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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 20.

Further delineation of a rare recessive encephalomyopathy linked to mutations in GFER thanks to Data Sharing of whole exome sequencing data.
This report highlights the clinical utility of whole exome sequencing and reverse phenotyping for the diagnosis of ultra-rare diseases and underlines the importance of a broad data sharing for accurate clinical delineation of previously unrecognized entities. PMID: 28155230 [PubMed - as supplied by publisher] (Source: Clinical Genetics)
Source: Clinical Genetics - February 2, 2017 Category: Genetics & Stem Cells Authors: Nambot S, Gavrilov D, Thevenon J, Bruel AL, Bainbridge M, Rio M, Goizet C, Rötig A, Jaeken J, Niu N, Xia F, Vital A, Houcinat N, Mochel F, Kuentz P, Lehalle D, Duffourd Y, Rivière JB, Thauvin-Robinet C, Beaudet AL, Faivre L Tags: Clin Genet Source Type: research

Respiratory Morbidity Following Pediatric Orthotopic Liver Transplantation.
Abstract We evaluated the pulmonary complications following orthotopic liver transplantation in children (age <18 y). Twenty-two patients (49%) developed respiratory complications. Pediatric end-stage liver disease(PELD) score >25 and positive fluid balance were independent risk factors. Patients with respiratory complication had significantly higher mortality and intensive care unit stay. PMID: 28159955 [PubMed - as supplied by publisher] (Source: Indian Pediatrics)
Source: Indian Pediatrics - February 2, 2017 Category: Pediatrics Authors: Alam S, Sapare A, Rao S, Aggarwal R, D'cruz AL Tags: Indian Pediatr Source Type: research

Palivizumab Prophylaxis in Preterm Infants and Subsequent Recurrent Wheezing: 6 Year Follow Up Study.
CONCLUSION: Palivizumab prophylaxis administered to preterm infants did not suppress the onset of atopic asthma, but resulted in a significantly lower incidence of recurrent wheezing during the first 6 years. Clinical trial registration available at www.clinicaltrials.gov, ID NCT01545245. PMID: 28152315 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 2, 2017 Category: Respiratory Medicine Authors: Mochizuki H, Kusuda S, Okada K, Yoshihara S, Furuya H, Simões EA Tags: Am J Respir Crit Care Med Source Type: research

The quality of a newly developed infant chest compression method applied by paramedics: a randomized crossover manikin trial.
CONCLUSIONS: Our novel infant CC method provides the highest percentage of CCs with the frequency recommended by the ERC guidelines as compared with standard techniques. It also allows to obtain optimal CC depth. PMID: 28150278 [PubMed - as supplied by publisher] (Source: Polish Heart Journal)
Source: Polish Heart Journal - February 2, 2017 Category: Cardiology Authors: Smereka J, Kasinski M, Smereka A, Ładny JR, Szarpak Ł Tags: Kardiol Pol Source Type: research

Indications to respiratory syncytial virus immunoprophylaxis in the 29 –32 wGA group: is there still room for debating?
AbstractGuidelines on immunoprophylaxis for prevention of RSV infection recommend it in preterm babies born before 29 wGA; in babies affected by bronchopulmonary dysplasia or congenital heart defects; and in post-heart transplantation patients. On the contrary, immunoprophylaxis is not recommended in preterm babies born between 29 and 35 wGA. We evaluated the impact of RSV-related healthcare expenditures in infants in the first 3  years of life in Italy, Lombardy Region. In light of the collected data and considering the cost of a complete palivizumab prophylaxis, extending it to babies 29–32 wGA, aged less than 6 mont...
Source: Italian Journal of Pediatrics - February 2, 2017 Category: Pediatrics Source Type: research

Neutrophil-to-Lymphocyte Ratio Predicts Outcome in Limited Disease Small-cell Lung Cancer
ConclusionNLR was found to be an independent prognostic factor for overall survival. The evaluation of NLR can help identify patients with poor prognosis and appears a useful prognostic marker in clinical practice. A prospective analysis is warranted to confirm these findings. (Source: Lung)
Source: Lung - February 2, 2017 Category: Respiratory Medicine Source Type: research

