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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 20.

Standardization procedure for the nasal nitric oxide measurement method using Niox MINO ® and the tidal-breathing technique with velum-closure.
This study allows us to confirm that we have been able to establish the normal range of nitric oxide quantity produced in the nasal/sinus cavities of healthy individuals using the Niox MINO Nasal® device and tidal-breathing with velum-closure manoeuvre. PMID: 27655510 [PubMed - as supplied by publisher] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - September 23, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Gaps in health research in the Dominican Republic.
Conclusions Limited research is directed toward addressing the health needs of Dominicans. The ongoing process of setting priorities for health research in the Dominican Republic should direct its efforts toward fixing this imbalance. PMID: 27657182 [PubMed - as supplied by publisher] (Source: Pan American Journal of Public Health)
Source: Pan American Journal of Public Health - September 23, 2016 Category: Global & Universal Tags: Rev Panam Salud Publica Source Type: research

Trends and current status of general thoracic surgery in Japan revealed by review of nationwide databases.
Authors: Okumura M Abstract Nationwide databases of cases treated for thoracic disease have been established by several academic associations in Japan, which contain information showing trends and current status in regard to surgical treatment. The Japanese Association of Thoracic Surgery (JATS), Japanese Association of Chest Surgery (JACS), Japan Lung Cancer Society (JLCS), Japanese Respiratory Society (JRS), and Japan Society for Respiratory Endoscopy (JSRE) have maintained databases of lung cancer cases treated in Japan. In 1986, the number of general thoracic surgery cases was 15,544, which increased to 75,306 ...
Source: Journal of Thoracic Disease - September 23, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Extraordinary stability of hemocyanins from L. polyphemus and E. californicum studied by Infrared Spectroscopy from 294 to 20 K
Phys. Chem. Chem. Phys., 2016, Accepted Manuscript DOI: 10.1039/C6CP03510H, PaperMireille Khalil, Zahia Boubegtiten, Nadja Hellmann, Petra Hellwig Hemocyanins are large oligomeric respiratory proteins found in many arthropods and molluscs. Here we give infrared spectroscopic evidence of a high stability towards exposure to sub-zero temperatures for hemocyanin from... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Phys. Chem. Chem. Phys. latest articles)
Source: RSC - Phys. Chem. Chem. Phys. latest articles - September 23, 2016 Category: Chemistry Authors: Mireille Khalil Source Type: research

Comparison of V[Combining Dot Above]O2peak and Achievement of V[Combining Dot Above]O2peak Criteria in Three Modes of Exercise in Female Triathletes
Abstract: Snoza, CT, Berg, KE, and Slivka, DR. Comparison of V[Combining Dot Above]O2peak and achievement of V[Combining Dot Above]O2peak criteria in three modes of exercise in female triathletes. J Strength Cond Res 30(10): 2816–2822, 2016—The purpose of this study was to compare peak aerobic capacity in female triathletes in 3 modes of exercise: treadmill, cycle, and arm ergometer. A second purpose was to determine the extent that physiologic criteria for achieving V[Combining Dot Above]O2peak were reached in each mode of exercise. Six criteria were examined: V[Combining Dot Above]O2 plateau, heart rate (HR), blood l...
Source: Journal of Strength and Conditioning Research - September 23, 2016 Category: Sports Medicine Tags: Original Research Source Type: research

Should We Let Sleeping Dogs Lie? Controversies of Treating Central Sleep Apnoea in HFrEF Following the SERVE-HF Study
Central sleep apnoea (CSA) is characterised by cycles of apnoea, hypopnoea and hyperpnoea during sleep due to abnormalities in the regulation of breathing within the respiratory centre in the brainstem. CSA, defined as an apnoea –hypopnoea index (AHI) of ≥15 events/h, is common in patients with heart failure (HF), with a prevalence of 20–45 %.1, 2 Its presence is reported to be a marker of severity of HF. It is also described in some studies to be independently associated with increased morbidity and mortality rates in patients with HF.3 (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - September 23, 2016 Category: Cardiology Authors: mehul Source Type: research

Cancer cachexia, sarcopenia and biochemical markers in patients with advanced non-small cell lung cancer —chemotherapy toxicity and prognostic value
ConclusionsAlbumin level has been shown to be more important predictive marker of chemotherapy toxicity and survival than cachexia and sarcopenia are. This approach in clinical settings can be used to guide the choice of oncologic treatment. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - September 23, 2016 Category: Cancer & Oncology Source Type: research

Economic evaluation of procalcitonin-guided antibiotic therapy in acute respiratory infections: a Chinese hospital system perspective
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM) Issue: Ahead of print (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - September 23, 2016 Category: Laboratory Medicine Source Type: research

