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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 2.

The cumulative effects of intravenous antibiotic treatments on hearing in patients with cystic fibrosis
Aminoglycosides (AGs) and glycopeptides are antibiotics essential for treating life-threatening respiratory infections in patients with cystic fibrosis (CF). The goal of this study was to examine the effects of cumulative intravenous (IV)-AG (amikacin and/or tobramycin) and/or glycopeptide (vancomycin) dosing on hearing status in patients with CF. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - February 24, 2017 Category: Respiratory Medicine Authors: Angela C. Garinis, Campbell P. Cross, Priya Srikanth, Kelly Carroll, M. Patrick Feeney, Douglas H. Keefe, Lisa L. Hunter, Daniel B. Putterman, David M. Cohen, Jeffrey A. Gold, Peter S. Steyger Tags: Original Article Source Type: research

Use of concomitant inhaled corticosteroids: pooled data from two phase III studies of aclidinium plus formoterol in COPD
npj Primary Care Respiratory Medicine, Published online: 24 February 2017; doi:10.1038/s41533-016-0009-3 (Source: npj Primary Care Respiratory Medicine)
Source: npj Primary Care Respiratory Medicine - February 24, 2017 Category: Primary Care Authors: Anthony D ’Urzo Dave Singh Esther Garcia Gil Source Type: research

Association between ventilatory settings and development of acute respiratory distress syndrome in mechanically ventilated patients due to brain injury
Conclusions In a cohort of brain-injured patients the development of ARDS was not common. Driving pressure was associated with the development of this disease. (Source: Journal of Critical Care)
Source: Journal of Critical Care - February 24, 2017 Category: Gastroenterology Source Type: research

Quality and readability assessment of websites related to recurrent respiratory papillomatosis
ConclusionThe quality and readability of English websites about RRP is alarmingly poor.Level of Evidence: NA.Laryngoscope, 2017 (Source: The Laryngoscope)
Source: The Laryngoscope - February 24, 2017 Category: ENT & OMF Authors: Michel R.M. San Giorgi, Olivier S.D. de Groot, Frederik G. Dikkers Tags: Laryngology Source Type: research

PEGylation prolongs the pulmonary retention of an anti-IL-17A Fab ’ antibody fragment after pulmonary delivery in three different species
Publication date: 15 April 2017 Source:International Journal of Pharmaceutics, Volume 521, Issues 1–2 Author(s): Danielle Freches, Harshad P. Patil, Maria Machado Franco, Catherine Uyttenhove, Sam Heywood, Rita Vanbever The PEGylation of antibody fragments has been shown to greatly prolong their residence time in the lungs in mice. The purpose of this research was to confirm the effect of PEGylation in higher animal species, that is, the rat and the rabbit. An anti-IL-17A Fab’ antibody fragment was conjugated to a two-armed 40kDa polyethylene glycol (PEG) via site-selective thiol PEGylation. PEGylation did not signifi...
Source: International Journal of Pharmaceutics - February 24, 2017 Category: Drugs & Pharmacology Source Type: research

Respiratory rate estimation from the photoplethysmogram via joint sparse signal reconstruction and spectra fusion
Publication date: May 2017 Source:Biomedical Signal Processing and Control, Volume 35 Author(s): Xiaorong Zhang, Quan Ding Respiratory rate (RR) estimation from the photoplethysmogram (PPG) is a challenging problem due to the nonstationarity of RR and disturbance. In this work, we propose a novel approach to estimate RR from the PPG signal using joint sparse signal reconstruction (JSSR) and spectra fusion (SF). A window of PPG signal is segmented into multiple overlapped measurements. Sparse spectra of these measurements are estimated by JSSR using the regularized M-FOCUSS algorithm. The kurtosis of each spectrum is used ...
Source: Biomedical Signal Processing and Control - February 24, 2017 Category: Biomedical Science Source Type: research