Blood product transfusion in emergency department patients: a case-control study of practice patterns and impact on outcome
ConclusionsA significant percentage of ED blood product transfusions are discordant with guideline recommendations. However, there was no association with ED transfusion and worse clinical outcome. (Source: International Journal of Emergency Medicine)
Source: International Journal of Emergency Medicine - February 2, 2017 Category: Emergency Medicine Source Type: research

Safety and Preclinical Efficacy of Aerosol Pioglitazone on Lung Adenoma Prevention in A/J Mice
We examined the animals for any physical toxicity and bronchoalveolar lavage fluids for inflammatory and cytotoxicity markers. Doses up to and including 450 μg/kg bw/d failed to demonstrate toxicity with aerosol pioglitazone. For chemoprevention experiments, A/J mice were randomized to treatment groups of inhaled doses of 0, 50, 150, or 450 μg/kg bw/d pioglitazone 1 or 8 weeks after the last dose of B[a]P. For the early treatment group, we found up to 32% decrease in lung adenoma formation with 450 μg/kg bw/d pioglitazone. We repeated the treatments in a second late-stage experiment and found up to 44% decreases i...
Source: Cancer Prevention Research - February 2, 2017 Category: Cancer & Oncology Authors: Seabloom, D. E., Galbraith, A. R., Haynes, A. M., Antonides, J. D., Wuertz, B. R., Miller, W. A., Miller, K. A., Steele, V. E., Suen, C. S., O'Sullivan, M. G., Ondrey, F. G. Tags: Research Articles Source Type: research

Clinical evaluation of the isothermal amplification assays for the detection of four common respiratory viruses in children with pneumonia
AbstractRespiratory viruses are recognized as serious causes of morbidity and mortality in lower respiratory tract infections in patients. Isothermal amplification assays are increasingly used in their detection because of their rapidity, simplicity and cost-effectiveness, when compared to traditional molecular diagnostic methods. However, systematic assessment of these assays in the clinical settings is rarely reported. MEDLINE (Pubmed) searches were done analysing subject headings and words in the abstract related to isothermal amplification assay and virus. Selected loop-mediated isothermal amplification assays (LAMP) f...
Source: Archives of Virology - February 2, 2017 Category: Virology Source Type: research

Necessity to critically review the automatic results of the Xpert Flu assay
While using the Xpert Flu assay we became aware of false-negative results. The study aimed to analyze the causes of these false-negative results. 159 respiratory specimens were tested in the Xpert Flu assay and in multiplex reverse transcription –polymerase chain reactions (RT-PCRs) for respiratory viruses. Discordant specimens were tested in the Influenza A/B r-gene assay. 152 (96%) and 151 (95%) specimens yielded concordant results for influenza A and B, respectively. 15 specimens tested negative in the Xpert Flu assay and positive in a multiplex RT-PCR. (Source: Diagnostic Microbiology and Infectious Disease)
Source: Diagnostic Microbiology and Infectious Disease - February 2, 2017 Category: Microbiology Authors: Ilka Engelmann, Enagnon Kazali Alidjinou, Mouna Lazrek, Anny Dewilde, Didier Hober Source Type: research

Cystic fibrosis radiographic biomarkers
The review article “Chest Imaging in CF Studies: What Counts, and Can be Counted?” by Szczesniak, et al. [1], appearing in the current issue of the Journal of Cystic Fibrosis is the third paper published in the recent past that review the types and utility of endpoints that could be useful to expedite potential ne w therapies for patients with cystic fibrosis (CF). Previous papers by Stanojevic and Ratjen [2] and Muhlebach, Clancy, et al. [3] have laid out the state of development on CF clinical endpoints (July 2016 issue) and potential biomarker endpoints (November 2016 issue), respectively. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - February 2, 2017 Category: Respiratory Medicine Authors: Anthony G. Durmowicz Tags: Editorial Source Type: research

Stratification of cardiovascular risk in patients with atrial fibrillation and obstructive sleep apnea —validity of the 2MACE score
ConclusionOSA prevalence is increased in AF patients and is associated with an increase 2MACE score —an indicator of major cardiovascular events. There is a linear relationship between severity of OSA and increasing 2MACE scores, indicating increasing cardiovascular risk related to OSA severity. (Source: Sleep and Breathing)
Source: Sleep and Breathing - February 2, 2017 Category: Respiratory Medicine Source Type: research