Baicalin attenuates bleomycin-induced pulmonary fibrosis via adenosine A2a receptor related TGF- β1-induced ERK1/2 signaling pathway
Baicalin has been reported to have anti-fibrosis effect; however, its mechanism still remains to be elucidated. Adenosine A2a receptor (A2aR) is a novel inflammation regulator, and transforming growth factor- β... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - September 23, 2016 Category: Respiratory Medicine Authors: Xiaoying Huang, Yicheng He, Yanfan Chen, Peiliang Wu, Di Gui, Hui Cai, Ali Chen, Mayun Chen, Caijun Dai, Dan Yao and Liangxing Wang Source Type: research

Flexible growing rods: a biomechanical pilot study of polymer rod constructs in the stability of skeletally immature spines
Surgical treatments for early onset scoliosis (EOS) correct curvatures and improve respiratory function but involve many complications. A distractible, or ‘growing rod,’ implant construct that is more flexible... (Source: Scoliosis)
Source: Scoliosis - September 23, 2016 Category: Orthopaedics Authors: Donita I. Bylski-Austrow, David L. Glos, Anne C. Bonifas, Max F. Carvalho, Matthew C. Coombs and Peter F. Sturm Source Type: research

Eligibility of real-life patients with COPD for inclusion in trials of inhaled long-acting bronchodilator therapy
Management guidelines of chronic obstructive pulmonary disease (COPD) are mainly based on results of randomised controlled trials (RCTs), but some authors have suggested limited representativeness of patients ... (Source: Respiratory Research)
Source: Respiratory Research - September 23, 2016 Category: Respiratory Medicine Authors: David M. G. Halpin, Marjan Kerkhof, Joan B. Soriano, Helga Mikkelsen and David B. Price Source Type: research

Complete genomic sequence and comparative analysis of four genital and respiratory isolates of bovine herpesvirus subtype 1.2b (BoHV-1.2b), including the prototype virus strain K22
We report here the complete genomic sequence of four BoHV-1.2b isolates. The DNA sequence identity of the four genomes is 98.9  %. Differences were primarily in regions containing direct repeats, specifically gene UL36 and the terminal repeat regions immediately flanking gene BICP22. BoHV-1.2b and BoHV-1.1 genomes are similar in size (~135 kb), completely orthologous with respect to regional structure and gene location, a nd have a 97.5 % DNA sequence homology. The most notable difference is the structure of the DNA replication origin of the two viruses. (Source: Archives of Virology)
Source: Archives of Virology - September 23, 2016 Category: Virology Source Type: research

Pulmonary artery perfusion versus no pulmonary perfusion during cardiopulmonary bypass in patients with COPD: a randomised clinical trial.
DISCUSSION: Pulmonary artery perfusion with normothermic oxygenated blood during cardiopulmonary bypass appears to improve postoperative oxygenation in patients with COPD undergoing cardiac surgery. Pulmonary artery perfusion with hypothermic HTK solution does not seem to improve postoperative oxygenation. TRIAL REGISTRATION NUMBER: NCT01614951; Pre-results. PMID: 27651908 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - September 23, 2016 Category: Respiratory Medicine Authors: Buggeskov KB, Sundskard MM, Jonassen T, Andersen LW, Secher NH, Ravn HB, Steinbrüchel DA, Jakobsen JC, Wetterslev J Tags: BMJ Open Respir Res Source Type: research

Pre-Frailty, frailty, and multimorbidity: Prevalences and associated characteristics from two French national surveys
ConclusionOur study highlights that in France, among individuals older than 55 years-old and free of disability, around 25% are either frail or multimorbid; another 30% to 40% being pre-frail. Pre-frailty, frailty and multimorbidity are known to be associated with adverse health outcomes and important economic costs. The health system must adapt to respond to the needs of its aging population. In addition, given the efficient impact of prevention actions, our findings emphasize the need to implement prevention strategies against Frailty and multimorbidity in France. (Source: The Journal of Nutrition, Health and Aging)
Source: The Journal of Nutrition, Health and Aging - September 23, 2016 Category: Nutrition Source Type: research