Evaluation of respiratory properties by means of fractional order models
Publication date: April 2017 Source:Biomedical Signal Processing and Control, Volume 34 Author(s): I. Assadi, A. Charef, D. Copot, R. De Keyser, T. Bensouici, C. Ionescu The goal of this paper is to model and analyze the properties of the respiratory system by means of fractional calculus. A linear fractional order system of commensurate order is obtained using the real and the imaginary parts of the measured respiratory impedance through an identification technique. In this context, the features used for the classification of some respiratory diseases are the identified parameters of the linear fractional order system of...
Source: Biomedical Signal Processing and Control - February 24, 2017 Category: Biomedical Science Source Type: research

A rapidly progressive hydatid disease imitating metastatic malignancy: An unusual multi-organ presentation. Report of a case and review of literature
Publication date: Available online 24 February 2017 Source:Respiratory Medicine Case Reports Author(s): Qays Ahmed Hassan Al-timimy Hydatid disease is still a major health and socio-economic problem in endemic regions. It is the most frequent parasitic infection that commonly affects the liver and rarely involves multiple organs. Herein, I report an extraordinary case of multi-organ hydatid disease that presented with rapidly progressive disseminated nature that mimic metastatic malignancy highlighting the interest of keeping a high level of clinical suspicion of this diagnosis especially in endemic regions. (Source: Resp...
Source: Respiratory Medicine Case Reports - February 24, 2017 Category: Respiratory Medicine Source Type: research

Failure of extracorporeal membrane oxygenation to rescue acute respiratory distress syndrome caused by dual infection of influenza A (H1N1) and invasive pulmonary aspergillosis
Publication date: Available online 23 February 2017 Source:Journal of the Formosan Medical Association Author(s): Po-An Su, Wen-Liang Yu (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - February 24, 2017 Category: Journals (General) Source Type: research

Severe community-acquired pneumonia: optimal management
Purpose of review: Community-acquired pneumonia (CAP) is the leading cause of mortality among infectious diseases. Several efforts have been implemented to achieve better outcomes, but an important proportion of patients continue dying. This review focuses on the newest research on prognostic factors and diagnostics, opening new perspectives in the management of CAP. Recent findings: CAP survival improved in recent years despite an increasing incidence of severe presentations. Appropriateness of antimicrobial choice, combination therapy and early administration of antibiotics has proved to be decisive. Novel biomarkers, a...
Source: Current Opinion in Infectious Diseases - February 23, 2017 Category: Infectious Diseases Tags: RESPIRATORY INFECTIONS: Edited by Michael S. Niederman Source Type: research

Antibiotic dosing for multidrug-resistant pathogen pneumonia
Purpose of review: Nosocomial pneumonia caused by multidrug-resistant pathogens is increasing in the ICU, and these infections are negatively associated with patient outcomes. Optimization of antibiotic dosing has been suggested as a key intervention to improve clinical outcomes in patients with nosocomial pneumonia. This review describes the recent pharmacokinetic/pharmacodynamic data relevant to antibiotic dosing for nosocomial pneumonia caused by multidrug-resistant pathogens. Recent findings: Optimal antibiotic treatment is challenging in critically ill patients with nosocomial pneumonia; most dosing guidelines do not...
Source: Current Opinion in Infectious Diseases - February 23, 2017 Category: Infectious Diseases Tags: RESPIRATORY INFECTIONS: Edited by Michael S. Niederman Source Type: research

Respiratory pathogen panels in the hospital: good or unnecessary?
Purpose of review: We aim to review the epidemiology of respiratory viral infections and the strengths and limitations of multiplex respiratory pathogen panels that are currently available along with their respective features and differences. Recent findings: We give particular emphasis to the pathogens included on each test and evaluate their performance in the hospital setting. Summary: We conclude with a discussion on the evidence for the clinical utility of respiratory pathogen multiplex panels in hospitalized patients, including the potential for coinfection with viral and bacterial pathogens. (Source: Current Opini...
Source: Current Opinion in Infectious Diseases - February 23, 2017 Category: Infectious Diseases Tags: RESPIRATORY INFECTIONS: Edited by Michael S. Niederman Source Type: research