The Art of Breathing: Flow
This is an image-based article and should be viewed in PDF form. Please click on the link to open the PDF version. (Source: European Respiratory Journal)
Source: European Respiratory Journal - February 2, 2017 Category: Respiratory Medicine Authors: Kotsimbos, T., Anderson, G. P. Tags: From the Museum Source Type: research

Moving towards tuberculosis elimination: a call for action from Italy and a possible model for other low tuberculosis incidence countries
In 2014 the World Health Assembly endorsed the new End Tuberculosis Strategy that aims at reducing the global incidence of the disease by 90% within 2035 [1]. (Source: European Respiratory Journal)
Source: European Respiratory Journal - February 2, 2017 Category: Respiratory Medicine Authors: Blasi, F., Matteelli, A., Sotgiu, G., Cirillo, D. M., Palmieri, F., Fattorini, L., Migliori, G. B. Tags: Respiratory infections and tuberculosis Editorials Source Type: research

Sleep apnoea and pulmonary hypertension in high-altitude dwellers: more than an association?
Increased pulmonary arterial pressure (PAP) is a hallmark of high-altitude exposure and, if exaggerated, may be associated with morbidity and mortality. High altitude also alters nocturnal breathing and altered nocturnal respiration has recently been reported to be associated with altered pulmonary and systemic vascular function in Andean high-altitude dwellers [1], suggesting the possibility of a causal link. Consistent with this hypothesis, in this issue of the European Respiratory Journal, Latshang et al. [2] report an association between pulmonary hypertension and sleep apnoea in Kyrgyz highlanders which remains s...
Source: European Respiratory Journal - February 2, 2017 Category: Respiratory Medicine Authors: Scherrer, U., Verges, S. Tags: Sleep medicine, Pulmonary vascular disease Editorials Source Type: research

Is twice the duration of washout sufficient time between multiple breath nitrogen washout tests?
We read the paper by K.M. Hardaker and co-workers with great interest. Their study confirmed our earlier data: that a washout-derived wait time between measurements of nitrogen-based multiple breath washout (MBW) was not influenced by disease severity, and that on average a wait time of twice the duration of the washout between nitrogen MBW tests eliminated potential measurement artefacts [1]. (Source: European Respiratory Journal)
Source: European Respiratory Journal - February 2, 2017 Category: Respiratory Medicine Authors: Salamon, E. R., Gain, K. R., Hall, G. L. Tags: Lung structure and function Original Articles: Correspondence Source Type: research

Overnight urinary isoprostanes as a marker of oxidative stress in obstructive sleep apnoea
Oxidative stress is thought to be of importance in the development of cardiovascular disease in obstructive sleep apnoea (OSA). However, our recent study [1] using data from two centres showed that markers of oxidative stress were not increased by the return of OSA caused by continuous positive airways pressure (CPAP) withdrawal for 2 weeks. Unexpectedly, we found decreased levels of urinary isoprostanes in early morning urine specimens and this, combined with increased levels of blood superoxide dismutase, raised the possibility that oxidative stress might be decreased by OSA. (Source: European Respiratory Journal)
Source: European Respiratory Journal - February 2, 2017 Category: Respiratory Medicine Authors: Turnbull, C. D., Akoumianakis, I., Antoniades, C., Stradling, J. R. Tags: Sleep medicine Original Articles: Research letters Source Type: research

Association between sleep apnoea and pulmonary hypertension in Kyrgyz highlanders
This case–control study evaluates a possible association between high altitude pulmonary hypertension (HAPH) and sleep apnoea in people living at high altitude. Ninety highlanders living at altitudes >2500 m without excessive erythrocytosis and with normal spirometry were studied at 3250 m (Aksay, Kyrgyzstan); 34 healthy lowlanders living below 800 m were studied at 760 m (Bishkek, Kyrgyzstan). Echocardiography, polysomnography and other outcomes were assessed. Thirty-six highlanders with elevated mean pulmonary artery pressure (mPAP) >30 mmHg (31–42 mmHg by echocardiography)...
Source: European Respiratory Journal - February 2, 2017 Category: Respiratory Medicine Authors: Latshang, T. D., Furian, M., Aeschbacher, S. S., Ulrich, S., Osmonov, B., Mirrakhimov, E. M., Isakova, J., Aldashev, A. A., Sooronbaev, T. M., Bloch, K. E. Tags: Sleep medicine, Pulmonary vascular disease Original Articles: Sleep, altitude and pulmonary hypertension Source Type: research