RIFM fragrance ingredient safety assessment, linalyl benzoate, CAS Registry Number 126-64-7.
Abstract The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic. Data from the suitable read across analog linalyl phenylacetate (CAS # 7143-69-3) show that this material does not have skin sensitization potential. The repeated dose toxicity endpoint was completed using linalyl cinnamate (CAS # 78-37-5) as a suitab...
Source: Food and Chemical Toxicology - September 23, 2016 Category: Food Science Authors: Api AM, Belsito D, Bhatia S, Bruze M, Calow P, Dagli ML, Dkant W, Fryer AD, Kromidas L, LA Cava S, Lalko JF, Lapczynski A, Liebler DC, Penning TM, Politano VT, Ritacco G, Salvito D, Schultz TW, Shen J, Sipes IG, Wall B, Wilcox DK Tags: Food Chem Toxicol Source Type: research

Evaluating targeted interventions via meta-population models with multi-level mixing.
Abstract Among the several means by which heterogeneity can be modeled, Levins' (1969) meta-population approach preserves the most analytical tractability, a virtue to the extent that generality is desirable. When model populations are stratified, contacts among their respective sub-populations must be described. Using a simple meta-population model, Feng et al. (2015) showed that mixing among sub-populations, as well as heterogeneity in characteristics affecting sub-population reproduction numbers, must be considered when evaluating public health interventions to prevent or control infectious disease outbreaks. T...
Source: Mathematical Biosciences - September 23, 2016 Category: Statistics Authors: Feng Z, Hill AN, Curns AT, Glasser JW Tags: Math Biosci Source Type: research

A global assessment of phthalates burden and related links to health effects.
Abstract Phthalates are ubiquitous environmental contaminants which are used in industry as plasticizers and additives in cosmetics. They are classified as Endocrine Disrupting Chemicals (EDCs) which impair the human endocrine system inducing fertility problems, respiratory diseases, childhood obesity and neuropsychological disorders. The aim of this review is to summarize the current state of knowledge on the toxicity that phthalates pose in humans based on human biomonitoring studies conducted over the last decade. Except for conventional biological matrices (such as urine and serum), amniotic fluid, human milk,...
Source: Environment International - September 23, 2016 Category: Environmental Health Authors: Katsikantami I, Sifakis S, Tzatzarakis MN, Vakonaki E, Kalantzi OI, Tsatsakis AM, Rizos AK Tags: Environ Int Source Type: research

Macitentan improves health-related quality of life for patients with pulmonary arterial hypertension: results from the randomized controlled SERAPHIN trial.
CONCLUSIONS: Macitentan significantly improved HRQoL in PAH patients compared with placebo and significantly reduced the risk of a clinically meaningful HRQoL deterioration. An association between better baseline HRQoL and improved long-term outcomes was shown. PMID: 27671974 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - September 23, 2016 Category: Respiratory Medicine Authors: Mehta S, Sastry BK, Souza R, Torbicki A, Ghofrani HA, Channick RN, Delcroix M, Pulido T, Simonneau G, Wlodarczyk J, Rubin LJ, Jansa P, Hunsche E, Galiè N, Perchenet L, Sitbon O Tags: Chest Source Type: research

Red Blood Cell Distribution Width in Patients With Chronic Obstructive Pulmonary Disease and Healthy Subjects.
CONCLUSION: RDW is independently associated with CVD and RVD in patients with COPD. In the healthy population, RDW is also associated with smoking status. PMID: 27670684 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - September 23, 2016 Category: Respiratory Medicine Authors: Ozgul G, Seyhan EC, Özgül MA, Günlüoğlu MZ Tags: Arch Bronconeumol Source Type: research

[Purple drank: A dangerous cocktail].
We report the effects of this new risky behavior in three patients: a 14-year-old girl and her boyfriend, both found in an initial state of drowsiness, followed by hallucinations and anticholinergic toxidrome; and another teenager whose chronic use led to addiction with increasing doses. It is important to identify signs of such intoxication and to inform patients about the risks of respiratory depression, drowsiness, and delirium linked to acute medication misuse. PMID: 27670723 [PubMed - as supplied by publisher] (Source: Archives de Pediatrie)
Source: Archives de Pediatrie - September 23, 2016 Category: Pediatrics Authors: Garcin L, Le Roch M, Agbessi CA, Lobut JB, Lecoeur A, Benoist G Tags: Arch Pediatr Source Type: research

A two-generation inhalation reproductive toxicity study upon the exposure to manganese chloride.
The objective of this study was therefore to investigate if these findings can be replicated using the Sprague Dawley rat and, if so, to identify those parts of the reproductive system are more susceptible. Male and female rats were exposed to manganese dichloride (MnCl2) via inhalation at concentrations of 0 (air-control); 5, 10 and 20μg/L air over 10 weeks (F0) and over 11 weeks (F1) prior to mating, and then throughout mating, gestation and lactation until termination after the F1 and F2 generation had reached Day 21 of lactation respectively. Animals were monitored for clinical signs of toxicity and for effects on bod...
Source: Neurotoxicology - September 23, 2016 Category: Neurology Authors: McGough D, Jardine L Tags: Neurotoxicology Source Type: research