Duration of pneumonia therapy and the role of biomarkers
Purpose of review: Increasing antimicrobial resistance is a worldwide phenomenon that is threatening public health. Lower respiratory infections are one of the leading causes of morbidity that contribute to antibiotic consumption and thus the emergence of multidrug-resistant microbial strains. The goal of shortening antibiotic regimens’ duration in common bacterial infections has been prioritized by antimicrobial stewardship programs as an action against this problem. Recent findings: Data coming from randomized controlled trials, meta-analyses, and systematic reviews support the shortening of antimicrobial regimens in ...
Source: Current Opinion in Infectious Diseases - February 23, 2017 Category: Infectious Diseases Tags: RESPIRATORY INFECTIONS: Edited by Michael S. Niederman Source Type: research

Prevention of ventilator-associated pneumonia
In conclusion, in the past year, new evidence elucidated limitations of new ETT cuffs in the prevention of VAP; whereas, subglottic secretion aspiration proved consistent benefits. Modulation of oropharyngeal colonization with chlorhexidine decreases risks of VAP and should be widely implemented. Finally, preventive measures with proven preventive value should be grouped into bundles. (Source: Current Opinion in Infectious Diseases)
Source: Current Opinion in Infectious Diseases - February 23, 2017 Category: Infectious Diseases Tags: RESPIRATORY INFECTIONS: Edited by Michael S. Niederman Source Type: research

The microbiome in mechanically ventilated patients
Purpose of review: Discovery of a normal lung microbiome requires reassessment of our concepts of HAP/VAP pathogenesis and has important implications for clinical diagnosis and management. Recent findings: Changes in the microbiome of dental plaque are associated with increased risk of HAP/VAP. A transition to a lung microbiome enriched with gut flora is found in ARDS with an increased inflammatory response in patients with this change in microbial flora. A characteristic microbiome pattern of higher amounts of bacterial DNA, lower community diversity, and greater relative abundance of a single species characterize pneumo...
Source: Current Opinion in Infectious Diseases - February 23, 2017 Category: Infectious Diseases Tags: RESPIRATORY INFECTIONS: Edited by Michael S. Niederman Source Type: research

Bacterial pneumonia as an influenza complication
Purpose of review: The pathogenesis and impact of coinfection, in particular bacterial coinfection, in influenza are incompletely understood. This review summarizes results from studies on bacterial coinfection in the recent pandemic influenza outbreak. Recent findings: Systemic immune mechanisms play a key role in the development of coinfection based on the complexity of the interaction of the host and the viral and bacterial pathogens. Several studies were performed to determine the point prevalence of bacterial coinfection in influenza. Coinfection in influenza is frequent in critically ill patients with Streptococcus ...
Source: Current Opinion in Infectious Diseases - February 23, 2017 Category: Infectious Diseases Tags: RESPIRATORY INFECTIONS: Edited by Michael S. Niederman Source Type: research

Reactive oxygen therapy: a novel therapy in soft tissue infection
Purpose of review: The global burden of disease in skin and soft tissue lesions is enormous. Many chronic, poorly healing lesions get treated with antibiotics despite the lack of evidence for long-term antibiotics. There is a global antibiotic resistance crisis driven largely by inappropriate use of large volumes of antibiotics. One solution is to reduce the selection pressure on bacteria by reducing the volume of antibiotic use in medicine, agriculture and the environment. There are few novel antimicrobials. One of the only novel agents to reach clinical use is one using reactive oxygen species (ROS), oxygen radicals, as ...
Source: Current Opinion in Infectious Diseases - February 23, 2017 Category: Infectious Diseases Tags: SKIN AND SOFT TISSUE INFECTIONS: Edited by Matteo Bassetti Source Type: research

Waste exposure and skin diseases.
Authors: Megna M, Napolitano M, Costa C, Balato N, Patruno C Abstract Waste is a composite mixture of different substances including endotoxins, organic dust and bio-aerosol stuffed with micro-organisms, as well as various toxic organic and inorganic chemicals, which may be intrinsically hazardous to human health. Therefore, health risks may derive from direct or indirect contact with garbage. Although few epidemiological and clinical surveys investigated on the adverse effects of garbage exposure on human health, particularly regarding respiratory, gastrointestinal, musculoskeletal and mucous membranes systems, on...
Source: Giornale Italiano di Dermatologia e Venereologia - February 23, 2017 Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research