Urinary prostanoids in preschool wheeze
In this study, we sought evidence for either increased PGD2 biosynthesis or reduced PGE2 biosynthesis, or a combination of both in children with preschool wheeze. To achieve this, we measured the major metabolites of PGD2 and PGE2 in the urine: 9α-hydroxy-11,15-dioxo-2,3,4,5-tetranor-prostan-1,20-dioic acid (tetranor-PGDM) and 9,15-dioxo-11α-hydroxy-13,14-dihydro-2,3,4,5-tetranor-prostan-1,20-dioic acid (tetranor-PGEM), respectively [5, 6]. (Source: European Respiratory Journal)
Source: European Respiratory Journal - February 2, 2017 Category: Respiratory Medicine Authors: Grigg, J., Whitehouse, A., Pandya, H., Turner, S., Griffiths, C. J., Vulliamy, T., T. Walton, R., Price, D. B., Sanak, M., Holloway, J. W., Noimark, L., Lesosky, M., Brugha, R., Koh, L., Nwokoro, C. Tags: Asthma and allergy, Paediatric pulmonology Original Articles: Research letters Source Type: research

Prospective study of insomnia and incident asthma in adults: the HUNT study
Insomnia is highly prevalent among asthmatics; however, few studies have investigated insomnia symptoms and asthma development. We aimed to investigate the association between insomnia and the risk of incident asthma in a population-based cohort. Among 17 927 participants free from asthma at baseline we calculated odds ratios and 95% confidence intervals for the risk of incident asthma among those with insomnia compared to those without. Participants reported sleep initiation problems, sleep maintenance problems and nonrestorative sleep. Chronic insomnia was defined as those reporting one or more insomnia symptom at baseli...
Source: European Respiratory Journal - February 2, 2017 Category: Respiratory Medicine Authors: Brumpton, B., Mai, X.-M., Langhammer, A., Laugsand, L. E., Janszky, I., Strand, L. B. Tags: Epidemiology, occupational and environmental lung disease, Asthma and allergy Original Articles: Asthma Source Type: research

Is twice the duration of washout sufficient time between multiple breath nitrogen washout tests?
Multiple breath washout (MBW) assesses both lung volume (functional residual capacity (FRC)) and ventilation inhomogeneity (lung clearance index (LCI)). The latter's insight into underlying lung pathology and response to intervention has triggered a recent MBW resurgence [1–4]. Validated commercial equipment has become available [5], increasing suitability for widespread use, and a European Respiratory Society/American Thoracic Society endorsed MBW consensus statement has been published to guide manufacturers and operators [6]. This document highlights the need for further evidence across several recommendation areas...
Source: European Respiratory Journal - February 2, 2017 Category: Respiratory Medicine Authors: Hardaker, K. M., Gustafsson, P., Cooper, P., Fitzgerald, D., Selvadurai, H., Robinson, P. D. Tags: Original Articles: Correspondence Source Type: research

An aggressive non-small cell lung cancer in nonsmokers: A case report of an unusual presentation of micropapillary lung adenocarcinoma
We describe a case of an unusual fast growing lung micropapillary-predominant adenocarcinoma in a nonsmoker male patient without pre-existing lung disease. Adenocarcinomas have been described to be slow growing tumors, however our patient presented a fast-growing rate over a period of 21 days. When the patient failed broad spectrum antibiotic coverage, malignancy became part of the differential diagnosis. Once malignancy was detected, prompt identification and treatment was started in order to improve prognosis of the patients. (Source: Respiratory Medicine Case Reports)
Source: Respiratory Medicine Case Reports - February 2, 2017 Category: Respiratory Medicine Source Type: research

Endobronchial neurogenic tumor: A combination of traumatic neuroma and neurofibroma
Publication date: Available online 2 February 2017 Source:Respiratory Medicine Case Reports Author(s): Amit Tandon Traumatic neuromas are uncommon and benign lesions arising from a peripheral nerve injury during surgery. Here we describe a case with histopathologic features of both a traumatic neuroma and neurofibroma in a patient without integumentary physical exam findings nor prior surgical history. A 54 year old male was admitted for surgical debridement of a foot ulcer. During pre-operative evaluation and review of imaging multiple CT scans revealed a stable, 4 mm endobronchial lesion in the left lower lobe. Given h...
Source: Respiratory Medicine Case Reports - February 2, 2017 Category: Respiratory Medicine Source Type: research