Sphingobacterium cibi sp. nov., isolated from the food-waste compost, and emended descriptions of Sphingobacterium spiritivorum (Holmes et al., 1982) Yabuuchi et al. (1983) and S. thermophilum Yabe et al. (2013).
Abstract A novel, pale yellow-colored, Gram-staining-negative, aerobic, rod-shaped and non-motile bacterium, designated strain CC-YY411T, was isolated from the food-waste compost and subjected to polyphasic taxonomy. Strain CC-YY411T exhibited highest pair-wise 16S rRNA gene sequence similarity to Sphingobacterium thermophilum JCM 17588T (94.6 %) while sharing 94.1-89.7 % similarities with other Sphingobacterium species. Novel strain established a discrete phylogenetic lineage within the clade that accommodated validly established members of the genus Sphingobacterium. The polar lipid profile of strain CC-YY411T c...
Source: International Journal of Systematic and Evolutionary Microbiology - September 23, 2016 Category: Microbiology Authors: Lai WA, Hameed A, Liu YC, Hsu YH, Lin SY, Young CC Tags: Int J Syst Evol Microbiol Source Type: research

An arsenate-reducing and alkane-metabolizing novel bacterium, Rhizobium arsenicireducens sp. nov., isolated from arsenic-rich groundwater.
Abstract A novel arsenic (As)-resistant, arsenate-respiring, alkane-metabolizing bacterium KAs 5-22(T), isolated from As-rich groundwater of West Bengal was characterized by physiological and genomic properties. Cells of strain KAs 5-22(T) were Gram-stain-negative, rod-shaped, motile, and facultative anaerobic. Growth occurred at optimum of pH 6.0-7.0, temperature 30 °C. 16S rRNA gene affiliated the strain KAs 5-22(T) to the genus Rhizobium showing maximum similarity (98.4 %) with the type strain of Rhizobium naphthalenivorans TSY03b(T) followed by (98.0 % similarity) Rhizobium selenitireducens B1(T). The geno...
Source: Archives of Microbiology - September 23, 2016 Category: Microbiology Authors: Mohapatra B, Sarkar A, Joshi S, Chatterjee A, Kazy SK, Maiti MK, Satyanarayana T, Sar P Tags: Arch Microbiol Source Type: research

Regulation of pulmonary endothelial barrier function by kinases.
Abstract The pulmonary endothelium is the target of continuous physiologic and pathologic stimuli that affect its crucial barrier function. The regulation, defense and repair of endothelial barrier function require complex biochemical processes. This review examines the role of endothelial phosphorylating enzymes, kinases, a class with profound, interdigitating influences on endothelial permeability and lung function. PMID: 27663990 [PubMed - as supplied by publisher] (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - September 23, 2016 Category: Respiratory Medicine Authors: Barabutis N, Verin AD, Catravas JD Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Correction of Lung Inflammation in a F508del CFTR murine Cystic Fibrosis model by the Sphingosine-1-Phosphate Lyase Inhibitor LX2931.
Abstract Progressive lung disease with early onset is the main cause of mortality and morbidity in Cystic Fibrosis patients. Here we report a reduction of Sphingosine-1-Phosphate (S1P) in the lung of unchallenged Cftrtm1EUR F508del CFTR mutant mice. This correlates with enhanced infiltration by inducible nitric oxide synthase (iNOS) expressing granulocytes, B- and T-cells. Furthermore, the ratio of macrophage derived dendritic cells (MoDC) to conventional dendritic cells (cDC) is higher in mutant mouse lung, consistent with unprovoked inflammation. Oral application of a S1P-lyase inhibitor (LX2931), increases S1P ...
Source: Am J Physiol Lung Ce... - September 23, 2016 Category: Respiratory Medicine Authors: Veltman M, Stolarczyk M, Radzioch D, Wojewodka G, De Sanctis JB, Dik WA, Dzyubachyk O, Oravecz T, De Kleer I, Scholte BJ Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Searching for better animal models of BPD: a perspective.
Abstract There have been many efforts to develop good animal models of bronchopulmonary dysplasia (BPD) in order to better understand the pathophysiology and mechanisms underlying development of BPD as well as to test potential strategies for its prevention and treatment. This perspective summarizes the features of common animal models of BPD and the strengths and limitations of such models. Potential optimal approaches to development of animal models are indicated, with the underlying concepts that require emphasis. PMID: 27663992 [PubMed - as supplied by publisher] (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - September 23, 2016 Category: Respiratory Medicine Authors: Ambalavanan N, Morty RE Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Respiratory self-gated 3D UTE for lung imaging in small animal MRI.
CONCLUSION: Low-resolution 3D GRASP reconstruction allowed for extraction of an effective gating signal for 3D-Img-SG. The DC-SG method did not work in cases for which respiratory frequencies were inconsistent. Magn Reson Med, 2016. © 2016 International Society for Magnetic Resonance in Medicine. PMID: 27663453 [PubMed - as supplied by publisher] (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - September 23, 2016 Category: Radiology Authors: Tibiletti M, Bianchi A, Kjørstad Å, Wundrak S, Stiller D, Rasche V Tags: Magn Reson Med Source Type: research

