September 21, 2016 Category: Molecular Biology Authors: Mourik BC, Leenen PJ, de Knegt GJ, Huizinga R, van der Eerden BC, Wang J, Krois CR, Napoli JL, Bakker-Woudenberg IA, de Steenwinkel JE Tags: Am J Respir Cell Mol Biol Source Type: research

Nasal High-Flow Therapy for Primary Respiratory Support in Preterm Infants
New England Journal of Medicine,Volume 375, Issue 12, Page 1142-1151, September 2016. (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - September 21, 2016 Category: Internal Medicine Authors: Calum T. Roberts Louise S. Owen Brett J. Manley Dag H. Fr øisland Susan M. Donath Kim M. Dalziel Margo A. Pritchard David W. Cartwright Clare L. Collins Atul Malhotra Peter G. Davis Source Type: research

Membrane progesterone receptor-{beta}, but not -{alpha}, in dorsal brain stem establishes sex-specific chemoreflex responses and reduces apnea frequency in adult mice
We tested the hypothesis that membrane progesterone receptors (mPR) contribute to respiratory control in adult male and female mice. Mice were implanted with osmotic minipumps for continuous infusion of small interfering RNA (siRNA) directed against mPRα, mPRβ, or a control solution in the fourth ventricle (to target brain stem respiratory areas) for 14 days. We then performed respiratory and metabolic recordings by whole body plethysmography at rest and in response to hypoxia (12% O2) or hypercapnia (5% CO2, 5 min each). For each treatment, we have verified with immunohistochemistry that the staining intensity ...
Source: Journal of Applied Physiology - September 21, 2016 Category: Physiology Authors: Boukari, R., Rossignol, O., Baldy, C., Marcouiller, F., Bairam, A., Joseph, V. Tags: ARTICLES Source Type: research

Effect of betamethasone, surfactant, and positive end-expiratory pressures on lung aeration at birth in preterm rabbits
Antenatal glucocorticoids, exogenous surfactant, and positive end-expiratory pressure (PEEP) ventilation are commonly provided to preterm infants to enhance respiratory function after birth. It is unclear how these treatments interact to improve the transition to air-breathing at birth. We investigated the relative contribution of antenatal betamethasone, prophylactic surfactant, and PEEP (3 cmH2O) on functional residual capacity (FRC) and dynamic lung compliance (CDL) in preterm (28 day GA) rabbit kittens at birth. Kittens were delivered by cesarean section and mechanically ventilated. FRC was calculated from X-ray images...
Source: Journal of Applied Physiology - September 21, 2016 Category: Physiology Authors: Crawshaw, J. R., Hooper, S. B., te Pas, A. B., Allison, B. A., Wallace, M. J., Kerr, L. T., Lewis, R. A., Morley, C. J., Leong, A. F., Kitchen, M. J. Tags: ARTICLES Source Type: research

It's all in the gills: evaluation of O2 uptake in Pacific hagfish refutes a major respiratory role for the skin [SHORT COMMUNICATION]
Alexander M. Clifford, Alex M. Zimmer, Chris M. Wood, and Greg G. Goss Hagfish skin has been reported as an important site for ammonia excretion and as the major site of systemic oxygen acquisition. However, whether cutaneous O2 uptake is the dominant route of uptake remains under debate; all evidence supporting this hypothesis has been derived using indirect measurements. Here, we used partitioned chambers and direct measurements of oxygen consumption and ammonia excretion to quantify cutaneous and branchial exchanges in Pacific hagfish (Eptatretus stoutii) at rest and following exhaustive exercise. Hagfish primarily rel...
Source: Journal of Experimental Biology - September 21, 2016 Category: Biology Authors: Clifford, A. M., Zimmer, A. M., Wood, C. M., Goss, G. G. Tags: SHORT COMMUNICATION Source Type: research

Effect of Systemic Lupus Erythematosus on the Risk of Incident Respiratory Failure: A National Cohort Study
ConclusionPatients with SLE are associated with an increased risk of incident respiratory failure, regardless of their age, sex, and pre-existing comorbidities; especially medical services with higher frequency. (Source: PLoS One)
Source: PLoS One - September 21, 2016 Category: Biomedical Science Authors: Jun-Jun Yeh Source Type: research

Etiology of Influenza-Like Illnesses from Sentinel Network Practitioners in R éunion Island, 2011-2012
In conclusion, this study highlights a substantial circulation of multiple respiratory pathogens in Réunion Is land throughout the year. It shows that ILI are not only attributable to influenza and underlines the need for biological surveillance. As the use of multiplex RT-PCR showed its efficacy, it is now used routinely in the surveillance of ILI. (Source: PLoS One)
Source: PLoS One - September 21, 2016 Category: Biomedical Science Authors: Elise Brottet Source Type: research