Matrix metalloproteinases and airway remodeling and function in primary ciliary dyskinesia
The balance between matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) is important in the regulation of airway damage. (Source: Respiratory Medicine)
Source: Respiratory Medicine - February 2, 2017 Category: Respiratory Medicine Authors: Massimo Pifferi, Andrew Bush, Davide Caramella, Maria Rita Metelli, Maria Di Cicco, Martina Piras, Giulia Gherarducci, Carlo Capristo, Fabrizio Maggi, Diego Peroni, Attilio L. Boner Tags: Clinical Trial Paper Source Type: research

Gastro-Esophageal Reflux
Gastroesophageal reflux (GERD) is a very common condition and affects approximately 7 –20% of the pediatric population. Symptoms from pathologic GERD include regurgitation, irritability when feeding, respiratory problems, and substernal pain. Treatment typically starts with dietary modifications and postural changes. Anti-reflux medications may then be added. Indications for operat ive management in the pediatric population include failure of medical therapy with poor weight gain or failure to thrive, continued respiratory symptoms, and complications such as esophagitis. (Source: Seminars in Pediatric Surgery)
Source: Seminars in Pediatric Surgery - February 2, 2017 Category: Pediatrics Authors: Bethany J. Slater, Steven S. Rothenberg Source Type: research

Twitch mouth pressure for detecting respiratory muscle weakness in suspicion of neuromuscular disorder
• Maximal inspiratory pressure measurement is noninvasive but requires cooperative patients• Twitch transdiaphragmatic pressure measurement requires the insertion of an esophageal catheter• Twitch mouth pressure measurement is nonvolitional/noninvasive and provides reliable results• Combinin g volitional and nonvolitional noninvasive tests constitutes an optimal strategy for assessing respiratory muscle function (Source: Neuromuscular Disorders)
Source: Neuromuscular Disorders - February 2, 2017 Category: Neurology Authors: Dante Brasil Santos, Gilbert Desmarais, Line Falaize, Adam Ogna, Sandrine Cognet, Bruno Louis, David Orlikowski, H élène Prigent, Frédéric Lofaso Source Type: research

Respiratory syncytial virus hospitalizations in infants of 28 weeks gestational age and less in the palivizumab era
(Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - February 2, 2017 Category: Infectious Diseases Authors: Bernhard Resch, Beatrice Egger, Stefan Kurath-Koller, Berndt Urlesberger Source Type: research

Role of Adenoidectomy in Chronic Nasal Obstruction After Nasal Steroid Therapy Failure
Conclusions This study demonstrates average rates of respiratory allergies, but high rates of asthma among patients that fail nasal steroid therapy for chronic nasal obstruction. Adenoidectomy is a highly efficacious intervention in this subset of patients. (Source: American Journal of Otolaryngology)
Source: American Journal of Otolaryngology - February 2, 2017 Category: Endocrinology Source Type: research

Role of second-hand smoke (SHS)-induced proteostasis/autophagy impairment in pediatric lung diseases
ConclusionsSHS-exposure induced proteostasis/autophagy impairment can mediate the initiation of chronic lung disease in pediatric subjects. Hence, our data warrants the evaluation of proteostasis/autophagy-inducing drugs, such as cysteamine, as a potential therapeutic intervention strategy for SHS-induced pediatric lung diseases. (Source: Molecular and Cellular Pediatrics)
Source: Molecular and Cellular Pediatrics - February 2, 2017 Category: Cytology Source Type: research

Selected highlights from other veterinary journals
This study aimed to evaluate exercise tolerance in EB and compare the results with the severity of BOAS in these dogs. A total of 28 EB were included in the study and a veterinary assessment of BOAS severity was made... (Source: Veterinary Record)
Source: Veterinary Record - February 2, 2017 Category: Veterinary Research Tags: Research Digest Source Type: research