Clinical value of the Integrated Pulmonary Index ® during sedation for interventional upper GI-endoscopy: A randomized, prospective tri-center study
The Integrated Pulmonary Index ® (IPI) is a mathematically-determined factor based on parameters of capnography and pulse oximetry, which should enable sensitive detection of impaired respiratory function. Aim was to investigate whether an additional measurement of the IPI during sedation for interventional endoscopy, compared t o standard monitoring alone, allows a reduction of sedation-related respiratory depression. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 23, 2016 Category: Gastroenterology Authors: Andrea Riphaus, Till Wehrmann, Tim Kronshage, Christoph Geist, Christian P. Pox, Stefan Heringlake, Wolff Schmiegel, Analena Beitz, Alexander Meining, Michaela M üller, Stefan von Delius Tags: Digestive Endoscopy Source Type: research

Segmental Arterial Mediolysis
A previously healthy 36-year-old man presented with a 1-day history of abdominal pain. The pain started in the epigastrium, spreading acutely to the right flank and back and increasing in severity. On arrival, vital signs were: temperature, 37.6 °C; heart rate, 63 beats/min; respiratory rate, 20 breaths/min; and blood pressure, 133/79 mm Hg. Physical examination revealed tenderness in the epigastrium, right lower quadrant, and left flank. Laboratory examinations showed a white blood cell count of 12,400/μL and a slightly elevated lipase concentration of 68 IU/L. (Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - September 23, 2016 Category: Emergency Medicine Authors: Jun Fujinaga, Akira Kuriyama Tags: Visual Diagnosis in Emergency Medicine Source Type: research

Cutaneous Mycobacterium abscessus infection following hair transplant
Summary A 28‐year‐old man presented with a 10‐day history of scalp nodules. He had undergone hair transplantation 2 months previously. Incision and drainage of one of the nodules yielded gelatinous material, which was sent for microscopy and culture, including low‐temperature culture. After 2 weeks of incubation, culture of the nodule yielded acid‐ and alcohol‐fast bacilli, which were identified as Mycobacterium abscessus, a rapidly growing, nontuberculous mycobacterium, which has been reported to cause cutaneous, soft tissue and respiratory infections following trauma, surgery or injection with nonsterile ne...
Source: Clinical And Experimental Dermatology - September 23, 2016 Category: Dermatology Authors: K. Eustace, V. Jolliffe, A. Sahota, K. Gholam Tags: Concise report Source Type: research

Effect of recombinant malarial antigen on monocyte functionality
Conclusions These antigens may modulate the monocyte functionality and hence may not have desired therapeutic effect. (Source: Transactions of the Royal Society of Tropical Medicine and Hygiene)
Source: Transactions of the Royal Society of Tropical Medicine and Hygiene - September 23, 2016 Category: Tropical Medicine Authors: Saha, A., Chauhan, S., Bagchi, T. Tags: Original Articles Source Type: research

Evaluation of model-based methods in estimating respiratory mechanics in the presence of variable patient effort
• A comparison of different methods for respiratory mechanics estimations during spontaneous and/or asynchronous breathing.• Models are evaluated using clinical data with samples of breathing cycles before and after sedation.• Different models have advantages and disadvantages, and the importa nce of these depends on the application for which respiratory mechanics is being used.• In general, a combined method of iterative interpolative pressure reconstruction and stacking multiple breaths has best performance over the dataset. (Source: Computer Methods and Programs in Biomedicine)
Source: Computer Methods and Programs in Biomedicine - September 23, 2016 Category: Bioinformatics Authors: Daniel P. Redmond, Yeong Shiong Chiew, Vincent Major, J. Geoffrey Chase Source Type: research