Isolation of yeast complex IV in native lipid nanodiscs
Publication date: December 2016 Source:Biochimica et Biophysica Acta (BBA) - Biomembranes, Volume 1858, Issue 12 Author(s): Irina A. Smirnova, Dan Sjöstrand, Fei Li, Markus Björck, Jacob Schäfer, Henrik Östbye, Martin Högbom, Christoph von Ballmoos, Gabriel C. Lander, Pia Ädelroth, Peter Brzezinski We used the amphipathic styrene maleic acid (SMA) co-polymer to extract cytochrome c oxidase (CytcO) in its native lipid environment from S. cerevisiae mitochondria. Native nanodiscs containing one CytcO per disc were purified using affinity chromatography. The longest cross-sections of the native nanodiscs were 11nm×14n...
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - September 21, 2016 Category: Biochemistry Source Type: research

Characterization of a Mouse Model of Oral Potassium Cyanide Intoxication
Potassium cyanide (KCN) is an inhibitor of cytochrome C oxidase causing rapid death due to hypoxia. A well-characterized model of oral KCN intoxication is needed to test new therapeutics under the Food and Drug Administration Animal Rule. Clinical signs, plasma pH and lactate concentrations, biomarkers, histopathology, and cyanide and thiocyanate toxicokinetics were used to characterize the pathology of KCN intoxication in adult and juvenile mice. The acute oral LD50s were determined to be 11.8, 11.0, 10.9, and 9.9 mg/kg in water for adult male, adult female, juvenile male, and juvenile female mice, respectively. The time ...
Source: International Journal of Toxicology - September 21, 2016 Category: Toxicology Authors: Sabourin, P. J., Kobs, C. L., Gibbs, S. T., Hong, P., Matthews, C. M., Patton, K. M., Sabourin, C. L., Wakayama, E. J. Tags: Regular Articles Source Type: research

The asthma-anxiety connection
The literature reports a significant association between various mental disorders and asthma, in particular depression and/or anxiety, with some more robust data regarding anxiety disorders. However, the nature of this association remains largely unclear. (Source: Respiratory Medicine)
Source: Respiratory Medicine - September 21, 2016 Category: Respiratory Medicine Authors: Stefano R. Del Giacco, Alessandra Cappai, Luisanna Gambula, Stefano Cabras, Silvia Perra, Paolo Emilio Manconi, Bernardo Carpiniello, Federica Pinna Source Type: research

The architecture of respiratory supercomplexes
Nature advance online publication 21 September 2016. doi:10.1038/nature19774 Authors: James A. Letts, Karol Fiedorczuk & Leonid A. Sazanov (Source: Nature AOP)
Source: Nature AOP - September 21, 2016 Category: Research Authors: James A. Letts Karol Fiedorczuk Leonid A. Sazanov Tags: Article Source Type: research

Systematic literature review on effectiveness of self ‐management support interventions in patients with chronic conditions and low socio‐economic status
ConclusionLimited evidence was found for the effectiveness of self‐management support interventions in chronic ill patients with low socio‐economic status. Essential characteristics and component(s) of effective self‐management support interventions for these patients could not be detected. Rigorous reporting on development and underlying theories of health behavioural components in the intervention is recommended.This article is protected by copyright. All rights reserved. (Source: Journal of Advanced Nursing)
Source: Journal of Advanced Nursing - September 21, 2016 Category: Nursing Authors: A Van Hecke, M Heinen, P Fern ández‐Ortega, M Graue, J Hendriks, B Høy, S Köpke, M Lithner, B van Gaal Tags: Review Source Type: research

Respiratory variation in tricuspid valve regurgitant orifice: a three-dimensional transthoracic echocardiographic perspective
(Source: European Journal of Echocardiography)
Source: European Journal of Echocardiography - September 21, 2016 Category: Cardiology Authors: Agmon, Y., Caspi, O. Tags: Image Focus Source Type: research

Postoperative pain management of liver transplantation in cystic fibrosis: Is it time to start US-guided neuraxial blocks ?
We report the first case of continuous thoracic epidural analgesia after pediatric liver transplantation in a 10-year-old boy affected with CF with macronodular cirrhosis. Despite a challenging coagulation profile, the echo-assisted procedure was safely performed and allowed extubation in the odds ratio, postoperative awakening and comfort, and quick resumption of respiratory physiotherapy. (Source: Saudi Journal of Anaesthesia)
Source: Saudi Journal of Anaesthesia - September 21, 2016 Category: Anesthesiology Authors: M Piazza G Martucci A Arcadipane Source Type: research

European Consensus Guidelines on the Management of Respiratory Distress Syndrome - 2016 Update.
We report the third update of the European Guidelines for the Management of RDS by a European panel of expert neonatologists including input from an expert perinatal obstetrician based on available literature up to the beginning of 2016. Optimizing the outcome for babies with RDS includes consideration of when to use antenatal steroids, and good obstetric practice includes methods of predicting the risk of preterm delivery and also consideration of whether transfer to a perinatal centre is necessary and safe. Methods for optimal delivery room management have become more evidence based, and protocols for lung protection, in...
Source: Neonatology - September 21, 2016 Category: Perinatology & Neonatology Authors: Sweet DG, Carnielli V, Greisen G, Hallman M, Ozek E, Plavka R, Saugstad OD, Simeoni U, Speer CP, Vento M, Visser GH, Halliday HL Tags: Neonatology Source Type: research