Frequent users of the emergency department services in the largest academic hospital in the Netherlands: a 5-year report
Conclusion: Frequent use of the ED has been depicted as inappropriate use of these services. However, our study shows that FUs consist of a relatively small number of patients and that FUs suffer from chronic, and often, severe somatic illnesses that require specialized medical care. (Source: European Journal of Emergency Medicine)
Source: European Journal of Emergency Medicine - February 23, 2017 Category: Emergency Medicine Tags: Original Articles Source Type: research

Update on asthma and cleaning agents
This article provides new information on the level of exposure, which is still high in professional cleaners and even more in domestic cleaners, and on the frequency of asthma in professional and domestic cleaners. An irritant mechanism is more common, although an immunological mechanism is possible, especially in healthcare workers exposed to disinfectants. (Source: Current Opinion in Allergy and Clinical Immunology)
Source: Current Opinion in Allergy and Clinical Immunology - February 23, 2017 Category: Allergy & Immunology Tags: OCCUPATIONAL DISEASE: Edited by Susan M. Tarlo and Piero Maestrelli Source Type: research

Progress with Structure–Activity Relationship modelling of occupational chemical respiratory sensitizers
Purpose of review: This appraises currently available computer-based (‘in silico’) models relating the molecular structure of low molecular weight compounds to their respiratory sensitization hazard. The present review places focus on the two main applications of such structure--activity relationship (SAR) models: hypotheses on disease mechanisms and toxicological prediction. Recent findings: Analyses of the chemical structures of low molecular weight organic compounds known to have caused occupational asthma has led to the development of mechanistic alerts usually based on electrophilic reaction chemistry and protein...
Source: Current Opinion in Allergy and Clinical Immunology - February 23, 2017 Category: Allergy & Immunology Tags: OCCUPATIONAL DISEASE: Edited by Susan M. Tarlo and Piero Maestrelli Source Type: research

Committee Opinion No.689 Summary: Delivery of a Newborn With Meconium-Stained Amniotic Fluid.
Authors: Abstract In 2006, the American Academy of Pediatrics and the American Heart Association published the 2005 guidelines on neonatal resuscitation. Before the 2005 guidelines, management of a newborn with meconium-stained amniotic fluid included suctioning of the oropharynx and nasopharynx on the perineum after the delivery of the head but before the delivery of the shoulders. The 2005 guidelines did not support this practice because routine intrapartum suctioning does not prevent or alter the course of meconium aspiration syndrome in vigorous newborns. However, the 2005 guidelines did support intubation of...
Source: Obstetrics and Gynecology - February 23, 2017 Category: OBGYN Tags: Obstet Gynecol Source Type: research

Committee Opinion No 689: Delivery of a Newborn With Meconium-Stained Amniotic Fluid.
Authors: Abstract In 2006, the American Academy of Pediatrics and the American Heart Association published the 2005 guidelines on neonatal resuscitation. Before the 2005 guidelines, management of a newborn with meconium-stained amniotic fluid included suctioning of the oropharynx and nasopharynx on the perineum after the delivery of the head but before the delivery of the shoulders. The 2005 guidelines did not support this practice because routine intrapartum suctioning does not prevent or alter the course of meconium aspiration syndrome in vigorous newborns. However, the 2005 guidelines did support intubation of...
Source: Obstetrics and Gynecology - February 23, 2017 Category: OBGYN Tags: Obstet Gynecol Source Type: research

Comparison of Pathogen Eradication Rate and Safety of Anti ‐bacterial Agents for Bronchitis: A Network Meta‐analysis
ConclusionsGemifloxacin and levofloxacin are more preferable than others for lowering respiratory tract inflammation and infections considering their balanced performance between pathogen eradication and adverse effects. This article is protected by copyright. All rights reserved (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - February 23, 2017 Category: Biochemistry Authors: Jinghua Wang, Haiyang Xu, Dunwei Wang, Mingxian Li Tags: Article Source Type: research

