Respiratory Medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.
This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 20.
Routine data linkage to identify and monitor diabetes in clozapine-treated patients with schizophrenia
The physical health of people with serious mental illness is an issue of major concern to individuals, their families, clinicians and healthcare policy-makers (The Schizophrenia Commission, 2012). Mortality rates remain around twice those found in the general population (Saha et al., 2007) with high levels of cardiovascular disease (Goff et al., 2005), metabolic disease (De Hert et al., 2006), diabetes (Newcomer and Haupt, 2002), and respiratory illness (Chafetz et al., 2008). Clozapine has been shown to be the most effective medication for treatment-resistant schizophrenia (Essali et al., 2009) but has important side-effe...
Source: Schizophrenia Research - September 7, 2016 Category: Psychiatry Authors: R. Pearsall, J. Gareze, J. Park, A. Walker, J. Langan-Martin, G. McLean, M. Connelly, D. Mackay, D.J. Smith Tags: Letter to the Editor Source Type: research
Post-Craniotomy Pain Management: Beyond Opioids
AbstractCraniotomy pain may be severe and is often undertreated. Pain management following craniotomy is a balancing act of achieving adequate analgesia but avoiding sedation, respiratory depression, hypercapnia, nausea and vomiting, and hypertension. Opioids are a first-line analgesic therapy; however, concern that opioid-related adverse effects (sedation, respiratory depression) may interfere with neurologic assessment and increase intracranial pressure has limited use of these drugs for intracranial surgery. Non-opioid analgesics avoid these effects and may be useful as part of a multimodal regimen for post-craniotomy p...
Source: Current Neurology and Neuroscience Reports - September 7, 2016 Category: Neuroscience Source Type: research
Taxonomic status of Syngamus nematodes parasitizing passeriform hosts from Central Europe: Morphological, morphometric and molecular identification
Publication date: October 2016 Source:Parasitology International, Volume 65, Issue 5, Part A Author(s): Gerard Kanarek, Grzegorz Zaleśny, Jiljí Sitko, Izabella Rząd The systematic position and validity of species within genus Syngamus have always been controversial. In this present work, we evaluated the taxonomic status and phylogenetic relationships between three species of Syngamus nematodes (S yngamus trachea, Syngamus taiga and Syngamus merulae) and one taxa, determined only to the generic level, collected from respiratory tracts of passeriform hosts from Central Europe using newly obtained sequences of 2 nuclear ...
Source: Parasitology International - September 7, 2016 Category: Parasitology Source Type: research
Cross ‐Sectional Survey and Surveillance for Influenza Viruses and MERS‐CoV among Egyptian Pilgrims Returning from Hajj during 2012‐2015
This article is protected by copyright. All rights reserved. (Source: Influenza and Other Respiratory Viruses)
Source: Influenza and Other Respiratory Viruses - September 7, 2016 Category: Virology Authors: Samir Refaey, Marwa Mohamed Amin, Katherine Roguski, Eduardo Azziz ‐Baumgartner, Timothy M. Uyeki, Manal Labib, Amr Kandeel Tags: Short Article Source Type: research
Circulation of multiple genotypes of H1N2 viruses in a swine farm in Italy over a two-month period
Publication date: Available online 7 September 2016 Source:Veterinary Microbiology Author(s): Maria Serena Beato, Luca Tassoni, Adelaide Milani, Annalisa Salviato, Guido Di Martino, Monica Mion, Lebana Bonfanti, Isabella Monne, Simon James Watson, Alice Fusaro In August 2012 repeated respiratory outbreaks caused by swine influenza A virus (swIAV) were registered for a whole year in a breeding farm in northeast Italy that supplied piglets for fattening. The virus, initially characterized in the farm, was a reassortant Eurasian avian-like H1N1 (H1avN1) genotype, containing a haemagglutinin segment derived from the pandemic ...
Source: Veterinary Microbiology - September 7, 2016 Category: Veterinary Research Source Type: research
A mixed treatment meta-analysis of antibiotic treatment options for bovine respiratory disease – An update
Publication date: Available online 31 August 2016 Source:Preventive Veterinary Medicine Author(s): A.M. O’Connor, C. Yuan, J.N. Cullen, J.F. Coetzee, N. da Silva, C. Wang Bovine respiratory disease is the most economically important disease of feedlot cattle in North America. Choice of antibiotic is a critical factor for producers and veterinarians. We previously published a mixed-treatment comparison meta-analysis that combined evidence from published trials and published estimates of comparative efficacy for 12 antibiotics registered for use in the USA. Some of the comparative efficacy estimates were based only on ind...