Diagnosis of Hepatozoon canis
WE wish to share with our colleagues the details of a case of Hepatozoon canis in a two-year-old female spaniel imported from Cyprus two days before presentation at a UK veterinary practice. It had been neutered 10 days previously, and presented with dyspnoea, generalised pruritus and a mammary mass. Clinical examination revealed pyrexia (39.8°C), tachycardia (heart rate 120) and tachypnoea (respiratory rate 80), with increased respiratory effort. Mucus membranes were pale; capillary refill time was less than two seconds. The coat condition was poor, with focal areas of lichenification and crusting. A blood sample was ...
Source: Veterinary Record - February 2, 2017 Category: Veterinary Research Authors: Skeldon, N., Klaassen, J., Hinds, M. Tags: Letter Source Type: research

Unraveling the contact patterns and network structure of pig shipments in the United States and its association with porcine reproductive and respiratory syndrome virus (PRRSV) outbreaks
In this study, we used social network analysis to characterize the swine shipment network structure and properties in a typical multisite swine production system in the US. We also aimed to evaluate the association between network properties and porcine respiratory and reproductive syndrome virus (PRRSV) transmission between production sites. We analyzed the 109,868 swine shipments transporting over 93 million swine between more than 500 production sites from 2012 to 2014. A total of 248 PRRSV positive occurrences were reported from 79 production sites during those 3 years. The temporal dynamics of swine shipments was eval...
Source: Preventive Veterinary Medicine - February 2, 2017 Category: Veterinary Research Source Type: research

Surfactant reduced the mortality of neonates with birth weight ⩾1500 g and hypoxemic respiratory failure: a survey from an emerging NICU network
Surfactant reduced the mortality of neonates with birth weight ⩾1500 g and hypoxemic respiratory failure: a survey from an emerging NICU network Journal of Perinatology advance online publication, February 2 2017. doi:10.1038/jp.2016.272 Authors: H Wang, X Gao, C Liu, C Yan, X Lin, Y Dong & B Sun (Source: Journal of Perinatology)
Source: Journal of Perinatology - February 2, 2017 Category: Perinatology & Neonatology Authors: H Wang X Gao C Liu C Yan X Lin Y Dong B Sun Source Type: research

Intermittent hypoxia revisited: a promising non-pharmaceutical strategy to reduce cardio-metabolic risk factors?
ConclusionA short course of recurrent IH appears to be a safe and effective non-pharmacological method of reducing key cardiovascular risk factors associated with metabolic disorders. (Source: Sleep and Breathing)
Source: Sleep and Breathing - February 2, 2017 Category: Respiratory Medicine Source Type: research

A third of patients diagnosed with asthma have no current symptoms, lending support to guideline recommendations
Publication date: Available online 2 February 2017 Source:The Lancet Respiratory Medicine Author(s): Aaron van Dorn (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - February 2, 2017 Category: Respiratory Medicine Source Type: research

Blood Patch for Pneumothorax: a Literature Review
This article reviewed the existing literature for the use of autologous blood patch in patients with a pneumothorax.Recent findingsIntra-pleural instillation of autologous blood for pneumothorax has been advocated in numerous case reports, case series, retrospective and prospective studies, often with very promising results. However, high-quality randomised evidence remains lacking. There is no standard approach to the application and delivery method of autologous blood patch, and its underlying mechanism is debated.SummaryAutologous blood patch for persistent air leak in pneumothorax is efficacious, readily available, che...
Source: Current Respiratory Care Reports - February 2, 2017 Category: Respiratory Medicine Source Type: research

The effect of the affordable care act dependent coverage provision on patients with cystic fibrosis
ConclusionsThe ACA dependent coverage provision did not increase private insurance coverage or use of routine care among CF patients who were potentially affected by this policy. Pediatr Pulmonol. 2016; 9999:XX–XX. © 2016 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - February 2, 2017 Category: Respiratory Medicine Authors: Dmitry Tumin, Susan S. Li, Benjamin T. Kopp, Stephen E. Kirkby, Joseph D. Tobias, Wayne J. Morgan, Don Hayes Tags: Original Article: Cystic Fibrosis Source Type: research