Evaluating Long Term Care Homes ’ IntraVenous Therapy Experiences (LIVE Study)
Traditionally, when long-term care (LTC) residents in Ontario, Canada require intravenous antibiotics, they have been transferred to hospital for this treatment. Hospital is not always the ideal location for the elderly to receive treatment as it often results in unfavorable health outcomes. There is evidence that receiving care in hospital may be associated with a reduction in quality of life, a decline in functional status and other unfavorable health outcomes for the elderly. This project aimed to ensure timely administration of intravenous (IV) therapy for lower respiratory tract infections (RTI), urinary tract infecti...
Source: Journal of the American Medical Directors Association - February 23, 2017 Category: Health Management Authors: Hrishikesh Navare, Daphne Broadhurst, Afeez Hazzan, Loretta Hillier, George Ioannidis, Mark Loeb, Hrishikesh Navare, Denis O'Donnell, Alexandra Papaioannou Tags: Education Source Type: research

Effective Use of Calcineurin Inhibitor in Combination Therapy for Interstitial Lung Disease in Patients With Dermatomyositis and Polymyositis
Objective: The current study demonstrated the potential use of calcineurin inhibitor (CNI) in combination therapy for interstitial lung disease (ILD) complicated with dermatomyositis (DM) and polymyositis (PM). Methods: Thirty DM/PM patients with ILD were enrolled in this study. Continuous intravenous administration of cyclosporine A (IV-CsA) was simultaneously started with corticosteroid in patients presenting more than two respiratory distress factors as follows: (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - February 23, 2017 Category: Rheumatology Tags: Original Articles Source Type: research

Issue Information
(Source: Respirology Case Reports)
Source: Respirology Case Reports - February 23, 2017 Category: Respiratory Medicine Tags: Issue Information Source Type: research

[Elderly patients and intensive care: Systematic review and geriatrician's point of view].
The objective of this review is to provide an overview of the literature about the management of elderly patients in intensive care unit and more specifically about epidemiology, admission criteria, mortality, functional prognosis and ethical aspects. We also discuss the data on cardiorespiratory arrest, shock, acute respiratory failure and delirium. The mortality rate of patients over 80 years old in intensive care unit can reach up to 70% at 1year, but is dependent on many factors, such as comorbidities or frailty. Above all, more than half of elderly patients recover their long-term autonomy. Their quality of life is co...
Source: Revue de Medecine Interne - February 23, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

The Association Between Neck Pain and Pulmonary Function: A Systematic Review
Abstract: The aim of this study was to systematically review the evidence on respiratory function changes in patients with chronic neck pain. MEDLINE, Elsevier, ProQuest, PubMed, Scopus, Springer, and Google scholar electronic databases were explored thorough December 2015. English-language studies investigating cervical musculoskeletal and respiratory parameters in patients with chronic neck pain were included. Characteristics of the patients, sampling method and size, musculoskeletal and respiratory parameters studied, and appropriateness of the statistical tests were considered. Studies were rated based on study design ...
Source: American Journal of Physical Medicine and Rehabilitation - February 23, 2017 Category: Rehabilitation Tags: Literature Review Source Type: research

Systematic Review of Postural Assessment in Individuals With Obstructive Respiratory Conditions: MEASUREMENT AND CLINICAL ASSOCIATIONS
CONCLUSIONS: Skeletal structural malalignment appears to be present in some individuals with an obstructive respiratory disease, although the extent of alterations and its clinical impact is variable. Photogrammetry is used to provide a comprehensive assessment of posture in these populations. (Source: Journal of Cardiopulmonary Rehabilitation)
Source: Journal of Cardiopulmonary Rehabilitation - February 23, 2017 Category: Rehabilitation Tags: Scientific Review Source Type: research