Source: Preventive Veterinary Medicine - September 7, 2016 Category: Veterinary Research Source Type: research
Beware the “red herring”
Abstract A young patient with relapsed diffuse large B‐cell lymphoma presented with new onset respiratory symptoms and hypereosinophilia in the early stage post high‐dose therapy/autologous stem cell rescue. Here, we present a step‐wise practical approach to this unexpected laboratory finding for a not uncommon infective complication in the immunosuppressed patient. (Source: Transplant Infectious Disease)
Source: Transplant Infectious Disease - September 7, 2016 Category: Transplant Surgery Authors: G.A. Zakout Tags: Case Report Source Type: research
Systematic identification of genes involved in metabolic acid stress resistance in yeast and their potential as cancer targets [RESEARCH ARTICLE]
ABSTRACT A hallmark of all primary and metastatic tumours is their high rate of glucose uptake and glycolysis. A consequence of the glycolytic phenotype is the accumulation of metabolic acid; hence, tumour cells experience considerable intracellular acid stress. To compensate, tumour cells upregulate acid pumps, which expel the metabolic acid into the surrounding tumour environment, resulting in alkalization of intracellular pH and acidification of the tumour microenvironment. Nevertheless, we have only a limited understanding of the consequences of altered intracellular pH on cell physiology, or of the genes and pathways ...
Source: DMM Disease Models and Mechanisms - September 7, 2016 Category: Biomedical Science Authors: Shin, J. J., Aftab, Q., Austin, P., McQueen, J. A., Poon, T., Li, S. C., Young, B. P., Roskelley, C. D., Loewen, C. J. R. Tags: Cancer RESEARCH ARTICLE Source Type: research
Visceral adipose tissue: A clue to the obesity-asthma endotype(s)?
Publication date: September–October 2016 Source:Revista Portuguesa de Pneumologia (English Edition), Volume 22, Issue 5 Author(s): R. Barros, L. Delgado (Source: Revista Portuguesa de Pneumologia)
Source: Revista Portuguesa de Pneumologia - September 7, 2016 Category: Respiratory Medicine Source Type: research
Advancing palliative and end-of-life science in cardiorespiratory populations: The contributions of nursing science
Publication date: Available online 6 September 2016 Source:Heart & Lung: The Journal of Acute and Critical Care Author(s): Patricia A. Grady Nursing science has a critical role to inform practice, promote health, and improve the lives of individuals across the lifespan who face the challenges of advanced cardiorespiratory disease. Since 1997, the National Institute of Nursing Research (NINR) has focused attention on the importance of palliative and end-of-life care for advanced heart failure and advanced pulmonary disease through the publication of multiple funding opportunity announcements and by supporting a cad...
Source: Heart and Lung: The Journal of Acute and Critical Care - September 7, 2016 Category: Respiratory Medicine Source Type: research
Nasal conchae function as aerodynamic baffles: Experimental computational fluid dynamic analysis in a turkey nose (Aves: Galliformes)
Publication date: Available online 6 September 2016 Source:Respiratory Physiology & Neurobiology Author(s): Jason M. Bourke, Lawrence M. Witmer We tested the aerodynamic function of nasal conchae in birds using CT data from an adult male wild turkey (Meleagris gallopavo) to construct 3D models of its nasal passage. A series of digital “turbinectomies” were performed on these models and computational fluid dynamic analyses were performed to simulate resting inspiration. Models with turbinates removed were compared to the original, unmodified control airway. Results revealed that the four conchae found in turkey...
Source: Respiratory Physiology and Neurobiology - September 7, 2016 Category: Respiratory Medicine Source Type: research
Life threatening hemoptysis from Hughes Stovin syndrome: Is it that rare?