KlebSeq, a Diagnostic Tool for Surveillance, Detection, and Monitoring of Klebsiella pneumoniae [Bacteriology]
In this report, we describe the design and validation of KlebSeq, a highly informative screening tool that detects Klebsiella species and identifies clinically important strains and characteristics by using highly multiplexed amplicon sequencing without a live-culturing step. We demonstrate the utility of this tool on several complex specimen types, including urine, wound swabs and tissue, and several types of respiratory and fecal specimens, showing K. pneumoniae species and clonal group identification and antimicrobial resistance and virulence profiling, including capsule typing. Use of this amplicon sequencing tool to s...
Source: Journal of Clinical Microbiology - September 23, 2016 Category: Microbiology Authors: Bowers, J. R., Lemmer, D., Sahl, J. W., Pearson, T., Driebe, E. M., Wojack, B., Saubolle, M. A., Engelthaler, D. M., Keim, P. Tags: Bacteriology Source Type: research

First Evaluation of GenoType MTBDRplus 2.0 Performed Directly on Respiratory Specimens in Central America [Mycobacteriology and Aerobic Actinomycetes]
The turnaround times for conventional methods used to detect Mycobacterium tuberculosis in sputum samples and to obtain drug susceptibility information are long in many developing countries, including Panama, leading to delays in appropriate treatment initiation and continued transmission in the community. We evaluated the performance of a molecular line probe assay, the Genotype MTBDRplus version 2.0 assay, in detecting M. tuberculosis complex directly in respiratory specimens from smear-positive tuberculosis cases from four different regions in Panama, as well as the most frequent mutations in genes conferring resistance...
Source: Journal of Clinical Microbiology - September 23, 2016 Category: Microbiology Authors: Lanzas, F., Ioerger, T. R., Shah, H., Acosta, W., Karakousis, P. C. Tags: Mycobacteriology and Aerobic Actinomycetes Source Type: research

Schizophyllum radiatum, an Emerging Fungus from Human Respiratory Tract [Mycology]
Schizophyllum is an important genus of basidiomycetes that, apart from being of genetic and biotechnological interest, is also reported to be a plant and animal pathogen. Schizophyllum commune is the best-known species and the only one reported from clinical specimens thus far, being recovered mainly from the respiratory tract. The aim of this study was to determine the species diversity of 23 clinical isolates of Schizophyllum from the United States using multilocus phylogenetic analysis and their in vitro susceptibilities to six drugs. The markers used for sequencing were the internal transcribed spacer (ITS), a portion ...
Source: Journal of Clinical Microbiology - September 23, 2016 Category: Microbiology Authors: Siqueira, J. P. Z., Sutton, D., Gene, J., Garcia, D., Guevara-Suarez, M., Decock, C., Wiederhold, N., Guarro, J. Tags: Mycology Source Type: research

Point-Counterpoint: A Nucleic Acid Amplification Test for Streptococcus pyogenes Should Replace Antigen Detection and Culture for Detection of Bacterial Pharyngitis [Point-Counterpoint]
Nucleic acid amplification tests (NAATs) have frequently been the standard diagnostic approach when specific infectious agents are sought in a clinic specimen. They can be applied for specific agents such as S. pyogenes, or commercial multiplex NAATs for detection of a variety of pathogens in gastrointestinal, bloodstream, and respiratory infections may be used. NAATs are both rapid and sensitive. For many years, S. pyogenes testing algorithms used a rapid and specific group A streptococcal antigen test to screen throat specimens, followed, in some clinical settings, by a throat culture for S. pyogenes to increase the sens...
Source: Journal of Clinical Microbiology - September 23, 2016 Category: Microbiology Authors: Pritt, B. S., Patel, R., Kirn, T. J., Thomson, R. B. Tags: Point-Counterpoint Source Type: research

Altered Breathing Pattern Valuation Relatively to Dyspnea Assessment and Treatment for Low Back Pain: Effects of Clinical Practice
The published article titled ‘The presence of respiratory disorders in individuals with low back pain: A systematic review” has generated much interest regarding the identification of respiratory problems and treatment in the field of Low Back Pain (LBP) (Beeckmans et al. 2016). We are exploring the respiratory characterist ics of individuals with LBP as a joint research, and the prominent outcomes of this systematic review have created countless novel philosophies. Therefore, we wish to share scientific information on this interesting topic, which requires further exploration according to the systematic review (Beeckm...
Source: Manual Therapy - September 23, 2016 Category: Physiotherapy Authors: Vikram Mohan, Aatit Paungmali, Patraporn Sitilertpisan Tags: Letter to the Editor Source Type: research