3D myocardial T1 mapping using saturation recovery
ConclusionThe proposed 3D SASHA sequence allows for high‐resolution free‐breathing whole‐heart T1‐mapping with T1 values in good agreement with the 2D SASHA and improved precision.Level of Evidence: 2J. Magn. Reson. Imaging 2017 (Source: Journal of Magnetic Resonance Imaging)
Source: Journal of Magnetic Resonance Imaging - February 2, 2017 Category: Radiology Authors: Giovanna Nordio, Markus Henningsson, Amedeo Chiribiri, Adriana D.M. Villa, Torben Schneider, Ren é M. Botnar Tags: Original Research Source Type: research

Quantifying the influence of respiration and cardiac pulsations on cerebrospinal fluid dynamics using real ‐time phase‐contrast MRI
ConclusionRT‐PCMRI can noninvasively measure instantaneous CSF velocity driven by cardiac pulsations, respiration, and coughing in real time. A comparable contribution of respiration and cardiac pulsations on CSF velocity was found during deep breathing but not during natural breathing.Level of Evidence: 1J. Magn. Reson. Imaging 2017. (Source: Journal of Magnetic Resonance Imaging)
Source: Journal of Magnetic Resonance Imaging - February 2, 2017 Category: Radiology Authors: Selda Yildiz, Suraj Thyagaraj, Ning Jin, Xiaodong Zhong, Soroush Heidari Pahlavian, Bryn A. Martin, Francis Loth, John Oshinski, Karim G. Sabra Tags: Original Research Source Type: research

Effect of tiotropium and olodaterol on symptoms and patient-reported outcomes in patients with COPD: results from four randomised, double-blind studies
npj Primary Care Respiratory Medicine, Published online: 2 February 2017; doi:10.1038/s41533-016-0002-x (Source: npj Primary Care Respiratory Medicine)
Source: npj Primary Care Respiratory Medicine - February 2, 2017 Category: Primary Care Authors: Gary T. Ferguson Jill Karpel Nathan Bennett Emmanuelle Clerisme-Beaty Lars Gr önke Florian Vo ß Roland Buhl Source Type: research

Ex vivo humidifying capacity and patient acceptability of stoma cloths in laryngectomized individuals
ConclusionAlthough less acceptable to patients who use an HME, stoma cloths do provide significant humidifying capacity and should be encouraged when HMEs are unavailable or inappropriate. © 2017 Wiley Periodicals, Inc. Head Neck, 2017 (Source: Head and Neck)
Source: Head and Neck - February 2, 2017 Category: ENT & OMF Authors: Liset Lansaat, Cindy van den Boer, Sara H. Muller, Vincent van der Noort, Michiel W. M. van den Brekel, Frans J. M. Hilgers Tags: Original Article Source Type: research

A complicated diagnosis of constrictive pericarditis in a patient with atrial fibrillation – The importance of temporary pacing inducing regular heart rhythm during invasive hemodynamic study
Conclusions CP should be considered in unexplained increase of cholestatic enzymes. In AFib, the TTE parameters based on respiratory variation may not be useful. However, a combination of the remaining TTE parameters can indicate CP and trigger further investigation. Temporary pacing to avoid beat-to-beat variability in AFib can “unmask” the ventricular pressures discordance, and thus be helpful in unclear CP cases. (Source: Cor et Vasa)
Source: Cor et Vasa - February 2, 2017 Category: Cardiology Source Type: research

Can Vaccinations Improve Heart Failure  Outcomes?
Publication date: Available online 1 February 2017 Source:JACC: Heart Failure Author(s): Ankeet S. Bhatt, Adam D. DeVore, Adrian F. Hernandez, Robert J. Mentz Heart failure (HF) is a chronic syndrome characterized by acute exacerbations. There is significant overlap between respiratory infections and exacerbation of underlying HF. Vaccination against respiratory infections in patients with HF could serve as a potential cost-effective intervention to improve patients’ quality of life and clinical outcomes. The benefits of influenza vaccination in secondary prevention of ischemic heart disease have been previously studie...
Source: JACC: Heart Failure - February 2, 2017 Category: Cardiology Source Type: research

Mitochondria and cancer chemoresistance
This article is part of a Special Issue entitled Respiratory complex I, edited by Giuseppe Gasparre, Rodrigue Rossignol and Pierre Sonveaux. (Source: Biochimica et Biophysica Acta (BBA) Bioenergetics)
Source: Biochimica et Biophysica Acta (BBA) Bioenergetics - February 2, 2017 Category: Biochemistry Source Type: research