Conclusion Adults who present with venous thrombosis and hemoptoic cough, with no predisposing factors of thrombosis, normal platelet count and coagulation, the possibility of Hughes-Stovin syndrome has to be considered. (Source: Respiratory Medicine Case Reports)
Source: Respiratory Medicine Case Reports - September 7, 2016 Category: Respiratory Medicine Source Type: research
Airway occlusion assessed by single breath N2 test and lung P-V curve in healthy subjects and COPD patients
Conclusion The coincidence between CVSBN and CVexp, and the presence of the inflection in the absence of phase IV indicate that the deviation of the PL-V curve from the exponential fit reliably assesses CV. (Source: Respiratory Physiology and Neurobiology)
Source: Respiratory Physiology and Neurobiology - September 7, 2016 Category: Respiratory Medicine Source Type: research
Respiratory-swallowing coordination in normal subjects: Lung volume at swallowing initiation
This study was designed to investigate the significance of bolus types and volumes, delivery methods and swallowing instructions on lung volume at swallowing initiation in normal subjects in a single experiment using a multifactorial approach. Our broad range goal was to determine optimal lung volume range associated with swallowing initiation to provide training targets for dysphagic patients with disordered respiratory-swallow coordination. Our hypothesis was that swallows would be initiated within a limited range of quiet breathing lung volumes regardless of bolus volume, consistency or task. Results confirmed this hypo...
Source: Respiratory Physiology and Neurobiology - September 7, 2016 Category: Respiratory Medicine Source Type: research
Cardiac catheterization in children with pulmonary arterial hypertension
This article is protected by copyright. All rights reserved. (Source: Pediatrics International)
Source: Pediatrics International - September 7, 2016 Category: Pediatrics Authors: Hiroyuki Matsuura Tags: Review Articles Source Type: research
Benzodiazepine use in seizure emergencies: A systematic review
Publication date: October 2016 Source:Epilepsy & Behavior, Volume 63 Author(s): Sheryl R. Haut, Syndi Seinfeld, John Pellock Purpose The aim of this review was to systematically examine safety and efficacy outcomes, as well as patient/caregiver satisfaction, from clinical studies in pediatric and adult patients treated with benzodiazepines (BZDs) through various administration routes in response to seizure emergencies. Methods A literature search was conducted to identify articles describing the use of various routes of administration (RoAs) of BZDs for the treatment of seizure emergencies through April 21, 2015, ...
Source: Epilepsy and Behavior - September 7, 2016 Category: Neurology Source Type: research
Astrovirus VA1 identified by next-generation sequencing in a nasopharyngeal specimen of a febrile Tanzanian child with acute respiratory disease of unknown etiology
; Laurent Kaiser (Source: Emerging Microbes and Infections)
Source: Emerging Microbes and Infections - September 7, 2016 Category: Infectious Diseases Authors: Samuel Cordey Francisco Brito Diem-Lan Vu Lara Turin Mary Kilowoko Esther Kyungu Blaise Genton Evgeny M Zdobnov Val érie D'Acremont Laurent Kaiser Source Type: research
Feasibility of monomodal analgesia with IV alfentanil during burn dressing changes at bedside (in spontaneously breathing non-intubated patients)
Conclusion Pain control with intravenous alfentanil alone is efficient and appears safe for most burn bedside repeated dressings in hospitalized patients. It achieves satisfactory analgesia during and after the procedure. It is now our standard analgesic method to provide repeated bedside dressings changes for burned patients. (Source: Burns)
Source: Burns - September 7, 2016 Category: Dermatology Source Type: research
Cutaneous Manifestations of Mucopolysaccharidoses
Abstract Mucopolysaccharidoses (MPSs) are a group of inherited lysosomal storage disorders characterized by deficiencies in specific enzymes involved in the catabolism of glycosaminoglycans (GAGs). These deficiencies cause excessive metabolites to accumulate in multiple organs. There are eight different MPS disorders, contributing to the wide variation in clinical presentation. Depending on the severity and subtype of the disease, some children live normal life spans, while others have a more grim prognosis. Children with MPS can present with neurologic, behavioral, skeletal, cardiovascular, gastrointestinal, or respirator...