Characterization and expression analysis of a thioredoxin-like protein gene in the sea cucumber Apostichopus japonicus
In this study, a cDNA of TRX-like protein gene from Apostichopus japonicus (denoted as AjTRX) was cloned and characterized. The full-length cDNA of AjTRXwas of 1870 bp, consisting of a 5′-UTR of 101 bp, a long 3′-UTR of 887 bp and a 882 bp open reading frame (ORF) encoding a 293 amino acids. The predicted molecular mass and the theoretical PI of the deduced amino acids of AjTRX were 32.3 kDa and 5.52, respectively. Phylogenetic trees showed that AjTRX had a closer evolution relationship with TRX from Strongylocentrotus purpuratus. AjTRX was found to be ubiquitously expressed in all examined tissues including longit...
Source: Fish and Shellfish Immunology - September 23, 2016 Category: Biology Source Type: research

Reduction of apoptosis and preservation of mitochondrial integrity under ischemia/reperfusion injury is mediated by estrogen receptor β
ConclusionsActivation of ER β is essential for the improvement of cardiac recovery after I/R through the inhibition of apoptosis and preservation of mitochondrial integrity and can be a achieved by a specific ERβ agonist. Furthermore, E2 modulates MLC2 activation after I/R independent of ERβ. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - September 23, 2016 Category: Biology Source Type: research

Maternally Derived Immunity Extends Swine Influenza A Virus Persistence within Farrow-to-Finish Pig Farms: Insights from a Stochastic Event-Driven Metapopulation Model
by Charlie Cador, Nicolas Rose, Lander Willem, Mathieu Andraud Swine Influenza A Viruses (swIAVs) have been shown to persist in farrow-to-finish pig herds with repeated outbreaks in successive batches, increasing the risk for respiratory disorders in affected animals and being a threat for public health. Although the general routes of swIAV transmission (i.e. direct contact and exposure to aerosols) were clearly identified, the transmission process between batches is still not fully understood. Maternally derived antibodies (MDAs) were stressed as a possible factor favoring within-herd swIAV persistence. However, the rela...
Source: PLoS One - September 23, 2016 Category: Biomedical Science Authors: Charlie Cador Source Type: research

IJERPH, Vol. 13, Pages 947: Effects of Particulate Matter and Its Chemical Constituents on Elderly Hospital Admissions Due to Circulatory and Respiratory Diseases
Various fractions of particulate matter have been associated with increased mortality and morbidity. The purpose of our study is to analyze the associations between concentrations of PM2.5, PM2.5 –10, PM10 and their chemical constituents (soluble ions) with hospital admissions due to circulatory and respiratory diseases among the elderly in a medium-sized city in Brazil. A time series study was conducted using Poisson regression with generalized additive models adjusted for confounders. St atistically significant associations were identified between PM10 and PM2.5–10 and respiratory diseases. Risks of hospitalization i...
Source: International Journal of Environmental Research and Public Health - September 23, 2016 Category: Environmental Health Authors: Tatiane Ferreira Maria Forti Clarice de Freitas Felipe Nascimento Washington Junger Nelson Gouveia Tags: Article Source Type: research

Cap-independent translation by DAP5 controls cell fate decisions in human embryonic stem cells [Research Papers]
This study unveils an additional level of gene expression regulation involving noncanonical, cap-independent translation of a select group of mRNAs. This is driven by death-associated protein 5 (DAP5/eIF4G2/NAT1), a translation initiation factor mediating IRES-dependent translation. We found that the DAP5 knockdown from human ESCs (hESCs) resulted in persistence of pluripotent gene expression, delayed induction of differentiation-associated genes in different cell lineages, and defective embryoid body formation. The latter involved improper cellular organization, lack of cavitation, and enhanced mislocalized apoptosis. RNA...
Source: Genes and Development - September 23, 2016 Category: Genetics & Stem Cells Authors: Yoffe, Y., David, M., Kalaora, R., Povodovski, L., Friedlander, G., Feldmesser, E., Ainbinder, E., Saada, A., Bialik, S., Kimchi, A. Tags: Research Papers Source Type: research

Smokers with respiratory symptoms but no airflow limitation, often have activity limitation, exacerbations and evidence of airway disease
Commentary on: Woodruff PG, Barr RG, Bleecker E, et al.. Clinical significance of symptoms in smokers with preserved pulmonary function. N Engl J Med 2016;374:1811–21 . Context COPD is, according to the Global Initiative for Chronic Obstructive Lung Disease, defined as persistent airflow limitation, that is, the key diagnostic criterion is a postbronchodilator forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) ratio <0.70.1 However, this definition has clear limitations in clinical practice, as it does not take symptoms into account and only applies to individuals in whom fixed airflow limit...
Source: Evidence-Based Medicine - September 23, 2016 Category: Internal Medicine Authors: Ulrik, C. S. Tags: EBM Prognosis, Smoking and tobacco, Health education, Smoking Source Type: research