A simple metric for cystic fibrosis respiratory exacerbations
One of the most remarkable changes in disease trajectory over the past few decades has occurred through successful modulation of the severe and progressive lung disease of cystic fibrosis (CF). Early mortality has been strikingly reduced, with anticipated median survival now approaching 56 years of age, along with sustained improvements in lung function, comorbidities, and quality of life. Many advances in clinical interventions and standardization of care to apply best practices has contributed to enhanced outcomes. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 23, 2017 Category: Pediatrics Authors: Steven H. Abman Tags: The Editors' Perspectives Source Type: research

Optimize vaccination of patients with liver transplant
Probing a large pediatric administrative database, investigators determined the rate of hospitalizations in the first 2 years of age following liver transplantation among 2554 recipients who received transplants between 2004 and the end of 2012. Focusing on hospitalization due to respiratory syncytial virus (RSV) infection and vaccine-preventable infections, they found that 16.3% of patients had RSV or vaccine-preventable infection hospitalizations, and 3.6% had such an occurrence during their transplant hospitalization. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 23, 2017 Category: Pediatrics Authors: Sarah S. Long Tags: The Editors' Perspectives Source Type: research

Low rate of viral respiratory infections in infants in the NICU
Outbreaks of respiratory tract viral infections in neonatal intensive care units (NICUs) have been reported over the years, frequently with serious consequences in these highly vulnerable infants. Acquisition of respiratory viruses without typical manifestations of infection but with nonspecific worsening of neonatal cardiorespiratory, neurologic, or sepsis symptoms also has been suggested. Seeking evidence of viral respiratory tract infection when premature infants in the NICU have setbacks has become common practice. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 23, 2017 Category: Pediatrics Authors: Sarah S. Long Tags: The Editors' Perspectives Source Type: research

Primary adrenal insufficiency is associated with impaired natural killer cell function: a potential link to increased mortality.
CONCLUSIONS: Adrenal insufficiency is associated with significantly decreased NKCC, thereby potentially compromising early recognition and elimination of virally infected cells. This potential impairment in anti-viral immune defense may contribute to the increased rate of respiratory infections and ultimately mortality in PAI. PMID: 28223394 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - February 23, 2017 Category: Endocrinology Authors: Bancos I, Hazeldine J, Chortis V, Hampson P, Taylor AE, Lord JM, Arlt W Tags: Eur J Endocrinol Source Type: research

[Thymomectomy by minimally invasive surgery. Comparative study videosurgery versus robot-assisted surgery].
CONCLUSIONS: The minimally invasive route is safe, relatively atraumatic and may be incorporated in the therapeutic arsenal for the treatment of Masaoka stage I and II thymoma as an alternative to conventional sternotomy. RATS and VATS are two minimally invasive techniques and the results in the short and medium term are acceptable. The clinical advantages of one over the other are sifficult to establish. RATS could handle larger and more complex lesions in view of the weight and size of the operating instrument. PMID: 28216170 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - February 23, 2017 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Positionpaper on Telemonitoring in Sleep-Related Breathing Disorders].
Authors: Randerath W, Bögel M, Franke C, Hellmann A, Jany B, Nilius G, Penzel T, Voshaar T, Wiater A Abstract The use of telemonitoring in the care of patients with Sleep-related Breathing Disorders (SBD) can enhance medical support significantly. Telemonitoring aims at helping physicians to detect therapy problems early and thus improve patients' therapy adherence. Diagnostics and therapy decisions in the telemonitoring process nevertheless remain the responsibility of sleep specialists. The selection of data monitored, their evaluation and resulting consequences fall to the physician, who makes decisions and pre...
Source: Pneumologie - February 23, 2017 Category: Respiratory Medicine Tags: Pneumologie Source Type: research

Excess respiratory viral infections and low antibody responses among HIV-exposed, uninfected infants
Conclusion: Six-month-old HEUs had a higher incidence of respiratory viral infections than HUUs. In addition to the low passive protection from maternal antibodies, low antibody responses of HEUs may contribute to increased morbidity and mortality. (Source: AIDS)
Source: AIDS - February 23, 2017 Category: Infectious Diseases Tags: Clinical Science Source Type: research