Source: Pediatric Dermatology - September 7, 2016 Category: Dermatology Authors: Mimi C. Tran, Joseph M. Lam Tags: Review Source Type: research
Safety and efficacy of dexmedetomidine sedation for elective fiberoptic bronchoscopy: A comparative study with propofol
Conclusion Dexmedetomidine and propofol-fentanyl are effective sedatives for patients undergoing flexible fiberoptic bronchoscopy. The sympatholytic and respiratory stability effects of dexmedetomidine make it an attractive and safe alternative for sedation during FOB. (Source: Egyptian Journal of Anaesthesia)
Source: Egyptian Journal of Anaesthesia - September 7, 2016 Category: Anesthesiology Source Type: research
Improvements in Lung Diffusion Capacity following Pulmonary Rehabilitation in COPD with and without Ventilation Inhomogeneity
Background: Lung diffusing capacity (DLCO) and lung volume distribution predict exercise performance and are altered in COPD patients. If pulmonary rehabilitation (PR) can modify DLCO parameters is unknown.Objectives: To investigate changes in DLCO and ventilation inhomogeneity following a PR program and their relation with functional outcomes in patients with COPD.Methods: This was a prospective, observational, multicentric study. Patients were evaluated before and after a standardized 3-week PR program. Functional assessment included body plethysmography, DLCO, transfer factor (KCO) and alveolar volume (VA), gas exchange...
Source: Respiration - September 6, 2016 Category: Respiratory Medicine Source Type: research
Overnight Extubation in Patients With Mechanical Ventilation
The timing of extubation in patients with mechanical ventilation is confronted by intensivists and physicians in the United States on a daily basis. Theoretically, earlier extubation has the potential to prevent ventilator-associated complications and decrease the length of intensive care unit (ICU) and hospital stays. However, overnight extubation may be riskier, in part because fewer and less experienced physicians, nurses, and respiratory therapists are available. Although the clinically important question of when to extubate arises daily in the ICU, current research on the optimal timing for extubation is insufficient....
Source: JAMA Internal Medicine - September 6, 2016 Category: Internal Medicine Source Type: research
An interactive videogame designed to improve respiratory navigator efficiency in children undergoing cardiovascular magnetic resonance
Advanced cardiovascular magnetic resonance (CMR) acquisitions often require long scan durations that necessitate respiratory navigator gating. The tradeoff of navigator gating is reduced scan efficiency, parti... (Source: Journal of Cardiovascular Magnetic Resonance)
Source: Journal of Cardiovascular Magnetic Resonance - September 6, 2016 Category: Radiology Authors: Sean M. Hamlet, Christopher M. Haggerty, Jonathan D. Suever, Gregory J. Wehner, Jonathan D. Grabau, Kristin N. Andres, Moriel H. Vandsburger, David K. Powell, Vincent L. Sorrell and Brandon K. Fornwalt Source Type: research
Welcoming proposal for parents of dysphonic children: case report
Conclusion: the proposal of groups with parents of dysphonic children is a valid therapeutic possibility, because it showed as a constructive work for all members. In addition, the welcoming of parents of dysphonic children is essential since they directly interfere in the therapeutic management. (Source: Revista CEFAC)
Source: Revista CEFAC - September 6, 2016 Category: Speech Therapy Source Type: research
Benzodiazepine use in seizure emergencies: A systematic review.
Abstract PURPOSE: The aim of this review was to systematically examine safety and efficacy outcomes, as well as patient/caregiver satisfaction, from clinical studies in pediatric and adult patients treated with benzodiazepines (BZDs) through various administration routes in response to seizure emergencies. METHODS: A literature search was conducted to identify articles describing the use of various routes of administration (RoAs) of BZDs for the treatment of seizure emergencies through April 21, 2015, using Embase™ and PubMed®. Eligible studies included (a) randomized controlled trials or (b) controlled no...
Source: Epilepsy and Behaviour - September 6, 2016 Category: Neurology Authors: Haut SR, Seinfeld S, Pellock J Tags: Epilepsy Behav Source Type: research
Obstructive Sleep Apnea Screening and Airway Structure Characterization During Wakefulness Using Tracheal Breathing Sounds.
Abstract Screening for obstructive sleep apnea (OSA) disorder during wakefulness is challenging. In this paper, we present a set of tracheal breathing sounds characteristics with classification power for separating individuals with apnea/hypopnea index (AHI) ≥ 10 (OSA group) from those with AHI ≤ 5 (non-OSA group) during wakefulness. Tracheal breathing sound signals were recorded during wakefulness in supine position; subjects were instructed to have a few deep breaths through their nose, then through their mouth. Study participants were 147 individuals (80 males) referred to overnight polysomnography (PSG...