A Retained Foreign Body Granuloma Mimicking a Left Ventricular Psuedoanuerysm.
Conclusion This case highlights the important clinical history features for diagnosing this surgical error, including persistent respiratory symptoms and a history of cardio-thoracic surgery. It also emphasizes on the need for implementing definite strategies to prevent the occurrence of gossypiboma in surgical practice. (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - September 23, 2016 Category: Surgery Source Type: research

Alterations in Systemic Extracellular Heme and Hemopexin Are Associated With Adverse Clinical Outcomes in Ugandan Children With Severe Malaria
Conclusions. The ratio of heme to hpx is associated with disease severity and adverse clinical outcomes in Ugandan children, and dysregulation of the heme axis may contribute to malaria pathogenesis. (Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - September 23, 2016 Category: Infectious Diseases Authors: Elphinstone, R. E., Conroy, A. L., Hawkes, M., Hermann, L., Namasopo, S., Warren, H. S., John, C. C., Liles, W. C., Kain, K. C. Tags: PATHOGENESIS AND HOST RESPONSE Source Type: research

Effect of Statin Use on Influenza Vaccine Effectiveness
Conclusions. Statin use was associated with reduced VE against influenza A(H3N2) but not influenza A(H1N1)pdm09 or influenza B. Further research is needed to assess biologic plausibility and confirm these results. (Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - September 23, 2016 Category: Infectious Diseases Authors: McLean, H. Q., Chow, B. D. W., VanWormer, J. J., King, J. P., Belongia, E. A. Tags: VIRUSES Source Type: research

Modest Waning of Influenza Vaccine Efficacy and Antibody Titers During the 2007-2008 Influenza Season
Conclusions. Both vaccines were efficacious but LAIV less so. IIV efficacy decreased slowly over time, but the vaccine remained significantly efficacious for the majority of the season. (Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - September 23, 2016 Category: Infectious Diseases Authors: Petrie, J. G., Ohmit, S. E., Truscon, R., Johnson, E., Braun, T. M., Levine, M. Z., Eichelberger, M. C., Monto, A. S. Tags: VIRUSES Source Type: research

Integrated Cardio-Respiratory Control: Insight in Diabetes
AbstractAutonomic dysfunction is a frequent and relevant complication of diabetes mellitus, as it is associated with increased morbidity and mortality. In addition, it is today considered as predictive of the most severe diabetic complications, like nephropathy and retinopathy. The classical methods of screening are the cardiovascular reflex tests and were originally interpreted as evidence of nerve damage. A more modern approach, based on the integrated control of cardiovascular and respiratory function, reveals that these abnormalities are to a great extent functional, at least in the early stage of the disease, thus sug...
Source: Current Diabetes Reports - September 23, 2016 Category: Endocrinology Source Type: research

Development and Dynamic Regulation of Mitochondrial Network in Human Midbrain Dopaminergic Neurons Differentiated from iPSCs
Publication date: Available online 22 September 2016 Source:Stem Cell Reports Author(s): Du Fang, Yu Qing, Shijun Yan, Doris Chen, Shirley ShiDu Yan Mitochondria are critical to neurogenesis, but the mechanisms of mitochondria in neurogenesis have not been well explored. We fully characterized mitochondrial alterations and function in relation to the development of human induced pluripotent stem cell (hiPSC)-derived dopaminergic (DA) neurons. Following directed differentiation of hiPSCs to DA neurons, mitochondria in these neurons exhibit pronounced changes during differentiation, including mature neurophysiology charact...
Source: Stem Cell Reports - September 23, 2016 Category: Stem Cells Source Type: research

Development of vaccines against pertussis caused by Bordetella holmesii using a mouse intranasal challenge model
We examined the protective potency of pertussis vaccines available in Japan and vaccines prepared from B. holmesii. A murine model of respiratory infection was exploited to evaluate protective potency. No Japanese commercial pertussis vaccines were effective against B. holmesii. In contrast, a wBH vaccine and an aBH vaccine prepared from B. holmesii were both protective. Passive immunization with sera from mice immunized with aBH vaccine established protection against B. holmesii, indicating that B. holmesii‐specific serum antibodies might play an important role in protection. Immuno‐proteomic analysis with sera from m...
Source: Microbiology and Immunology - September 23, 2016 Category: Microbiology Authors: Momoko Saito, Keita Odanaka, Nao Otsuka, Kazunari Kamachi, Mineo Watanabe Tags: Original Article Source Type: research