Strategies to broaden the cross-protective efficacy of vaccines against porcine reproductive and respiratory syndrome virus
This article summarizes the impediments for the development of a highly protective PRRS vaccine and reviews the vaccinology approaches that have been attempted to overcome one of the most formidable challenges, which is the substantial genetic variation among PRRSV isolates, to broaden the antigenic coverage of PRRS vaccines. (Source: Veterinary Microbiology)
Source: Veterinary Microbiology - September 21, 2016 Category: Veterinary Research Source Type: research

Rapid detection of viral antibodies based on multifunctional Staphylococcus aureus nanobioprobes
In this study, a simple way to conjugate antigens to the S. aureus nanobioparticles was developed by utilizing a cell wall binding domain (CBD) from a bacteriophage lysin PlyV12. Based on this novel design, simple agglutination tests of the IgG antibodies of Ebola virus (EBOV) nucleoprotein (NP) and Middle East Respiratory Virus (MERS) NP in rabbit sera were successfully developed by conjugating the S. aureus nanobioparticles with two fusion proteins EBOV NP- CBD and MERS NP-CBD, respectively. The conjugation was done easily by just mixing the fusion proteins with the S. aureus nanoparticles. The detection time was within ...
Source: Enzyme and Microbial Technology - September 21, 2016 Category: Biotechnology Source Type: research

The differential effects of azithromycin on the airway epithelium in  vitro and in vivo
Abstract Macrolides including azithromycin (AZM) can improve clinical symptoms in asthma regardless of infection status. The mechanisms underlying these beneficial effects are yet to be elucidated. The aim of this study was to determine the effect of AZM on the airway epithelial barrier both in an in vitro model and in patients with asthma. Primary human bronchial epithelial cells (HBEC) were grown at air liquid interface (ALI) and challenged using lipopolysaccharides from Pseudomonas aeruginosa. AZM was added at various stages and barrier integrity assessed using transepithelial electrical resistance (TEER) and permeabil...
Source: Physiological Reports - September 21, 2016 Category: Physiology Authors: Mariel Slater, Elizabeth Torr, Tim Harrison, Doug Forrester, Alan Knox, Dominick Shaw, Ian Sayers Tags: Original Research Source Type: research

Structural and functional characterisation of the cyanobacterial PetC3 Rieske protein family
Publication date: Available online 20 September 2016 Source:Biochimica et Biophysica Acta (BBA) - Bioenergetics Author(s): Sebastian Veit, Kazuki Takeda, Yuichi Tsunoyama, Frauke Baymann, Reinat Nevo, Ziv Reich, Matthias Rögner, Kunio Miki, Sascha Rexroth The cyanobacterium Synechocystis PCC 6803 possesses three Rieske isoforms: PetC1, PetC2 and PetC3. While PetC1 and PetC2 have been identified as alternative subunits of the cytochrome b 6 f complex (b 6 f), PetC3 was localized exclusively within the plasma membrane. The spatial separation of PetC3 from the photosynthetic and respiratory protein complexes raises doubt in...
Source: Biochimica et Biophysica Acta (BBA) Bioenergetics - September 21, 2016 Category: Biochemistry Source Type: research

Doxycycline poudrage: An old agent for a new technique
Conclusion Doxycycline, as an old agent, when poudraged during medical thoracoscopy proved to be safe and effective agent for pleurodesis in symptomatic malignant pleural effusion. (Source: Egyptian Journal of Chest Diseases and Tuberculosis)
Source: Egyptian Journal of Chest Diseases and Tuberculosis - September 21, 2016 Category: Respiratory Medicine Source Type: research

Defining morphology of periodic leg movements in sleep: an evidence-based definition of a minimum window of sustained activity
ConclusionAn added criterion requiring 0.5  s of high EMG activity within a valid CLM improves the accuracy of automatic scoring algorithms in relation to the gold standard of expert visual scorers. Our results suggest that this rule is an accurate representation of the morphology feature used by experts. This new rule has the potential to improve consistency and accuracy of visual and automatic scoring of PLM. (Source: Sleep and Breathing)
Source: Sleep and Breathing - September 21, 2016 Category: Respiratory Medicine Source Type: research

Effect of Maternal Influenza Vaccination on Hospitalization for Respiratory Infections in Newborns: A Retrospective Cohort Study
Conclusions: Maternal influenza vaccination was associated with a reduction in the incidence of hospital admission for acute respiratory illness among infants (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - September 20, 2016 Category: Infectious Diseases Tags: Original Studies Source Type: research

Limited Evidence on the Management of Respiratory Tract Infections in Down’s Syndrome: A Systematic Review
Conclusions: The evidence base for the management of RTIs in people with Down’s syndrome is incomplete; current studies included children only and carry a moderate to serious risk of bias. Methodologic rigorous studies are warranted to guide clinicians in how best to prevent and treat RTIs in children with Down’s syndrome. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - September 20, 2016 Category: Infectious Diseases Tags: Original Studies Source Type: research