Source: Annals of Biomedical Engineering - September 6, 2016 Category: Biomedical Engineering Authors: Elwali A, Moussavi Z Tags: Ann Biomed Eng Source Type: research
Balneicella halophila gen. nov., sp. nov., an anaerobic bacterium, isolated from a thermal spring and description of Balneicellaceae fam. nov.
Abstract A mesophilic anaerobic bacterium, designated KHALHBD91T was isolated from the moderately hot spring of Hamman Biadha, Tunisia. The strain was Gram staining negative, non sporulating, non motile and rod shaped, appearing singly (0.5-2.0µm x 0.5-1µm).It grew anaerobically at temperatures between 20 and 50°C (optimum 37°C) and at pH between 5.5-7.8 (optimum 7.0). It required NaCl for growth, and with growth observed to 8.5% and an optimum at 2.5%. Strain KHALHBD91T used glucose, galactose, maltose, pyruvate, lactate, fumarate, yeast extract as electron donors. The end-products from glucose fermentation w...
Source: International Journal of Systematic and Evolutionary Microbiology - September 6, 2016 Category: Microbiology Authors: Fadhlaoui K, Ben Hania W, Postec A, Hamdi M, Ollivier B, Fardeau ML Tags: Int J Syst Evol Microbiol Source Type: research
Associations of Source-Specific Fine Particulate Matter With Emergency Department Visits in California.
Abstract While many studies have investigated the health effects associated with acute exposure to fine particulate matter (particulate matter with an aerodynamic diameter less than or equal to 2.5 μm (PM2.5)), very few have considered the risks of specific sources of PM2.5 We used city-specific source apportionment in 8 major metropolitan areas in California from 2005-2009 to examine the associations of source-specific PM2.5 exposures from vehicular emissions, biomass burning, soil, and secondary nitrate and sulfate sources with emergency department visits (EDVs) for cardiovascular and respiratory diseases, incl...
Source: Am J Epidemiol - September 6, 2016 Category: Epidemiology Authors: Ostro B, Malig B, Hasheminassab S, Berger K, Chang E, Sioutas C Tags: Am J Epidemiol Source Type: research
Aerobic capacity and hepatic mitochondrial lipid oxidation alters susceptibility for chronic high fat diet induced hepatic steatosis.
In conclusion, intrinsically high aerobic capacity confers protection against high fat diet-induced hepatic steatosis through elevated hepatic mitochondrial oxidative capacity. PMID: 27600823 [PubMed - as supplied by publisher] (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - September 6, 2016 Category: Endocrinology Authors: Morris EM, Meers GM, Koch LG, Britton SL, Fletcher JA, Shankar K, Fu X, Burgess SC, Ibdah JA, Rector RS, Thyfault JP Tags: Am J Physiol Endocrinol Metab Source Type: research
Severe Anemia and Lung Nodule in an Immunocompetent Adopted Girl with Strongyloides stercoralis Infection.
We report a case of S. stercoralis infection causing severe anemia (hemoglobin 4.9 g/dL) and a lung nodule in a 14-year-old girl of Ethiopian origin adopted by an Italian couple. Severe anemia due to strongyloidiasis has been rarely reported, and mostly in severely ill patients, whereas our patient was immunocompetent and in good general conditions. Also, lung nodules have been only occasionally described in absence of respiratory symptoms. We discuss the management of patients with these findings, and we suggest to update the screening of immigrants from countries endemic for strongyloidiasis, including serology. PMI...
Source: Am J Trop Med Hyg - September 6, 2016 Category: Infectious Diseases Authors: Buonfrate D, Gobbi F, Beltrame A, Bisoffi Z Tags: Am J Trop Med Hyg Source Type: research
The Prognostic Role of Obstructive Sleep Apnea at the Onset of Amyotrophic Lateral Sclerosis.