Predictive value of thyroid hormones on the first day in adult respiratory distress syndrome patients admitted to ICU: comparison with SOFA and APACHE II scores
CONCLUSION:In critically ill patients, serum fT3 concentrations makedly decreased after ICU admission among non-survivors. According to our findings, fT3 levels might have additive discriminatory power to age. SOFA na APACHE II scores in predicting short-term mortality in ARDS patients admitted to ICU.   (Source: Annals of Saudi Medicine)
Source: Annals of Saudi Medicine - February 23, 2017 Category: Journals (General) Tags: ISSUE 6 Source Type: research

Oral and Sublingual Immunotherapy: Potential Causes for Eosinophilic Gastrointestinal Disorders
Food allergy is a common health problem worldwide, with increasing prevalence during recent decades. The only approved treatments for food allergy are food avoidance and administration of emergency medications in case of accidental exposure, which negatively affects patients' quality of life, so new treatments are highly desirable. Different food immunotherapy modalities have recently been used, with variable success rates in the induction of desensitization and tolerance, and different numbers and types of adverse reactions. Adverse reactions, especially intolerable gastrointestinal symptoms, are the most important causes...
Source: International Archives of Allergy and Immunology - February 23, 2017 Category: Allergy & Immunology Source Type: research

Drainage of pleural effusion improves diaphragmatic function in mechanically ventilated patients.
CONCLUSIONS: Drainage of a unilateral pleural effusion during weaning from mechanical ventilation improves diaphragmatic contractile activity and respiratory system performance. PMID: 28215134 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - February 23, 2017 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Rapid response team diagnoses: frequencies and related hospital mortality.
CONCLUSIONS: The RRT activation trigger provides only a general indication of the diagnosis. Some problems appear preventable and could provide a focus for unit-based quality initiatives. The mortality of some diagnoses is substantial, and this may help in setting treatment goals, but more work is needed to understand the association of RRT diagnosis and outcome. PMID: 28215135 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - February 23, 2017 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Rib fracture fixation in the 65 years and older population: A paradigm shift in management strategy at a Level I trauma center
BACKGROUND: Rib fractures after chest wall trauma are a common injury; however, they carry a significant morbidity and mortality risk. The impact of rib fractures in the 65-year and older patient population has been well documented as have the mortality and pneumonia rates. We hypothesize that patients 65 years and older receiving rib plating (RP) have decreased mortality, complication rates, and an accelerated return to normal functional states when compared with controls. METHODS: With institutional review board approval, a retrospective review analyzed patients 65 years and older with rib fractures admitted from 2009 t...
Source: Journal of Trauma and Acute Care Surgery - February 23, 2017 Category: Surgery Tags: Original Articles Source Type: research

Ultrasound assessment of volume responsiveness in critically ill surgical patients: Two measurements are better than one
BACKGROUND: The intended physiologic response to a fluid bolus is an increase in stroke volume (SV). Several ultrasound (US) measures have been shown to be predictive. The best measure(s) in critically ill surgical patients remains unclear. METHODS: This is a prospective observational study in critically ill surgical patients receiving a bolus of crystalloid, colloid or blood. A transthoracic echocardiogram was performed before (pre–transthoracic echocardiogram) and after. A positive volume response (+VR) was defined as a ≥15% increase in SV. Predictive measures were: left ventricular velocity time integral (VTI), res...
Source: Journal of Trauma and Acute Care Surgery - February 23, 2017 Category: Surgery Tags: EAST 2016 Plenary Paper Source Type: research

Damage control laparotomy utilization rates are highly variable among Level I trauma centers: Pragmatic, Randomized Optimal Platelet and Plasma Ratios findings
BACKGROUND: Damage control laparotomy (DCL) is intended to limit deleterious effects from trauma-induced coagulopathy. DCL has been associated with mortality reduction, but may increase complications including sepsis, abscess, respiratory failure, hernia, and gastrointestinal fistula. We hypothesized that (1) DCL incidence would vary between institutions; (2) mortality rates would vary with DCL rates; (3) standard DCL criteria of pH, international normalized ratio, temperature and major intra-abdominal vascular injury would not adequately capture all patients. METHODS: Trauma patients at 12 Level 1 North American trauma c...
Source: Journal of Trauma and Acute Care Surgery - February 23, 2017 Category: Surgery Tags: AAST 2016 Plenary Papers Source Type: research