Identification of novel missense HEXB gene mutation in Iranian-child with juvenile Sandhoff disease
Publication date: Available online 1 February 2017 Source:Meta Gene Author(s): Reza Ebrahimzadeh-Vesal, Sousan Hosseini, Morteza Moghaddassian, Mohammad Reza Abbaszadegan Sandhoff disease is an autosomal recessive lysosomal storage disease caused by mutation in the HEXB gene. Accumulation of GM2 gangliosides resulting in advanced motor neuron manifestation and death from respiratory failure and infections in infantiles. Pathogenic mutations in the HEXB gene were detected that leads to enzyme activity reduction and therefore interruption of normal metabolic cycles of GM2 ganglioside in Sandhoff patients. We included one Ir...
Source: Meta Gene - February 2, 2017 Category: Genetics & Stem Cells Source Type: research

Imaging of nontraumatic thoracic emergencies
Purpose of review: Acute chest symptoms form an important incentive for imaging in the emergency setting. This review discusses the radiologic features of various vascular and pulmonary diseases leading to acute respiratory distress and recent developments on important emergency radiologic examinations. Recent findings: Recently, triple-rule-out computed tomography protocol was introduced in diagnosis of chest pain, and advancing computed tomography technology and knowledge have led to discussion on treatment of pulmonary embolism. Diffuse pulmonary opacities remain a diagnostic dilemma in the emergency setting and althou...
Source: Current Opinion in Pulmonary Medicine - February 1, 2017 Category: Respiratory Medicine Tags: IMAGING: Edited by Johny Verschakelen Source Type: research

Does increased traffic flow around unconventional resource development activities represent the major respiratory hazard to neighboring communities?: knowns and unknowns
The objective of this review is to demonstrate that the focus on air emissions causing respiratory effects and associated with gas development may be misplaced by attributing those exposures mainly to well pad activities. Recent findings: The most recent publications on the health effects of hydraulic fracturing operations seem to parallel findings from studies of diesel particulate exposure near roadways and the health effects associated with those exposures. It seems at least possible that some, if not all, of the respiratory effects associated with unconventional resource development may be traffic-related. Road traffi...
Source: Current Opinion in Pulmonary Medicine - February 1, 2017 Category: Respiratory Medicine Tags: OBSTRUCTIVE, OCCUPATIONAL AND ENVIRONMENTAL DISEASES: Edited by Basil Varkey and Manish Joshi Source Type: research

Neuromuscular weakness in chronic obstructive pulmonary disease: chest wall, diaphragm, and peripheral muscle contributions
Purpose of review: Chronic obstructive lung disease affects the lung parenchyma and airways leading to well described effects in respiratory function. This review describes the current knowledge and advances regarding neuromuscular function and chest wall mechanics, which are affected in chronic obstructive pulmonary disease (COPD). Recent findings: In COPD, progressive lung hyperinflation becomes constrained by a chest wall with decreasing capacity to expand, resulting in respiratory muscle inefficiency. There is evidence of neuromuscular uncoupling, that is, the respiratory muscle is unable to increase its output in pro...
Source: Current Opinion in Pulmonary Medicine - February 1, 2017 Category: Respiratory Medicine Tags: OBSTRUCTIVE, OCCUPATIONAL AND ENVIRONMENTAL DISEASES: Edited by Basil Varkey and Manish Joshi Source Type: research

Chronic obstructive pulmonary disease and sleep related disorders
This article discusses the impact of sleep disorders on COPD patients and the potential benefits of managing sleep disorders on respiratory disease control and quality of life. (Source: Current Opinion in Pulmonary Medicine)
Source: Current Opinion in Pulmonary Medicine - February 1, 2017 Category: Respiratory Medicine Tags: OBSTRUCTIVE, OCCUPATIONAL AND ENVIRONMENTAL DISEASES: Edited by Basil Varkey and Manish Joshi Source Type: research

Obstructive and environmental respiratory diseases: updates and new facets
No abstract available (Source: Current Opinion in Pulmonary Medicine)
Source: Current Opinion in Pulmonary Medicine - February 1, 2017 Category: Respiratory Medicine Tags: OBSTRUCTIVE, OCCUPATIONAL AND ENVIRONMENTAL DISEASES: Edited by Basil Varkey and Manish Joshi Source Type: research