CONCLUSIONS: Our study highlights the importance of an early diagnosis of OSA in ALS patients, allowing the identification of ALS patients with an OSA phenotype (AHIo ≥5), who are characterized by a worse prognosis. PMID: 27595268 [PubMed - as supplied by publisher] (Source: Neuro-Degenerative Diseases)
Source: Neuro-Degenerative Diseases - September 6, 2016 Category: Neurology Authors: Quaranta VN, Carratù P, Damiani MF, Dragonieri S, Capozzolo A, Cassano A, Resta O Tags: Neurodegener Dis Source Type: research
Effect of Early Versus Late Tracheostomy or Prolonged Intubation in Critically Ill Patients with Acute Brain Injury: A Systematic Review and Meta-Analysis
ConclusionsPerforming an early tracheostomy in acutely brain-injured patients may reduce long-term mortality, duration of mechanical ventilation, and ICU length of stay. However, waiting longer leads to fewer tracheostomy procedures and similar short-term mortality. Future research to explore the optimal timing of tracheostomy in this patient population should focus on patient-centered outcomes including patient comfort, functional outcomes, and long-term mortality. (Source: Neurocritical Care)
Source: Neurocritical Care - September 6, 2016 Category: Neurology Source Type: research
The diaphragm is better protected from oxidative stress than hindlimb skeletal muscle during CLP-induced sepsis.
DISCUSSION: These differences could be explained by higher basal enzymatic antioxidant activities in diaphragm compared to hindlimb skeletal muscles. Together, these results demonstrate that diaphragm is better protected from oxidative stress than hindlimb skeletal muscles during CLP-induced sepsis. PMID: 27595775 [PubMed - as supplied by publisher] (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - September 6, 2016 Category: Biochemistry Authors: Talarmin H, Derbré F, Lefeuvre-Orfila L, Léon K, Droguet M, Pennec JP, Giroux-Metgès MA Tags: Redox Rep Source Type: research
Modified High Molecular Weight Hyaluronan Promotes Allergen-Specific Immune Tolerance.
CONCLUSIONS: XHA and potentially other strategies that target CD44 are promising alternatives for the treatment of asthma and allergic sinusitis. PMID: 27598620 [PubMed - as supplied by publisher] (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - September 6, 2016 Category: Respiratory Medicine Authors: Gebe JA, Yadava K, Ruppert SM, Marshall P, Hill P, Falk BA, Sweere JM, Han H, Kaber G, Medina C, Mikecz K, Ziegler SF, Balaji S, Keswani SG, de Jesus Perez VA, Butte MJ, Nadeau K, Altemeier WA, Fanger N, Bollyky PL Tags: Am J Respir Cell Mol Biol Source Type: research
Chronic Respiratory Symptoms with Normal Spirometry: A Reliable Clinical Entity?
Abstract The 2001 Global Initiative for Chronic Obstructive Lung Disease (GOLD) Report defined five stages of spirometric severity (post-bronchodilator FEV1/FVC≥0.7): 0, and 1 (mild) to 4 (very severe). GOLD Stage 0 was defined by chronic cough and sputum production or chronic mucus hypersecretion (CMH) alone with preserved FEV1/FVC. Subsequently, GOLD 0 was discarded as further evidence of COPD development in subjects with GOLD 0 was not more likely to develop. When expanding symptomatic burden in GOLD 0 to include other chronic respiratory symptoms, such as dyspnea, wheeze, poor quality of life, limited physic...
Source: American Journal of Respiratory and Critical Care Medicine - September 6, 2016 Category: Respiratory Medicine Authors: Rodriguez-Roisin R, Han MK, Vestbo J, Wedzicha JA, Woodruff PG, Martinez FJ Tags: Am J Respir Crit Care Med Source Type: research
PIPc study: development of indicators of potentially inappropriate prescribing in children (PIPc) in primary care using a modified Delphi technique
Conclusions The PIPc indicators are a set of prescribing criteria developed for use in children in primary care in the absence of clinical information. The utility of these criteria will be tested in further studies using prescribing databases. (Source: BMJ Open)
Source: BMJ Open - September 6, 2016 Category: Journals (General) Authors: Barry, E., O'Brien, K., Moriarty, F., Cooper, J., Redmond, P., Hughes, C. M., Bennett, K., Fahey, T., Smith, S. M., The PIPc Project Steering group Tags: Open access, General practice / Family practice, Paediatrics Research Source Type: research
The lymphatic vascular system of the mouse head
AbstractHistological studies of the lymphatic vascular system in adult mice are hampered because bones cannot be sectioned properly. Here, we decalcified the heads of 14-day-old mice, embedded them in paraffin and stained resultant serial sections with the lymphendothelial-specific antibodies Lyve-1 and Podoplanin. We show that the tissues with the highest lymphatic vascular density are the dermis and the oral mucous membranes. In contrast, the nasal mucous membrane is devoid of lymphatics, except for its most basal parts below the vomeronasal organ. The inferior nasal turbinate contains numerous lymphatics and is connecte...