Extracorporeal membrane oxygenation after traumatic injury
CONCLUSION: The use of venovenous ECMO for acute lung injury after trauma should be considered in special patient populations. Ability to tolerate systemic anticoagulation was associated with improved survival. LEVEL OF EVIDENCE: Therapeutic study, level V. (Source: Journal of Trauma and Acute Care Surgery)
Source: Journal of Trauma and Acute Care Surgery - February 23, 2017 Category: Surgery Tags: Brief Reports Source Type: research

First versus second year respiratory syncytial virus prophylaxis in chronic lung disease (2005 –2015)
Conclusions: SY and FY children had similar risks for RIH and RSVH. The findings imply that SY children with CLD are correctly selected for palivizumab based on neonatal illness severity and merit prophylaxis.What is Known:• Children with chronic lung disease have a 10-fold higher risk for RSV-positive hospitalization in comparison to healthy term infants and commonly receive palivizumab prophylaxis as a preventative measure against serious RSV-related lower respiratory tract infections.• The American Academy of Pediatrics [2] and the Canadian Paediatric Society [30] have recently modified their recommendations for RSV...
Source: European Journal of Pediatrics - February 23, 2017 Category: Pediatrics Source Type: research

The spectrum and outcome of surgical sepsis in Pietermaritzburg, South Africa.
CONCLUSIONS: The spectrum of SS in SA is different to that seen in the developed world. Intra-abdominal sepsis is the most common SS and is overwhelmingly caused by acute appendicitis. Diabetic foot infection is a major cause of SS, reflecting the increasing burden of non-communicable chronic diseases in SA. PMID: 28220740 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - February 23, 2017 Category: African Health Tags: S Afr Med J Source Type: research

[Media Watch] From Anthrax to Zika: memoirs of a disease detective
Swine flu, Middle East respiratory syndrome coronavirus, Ebola virus disease, Zika virus disease: in the past decade alone we have certainly not been bereft of headline-grabbing viral disease outbreaks. As soon as the media frenzy around the prevailing disease of the day begins to die down, it never takes long for a new contagion to step into the limelight. But as the world's attention and resources shift reactively from one high-profile outbreak to the next, is there sufficient emphasis on reflecting on these events and addressing the structural weaknesses that compromise our ability to prevent or mitigate the impact of f...
Source: The Lancet Infectious Diseases - February 23, 2017 Category: Infectious Diseases Authors: James W Rudge Tags: Media Watch Source Type: research

Persistent asthma phenotype related with late-onset, high atopy, and low socioeconomic status in school-aged Korean children
Treatment guidelines for asthma have been established based on asthma severity; there are limitations in the identification of underlying pathophysiology and prediction of prognosis in heterogeneous phenotypes... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - February 23, 2017 Category: Respiratory Medicine Authors: Eun Lee, Si Hyeon Lee, Ji-Won Kwon, Young-Ho Kim, Jisun Yoon, Hyun-Ju Cho, Song-I Yang, Young-Ho Jung, Hyung Young Kim, Ju-Hee Seo, Hyo Bin Kim, So Yeon Lee, Ho-Jang Kwon and Soo-Jong Hong Source Type: research

Efficacy of 1, 5, and 20  mg oral sildenafil in the treatment of adults with pulmonary arterial hypertension: a randomized, double-blind study with open-label extension
This study assessed whether lower doses were... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - February 23, 2017 Category: Respiratory Medicine Authors: Carmine Dario Vizza, B. K. S. Sastry, Zeenat Safdar, Lutz Harnisch, Xiang Gao, Min Zhang, Manisha Lamba and Zhi-Cheng Jing Source Type: research