Source: Cell and Tissue Research - September 6, 2016 Category: Cytology Source Type: research
Development of a multiplex real-time RT-PCR assay for detection of human parainfluenza viruses in patients with respiratory symptoms
Future Virology Ahead of Print. (Source: Future Virology)
Source: Future Virology - September 6, 2016 Category: Virology Authors: Mahboobeh Ramezannia Seyed Masoud Hosseini Fatemeh Fotouhi Behzad Khansarinejad Vahideh Mazaheri Source Type: research
Two outer membrane proteins are bovine lactoferrin-binding proteins in Mannheimia haemolytica A1
AbstractMannheimia haemolytica is a Gram negative bacterium that is part of the bovine respiratory disease, which causes important economic losses in the livestock industry. In the present work, the interaction betweenM. haemolytica A1 and bovine lactoferrin (BLf) was studied. This iron-chelating glycoprotein is part of the mammalian innate-immune system and is present in milk and mucosal secretions; Lf is also contained in neutrophils secondary granules, which release this glycoprotein at infection sites. It was evidenced thatM. haemolytica was not able to use iron-charged BLf (BholoLf) as a sole iron source; nevertheless...
Source: Veterinary Research - September 6, 2016 Category: Veterinary Research Source Type: research
Axonopathy in the Central Nervous System Is the Hallmark of Mice with a Novel Intragenic Null Mutation of Dystonin [Cellular Genetics]
This study describes the discovery and molecular, clinical, as well as pathological characterization of a new spontaneously occurring mutation in the dystonin gene in C57BL/6N mice. The mutation represents a 40-kb intragenic deletion allele of the dystonin gene on chromosome 1 with exactly defined deletion borders. It was demonstrated by Western blot, mass spectrometry, and immunohistology that mice with a homozygous mutation were entirely devoid of the dystonin protein. Pathomorphological lesions were restricted to the brain stem and spinal cord and consisted of swollen, argyrophilic axons and dilated myelin sheaths in th...
Source: Genetics - September 6, 2016 Category: Genetics & Stem Cells Authors: Seehusen, F., Kiel, K., Jottini, S., Wohlsein, P., Habierski, A., Seibel, K., Vogel, T., Urlaub, H., Kollmar, M., Baumgartner, W., Teichmann, U. Tags: Cellular Genetics Source Type: research
SimLife a new model of simulation using a pulsated revascularized and reventilated cadaver for surgical education
Conclusion We present a technique of perfusion and ventilation of a fresh human cadaver that restores pulsatile circulation and respiratory movements of the model. (Source: Journal of Visceral Surgery)
Source: Journal of Visceral Surgery - September 6, 2016 Category: Surgery Source Type: research
Serum levels of magnesium and their relationship with CRP in patients with OSA
ConclusionOur results show that Mg levels changed depending on the presence and severity of OSA. Low levels were associated with a higher CRP concentration in patients with OSA. (Source: Sleep and Breathing)
Source: Sleep and Breathing - September 6, 2016 Category: Respiratory Medicine Source Type: research
Reduced respiratory motion artifacts using structural similarity in fast 2D dynamic contrast enhanced MRI of liver lesions
We present a fast method to improve multislice dynamic contrast enhanced MRI (DCE‐MRI) of liver lesions by removing motion corrupted images as identified by a structural similarity (SSIM) algorithm. The correction improves the reproducibility of the DCE‐MRI parameter Ktrans in liver metastasis and reduces contamination of the Ktrans values of lesions by that of surrounding normal liver tissue. (Source: NMR in Biomedicine)
Source: NMR in Biomedicine - September 6, 2016 Category: Radiology Authors: Edwin E.G.W. Voert, Linda Heijmen, Cornelis J.A. Punt, Johannes H.W. Wilt, Hanneke W.M. Laarhoven, Arend Heerschap Tags: RESEARCH ARTICLE Source Type: research
Strength Testing in Motor Neuron Diseases
AbstractLoss of muscle strength is a cardinal feature of all motor neuron diseases. Functional loss over time, including respiratory dysfunction, inability to ambulate, loss of ability to perform activities of daily living, and others are due, in large part, to decline in strength. Thus, the accurate measurement of limb muscle strength is essential in therapeutic trials to best understand the impact of therapy on vital function. While qualitative strength measurements show declines over time, the lack of reproducibility and linearity of measurement make qualitative techniques inadequate. A variety of quantitative measures ...
Source: Neurotherapeutics - September 6, 2016 Category: Neurology Source Type: research
Guillain-Barr é syndrome in patients with a recent history of Zika in Cúcuta, Colombia: A descriptive case series of 19 patients from December 2015 to March 2016
Conclusions All cases of this GBS outbreak had a recent history ZIKV infection, reinforcing existing evidence for the association between GBS and ZIKV. Future genetic and immunologic studies are warranted to further investigate the cause of the outbreak in detail. (Source: Journal of Critical Care)
Source: Journal of Critical Care - September 6, 2016 Category: Gastroenterology Source Type: research
Botulinum toxin injection in laryngeal dyspnea
This study is a retrospective study describing patients who underwent an injection of botulinum toxin for laryngeal dyspnea in the ENT Department from 2005 to 2015 years. The inclusion criteria were a dyspnea associated with a laryngeal dysfunction, confirmed by flexible fiberoptic nasopharyngolaryngoscopy. Information concerning the causes of the dyspnea, the botulinum toxin BT-A injections procedure, post-injection follow-up, and respiratory outcome were c ollected for all patients included. In the group of 13 patients included, the main cause identified as principal factor linked with the short breath was: a bilateral...
Source: European Archives of Oto-Rhino-Laryngology - September 6, 2016 Category: ENT & OMF Source Type: research
The cytochrome b Zn binding amino acid residue histidine 291 is essential for ubihydroquinone oxidation at the Qo site of bacterial cytochrome bc1
Publication date: November 2016 Source:Biochimica et Biophysica Acta (BBA) - Bioenergetics, Volume 1857, Issue 11 Author(s): Francesco Francia, Marco Malferrari, Pascal Lanciano, Stefan Steimle, Fevzi Daldal, Giovanni Venturoli The ubiquinol:cytochrome (cyt) c oxidoreductase (or cyt bc 1) is an important membrane protein complex in photosynthetic and respiratory energy transduction. In bacteria such as Rhodobacter capsulatus it is constituted of three subunits: the iron-sulfur protein, cyt b and cyt c 1, which form two catalytic domains, the Qo (hydroquinone (QH2) oxidation) and Qi (quinone (Q) reduction) sites. At the Qo...
Source: Biochimica et Biophysica Acta (BBA) Bioenergetics - September 6, 2016 Category: Biochemistry Source Type: research
STOP-Bang questionnaire: translation to Portuguese and cross-cultural adaptation for use in Brazil
Conclusions: The STOP-Bang questionnaire proved to be understandable, clear, and applicable. The original instrument and the translated version, cross-culturally adapted for use in Brazil, were consistently equivalent. Therefore, it can become a widely used screening tool for patients with suspected obstructive sleep apnea.Resumo Objetivo: Realizar a tradu ção e adaptação transcultural do questionário Snoring, Tiredness, Observed apnea, high blood Pressure, Body mass index, Age, Neck circumference, and Gender (STOP-Bang) para a língua portuguesa falada no Brasil, de forma a possibilitar sua aplicação como instrumen...
Source: Jornal Brasileiro de Pneumologia - September 5, 2016 Category: Respiratory Medicine Source Type: research
Influence of heart failure on resting lung volumes in patients with COPD
Conclusions: Despite the restrictive effects of CHF, patients with COPD+CHF have relatively higher inspiratory limits (a greater inspiratory fraction). However, those patients use only a part of those limits, probably in order to avoid critical reductions in inspiratory reserve and increases in elastic recoil.RESUMO Objetivo: Avaliar a influ ência da insuficiência cardíaca crônica (ICC) nos volumes pulmonares de repouso em pacientes com DPOC, ou seja, fração inspiratória -capacidade inspiratória (CI)/CPT - e reserva inspiratória relativa - [1 − (volume pulmonar inspirat ório final/CPT)]. Métodos: Após cuidado...
Source: Jornal Brasileiro de Pneumologia - September 5, 2016 Category: Respiratory Medicine Source Type: research